Comparación de modelos mensuales y anuales para estimar el coeficiente de Hargreaves en la Comunidad Valenciana

El modelo de Hargreaves (HG) para estimar evapotranspiración de referencia (ETo) es una alternativa interesante a la ecuación de Penman Monteith (PM), propuesta como método estándar por la FAO, pero que no es aplicable en muchas situaciones porque requiere muchas variables climáticas que no suelen estar disponibles o cuyos valores medidos no son fiables. Para la aplicación de esta ecuación se recomienda una calibración local preliminar del llamado coeficiente de Hargreaves (AHC). Sin embargo, la obtención de valores concretos de AHC tiene un uso limitado, dado que se requieren valores locales de PM, que se aplicará realmente para determinar la ETo de la estación. Asimismo los valores de AHC no pueden extrapolarse. Por ello es preciso proponer y estudiar modelos para estimar el AHC, dado que en las condiciones en las que la ecuación de HG pretende ser útil no habrá posibilidad de calibración previa mediante valores de PM. Este estudio analiza si están justificadas las parametrizaciones mensuales o estacionales del AHC. Para ello se compararon tres escalas temporales en el desarrollo de los modelos de AHC: la anual, la mensual y la estacional. Los resultados sugieren que el desarrollo de modelos mensuales podría reducir el error relativo alrededor del 2% para AHC diarios y alrededor de 1% para AHC medios mensuales, es decir, un único modelo anual de AHC podría ser insuficiente para recoger toda la variabilidad anual de AHC. Por ello, la aplicación de modelos mensuales (o estacionales) podría estar justificado para una correcta estimación de los AHC. Asimismo, los resultados muestran que la estimación mensual del AHC fue más ajustada de mayo a septiembre que de octubre a abril, y, particularmente, que de noviembre a enero

Assessment of weed control via foliar application of quinate

En estudios previos se detectó una importante acumulación de quinato en la parte aérea de las plantas tratadas con herbicidas inhibidores de la biosíntesis de aminoácidos, lo que podría explicar su capacidad de inducir la respuesta tóxica. También se evaluó el potencial efecto fitotóxico en función del modo de aplicación exógena, que fue superior tras aplicaciones radicales que foliares. En este trabajo se planteó valorar la utilización del quinato, pulverizado exógenamente, para el control del crecimiento de ciertas malas hierbas. Se realizaron aplicaciones foliares de quinato mediante pulverización en post-emergencia sobre plantas en diferentes estados fenológicos de “Sinapis alba”, “Papaver rhoeas”, “Lolium rigidum”, “Bromus diandrus” y “Cynodon dactylon”. Los resultados muestran que dicho compuesto presentó un mayor control y un efecto fitotóxico más evidente en las especies dicotiledóneas que en las monocotiledóneas, siendo “P. rhoeas” la única especie susceptible de ser controlada en sus estadios iniciales con este compuesto. En “S. alba” únicamente se produjo una reducción temporal del crecimiento sin llegar a ser letal.In previous studies quinate was accumulated in leaves of plants treated with amino acid biosynthesis inhibiting herbicides, which begged the question of whether quinate have the capacity of inducing the toxic effects of the herbicides. The phytotoxic effects of exogenous application were more evident when quinate was applied to the nutrient solution than when it was sprayed onto the foliage. The objective of this study was to evaluate whether sprayed quinate could control the growth of some weed species. This was evaluated by spraying quinate to the leaves of plants of “Sinapis alba”, “Papaver rhoeas”, “Lolium rigidum”, “Bromus diandrus” and “Cynodon dactylon” at different phenological states in postemergence. Exogenous application of quinate was more phytotoxic on dicotyledonous species than monocotyledonous species. “Papaver rhoeas” was the only species tested that would be potentially affected and controlled with the application of quinate, specifically in the initial states of plant development. Growth of “S. alba” was only temporally arrested after quinate application, but the treatment was not lethal

A Functional Safety OpenMP∗ for Critical Real-Time Embedded Systems

OpenMP* has recently gained attention in the embedded domain by virtue of the augmentations implemented in the last specification. Yet, the language has a minimal impact in the embedded real-time domain mostly due to the lack of reliability and resiliency mechanisms. As a result, functional safety properties cannot be guaranteed. This paper analyses in detail the latest specification to determine whether and how the compliant OpenMP implementations can guarantee functional safety. Given the conclusions drawn from the analysis, the paper describes a set of modifications to the specification, and a set of requirements for compiler and runtime systems to qualify for safety critical environments. Through the proposed solution, OpenMP can be used in critical real-time embedded systems without compromising functional safety.This work was funded by the EU project P-SOCRATES (FP7-ICT-2013- 10) and the Spanish Ministry of Science and Innovation under contract TIN2015- 65316-P.Peer ReviewedPostprint (author's final draft

Gas–Solid Heterogeneous Postsynthetic Modification of Imine-Based Covalent Organic Frameworks

This is the peer-reviewed version of the following article: Martín-Illian, J. A., Royuela, S., Ramos, M. M., Segura, J. L., & Zamora, F. (2020). Gas‐Solid Heterogeneous Post‐Synthetic Modification of Imine‐based Covalent Organic Frameworks. Chemistry–A European Journal. 26 (29), 6495-6498, which has been published in final form at https://doi.org/10.1002/chem.202000224. This article may be used for non-commercial purposes in accordance with Wiley-VCH Terms and Conditions for Self-ArchivingThe copper-catalyzed azide–alkyne cycloaddition (CuAAC) click reaction is among the most extensively used strategies for the post-polymerization modification of COFs. This work shows a new procedure for the postsynthetic functionalization of imine-based COFs by using a heterogeneous solid–gas reaction between alkyne-functionalized COFs and azides in the absence of a copper catalyst. This new alternative represents a step forward towards a greener postsynthetic modification of COFs opening a high potential for the development of new applicationsThis work was financially supported by MINECO (MAT2016‐77608‐C3‐1‐P and 2‐P

Acceso a jeringas estériles entre los jóvenes de Madrid y Barcelona que se inyectan drogas y su asociación con las prácticas de riesgo

[EN] To evaluate access to sterile syringes and its association with injection risk behaviour in Madrid and Barcelona. Cross-sectional community study by computer-assisted personal interview in 465 young heroin injectors between 2001 and 2003. Some 4.2% had not obtained any free sterile syringes in the previous 12 months. In Madrid 32.1% had obtained all their sterile syringes free of charge (ASSF), versus 44.6% in Barcelona (p<0.01). Not sharing (not using syringes used by someone else and not front/backloading) was associated with obtaining ASSF (OR=1.69) and with sporadic injection (OR=1.83). Not reusing one's own syringes was associated with the same two variables (OR=4.02 and OR=2.50, respectively). Access to sterile syringes is very high in Madrid and Barcelona, although the two cities have different approaches. The acquisition of all syringes free of charge should be facilitated, especially among frequent injectors. [ES] Evaluar el acceso a jeringas estériles y su asociación con prácticas de inyección de riesgo en Madrid y Barcelona. Material y método: Estudio transversal en la comunidad de 465 jóvenes que se inyectan heroína, realizado entre 2001 y 2003, mediante entrevista asistida por ordenador. Un 4,2% no obtuvo jeringas estériles gratuitas en los últimos 12 meses. En Madrid, el 32,1% obtuvo todas las jeringas estériles gratis (TJEG), frente al 44,6% de Barcelona (p < 0,01). No compartir (no utilizar jeringas ajenas usadas o droga diluida en las usadas por otros) se asoció con obtener TJEG (odds ratio [OR] = 1,69) e inyectarse esporádicamente (OR = 1,83). No reutilizar las jeringas propias se asoció con las mismas variables (OR = 4,02 y OR = 2,50, respectivamente). En Madrid y Barcelona el acceso a jeringas estériles es muy elevado, aunque con modelos diferentes. Debe facilitarse la obtención de todas las jeringas estériles gratis, especialmente entre los jóvenes que se inyectan con mayor frecuencia.This research was financed primarily by the Fundación para Investigación y la Prevención del Sida en España (FIPSE 3035/99 - Foundation for AIDS Research and Prevention in Spain); the analysis was possible thanks to the support of the Ciber de Epidemiología y Salud Pública.S

Prevalence and factors associated with a higher risk of neck and back pain among permanent wheelchair users: a cross-sectional study

[EN] Study design: Cross-sectional study. Objectives: To determine the prevalence of, and factors associated with, spinal pain among wheelchair users. Setting: Four Spanish hospitals specialized in providing care for wheelchair users. Methods: Persons who had used a wheelchair for a median (IRQ) of 10 (5;19) years, 27% of them due to reasons other than spinal cord injury, were recruited consecutively (n = 750). Data on 43 demographic, psychosocial, ergonomic, and clinical variables were collected, and analyzed. Main outcome measures were: Point prevalence of neck (NP), thoracic (TP), low back pain (LBP), and pain at any spinal level (PASL); and factors associated with them. Results: Point prevalence was 56% for NP, 54% for TP, 45% for LBP, and 76% for PSAL. PASL was associated with a lower quality of life (OR (95% CI) 0.91 (0.86; 0.97)). Multivariable regression models showed that the main factors associated with significant pain (≥1.5 VAS points) were: (a) For NP: Cervical spinal injury and wheelchair seat cushion thickness, (b) For TP: Thoracic spinal injury and sagittal index, (c) For LBP: Thoracic or lumbar spinal injury, with some sensitivity remaining, (d) For PASL: Being female, living alone, and using a non-power wheelchair. Discrimination (AUC) of these models ranged between 0.638 and 0.818. p-values in the Hosmer-Lemeshow test ranged between 0.420 and 0.701. Conclusions: Prevalence of spinal pain among wheelchair users is high. It is associated with a lower quality of life. Future studies should assess whether using a power wheelchair affects PASL, and if the thickness of seat cushion affects NP. Sponsorship: Spanish Back Pain Research NetworkS

Coupling of alpha(1)-Adrenoceptors to ERK1/2 in the Human Prostate

Introduction: alpha(1)-Adrenoceptors are considered critical for the regulation of prostatic smooth muscle tone. However, previous studies suggested further alpha(1)-adrenoceptor functions besides contraction. Here, we investigated whether alpha(1)-adrenoceptors in the human prostate may activate extracellular signal-regulated kinases (ERK1/2). Methods: Prostate tissues from patients undergoing radical prostatectomy were stimulated in vitro. Activation of ERK1/2 was assessed by Western blot analysis. Expression of ERK1/2 was studied by immunohistochemistry. The effect of ERK1/2 inhibition by U0126 on phenylephrine-induced contraction was studied in organ-bath experiments. Results: Stimulation of human prostate tissue with noradrenaline (30 mu M) or phenylephrine (10 mu M) resulted in ERK activation. This was reflected by increased levels of phosphorylated ERK1/2. Expression of ERK1/2 in the prostate was observed in smooth muscle cells. Incubation of prostate tissue with U0126 (30 mu M) resulted in ERK1/2 inhibition. Dose-dependent phenylephrine-induced contraction of prostate tissue was not modulated by U0126. Conclusions: alpha(1)-Adrenoceptors in the human prostate are coupled to ERK1/2. This may partially explain previous observations suggesting a role of alpha(1)-adrenoceptors in the regulation of prostate growth. Copyright (C) 2011 S. Karger AG, Base

The prognostic value of catastrophizing for predicting the clinical evolution of low back pain patients: a study in routine clinical practice within the Spanish National Health Service

Francisco Javier Cano García es miembro de la Spanish Back Pain Research Network (Red Española de Investigadores en Dolencias de la Espalda (REIDE) y coautor del artículoBackground context Experimental studies suggest that catastrophizing may worsen the prognosis of low back pain (LBP) and LBP-related disability and increase the risk of chronicity. Purpose To assess the prognostic value of baseline catastrophizing for predicting the clinical evolution of LBP patients in routine clinical practice and the association between the evolution of pain and catastrophizing. Study design/setting Prospective study in routine clinical practice of the Spanish National Health Service. Patient sample One thousand four hundred twenty-two acute and chronic adult LBP patients treated in primary and hospital care. Outcome measures Pain, disability, and catastrophizing measured through validated instruments. Methods Patients were managed according to routine clinical practice. Outcome measures were assessed at baseline and 3 months later. Logistic regression models were developed to estimate the association between baseline catastrophizing score and the improvement of LBP and disability, adjusting for baseline LBP and leg pain (LP) severity, disability, duration of the pain episode, workers' compensation coverage, radiological findings, failed back surgery, and diagnostic procedures and treatments undertaken throughout the study. Another model was developed to estimate the association between the evolution of LBP and the change in catastrophizing, adjusting for the same possible confounders plus the evolution of LP and disability. Models were repeated excluding the treatments undergone after the baseline assessment. Results Regression models showed that the degree of baseline catastrophizing does not predict the evolution of LBP and disability. Conversely, as the degree of pain improvement increases, so does the odds ratio for improvement in catastrophizing, ranging from three (95% confidence interval [95% CI], 2.00–4.50; p<.001) for improvements in pain between 1.1 and 4 visual analog scale (VAS) points, to 7.3 (95% CI, 3.49–15.36; p<.001) for improvements in pain more than 6.1 VAS points. Similar results were obtained when treatments were excluded from the models. Conclusions In routine practice, assessing the baseline score for catastrophizing does not help clinicians to predict the evolution of LBP and disability at 3 months.Spanish Ministry of Health’s Agency for QualityKovacs Foundatio

Shear traction‐separation laws of European beech under mode II loading by 3D digital image correlation

Funding Information: Part of the work was undertaken during a short-term scientific stay by the first author at the Faculty of Engineering (University of Porto) in 2021, with the financial support provided by Programa Propio de I+D+i 2021 de la Universidad Politécnica de Madrid. The work is part of the R&D&I Project PID2020-112954RA-I00 funded by MCIN/AEI/10.13039/501100011033. The authors gratefully acknowledge also Fundação para a Ciência e a Tecnologia (FCT-MCTES) for the financial support of the Laboratório Associado de Energia, Transportes e Aeronáutica (LAETA) by the project MCIN/AEI/10.13039/501100011033 and the Research and Development Unit for Mechanical and Industrial Engineering (UNIDEMI) by the project UIDB/00667/2020. Publisher Copyright: © 2022, The Author(s).An experimental and numerical study on mode II fracture behaviour of European beech (Fagus sylvatica L.) in the RL and TL crack propagation systems is performed. It is a hardwood species that has attracted increasing interest for structural use in Europe in recent years. Three-point end notched flexure tests are performed. The R-curves of both crack propagation systems are obtained, from which the critical strain energy release rate (GIIc) is derived by applying the compliance-based beam method. This data reduction scheme avoids crack length monitoring during its propagation, which is an advantage in wood. Using a direct method, the shear traction‐separation laws in mode II loading are determined. Full field displacements around the crack tip are monitored by 3D digital image correlation technique, and the crack tip shear displacements are analysed. The proposed method is numerically validated by finite element analysis. Cohesive zone models are developed implementing a shear traction–separation law with exponential damage evolution zone and the average value of the experimental elastic and fracture properties. The numerical results for the different properties including upper and lower limits represent well the experimental data.publishersversionepub_ahead_of_prin

Physician-Related Variability in the Outcomes of an Invasive Treatment for Neck and Back Pain: A Multi-Level Analysis of Data Gathered in Routine Clinical Practice

[EN] Neuro-reflexotherapy (NRT) is a proven effective, invasive treatment for neck and back pain. To assess physician-related variability in results, data from post-implementation surveillance of 9023 patients treated within the Spanish National Health Service by 12 physicians were analyzed. Separate multi-level logistic regression models were developed for spinal pain (SP), referred pain (RP), and disability. The models included all patient-related variables predicting response to NRT and physician-related variables. The Intraclass Correlation Coefficient (ICC) and the Median Odds Ratio (MOR) were calculated. Adjusted MOR (95% CI) was 1.70 (1.47; 2.09) for SP, 1.60 (1.38; 1.99) for RP, and 1.65 (1.42; 2.03) for disability. Adjusted ICC (95%CI) values were 0.08 (0.05; 0.15) for SP, 0.07 (0.03; 0.14) for RP, and 0.08 (0.04; 0.14) for disability. In the sensitivity analysis, in which the 6920 patients treated during the physicians’ training period were excluded, adjusted MOR was 1.38 (1.17; 1.98) for SP, 1.37 (1.12; 2.31) for RP, and 1.25 (1.09; 1.79) for disability, while ICCs were 0.03 (0.01; 0.14) for SP, 0.03 (0.00; 0.19) for RP, and 0.02 (0.00; 0.10) for disability. In conclusion, the variability in results obtained by different NRT-certified specialists is reasonable. This suggests that current training standards are appropriateS