‘Asesinato en el Comité Central’ (Vicente Aranda, 1982): el ‘thriller’ político como esperpento1

Asesinato en el Comité Central, de Vicente Aranda (1982), es la segunda adaptación cinematográfica (tras Tatuaje, de Bigas Luna, 1976) del personaje literario Pepe Carvalho, creado por Manuel Vázquez Montalbán. Se trata de un thriller político que en su momento no tuvo ni fortuna crítica ni éxito de taquilla y que, en parte, fue repudiado por su propio director. Sin embargo, el tiempo nos permite proceder a una relectura que valore su clara raíz esperpéntica, que considere el texto como síntoma de hartazgo con el género producido por un contexto histórico y cultural muy particular.‘Murder in the Central Committee’ (Vicente Aranda, 1982): A Grotesque and Absurd Ending for Spanish Political ThrillerMurder in the Central Committee (1982) is the second film adaptation of Pepe Carvalho, the famous literary detective created by Manuel Vázquez Montalbán (following Tatuaje by Bigas Luna in 1976). The film is a political thriller which was poorly received both by critics and at the box office, and was also partially forsaken by its own director, Vicente Aranda. Nevertheless, the passing of time allows us to revisit the film and evaluate its clearly grotesque and absurd roots, which the text considers to be a symptom of the abundance of thrillers produced during the very specific historic and cultural context of the time

La pistola y el corazón. Conversaciones con Agustín Díaz Yanes

Sociedad de Derechos de Autor de Medios Audiovisuales (DAMA). Proyecto I+D+i “El cine y la televisión en la España de la post-Transición (1979-1992)”. Ministerio de Economía y Competitividad de España, Gobierno de España, CSO2012-31895

‘Murder in the Central Committee’ (Vicente Aranda, 1982): A Grotesque and Absurd Ending for Spanish Political Thriller

Asesinato en el Comité Central, de Vicente Aranda (1982), es la segunda adaptación cinematográfica (tras Tatuaje, de Bigas Luna, 1976) del personaje literario Pepe Carvalho, creado por Manuel Vázquez Montalbán. Se trata de un thriller político que en su momento no tuvo ni fortuna crítica ni éxito de taquilla y que, en parte, fue repudiado por su propio director. Sin embargo, el tiempo nos permite proceder a una relectura que valore su clara raíz esperpéntica, que considere el texto como síntoma de hartazgo con el género producido por un contexto histórico y cultural muy particular.Murder in the Central Committee (1982) is the second film adaptation of Pepe Carvalho, the famous literary detective created by Manuel Vázquez Montalbán (following Tatuaje by Bigas Luna in 1976). The film is a political thriller which was poorly received both by critics and at the box office, and was also partially forsaken by its own director, Vicente Aranda. Nevertheless, the passing of time allows us to revisit the film and evaluate its clearly grotesque and absurd roots, which the text considers to be a symptom of the abundance of thrillers produced during the very specific historic and cultural context of the time.Este trabajo se ha realizado en el ámbito y con la ayuda del proyecto “Cine y televisión 1986-1995: modernidad y emergencia de la cultura global”, Ministerio de Economía y Competitividad, Secretaría de Estado de Investigación, Desarrollo e Innovación (CSO2016- 78354-P

Pictura et sequentia: huellas de las bellas artes en la narración figurativa de Antonio Altarriba entre 1977 y 19911

Los primeros años como creador de historietas de Antonio Altarriba son esenciales para entender algunos de los mejores hallazgos narrativos y estéticos del cómic español de finales del siglo XX. Además, la producción de Altarriba entre 1977 y 1991, en colaboración con diversos artistas gráficos, refleja algunas de las obsesiones estéticas y de las huellas de la historia del arte en la producción temprana del autor. Será el inicio de la construcción de un imaginario propio tan fértil como sugerente. Esta investigación rastrea esas citas y amplía el estudio del corpus secuencial de Altarriba, para apuntar algunas de las claves que han contribuido a señalarle como uno de los autores españoles más destacados de la narración gráfica contemporánea.Antonio Altarriba’s first years as a comic creator are essential to understand some of the best narrative and aesthetic findings of Spanish contemporary comics. Altarriba’s production between 1977 and 1991, in collaboration with many different graphic artists, reflects some of the aesthetic obsessions and references of art history in the early work of the author. During this period, he will build a very fertile, creative and suggestive imaginary. This research traces Altarriba’s influences and expands the study of his little-known earliest work. In doing so, it points out some of his authorial marks, which have established Altarriba as one of the most outstanding authors of Spanish contemporary graphic narration.Os primeiros anos como criador de quadrinhos do Antonio Altarriba são essenciais para compreender alguns dos melhores achados narrativos e estéticos dos quadrinhos espanhóis dos finais do século XX. Ademais, a produção do Altarriba entre os anos 1977 e 1991, em colaboração com diversos desenhistas, reflete algumas das obsessões estéticas e das impressões sobre a história do arte na produção temprana do autor. Será o início da construção dum imaginário próprio tão fertil como sugerente. Esta investigação rastreja essas citas e amplia o estudo do corpus sequencial de Altarriba, para assinalar algumas das chaves que tem contribuído a marcar ele como um dos autores espanhóis mais destacados da narração gráfica contemporánea

An evaluation on the clinical outcome prediction of rotor detection in non-invasive phase maps

[EN] Phase maps obtained from Electrocardiographic imaging (ECGI) have been used in the past for rotor identification and ablation guidance in atrial fibrillation (AF). In this study, we propose a new rotor detection algorithm and evaluate its potential use for prediction of pulmonary vein isolation (PVI) success. The mean precision and recall of the algorithm were evaluated by using manually annotated ECGI phase maps and resulted in 0.82 and 0.75, respectively. Phase singularities and rotors were then quantified on ECGI signals from 29 patients prior to PVI. A significantly higher concentration of phase singularities (PSs) in the pulmonary veins in patients with a successful PVI was found. Our results suggest that rotorrelated metrics obtained from ECGI derived phase maps contain relevant information to predict clinical outcome in PVI patients.This work was supported by PersonalizeAF project. This project has received funding from the European Union's Horizon 2020 research and innovation program under the Marie Skodowska-Curie grant agreement No 860974.Fambuena-Santos, C.; Hernández-Romero, I.; Molero-Alabau, R.; Climent, AM.; Guillem Sánchez, MS. (2021). An evaluation on the clinical outcome prediction of rotor detection in non-invasive phase maps. 1-4. https://doi.org/10.22489/CinC.2021.2511

An Evaluation on the Clinical Outcome Prediction of Rotor Detection in Non-Invasive Phase Maps. Abstract

[EN] Phase maps obtained from Electrocardiographic imaging (ECGI) have been used in the past for rotor identification and ablation guidance in atrial fibrillation (AF). In this study, we propose a new rotor detection algorithm and evaluate its potential use for prediction of pulmonary vein isolation (PVI) success. The mean precision and recall of the algorithm were evaluated by using manually annotated ECGI phase maps and resulted in 0.82 and 0.75, respectively. Phase singularities and rotors were then quantified on ECGI signals from 29 patients prior to PVI. A significantly higher concentration of phase singularities (PSs) in the pulmonary veins in patients with a successful PVI was found. Our results suggest that rotorrelated metrics obtained from ECGI derived phase maps contain relevant information to predict clinical outcome in PVI patients.This work was supported by PersonalizeAF project. This project has received funding from the European Union's Horizon 2020 research and innovation program under the Marie Skodowska-Curie grant agreement No 860974.Fambuena-Santos, C.; Hernández-Romero, I.; Molero-Alabau, R.; Climent, AM.; Guillem Sánchez, MS. (2021). An evaluation on the clinical outcome prediction of rotor detection in non-invasive phase maps. 1-4. https://doi.org/10.22489/CinC.2021.2511

Liver osteopontin is required to prevent the progression of age-related nonalcoholic fatty liver disease

[EN] Osteopontin (OPN), a senescence-associated secretory phenotype factor, is increased in patients with nonalcoholic fatty liver disease (NAFLD). Cellular senescence has been associated with age-dependent hepatosteatosis. Thus, we investigated the role of OPN in the age-related hepatosteatosis. For this, human serum samples, animal models of aging, and cell lines in which senescence was induced were used. Metabolic fluxes, lipid, and protein concentration were determined. Among individuals with a normal liver, we observed a positive correlation between serum OPN levels and increasing age. This correlation with age, however, was absent in patients with NAFLD. In wild-type (WT) mice, serum and liver OPN were increased at 10 months old (m) along with liver p53 levels and remained elevated at 20m. Markers of liver senescence increased in association with synthesis and concentration of triglycerides (TG) in 10m OPN-deficient (KO) hepatocytes when compared to WT hepatocytes. These changes in senescence and lipid metabolism in 10m OPN-KO mice liver were associated with the decrease of 78 kDa glucose-regulated protein (GRP78), induction of ER stress, and the increase in fatty acid synthase and CD36 levels. OPN deficiency in senescent cells also diminished GRP78, the accumulation of intracellular TG, and the increase in CD36 levels. In 20m mice, OPN loss led to increased liver fibrosis. Finally, we showed that OPN expression in vitro and in vivo was regulated by p53. In conclusion, OPN deficiency leads to earlier cellular senescence, ER stress, and TG accumulation during aging. The p53-OPN axis is required to inhibit the onset of agerelated hepatosteatosis.This work was supported by Ayudas para apoyar grupos de investigación del sistema Universitario Vasco (IT971‐16 to P.A.), MINECO‐FEDER (SAF2017‐87301‐R to M.L.M‐Ch) MCIU/AEI/FEDER, UE (RTI2018‐095134‐B‐100 to P.A. and RTI2018‐099413‐B‐I00 to RN, Asociación Española contra el Cáncer, Canceres raros (M.L.M‐Ch), La Caixa Foundation (to M.L.M‐Ch), Ayudas Fundación BBVA a equipos de Investigación Científica 2018 (to M.L.M‐Ch), Xunta de Galicia (RN: 2015‐CP080 and 2016‐ PG057), Fundación BBVA (RN), and European Foundation for the Study of Diabetes (RN). ISCIII‐FEDER PI17/00535 (to C.G‐M.), ISCIII‐FEDER CP14/00181 and PI16/00823 (to A.G‐ R.), and Francisco Cobos Foundation (to A.G‐R.). CiC bioGUNE thanks MINECO for the Severo Ochoa Excellence Accreditation (SEV‐2016‐ 0644