Rubella Immunization of Adult Females Using HPV-77 DK-12 Live Attenuated Rubella Virus

This study demonstrates the serologic response as measured by the HAl test and the side reactions of the HPV-77 DK-12 live rubella vaccine in a small group of adult females. One hundred percent seroconversion was obtained using this vaccine. The mean titers obtained in two separate time periods post-vaccination are higher than those reported for several other rubella virus vaccines. A 66% occurrence of joint symptomatology was recorded post-vaccination with a mean duration of 11.6 days; 24% of women who received placebo reported joint complaints which had a mean duration of 2.0 days. The difference between these two rates is somewhat greater than that reported for other HPV-77 strain vaccines and the average duration of these complaints is longer. The other symptoms reported postvaccination seemed insignificant when comparing both the placebo and the vaccine group. One woman became pregnant three months after vaccination and was subsequently therapeutically aborted. At the time of therapeutic abortion, attempts were unsuccessful to recover rubella virus from the products of conception and cervical swabs

The OpenMolcas Web: A Community-Driven Approach to Advancing Computational Chemistry

The developments of the open-source OpenMolcas chemistry software environment since spring 2020 are described, with a focus on novel functionalities accessible in the stable branch of the package or via interfaces with other packages. These developments span a wide range of topics in computational chemistry and are presented in thematic sections: electronic structure theory, electronic spectroscopy simulations, analytic gradients and molecular structure optimizations, ab initio molecular dynamics, and other new features. This report offers an overview of the chemical phenomena and processes OpenMolcas can address, while showing that OpenMolcas is an attractive platform for state-of-the-art atomistic computer simulations

Penicillin-resistant Viridans Streptococcus Endocarditis Related to the Administration of Penicillin G or Carbenicillin and Alterations in Mouth Flora

Of 135 patients with streptococcal (non-group D) endocarditis seen at the Henry Ford Hospital (1957-1973), 133 had isolates which were penicillin- sensitive (inhibited by ≤ 0.2 μg/ml of penicillin C). The remaining two causative organisms were inhibited by 0.8 μg/ml of penicillin G and both of the infected patients received antibiotics just prior to the onset of endocarditis. The first patient received oral penicillin C for rheumatic fever prophylaxis and the second high dose parenteral carbenicillin. Using high dose parenteral therapy with ampicillin and streptomycin, the first patient was cured while the other patient relapsed. The second patient responded to retreatment with clindamycin. As reported in prior studies following oral penicillin administration, these current studies demonstrated penicillinresistant viridans streptococci in the oropharynx of patients receiving parenteral carbenicillin (avg. MIC 0.56 μg/ml). Therefore, carbenicillin-induced changes in the oral flora are important in selecting antibiotics for prophylaxis or treatment of endocarditis in a patient with pre-existing valvular disease

Nocardia Asteroides aortitis with perforation of the aorta

A 53-year-old man died of nocardial aortitis eight months after undergoing aortic valve replacement. Autopsy revealed vegetation in the area of a previous aortotomy incision and a small perforation of the aorta enclosed by pericardium immediately above the prosthetic valve ring. Prosthetic valve endocarditis was not present. Multiple splenic infarcts, microabscesses of both kidneys, and myocarditis were identified. Antemortem blood cultures and postmortem cultures of the aortic vegetation grew Nocardia asteroides

The OpenMolcas <i>Web</i>: A Community-Driven Approach to Advancing Computational Chemistry

The developments of the open-source Open-Molcas chemistry software environment since spring 2020 are described, with a focus on novel functionalities accessible in the stable branch of the package or via interfaces with other packages. These developments span a wide range of topics in computational chemistry and are presented in thematic sections: electronic structure theory, electronic spectroscopy simulations, analytic gradients and molecular structure optimizations, ab initio molecular dynamics, and other new features. This report offers an overview of the chemical phenomena and processes OpenMolcas can address, while showing that OpenMolcas is an attractive platform for state-of-the-art atomistic computer simulations