Poly(styrene-alt-maleic anhydride) derivatives as potent anti-HIV microbicide candidates

Topical microbicides offer women the opportunity to protect themselves from sexual HIV transmission under their own control. A series of poly[styrene-alt-(maleic anhydride)] derivatives were prepared by amidation or hydrolysis of the anhydride moiety. The derivatives were shown to be of low cell toxicity and effectively inhibited HIV-1 infections in an in vitro cellular model. Poly[styrene-alt-(maleic acid, sodium salt)] was the most potent inhibitor, being 100-fold more potent than dextran sulfate suggesting its potential application as a new class of polyanionic microbicides. (C) 2009 Elsevier Ltd. All rights reserved.National Natural Science Foundation of China [20842001]; Chinese 863 Project [2006AA02Z164]; Ministry of Health of China [2008ZX10001-015

Phantom study of a self-shielded X-ray bone age assessment instrument against scattered radiation in children

Hand-wrist radiography is the most common and accurate method for evaluating children's bone age. To reduce the scattered radiation of radiosensitive organs in bone age assessment, we designed a small X-ray instrument with radioprotection function by adding metal enclosure for X-ray shielding. We used a phantom operator to compare the scattered radiation doses received by sensitive organs under three different protection scenarios (proposed instrument, radiation personal protective equipment, no protection). The proposed instrument showed greater reduction in the mean dose of a single exposure compared with radiation personal protective equipment especially on the left side which was proximal to the X-ray machine (≥80.0% in eye and thyroid,  ≥99.9% in breast and gonad). The proposed instrument provides a new pathway towards more convenient and efficient radioprotection. [Abstract copyright: © 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

SonoKnife: Feasibility of a line-focused ultrasound device for thermal ablation therapy

Purpose: To evaluate the feasibility of line-focused ultrasound for thermal ablation of superficially located tumors