Quantitative Trait Loci Associated with Milling and Baking Quality in a Soft X Hard Wheat Cross

Interclass hybridization between soft and hard wheat (Triticum aestivum L.) results in new genetic combinations of potential value

Les animaux comme révélateurs et passeurs de frontières.

peer reviewe

Histopathologic and Ultrastructural Features and Claudin Expression in Papillary Tumors of the Pineal Region

International audienc

Early skin-to-skin contact and risk of late-onset-sepsis in very and extremely preterm infants

International audienceBackgroundTo evaluate the association between exposure to early skin-to-skin contact (SSC) and incidence of late-onset sepsis (LOS) in extremely and very preterm infants.MethodsObservational study using the national population-based EPIPAGE-2 cohort in 2011. A propensity score for SSC exposure was used to match infants with and without exposure to SSC before day 4 of life and binomial log regression used to estimate risk ratios and CIs in the matched cohort. The primary outcome was at least one episode of LOS during hospitalization. Secondary outcomes were the occurrence of any late-onset neonatal infection (LONI), LOS with Staphylococcus or Staphylococcus aureus, incidence of LOS and LONI per 1000 central venous catheter days.ResultsAmong the 3422 included infants, 919 were exposed to early SSC. The risk ratio (RR) for LOS was 0.86 (95% CI, 0.67–1.10), for LONI was 1.00 (95% CI, 0.83–1.21), and for LOS with Coagulase-negative Staphylococcus or Staphylococcus aureus infection was 0.91 (95% CI, 0.68–1.21) and 0.77 (95% CI, 0.31–1.87). The incidence RR for LOS per-catheter day was 0.87 (95% CI, 0.64–1.18).ConclusionEarly SSC exposure was not associated with LOS or LONI risk. Thus, their prevention should not be a barrier to a wider use of SSC

Mitotic index, microvascular proliferation, and necrosis define 3 pathological subgroups of prognostic relevance among 1p/19q co-deleted anaplastic oligodendrogliomas.

CERVOXY COLLInternational audienc

Les approches écosystémiques de la santé dans la francophonie

Ce numéro spécial de [VertigO] – La revue électronique en science de l'environnement « Les approches écosystémiques de la santé dans la francophonie » présente différents écrits (articles, essais et billets) sur la pratique des approches écosystémiques de la santé à travers la présentation de ses défis, ses réalités et ses réalisations. Peu de publications valorisant l’apport important des francophones à ce courant ont été développées. Ce numéro spécial vise donc à offrir des publications en français qui permettront une meilleure diffusion de ces approches. Ce projet a été entrepris par la section Québec-Acadie-Atlantique de la Communauté de pratique canadienne sur les approches écosystémiques de la santé (CoPEH-Canada) en collaboration avec la Communauté de pratique Écosanté pour l’Afrique de l’Ouest et du centre (CoPES-AOC), le Groupe de recherche en épidémiologie des zoonoses et santé publique (GREZOSP) et l’École des Hautes Études en santé publique (EHESP) de Rennes

Prognostic Relevance of Histomolecular Classification of Diffuse Adult High-Grade Gliomas with Necrosis

CERVOXY COLLInternational audienc

Primary progressive aphasias associated with C9orf72 expansions: Another side of the story

International audienceC9orf72 repeat expansions are rarely associated with primary progressive aphasias (PPA). In-depth characterization of the linguistic deficits, and the underlying patterns of grey-matter atrophy in PPA associated with the C9orf72 expansions (PPA-C9orf72) are currently lacking. In this study, we comprehensively analyzed a unique series of 16 patients affected by PPA-C9orf72. Eleven patients were issued from two independent French and Finnish cohorts, and five were identified by means of literature review. Voxel-based morphometry (VBM) studies were performed on three of them. This study depicts the spectrum of C9orf72-related aphasic phenotypes, and illustrates their linguistic presentation. The non-fluent/agrammatic variant was the most frequent phenotype in our series (9/16 patients, 56%), with apraxia of speech being the main defining feature. Left frontal lobe atrophy was present in these subjects, peaking in inferior frontal gyrus. Three patients (19%) showed the semantic variant, with progression of atrophy in temporo-polar regions, later involving orbitofrontal cortex. Anterior temporal lobe dysfunction was also particularly relevant in two patients (12.5%) with mixed forms of PPA. Lastly, two patients (12.5%) had unclassifiable PPA with predominating word-finding difficulties. No PPA-C9orf72 patients in our series fulfilled the criteria of the logopenic variant. Importantly, this study underlines the role of C9orf72 mutation in the disruption of the most anterior parts of the language network, including prefrontal and temporo-polar areas. It provides guidelines for C9orf72 testing in PPA patients, with important clinical impact as gene-specific therapies are upcoming