3,799 research outputs found
Eligibility for randomized trials of treatments specifically for intracerebral hemorrhage: community-based study
Linkages of agroecosystems producing farmed seafood on food security, nutritional status and adolescent health in Bangladesh
Funding Information: We wish to acknowledge funding from Innovative Methods and Metrics for Agriculture and Nutrition Actions (IMMANA) to write this review. The research of BdR and AAS is supported by the Scottish Government's Rural and Environment Science and Analytical Services Division (RESAS). NR is funded by the University of Copenhagen, AG and TA are funded by the International Centre for Diarrhoeal Disease Research Bangladesh, AAM is funded by Noakhali Science and Technology University Bangladesh and FM and DL are funded by the University of Stirling.Peer reviewedPublisher PD
Deletion of low molecular weight protein tyrosine phosphatase (Acp1) protects against stress-induced cardiomyopathy.
The low molecular weight protein tyrosine phosphatase (LMPTP), encoded by the ACP1 gene, is a ubiquitously expressed phosphatase whose in vivo function in the heart and in cardiac diseases remains unknown. To investigate the in vivo role of LMPTP in cardiac function, we generated mice with genetic inactivation of the Acp1 locus and studied their response to long-term pressure overload. Acp1(-/-) mice develop normally and ageing mice do not show pathology in major tissues under basal conditions. However, Acp1(-/-) mice are strikingly resistant to pressure overload hypertrophy and heart failure. Lmptp expression is high in the embryonic mouse heart, decreased in the postnatal stage, and increased in the adult mouse failing heart. We also show that LMPTP expression increases in end-stage heart failure in humans. Consistent with their protected phenotype, Acp1(-/-) mice subjected to pressure overload hypertrophy have attenuated fibrosis and decreased expression of fibrotic genes. Transcriptional profiling and analysis of molecular signalling show that the resistance of Acp1(-/-) mice to pathological cardiac stress correlates with marginal re-expression of fetal cardiac genes, increased insulin receptor beta phosphorylation, as well as PKA and ephrin receptor expression, and inactivation of the CaMKIIδ pathway. Our data show that ablation of Lmptp inhibits pathological cardiac remodelling and suggest that inhibition of LMPTP may be of therapeutic relevance for the treatment of human heart failure
SCADA Online Product Quality Control
Controlling the quality of the product during the manufacturing phase is the process of analysis, control, management of factors and variables that affect the quality of the final product. Integrating the computer in the industrial manufacturing control will ensure the quality of the product, as well as to provide the necessary data for the production process progress, the ingredients ratio used in each production batch and statistical data of the changes that may occur in the composition of the product. Traditional methods to control the quality of the product are inadequate and inappropriate; they need to be changed to keep pace with the huge development in the field of industrial automation, control systems, industrial quality and computer technology used in various industries as well as clear development in the field of industrial sensors. This study falls into three-research area: integration of SPC and EPC, SCADA batch processes monitoring and control, and concrete batching plant. The objectives of this study are (a) To design a SCADA system for batch process monitoring and quality management, (b) To establish an integrated SPC/EPC methodology for a batch process, and (c) to illustrate the proposed approach with an application of the analysis and monitoring of an industrial concrete batching plant. The concrete batching plant has different batch processing subsystems, but the aggregate batching process has the greatest impact on product quality, unfortunately, this industrial process is poorly automated, in most plants in Gaza strip. The traditional control or even the manual control is still common which leads to uneven mixtures and inconsistent product quality subject to several disturbances. A complete PLC system is designed for full-automated concrete plant, with new aggregate weighing and batching algorithm implemented for adaptive flow rate and feeding speed control. Through this study ,the implemented algorithm and SCADA system , process engineers at the industrial plants are now able to use a valuable decision making tool when the production process is affected by certain disruptions, with obvious consequences on product quality, productivity and competitiveness
Augmented feedback approach to double-leg squat training for patients with knee osteoarthritis: a preliminary study
The aim of this preliminary study was to explore the effects of two types of augmented feedback on the strategy used by healthy participants and patients with knee osteoarthritis (OA) to perform a double-leg squat. Seven patients with knee OA and seven healthy participants performed three sets of eight double-leg squats: one without feedback, one with real-time kinematic feedback and one with real-time kinetic feedback. Kinematic and kinetic outcome measures (peak knee flexion angle, peak knee extensor moment, and symmetry of the support knee moment between the injured and non-injured knees) demonstrate the potential influence of real-time kinetic feedback on the motor strategy used to perform a double-leg squat in both groups. This feedback could be used to develop more efficient and effective motor strategies for squatting in patients with knee OA and further evaluation is warranted
Augmented feedback approach to double-leg squat training for patients with knee osteoarthritis: a preliminary study
The aim of this preliminary study was to explore the effects of two types of augmented feedback on the strategy used by healthy participants and patients with knee osteoarthritis (OA) to perform a double-leg squat. Seven patients with knee OA and seven healthy participants performed three sets of eight double-leg squats: one without feedback, one with real-time kinematic feedback and one with real-time kinetic feedback. Kinematic and kinetic outcome measures (peak knee flexion angle, peak knee extensor moment, and symmetry of the support knee moment between the injured and non-injured knees) demonstrate the potential influence of real-time kinetic feedback on the motor strategy used to perform a double-leg squat in both groups. This feedback could be used to develop more efficient and effective motor strategies for squatting in patients with knee OA and further evaluation is warranted
Adolescent girls in aquaculture ecozones at risk of nutrient deficiency in Bangladesh development and validation of an integrated metric
Acknowledgements We wish to acknowledge funding from the Innovative Methods and Metrics for Agriculture and Nutrition Actions (IMMANA) to undertake this research. We acknowledge the Nutritional Analytical Service, University of Stirling, United Kingdom for laboratory analyses. The work of BdR and AAS is funded by the Scottish Government Rural & Environment Science & Analytical Services. Funding This work is funded through the Innovative Methods and Metrics for Agriculture and Nutrition Actions (IMMANA) programme. IMMANA Phase 1 is funded with UK Aid from the UK government, led by the London School of Hygiene and Tropical Medicine (LSHTM).Peer reviewedPublisher PD
Application of compression test in analysis of mechanical and color changes in grapefruit juice powder as related to glass transition and water activity
Physicochemical and structural properties of grapefruit juice powder were studied as affected by water activity. Powdered juice was obtained by freeze-drying and equilibrated at different water vapor pressure atmospheres in order to give samples with water activity in the range of 0-084 The mechanical properties of the powder were measured by confined compression tests and the compressed samples, which presented uniform surface and thickness, were subjected to color analysis The maximum force attained during the compression tests and the color coordinates could be quantified with good reproducibility. The results were related to water activity and to glass transition temperature The occurrence of mechanical changes in the powder was shown to precede significant color changes with increasing water activity. Considering the susceptibility to stickiness, the stability limit was observed at T-T(g) approximate to 2 degrees C, with a high degree of mechanical changes being detected at T-Tg 16 degrees C, whereas for significant color changes this critical temperature difference was around 32 degrees CAuthors thank the Ministerio de Educacion y Ciencia and the Fondo Europeo de Desarrollo Regional (FEDER) for the financial support throughout the projects AGL2002-01793 and AGL 200505994. Vania R. N. Tells acknowledges the support of the Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES) as an external grant (Proc. BEX 4452/06-2).Telis, VRN.; Martínez Navarrete, N. (2010). Application of compression test in analysis of mechanical and color changes in grapefruit juice powder as related to glass transition and water activity. Food Science and Technology. 43(5):744-751. https://doi.org/10.1016/j.lwt.2009.12.007S74475143
Factors affecting the micronutrient status of adolescent girls living in complex agro-aquatic ecological zones of Bangladesh
Acknowledgements The study was conducted in collaboration with Noakhali Science and Technology University (NSTU), icddr,b, University of Stirling, University of Copenhagen, University of Aberdeen, and the University of Glasgow. We acknowledge with gratitude the commitment of all investigators from all of the collaborating institutes. icddr,b is also grateful to the Governments of Bangladesh, Canada, Sweden, and the UK for providing core support. Funding This work is funded through the Innovative Methods and Metrics for Agriculture and Nutrition Action (IMMANA) programme, led by the London School of Hygiene & Tropical Medicine (LSHTM). IMMANA is co-funded with UK Aid from the UK government and by the Bill & Melinda Gates Foundation INV-002962 / OPP1211308. Under the grant conditions of the Foundation, a Creative Commons Attribution 4.0 Generic License has already been assigned to the Author Accepted Manuscript version that might arise from this submission.Peer reviewedPublisher PD
Entanglement dynamics of two-bipartite system under the influence of dissipative environments
An experimental scheme is suggested that permits a direct measure of
entanglement in a two-qubit cavity system. It is realized in the cavity-QED
technology utilizing atoms as flying qubits. With this scheme we generate two
different measures of entanglement, namely logarithmic negativity and
concurrence. The phenomenon of sudden death entanglement (ESD) in a bipartite
system subjected to dissipative environment is examined. We show that the
sudden death time of the entangled states depends on the initial preparation of
the entangled state and the temperature of the reservoir.Comment: 21 pages, 13 figure
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