Interactive maps: What we know and what we need to know

This article provides a review of the current state of science regarding cartographic interaction a complement to the traditional focus within cartography on cartographic representation. Cartographic interaction is defined as the dialog between a human and map mediated through a computing device and is essential to the research into interactive cartography geovisualization and geovisual analytics. The review is structured around six fundamental questions facing a science of cartographic interaction: (1) what is cartographic interaction (e.g. digital versus analog interactions interaction versus interfaces stages of interaction interactive maps versus mapping systems versus map mash-ups); (2) why provide cartographic interaction (e.g. visual thinking geographic insight the stages of science the cartographic problematic); (3) when should cartographic interaction be provided (e.g. static versus interactive maps interface complexity the productivity paradox flexibility versus constraint work versus enabling interactions); (4) who should be provided with cartographic interaction (e.g. user-centered design user ability expertise and motivation adaptive cartography and geocollaboration); (5) where should cartographic interaction be provided (e.g. input capabilities bandwidth and processing power display capabilities mobile mapping and location-based services); and (6) how should cartographic interaction be provided (e.g. interaction primitives objective-based versus operator-based versus operand-based taxonomies interface styles interface design)? The article concludes with a summary of research questions facing cartographic interaction and offers an outlook for cartography as a field of study moving forward

Meta-Analysis Reveals Both the Promises and the Challenges of Clinical Metabolomics

Clinical metabolomics is a rapidly expanding field focused on identifying molecular biomarkers to aid in the efficient diagnosis and treatment of human diseases. Variations in study design, metabolomics methodologies, and investigator protocols raise serious concerns about the accuracy and reproducibility of these potential biomarkers. The explosive growth of the field has led to the recent availability of numerous replicate clinical studies, which permits an evaluation of the consistency of biomarkers identified across multiple metabolomics projects. Pancreatic ductal adenocarcinoma (PDAC) is the third-leading cause of cancer-related death and has the lowest five-year survival rate primarily due to the lack of an early diagnosis and the limited treatment options. Accordingly, PDAC has been a popular target of clinical metabolomics studies. We compiled 24 PDAC metabolomics studies from the scientific literature for a detailed meta-analysis. A consistent identification across these multiple studies allowed for the validation of potential clinical biomarkers of PDAC while also highlighting variations in study protocols that may explain poor reproducibility. Our meta-analysis identified 10 metabolites that may serve as PDAC biomarkers and warrant further investigation. However, 87% of the 655 metabolites identified as potential biomarkers were identified in single studies. Differences in cohort size and demographics, p-value choice, fold-change significance, sample type, handling and storage, data collection, and analysis were all factors that likely contributed to this apparently large false positive rate. Our meta-analysis demonstrated the need for consistent experimental design and normalized practices to accurately leverage clinical metabolomics data for reliable and reproducible biomarker discovery

Efficiency, equality and labelling: an experimental investigation of focal points in explicit bargaining

Efficiency, equality and labelling: an experimental investigation of focal points in explicit bargainin

Guidance, Navigation, and Control for Agile Small Spacecraft with Articulating Solar Arrays

Payload operations for small satellites are often impacted by the need to allocate time for modifying the attitude to perform power generation or orbit maneuvering. A typical small satellite design would consist of a single rigid body with body-mounted solar cells, making the power generation subject to the spacecraft’s attitude. Often to achieve the high power generation that is required to enable the payload function, the attitude must be specifically set to maximize the solar cell area facing the Sun, which typically means diverting it from an attitude that is useful for payload operations for some period of time. At the scale of modern global constellations, these downtimes in the payload operation schedule can greatly reduce the overall capability of the system. By including deployable, articulating solar arrays in the design of small spacecraft, array pointing can be decoupled from the mainpayload pointing operations. With these pieces decoupled, payload operations can proceed uninterrupted while the articulating arrays ensure sufficient power generation. In this paper, the dynamic equations of the multibody system are derived, and guidance, navigation, and control (GNC) considerations are presented for achieving decoupled attitude and articulation objectives. Results from simulation of a sample mission show that agile target tracking attitude maneuvers can be performed together with array solar tracking with negligible impact on overall payload pointing performance

Ab initio many-body calculations of nucleon scattering on 4He, 7Li, 7Be, 12C and 16O

We combine a recently developed ab initio many-body approach capable of describing simultaneously both bound and scattering states, the ab initio NCSM/RGM, with an importance truncation scheme for the cluster eigenstate basis and demostrate its applicability to nuclei with mass numbers as high as 17. Using soft similarity renormalization group evolved chiral nucleon-nucleon interactions, we first calculate nucleon-4He phase shifts, cross sections and analyzing power. Next, we investigate nucleon scattering on 7Li, 7Be, 12C and 16O in coupled-channel NCSM/RGM calculations that include low-lying excited states of these nuclei. We check the convergence of phase shifts with the basis size and study A=8, 13, and 17 bound and unbound states. Our calculations predict low-lying resonances in 8Li and 8B that have not been experimentally clearly identified yet. We are able to reproduce reasonably well the structure of the A=13 low lying states. However, we find that A=17 states cannot be described without an improved treatment of 16O one-particle-one-hole excitations and alpha clustering.Comment: 18 pages, 20 figure

Considering uncertainties expands the lower tail of maize yield projections

Crop yields are sensitive to extreme weather events. Improving the understanding of the mechanisms and the drivers of the projection uncertainties can help to improve decisions. Previous studies have provided important insights, but often sample only a small subset of potentially important uncertainties. Here we expand on a previous statistical modeling approach by refining the analyses of two uncertainty sources. Specifically, we assess the effects of uncertainties surrounding crop-yield model parameters and climate forcings on projected crop yield. We focus on maize yield projections in the eastern U.S.in this century. We quantify how considering more uncertainties expands the lower tail of yield projections. We characterized the relative importance of each uncertainty source and show that the uncertainty surrounding yield model parameters is the main driver of yield projection uncertainty

Vitamin D Status of Infants in Northeastern Rural Bangladesh: Preliminary Observations and a Review of Potential Determinants

Vitamin D deficiency is a global public-health concern, even in tropical regions where the risk of deficiency was previously assumed to be low due to cutaneous vitamin D synthesis stimulated by exposure to sun. Poor vitamin D status, indicated by low serum concentrations of 25-hydroxyvitamin D [25(OH)D], has been observed in South Asian populations. However, limited information is available on the vitamin D status of young infants in this region. Therefore, to gain preliminary insights into the vitamin D status of infants in rural Bangladesh, 25(OH)D was assessed in a group of community-sampled control participants in a pneumonia case-control study in rural Sylhet, Bangladesh (25°N) during the winter dry season (January-February). Among 29 infants aged 1-6 months, the mean 25(OH)D was 36.7 nmol/L [95% confidence interval (CI) 30.2-43.2]. The proportion of infants with vitamin D deficiency defined by 25(OH)D <25 nmol/L was 28% (95% CI 10-45), 59% (95% CI 40-78) had 25(OH)D<40 nmol/L, and all were below 80 nmol/L. From one to six months, there was a positive correlation between age and 25(OH)D (Spearman=0.65; p=0.0001). Within a larger group of 74 infants and toddlers aged 1-17 months (cases and controls recruited for the pneumonia study), young age was the only significant risk factor for vitamin D deficiency [25(OH)D <25 nmol/L]. Since conservative maternal clothing practices (i.e. veiling) and low frequency of intake of foods from animal source (other than fish) were common among the mothers of the participants, determinants of low maternal-infant 25(OH)D in Bangladesh deserve more detailed consideration in future studies. In conclusion, the vitamin D status in young infants in rural Sylhet, Bangladesh, was poorer than might be expected based on geographic considerations. The causes and consequences of low 25(OH)D in infancy and early childhood in this setting remain to be established

A Collaborative Process for Developing Map Symbol Standards

AbstractGeographic information is commonly disseminated and consumed via visual representations of features and their environmental context on maps. Map design inherently involves generalizing reality, and one method by which mapmakers do so is through the use of symbols to represent features. Here we focus on the challenges associated with supporting mapmakers who need to work together to reach consensus on standardizing their map symbols. Based on a needs assessment study with mapmakers at the U.S. Department of Homeland Security, we designed a new, mixed-method symbol standardization process that takes place through a web-based, asynchronous platform. A study to test this new standardization process with mapmakers at DHS revealed that our process allowed participants to identify many issues related to symbol design, meaning, and categorization. The approach elicited sustained, iterative engagement and critical thinking from participants, and results from a post-study survey indicate that participants found it to be useful and usable. Results from our study and user feedback allow us to suggest multiple ways in which our approach and platform can be improved for future applications