Esterilidade induzida em Rhodnius prolixus Stal. tratados com metepa (oxido de tris (1-(2 metil) aziridinil) fosforo) e a ação do mesmo sobre Trypanosoma cruzi

Analisaram-se os fatores que intervêm na esterilidade induzida quimicamente em R. prolixus, mediante aplicações tópicas de metepa em várias doses. Sugere-se a realização de investigações mais profundas sobre a suscetibilidade individual, objetivando o conhecimento da composição populacional em contato com o quimioesterilizante e o provável aparecimento da resistência. Investigou-se também a ação de metepa sobre T. cruzi em triatomineos infectados experimentalmente, com resultados negativos.The factors that interfere with the chemosterilization of R. prolixus, when metepa is applied topically, are analysed. It is suggested that similar studies, based on individual fertility of insects, be periodically made to detect the appearance of resistance in triatominae populations. Data with indicates that metepa has no effect on T. cruzi when R. prolixus were infected with the parasite after chemosterilization, are presented.Se analizan los factores que interfieren en la esterilidad inducida químicamente en R. Prolixus mediante aplicaciones tópicas en distintas dosis de metepa. Se sugiere profundizar el estudio de la susceptibilidad individual para conocer la composición de la población frente al quimioesterilizante y la probable aparición de resistencia. Se investiga además la acción del metepa sobre T. cruzi en triatominos infectados experimentalmente, obteniéndose resultados negativos

Falls in spinocerebellar ataxias: Results of the EuroSCA Fall Study

To investigate the frequency, details, and consequences of falls in patients with autosomal dominant spinocerebellar ataxias (SCAs) and to derive specific disease-related risk factors that are associated with an increased fall frequency. Two hundred twenty-eight patients with SCA1, SCA2, SCA3, or SCA6, recruited from the EuroSCA natural history study, completed a fall questionnaire that assessed the frequency, consequences, and several details of falls in the previous 12 months. Relevant disease characteristics were retrieved from the EuroSCA registry. The database of the natural history study provided the ataxia severity scores as well as the number and nature of non-ataxia symptoms. Patients (73.6%) reported at least one fall in the preceding 12 months. There was a high rate of fall-related injuries (74%). Factors that were associated with a higher fall frequency included: disease duration, severity of ataxia, the presence of pyramidal symptoms, the total number of non-ataxia symptoms, and the genotype SCA3. Factors associated with a lower fall frequency were: the presence of extrapyramidal symptoms (more specifically dystonia of the lower limbs) and the genotype SCA2. The total number of non-ataxia symptoms and longer disease duration were independently associated with a higher fall frequency in a logistic regression analysis, while the presence of extrapyramidal symptoms was independently associated with a lower fall frequency. Our findings indicate that, in addition to more obvious factors that are associated with frequent falls, such as disease duration and ataxia severity, non-ataxia manifestations in SCA play a major role in the fall etiology of these patients