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Ceramic stationary gas turbine
The performance of current industrial gas turbines is limited by the temperature and strength capabilities of the metallic structural materials in the engine hot section. Because of their superior high-temperature strength and durability, ceramics can be used as structural materials for hot section components (blades, nozzles, combustor liners) in innovative designs at increased turbine firing temperatures. The benefits include the ability to increase the turbine inlet temperature (TIT) to about 1200{degrees}C ({approx}2200{degrees}F) or more with uncooled ceramics. It has been projected that fully optimized stationary gas turbines would have a {approx}20 percent gain in thermal efficiency and {approx}40 percent gain in output power in simple cycle compared to all metal-engines with air-cooled components. Annual fuel savings in cogeneration in the U.S. would be on the order of 0.2 Quad by 2010. Emissions reductions to under 10 ppmv NO{sub x} are also forecast. This paper describes the progress on a three-phase, 6-year program sponsored by the U.S. Department of Energy, Office of Industrial Technologies, to achieve significant performance improvements and emissions reductions in stationary gas turbines by replacing metallic hot section components with ceramic parts. Progress is being reported for the period September 1, 1994, through September 30, 1995
The velocity of ball-carriers and tacklers during shoulder tackles
The most frequently executed type of tackle in rugby is the shoulder tackle. A shoulder tackle occurs when the tackler uses either shoulder as the first point of contact with the ball carrier. The aim of this study was to compare the velocity of the ball-carrier and tackler engaged in shoulder tackles, and determine whether factors such as the number of passes from the previous phase, match period, quality of attack, match location and position of tackler had an effect on the mean and approaching velocities of the ball-carrier and tackler. The velocity of the ball-carrier and tackler during shoulder tackles (n=12) were determined using a 2D analysis tool. The tackles were also coded according to pass number, match period, quality of defence and attack, match status, defensive shape and movement, position of tackler and ball-carrier. The ball-carrier's velocity (4.10±1.85m.s-1) when entering contact was significantly higher than the tackler's velocity (5.19±3.22 m.s–1)(p<0.05). The ball-carrier's velocity was significantly higher when entering contact further from the set piece (p<0.001), when playing away from home (p<0.001) and when ranked in the top three (p<0.001). The findings of this study provide insight into the complexities of the tackle in rugby
Immune-mediated competition in rodent malaria is most likely caused by induced changes in innate immune clearance of merozoites
Malarial infections are often genetically diverse, leading to competitive interactions between parasites. A quantitative understanding of the competition between strains is essential to understand a wide range of issues, including the evolution of virulence and drug resistance. In this study, we use dynamical-model based Bayesian inference to investigate the cause of competitive suppression of an avirulent clone of Plasmodium chabaudi (AS) by a virulent clone (AJ) in immuno-deficient and competent mice. We test whether competitive suppression is caused by clone-specific differences in one or more of the following processes: adaptive immune clearance of merozoites and parasitised red blood cells (RBCs), background loss of merozoites and parasitised RBCs, RBC age preference, RBC infection rate, burst size, and within-RBC interference. These processes were parameterised in dynamical mathematical models and fitted to experimental data. We found that just one parameter μ, the ratio of background loss rate of merozoites to invasion rate of mature RBCs, needed to be clone-specific to predict the data. Interestingly, μ was found to be the same for both clones in single-clone infections, but different between the clones in mixed infections. The size of this difference was largest in immuno-competent mice and smallest in immuno-deficient mice. This explains why competitive suppression was alleviated in immuno-deficient mice. We found that competitive suppression acts early in infection, even before the day of peak parasitaemia. These results lead us to argue that the innate immune response clearing merozoites is the most likely, but not necessarily the only, mediator of competitive interactions between virulent and avirulent clones. Moreover, in mixed infections we predict there to be an interaction between the clones and the innate immune response which induces changes in the strength of its clearance of merozoites. What this interaction is unknown, but future refinement of the model, challenged with other datasets, may lead to its discovery
South Africa's Socio-Techno Divide: A critical disourse analysis of government speeches
This paper aims at contributing to the debate about the digital divide. We first focus on what to us constitutes the root problem: the typical approaches to the development of people through and by the use of information and communication technologies (ICT). In contrast to governmental, political and technological attempts that focus almost exclusively on providing access to digital communication technologies, and expect "development" naturally to flow from that, we argue for a focus on "development" which is based on our notion of sustainable socio-economic development. We refer to "technocentric approaches" when the approaches propose and pursue technological interventions and show little regard for the actual needs of the people involved. At the other end of the scale, where the focus is on people and their developmental needs, we will speak of "sociocentric approaches". This presents us with a different divide, which we will refer to as the "socio-techno divide". We argue that it is this divide that has to be addressed - not the digital divide - and then present an analysis of the socio-techno divide. This analysis takes the form of two types of Critical Discourse Analysis (CDA), namely Foucauldian and Habermassian. The analysis of the South African government's rhetoric illuminates the issues that need our attention and indicates an agenda for constructive engagement about the use of ICT for development in the Third and Fourth worlds
Properties of the conditionally filtered equations: Conservation, normal modes, and variational formulation
This is the author accepted manuscript. The final version is available from Wiley via the DOI in this record.Conditionally filtered equations have recently been proposed as a basis for modelling
the atmospheric boundary layer and convection. Conditional filtering decomposes the
fluid into a number of categories or components, such as convective updrafts and the
background environment, and derives governing equations for the dynamics of each
component. Because of the novelty and unfamiliarity of these equations, it is important
to establish some of their physical and mathematical properties, and to examine whether
their solutions might behave in counter-intuitive or even unphysical ways. It is also
important to understand the properties of the equations in order to develop suitable
numerical solution methods. The conditionally filtered equations are shown to have
conservation laws for mass, entropy, momentum or axial angular momentum, energy,
and potential vorticity. The normal modes of the conditionally filtered equations include
the usual acoustic, inertio-gravity, and Rossby modes of the standard compressible Euler
equations. In addition, they posses modes with different perturbations in the different
fluid components that resemble gravity modes and inertial modes but with zero pressure
perturbation. These modes make no contribution to the total filter-scale fluid motion,
and their amplitude diminishes as the filter scale diminishes. Finally, it is shown that
the conditionally filtered equations have a natural variational formulation, which can be
used as a basis for systematically deriving consistent approximations.We are grateful to two anonymous reviewers for their constructive comments on an earlier version of this paper. This work was funded by the Natural Environment Research Council under grant NE/N013123/1 as part of the ParaCon programme
Industrial bees: the impact of apicultural intensification on local disease 1 prevalence
This is the author accepted manuscript. The final version is available from Wiley via the DOI in this record.1) It is generally thought that the intensification of farming will result in higher disease prevalences,
although there is little specific modelling testing this idea. Focussing on honeybees, we build multi18 colony models to inform how ‘apicultural intensification’ is predicted to impact honeybee pathogen
epidemiology at the apiary scale.
2) We used both agent-based and analytical models to show that three linked aspects of apicultural
intensification (increased population sizes, changes in population network structure, and increased
between-colony transmission) are unlikely to greatly increase disease prevalence in apiaries.
Principally this is because even low-intensity apiculture exhibits high disease prevalence.
3) The greatest impacts of apicultural intensification are found for diseases with relatively low R0 (basic
reproduction number), however, such diseases cause little overall disease prevalence and therefore
the impacts of intensification are minor. Furthermore, the smallest impacts of intensification are for
diseases with high R0 values, which we argue are typical of important honeybee diseases.
4) Policy Implications: Our findings contradict the idea that apicultural intensification by crowding
honeybee colonies in large, dense apiaries leads to notably higher disease prevalences for
established honeybee pathogens. More broadly, our work demonstrates the need for informative
models of all agricultural systems and management practices in order to understand the implications
of management changes on diseasesBiotechnology & Biological Sciences Research Council (BBSRC
How ownership rights over microorganisms affect infectious disease control and innovation: A root-cause analysis of barriers to data sharing as experienced by key stakeholders.
Genetic information of pathogens is an essential input for infectious disease control, public health and for research. Efficiency in preventing and responding to global outbreaks relies on timely access to such information. Still, ownership barriers stand in the way of timely sharing of genetic data from pathogens, frustrating efficient public health responses and ultimately the potential use of such resources in innovations. Under a One Health approach, stakeholders, their interests and ownership issues are manifold and need to be investigated. We interviewed key actors from governmental and non-governmental bodies to identify overlapping and conflicting interests, and the overall challenges for sharing pathogen data, to provide essential inputs to the further development of political and practical strategies for improved data sharing practices
A single-column model intercomparison of a heavily drizzling stratocumulus-topped boundary layer
This study presents an intercomparison of single-column model simulations of a nocturnal heavily drizzling marine stratocumulus-topped boundary layer. Initial conditions and forcings are based on nocturnal flight observations off the coast of California during the DYCOMS-II field experiment. Differences in turbulent and microphysical parameterizations between models were isolated by slightly idealizing and standardizing the specification of surface and radiative fluxes. For most participating models, the case was run at both typical operational vertical resolution of about 100 m and also at high vertical resolution of about 10 m. As in prior stratocumulus intercomparisons, the simulations quickly develop considerable scatter in liquid water path (LWP) between models. However, the simulated dependence of cloud base drizzle fluxes on LWP in most models is broadly consistent with recent observations. Sensitivity tests with drizzle turned off show that drizzle substantially decreases LWP for many models. The sensitivity of entrainment rate to drizzle is more muted. Simulated LWP and entrainment are also sensitive to the inclusion of cloud droplet sedimentation. Many models underestimate the fraction of drizzle that evaporates below cloud base, which may distort the simulated feedbacks of drizzle on turbulence, entrainment, and LWP
Identification of compounds responsible for the anthelmintic effects of chicory (Cichorium intybus) by molecular networking and bio-guided fractionation
10 páginas, 7 figuras.Increasing resistance towards anthelmintic drugs has necessitated the search for alternative treatments for the control of gastrointestinal nematode parasites. Animals fed on chicory (Cichorium intybus L.), a temperate (pasture) crop, have reduced parasite burdens, hence making C. intybus a potentially useful source for novel anthelmintic compounds or a diet-based preventive/therapeutic option. Here, we utilized in vitro bioassays with the parasitic nematode Ascaris suum and molecular networking techniques with five chicory cultivars to identify putative active compounds. Network analysis predicted sesquiterpene lactones (SL) as the most likely group of anthelmintic compounds. Further bioassay-guided fractionation supported these predictions, and isolation of pure compounds demonstrated that the SL 8-deoxylactucin (8-DOL) is the compound most strongly associated with anti-parasitic activity. Furthermore, we showed that 8-DOL acts in a synergistic combination with other SL to exert the anti-parasitic effects. Finally, we established that chicory-derived extracts also showed activity against two ruminant nematodes (Teladorsagia circumcincta and Cooperia oncophora) in in vitro assays. Collectively, our results confirm the anti-parasitic activity of chicory against a range of nematodes, and pave the way for targeted extraction of active compounds or selective breeding of specific cultivars to optimize its future use in human and veterinary medicine.We are very grateful for the guidance and support by Dr. Thomas Ostenfeld Larsen and Christopher Phippen, Technical University of Denmark, Natural product discovery, and the laboratory assistance of Mette Schjelde, University of Copenhagen. This work was funded by the Danish Council for Independent Research (Grant DFF–6111-00394). Fractionation and purification of compounds were further supported by the Green Development and Demonstration Program (GUDP) (Project No. 34009-17-1220). MPE was supported by CONICYT Chile (FONDE-CYT Postdoctorado #317087
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