781 research outputs found

    QLI: QUALITY OF LIFE, UTILITY, AND WILLINGNESS TO PAY IN PATIENTS WITH DIABETES

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    Group classification of (1+1)-Dimensional Schr\"odinger Equations with Potentials and Power Nonlinearities

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    We perform the complete group classification in the class of nonlinear Schr\"odinger equations of the form iψt+ψxx+ψγψ+V(t,x)ψ=0i\psi_t+\psi_{xx}+|\psi|^\gamma\psi+V(t,x)\psi=0 where VV is an arbitrary complex-valued potential depending on tt and x,x, γ\gamma is a real non-zero constant. We construct all the possible inequivalent potentials for which these equations have non-trivial Lie symmetries using a combination of algebraic and compatibility methods. The proposed approach can be applied to solving group classification problems for a number of important classes of differential equations arising in mathematical physics.Comment: 10 page

    New results on group classification of nonlinear diffusion-convection equations

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    Using a new method and additional (conditional and partial) equivalence transformations, we performed group classification in a class of variable coefficient (1+1)(1+1)-dimensional nonlinear diffusion-convection equations of the general form f(x)ut=(D(u)ux)x+K(u)ux.f(x)u_t=(D(u)u_x)_x+K(u)u_x. We obtain new interesting cases of such equations with the density ff localized in space, which have large invariance algebra. Exact solutions of these equations are constructed. We also consider the problem of investigation of the possible local trasformations for an arbitrary pair of equations from the class under consideration, i.e. of describing all the possible partial equivalence transformations in this class.Comment: LaTeX2e, 19 page

    Benchmarking the power of amateur observatories for TTV exoplanets detection

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    This document is the Accepted Manuscript version of the following article: Roman v. Baluev, et al, ‘Benchmarking the power of amateur observatories for TTV exoplanets detection’, Monthly Notices of the Royal Astronomical Society, Vol. 450(3): 3101-3113, first published online 9 May 2015. The version of record is available at doi: https://doi.org/10.1093/mnras/stv788 © 2015 The Authors. Published by Oxford University Press on behalf of the Royal Astronomical Society.We perform an analysis of ~80000 photometric measurements for the following 10 stars hosting transiting planets: WASP-2, -4, -5, -52, Kelt-1, CoRoT-2, XO-2, TrES-1, HD 189733, GJ 436. Our analysis includes mainly transit lightcurves from the Exoplanet Transit Database, public photometry from the literature, and some proprietary photometry privately supplied by other authors. Half of these lightcurves were obtained by amateurs. From this photometry we derive 306 transit timing measurements, as well as improved planetary transit parameters. Additionally, for 6 of these 10 stars we present a set of radial velocity measurements obtained from the spectra stored in the HARPS, HARPS-N, and SOPHIE archives using the HARPS-TERRA pipeline. Our analysis of these TTV and RV data did not reveal significant hints of additional orbiting bodies in almost all of the cases. In the WASP-4 case, we found hints of marginally significant TTV signals having amplitude 10-20 sec, although their parameters are model-dependent and uncertain, while radial velocities did not reveal statistically significant Doppler signals.Peer reviewe

    Developmental changes in the role of different metalinguistic awareness skills in Chinese reading acquisition from preschool to third grade

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    Copyright @ 2014 Wei et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.The present study investigated the relationship between Chinese reading skills and metalinguistic awareness skills such as phonological, morphological, and orthographic awareness for 101 Preschool, 94 Grade-1, 98 Grade-2, and 98 Grade-3 children from two primary schools in Mainland China. The aim of the study was to examine how each of these metalinguistic awareness skills would exert their influence on the success of reading in Chinese with age. The results showed that all three metalinguistic awareness skills significantly predicted reading success. It further revealed that orthographic awareness played a dominant role in the early stages of reading acquisition, and its influence decreased with age, while the opposite was true for the contribution of morphological awareness. The results were in stark contrast with studies in English, where phonological awareness is typically shown as the single most potent metalinguistic awareness factor in literacy acquisition. In order to account for the current data, a three-stage model of reading acquisition in Chinese is discussed.National Natural Science Foundation of China and Knowledge Innovation Program of the Chinese Academy of Sciences

    Functional heterogeneity of POMC neurons relies on mTORC1 signaling.

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    Hypothalamic pro-opiomelanocortin (POMC) neurons are known to trigger satiety. However, these neuronal cells encompass heterogeneous subpopulations that release γ-aminobutyric acid (GABA), glutamate, or both neurotransmitters, whose functions are poorly defined. Using conditional mutagenesis and chemogenetics, we show that blockade of the energy sensor mechanistic target of rapamycin complex 1 (mTORC1) in POMC neurons causes hyperphagia by mimicking a cellular negative energy state. This is associated with decreased POMC-derived anorexigenic α-melanocyte-stimulating hormone and recruitment of POMC/GABAergic neurotransmission, which is restrained by cannabinoid type 1 receptor signaling. Electrophysiology and optogenetic studies further reveal that pharmacological blockade of mTORC1 simultaneously activates POMC/GABAergic neurons and inhibits POMC/glutamatergic ones, implying that the functional specificity of these subpopulations relies on mTORC1 activity. Finally, POMC neurons with different neurotransmitter profiles possess specific molecular signatures and spatial distribution. Altogether, these findings suggest that mTORC1 orchestrates the activity of distinct POMC neurons subpopulations to regulate feeding behavior

    The state-of-the-art determination of urinary nucleosides using chromatographic techniques “hyphenated” with advanced bioinformatic methods

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    Over the last decade metabolomics has gained increasing popularity and significance in life sciences. Together with genomics, transcriptomics and proteomics, metabolomics provides additional information on specific reactions occurring in humans, allowing us to understand some of the metabolic pathways in pathological processes. Abnormal levels of such metabolites as nucleosides in the urine of cancer patients (abnormal in relation to the levels observed in healthy volunteers) seem to be an original potential diagnostic marker of carcinogenesis. However, the expectations regarding the diagnostic value of nucleosides may only be justified once an appropriate analytical procedure has been applied for their determination. The achievement of good specificity, sensitivity and reproducibility of the analysis depends on the right choice of the phases (e.g. sample pretreatment procedure), the analytical technique and the bioinformatic approach. Improving the techniques and methods applied implies greater interest in exploration of reliable diagnostic markers. This review covers the last 11 years of determination of urinary nucleosides conducted with the use of high-performance liquid chromatography in conjunction with various types of detection, sample pretreatment methods as well as bioinformatic data processing procedures
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