A Description of Local and Nonlocal Eddy–Mean Flow Interaction in a Global Eddy-Permitting State Estimate

The assumption that local baroclinic instability dominates eddy–mean flow interactions is tested on a global scale using a dynamically consistent eddy-permitting state estimate. Interactions are divided into local and nonlocal. If all the energy released from the mean flow through eddy–mean flow interaction is used to support eddy growth in the same region, or if all the energy released from eddies through eddy–mean flow interaction is used to feed back to the mean flow in the same region, eddy–mean flow interaction is local; otherwise, it is nonlocal. Different regions have different characters: in the subtropical region studied in detail, interactions are dominantly local. In the Southern Ocean and Kuroshio and Gulf Stream Extension regions, they are mainly nonlocal. Geographical variability of dominant eddy–eddy and eddy–mean flow processes is a dominant factor in understanding ocean energetics.Woods Hole Oceanographic InstitutionUnited States. National Aeronautics and Space Administration (Grant NNX09AI87G)United States. National Aeronautics and Space Administration (Grant NNX08AR33G

Comprehensive transcriptome of the maize stalk borer, Busseola fusca, from multiple tissue types, developmental stages, and parasitoid wasp exposures

International audienc

Induction of mitochondrial recycling reverts age-associated decline of the hematopoietic and immune systems

Aging compromises hematopoietic and immune system functions, making older adults especially susceptible to hematopoietic failure, infections and tumor development, and thus representing an important medical target for a broad range of diseases. During aging, hematopoietic stem cells (HSCs) lose their blood reconstitution capability and commit preferentially toward the myeloid lineage (myeloid bias) <sup>1,2</sup> . These processes are accompanied by an aberrant accumulation of mitochondria in HSCs <sup>3</sup> . The administration of the mitochondrial modulator urolithin A corrects mitochondrial function in HSCs and completely restores the blood reconstitution capability of 'old' HSCs. Moreover, urolithin A-supplemented food restores lymphoid compartments, boosts HSC function and improves the immune response against viral infection in old mice. Altogether our results demonstrate that boosting mitochondrial recycling reverts the aging phenotype in the hematopoietic and immune systems

GrpE, Hsp110/Grp170, HspBP1/Sil1 and BAG Domain Proteins: Nucleotide Exchange Factors for Hsp70 Molecular Chaperones.

Molecular chaperones of the Hsp70 family are key components of the cellular protein folding machinery. Substrate folding is accomplished by iterative cycles of ATP binding, hydrolysis and release. The ATPase activity of Hsp70 is regulated by two main classes of cochaperones: J-domain proteins stimulate ATPase hydrolysis by Hsp70, while nucleotide exchange factors (NEF) facilitate its conversion from the ADP-bound to the ATP-bound state, thus closing the chaperone folding cycle. Beginning with the discovery of the prototypical bacterial NEF GrpE, a large diversity of Hsp70 nucleotide exchange factors has been identified, connecting Hsp70 to a multitude of cellular processes in the eukaryotic cell. Here we review recent advances towards structure and function of nucleotide exchange factors from the Hsp110/Grp170, HspBP1/Sil1 and BAG domain protein families and discuss how these cochaperones connect protein folding with quality control and degradation pathways