Livre exposé : enjeux et méthodes d\u27une muséographie de l\u27écrit (Le)

Journées d\u27étude organisées en novembre 1999 par l\u27ENSSIB, la Bibliothèque municipale de Lyon et le Conseil de l\u27Europe dans le cadre du projet d\u27Itinéraire culturel du livre. Hubert Bari : Exposer le livre, est-ce imposer l\u27ennui ? Lenka Blazková : Les livres dans les musées en République Tchèque. Rosaria Campioni : La situation en Emilie-Romagne. Laura Gensini : Proposal for a book exhibition : elements ans methods of conservation and display. Mario Guaraldi : Nouveaux modèles de l\u27édition. Alan Marshall : Un musée des techniques comme outil de travail. James Mosley : La St. Bride printing Library. Daniel Traister : Exhibiting European books in American libraries

Le Soprintendenze bibliografiche dello Stato

The intervention sums up the story of the bibliographic Superintendences, ministerial offices funded in 1919 and transferred to the Regions in 1972, and talks about their positioning within the history of the cultural policies from the Italian unification onwards. Sources used have been legislative and regulatory acts, essays on the subject from different periods and written testimonies of sector's operators. The immediate reason for this has been the need to study the development of state and regional policies on this matter when reform interventions deeply modify the balance of the last forty years. The survey has outlined also the persistence of never-solved problems in the planning of public interventions: for example, different functions have been managed by eclectic structures and at the same time the performance of the single functions has been fragmented based on their own institutions

SARS-CoV-2 Isolation From Ocular Secretions of a Patient With COVID-19 in Italy With Prolonged Viral RNA Detection

Coronavirus disease 2019 (COVID-19), the disease caused by the novel severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) that originated in China in December 2019, was recently recognized as pandemic threat by the World Health Organization, with the potential of rapidly overloading health care systems and causing substantial mortality worldwide. Human-to-human transmission occurs mainly through respiratory droplets, but other routes are under investigation, because SARS-CoV-2 has been detected in several body fluids. So far, few data are available on ocular samples from patients with COVID-19, although conjunctivitis has been occasionally reported among COVID-19 symptoms, similar to infections caused by other human coronaviruses. During the SARS epidemic, eye exposure to infectious fluids was associated with an increased risk for SARS-CoV transmission to health care workers. Although SARS-CoV RNA was occasionally found in ocular specimens during the early phase of illness, its infectivity is unknown

Use of Pembrolizumab for Treatment of Progressive Multifocal Leukoencephalopathy in People Living with HIV

Progressive Multifocal Leukoencephalopathy (PML) is a demyelinating disease occurring in advanced HIV infection, caused by the reactivation of poliomavirus JC (JCV). The use of pembrolizumab for treatment is based on the inhibition of programmed cell death protein 1 (PD-1), potentially improving the anti JCV-specific response. We used pembrolizumab with combined antiretroviral treatment (cART) on a compassionate-use basis. At each administration, clinical evaluation, MRI and laboratory testing, including CD3, CD4, CD8, PD-1 markers, HIV-RNA and JCV-DNA in cerebrospinal fluid (CSF)/plasma pairs, were performed. The JCV-specific T cell response was analysed by Elispot assay. This study included five HIV patients: four male, median age 43 years (29–52), median CD4 and CD8 count 150 (15–158) and 973 (354–1250) cell/mm3, respectively; median JCV-DNA and HIV-RNA in CSF/plasma pairs 9.540/1.503 cps/mL and 2.230/619 cp/mL, respectively. Overall, patients received between two and seven doses of pembrolizumab. After treatment, we observed JCV-DNA reduction and PD-1 down-regulation both in CSF and in plasma (high in circulating CD4 and CD8 at baseline), which remained stable at low levels in all patients. Three out of five patients showed stability of clinical picture and neuroimaging, while two others died. More data are needed in order to identify predictors of response to therapy

A banchetto con gli amici. Scritti per Massimo Montanari

Massimo Montanari ha insegnato all’Università di Bologna per più di quarant’anni, prima Storia medievale e poi Storia dell'alimentazione, e ha dato vita al Master europeo in “Storia e cultura dell'alimentazione”. È senz’altro uno dei maggiori esperti internazionali di una storia dell’alimentazione intesa come sistema culturale che può restituire il passato nella sua interezza, ma è altrettanto noto per i suoi studi di storia agraria, anch’essi sempre intesi a raggiungere una ricostruzione a tutto tondo delle società medievali, indagandone le strutture economiche e sociali insieme con quelle politiche e culturali. Questo libro, concepito come omaggio alla sua figura di studioso e di maestro, cerca di restituire il poliedrico spettro dei suoi interessi intellettuali e delle relazioni professionali e umane che ha saputo costruire nel tempo. Studiosi, allievi, collaboratori e amici hanno partecipato a questo metaforico banchetto contribuendo, ciascuno secondo il proprio stile, alla vivace conversazione propria di una tavola riccamente imbandita