Nuevos enfoques para la valoración y protección del patrimonio marplatense una propuesta metodológica necesaria

El objeto del trabajo es proponer una nueva forma de evaluación, valoración y protección de los bienes declarados de interés patrimonial de Mar del Plata, principalmente de aquellos encuadrados en una categoría (Categoría “C”, según las normas locales vigentes) que refiere al llamado patrimonio doméstico o modesto (80% del total de bienes patrimoniales). Ello surge de la necesidad de revisar y redefinir su valoración a la luz de los cambios propios de la dinámica urbana de Mar del Plata de los últimos años que, paulatinamente pusieron en riesgo la factibilidad concreta de protección. Se propone un análisis a través de nuevos enfoques donde intervienen no sólo aspectos estéticos e históricos, sino también aquellos relacionados con su situación de entorno, el reconocimiento de la transferencia social y aún con voluntades y actitudes de sus propietarios. Vale decir, una modalidad (método) de evaluación más abarcativa que, integrando aspectos patrimoniales, urbanísticos y socioeconómicos, posibilite una respuesta más acorde y pertinente de articulación a tales dinámicas de la ciudad. Ello constituiría un avance en la optimización de políticas de preservación acordes a la realidad marplatense, fundamentalmente sobre aquella porción de su arquitectura que, pese a no alcanzar categorías monumentales, resulta representativa de las tradiciones constructivas e historias urbanas que cimentaron su identidad.Tópico 1: Aspectos teóricos, históricos, legales, económicos y tecnológicos de la restauración y conservación de bienes patrimoniales

EVALUASI EFEKTIVITAS DAN KONTRIBUSI PENERIMAAN PAJAK KENDARAAN BERMOTOR DAN BEA BALIK NAMA KENDARAAN BERMOTOR TERHADAP PENDAPATAN ASLI DAERAH: (Studi Badan Pengelolaan Pajak Dan Retribusi Daerah Kota Medan)

Penelitian ini bertujuan untuk mengetahui seberapa besar efektif Pajak Kendaraan Bermotor dan Bea Balik Nama Kendaraan Bermotor terhadap PAD kota Medan, dan mengetahui seberapa besar kontribusi Pajak Kendaraan Bermotor dan Bea Balik Nama Kendaraan Bermotor terhadap PAD  kota Medan. Populasi penelitian ini adalah efektivitas dan kontibusi Pajak Kendaraan Bermotor dan Bea Balik Nama Kendaraan Bermotor yang terdaftar di BPPRD kota Medan yang melaksanakan kewajibannnya untuk membayarkan Pajak Kendaraan Bermotor dan Bea Balik Nama Kendaraan Bermotor di BPPRD kota Medan. Sampel penelitian ini adalah  jumlah target dan realisasi Pajak Kendaraan Bermotor dan Bea Balik Nama Kendaraan Bermotor yang membayarkan kewajibannya kepada BPPRD kota Medan dari tahun 2017-2021. Metode analisis yang digunakan adalah analisis Deskriptif dengan rumus tingkat efektivitas dan tingkat kontribusi.Berdasarkan  hasil penelitian menunjukkan bahwa tingkat efektivitas pajak kendaraan bermotor rata-rata 75,80% secara keseluruhan dari tahun 2017-2021 tergolong “kurang efektif”   dan  untuk  efektivitas  Bea Balik Nama Kendaraan Bermotor  rata-rata 83,69% secara keseluruhan dari tahun 2017-2021 tergolong  “cukup efektif” sedangkan  tingkat kontribusi Pajak Kendaraan Bermotor secara keseluruhan dari tahun 2012-2016  dengan  rata-rata kontribusi PKB sebesar 20,48% lebih baik dibanding tingkat kontribusi penerimaan  PKB dari tahun 2017-2021 dengan  rata-rata kontribusi PKB sebesar 16,39%, dan Tingkat kontribusi BBNKB secara keseluruhan dari tahun 2012-2016  dengan  rata-rata kontribusi BBNKB sebesar 20,51% lebih baik dibanding tingkat kontribusi penerimaan  BBNKB dari tahun 2017-2021 dengan  rata-rata kontribusi BBNKB sebesar  18,20%

Brain regions and functional interactions supporting early word recognition in the face of input variability

Perception and cognition in infants have been traditionally investigated using habituation paradigms, assuming that babies' memories in laboratory contexts are best constructed after numerous repetitions of the very same stimulus in the absence of interference. A crucial, yet open, question regards how babies deal with stimuli experienced in a fashion similar to everyday learning situations-namely, in the presence of interfering stimuli. To address this question, we used functional near-infrared spectroscopy to test 40 healthy newborns on their ability to encode words presented in concomitance with other words. The results evidenced a habituation-like hemodynamic response during encoding in the left-frontal region, which was associated with a progressive decrement of the functional connections between this region and the left-temporal, right-temporal, and right-parietal regions. In a recognition test phase, a characteristic neural signature of recognition recruited first the right-frontal region and subsequently the right-parietal ones. Connections originating from the right-temporal regions to these areas emerged when newborns listened to the familiar word in the test phase. These findings suggest a neural specialization at birth characterized by the lateralization of memory functions: the interplay between temporal and left-frontal regions during encoding and between temporo-parietal and right-frontal regions during recognition of speech sounds. Most critically, the results show that newborns are capable of retaining the sound of specific words despite hearing other stimuli during encoding. Thus, habituation designs that include various items may be as effective for studying early memory as repeated presentation of a single word.European Research Council under European Union 269502 CONICYT-Chile Program PIA/BASAL FB0003 "Progetto strategico NEURAT" from the University of Padua CONICYT-Chile Program PAI/Academia 7913002

MET Inhibition Sensitizes Rhabdomyosarcoma Cells to NOTCH Signaling Suppression

Drug resistance; Soft tissue sarcoma; Targeted therapyResistencia a las drogas; Sarcoma de tejido blando; Terapia dirigidaResistència als fàrmacs; Sarcoma dels teixits tous; Teràpia dirigidaRhabdomyosarcoma (RMS) is a pediatric myogenic soft tissue sarcoma. The Fusion-Positive (FP) subtype expresses the chimeric protein PAX3-FOXO1 (P3F) while the Fusion-Negative (FN) is devoid of any gene translocation. FP-RMS and metastatic FN-RMS are often unresponsive to conventional therapy. Therefore, novel therapeutic approaches are needed to halt tumor progression. NOTCH signaling has oncogenic functions in RMS and its pharmacologic inhibition through γ-secretase inhibitors blocks tumor growth in vitro and in vivo. Here, we show that NOTCH signaling blockade resulted in the up-regulation and phosphorylation of the MET oncogene in both RH30 (FP-RMS) and RD (FN-RMS) cell lines. Pharmacologic inhibition of either NOTCH or MET signaling slowed proliferation and restrained cell survival compared to control cells partly by increasing Annexin V and CASP3/7 activation. Co-treatment with NOTCH and MET inhibitors significantly amplified these effects and enhanced PARP1 cleavage in both cell lines. Moreover, it severely hampered cell migration, colony formation, and anchorage-independent growth compared to single-agent treatments in both cell lines and significantly prevented the growth of FN-RMS cells grown as spheroids. Collectively, our results unveil the overexpression of the MET oncogene by NOTCH signaling targeting in RMS cells and show that MET pathway blockade sensitizes them to NOTCH inhibition.This research was funded by Associazione Italiana per la Ricerca sul Cancro (AIRC) #15312 to RR and #24696 to FM; Italian Ministry of Health (Ricerca Corrente) to BDA, CQ, and RR; AIRC 5xmille #9962 to FL; Italian Ministry of Health (Fondi 5xmille 2021-2022) to RR; Alleanza Contro il Cancro (ACC) Italian Network-Working Group Sarcomas to BDA, RM, and RR; Fondi Ateneo 2019 to FM; MIUR-Italy: Grant to Department of Science, Roma Tre University (Dipartimento di Eccellenza, ARTICOLO 1, COMMI 314—337 LEGGE 232/2016) to MCe and PM

How Has COVID-19 Affected Mental Health and Lifestyle Behaviors after 2 Years? The Third Step of a Longitudinal Study of Italian Citizens

: The COVID-19 pandemic and its protective measures had a tremendous effect on the general population's mental health and deeply affected their lifestyle. The present study carried out a longitudinal analysis to evaluate the long-lasting psychological effects of the pandemic and its impact on the general population's day-to-day routine. Three points in time were considered: the initial period of the lockdown (T1; n = 2766; March 2020), the final period of the lockdown (T2; n = 439; May 2020) and two years after the lockdown (T3; n = 268; July 2022). Frequency analyses were carried out to examine which behavioral changes were maintained following the COVID-19 pandemic and lockdown; furthermore, a repeated measures ANOVA test was run to measure differences in depression, stress, and anxiety levels between the three periods considered; lastly, multivariable ordinal logistic regression analyses were carried out to examine which variables were associated with psychological distress more than two years after the lockdown. The results highlighted that depression at T3 was associated with depression at T2 and negative affect, whereas stress at T3 was associated with stress at T2 and detachment. The psychological effects and lifestyle changes are also discussed

Correlations between chest-CT and laboratory parameters in SARS-CoV-2 pneumonia: A single-center study from Italy

To investigate the relationship between damaged lung assessed by chest computed tomography (CT) scan and laboratory biochemical parameters with the aim of finding other diagnostic tools. Patients who underwent chest CT for suspected Corona Virus Disease-2019 (COVID-19) pneumonia at the emergency department admission in the first phase of COVID-19 epidemic in Italy were retrospectively analyzed. Patients with both negative chest CT and absence of the novel coronavirus in nasopharyngeal or oropharyngeal real-time reverse transcriptase polymerase chain reaction (RT-PCR) swabs were excluded from the study. A total of 462 patients with positive CT scans for interstitial pneumonia were included in the study (250 males and 212 females, mean age 57 ± 17 years, range 18–89). Of these, 344 were positive to RT-PCR test, 118 were negative to double RT-PCR tests. CTs were analyzed for quantification of affected lung volume visually and by dedicated software. Statistical analysis to evaluate the relationship between laboratory analyses and CT patterns and amount of damaged lung related with COVID-19 pneumonia was performed in 2 groups of patients: positive RT-PCR COVID-19 group and negative RT-PCR COVID-19 group, but both with positive CT scans for interstitial pneumonia. Lymphocytopenia, C-reactive protein (CRP), lactate dehydrogenase (LDH), d-dimer, and fibrinogen increased levels occurred in most patients without statistically significant differences between the 2 groups with CT scans suggestive for COVID-19. In fact, in both groups the volume of lung damage was strongly associated with altered laboratory test results, even for patients with negative RT-PCR test. The decreased number of lymphocytes, and the increased levels of CRP, LDH, d-dimer, and fibrinogen levels are associated with SARS-CoV 2 related pneumonia. This may be useful as an additional diagnostic tool in patients with double negative RT-PCR assay and with highly suspected clinic and chest CT features for COVID-19 to isolate patients in a pandemic period.publishedVersio

Did You Commit a Crime There? Investigating the Visual Exploration Patterns of Guilty, Innocent, Honest, and Dishonest Subjects When Viewing a Complex Mock Crime Scene

Previous studies with the eye-tracking technology have predominantly tracked eye parameters in response to a single simple stimulus, and have generated interesting - sometimes inconsistent - results in research on deceptive behavior. The present study analyzed visual patterns in response to a complex image, to investigate potential differences in eye fixation between guilty versus innocent, and honest versus dishonest participants. One hundred and sixty participants were assigned to one of four experimental groups, defined by the parameters of honesty (dishonesty) and guilt (innocence), and asked to complete a computer-based task, looking at neutral and target images (i.e., images of the mock crime scene). RealEye software was used to capture participants’ eye movements when viewing the images. The findings revealed significant differences in eye movements between the four experimental groups in the pictures in which the area where the crime took place was clearly visible. Dishonest and guilty participants recorded fewer and shorter fixations in the area of the image where the crime took place than those who entered the crime scene but did not commit the crime. No differences between groups emerged in the visual patterns in response to neutral images, confirming that the number and duration of fixations in response to the target images may be attributed to the experimental condition

From emotional (dys)regulation to internet addiction: a mediation model of problematic social media use among italian young adults

Internet addiction (IA) has mostly been investigated with the fear of missing out and difficulties in emotional regulation. The present study examined the link between IA and variables related to problematic social media use (i.e., fear of missing out, social media addiction), together with emotional (dys)regulation and personality traits, providing new insights and an integrated assessment of IA. In total, 397 participants, aged 18-35 years (M = 22.00; SD = 3.83), were administered a set of questionnaires pertaining to IA, problematic social media use, emotional (dys)regulation, and personality traits. Pearson's correlations showed significant associations between IA and the investigated variables, and the tested mediation model highlighted the crucial role played by emotional (dys)regulation in the fear of missing out and problematic use of social networks. Overall, the findings provide support for a new integrated model for understanding the features, predictors, and risk factors of IA

Lung Ultrasound B-Lines in the Evaluation of the Extent of Interstitial Lung Disease in Systemic Sclerosis

Background: Chest computed tomography (CT) is the gold standard for the evaluation of systemic sclerosis-related interstitial lung disease (SSc-ILD). Lung ultrasound (LUS) is a radiation-free tool that identifies the B-lines as a main feature of ILD. We aimed to investigate the role of LUS in the evaluation of the extent of SSc-ILD. Methods: Adult SSc patients underwent pulmonary function tests (PFTs), LUS and CT. The CT images were qualitatively, semi-quantitatively (the Wells score on five levels and the categorical Goh et al. staging) and quantitatively (histogram-based densitometry) analysed for ILD. LUS quantified B-lines in 21 intercostal spaces on both the anterior and posterior chest wall. Results: Out of the 77 SSc patients eligible for the study, 35 presented with ILD on CT (21 limited, 14 extensive). Total B-lines significantly differentiated ILD vs. no ILD (median 24 vs. 8, p < 0.001). Posterior and total B-lines significantly differentiated limited from absent ILD, while anterior B-lines distinguished extensive from limited ILD. Total B-lines correlated with the Wells score (r = 0.446, p < 0.001) and MLA (r = -0.571, p < 0.001); similar results were confirmed when anterior and posterior B-lines were analysed separately. Conclusions: LUS is a useful tool to identify SSc-ILD and to correlate with different evaluations of ILD extent and severity

Francisco de Asís en San Pietro in Montorio : los frescos de la Real Academia de España

Bibliografía: p. 140-159Sumario: La AECID está realizando el plan de conservación y puesta en valor del complejo de San Pietro in Montorio en Roma, antiguo convento franciscano, sede de la Real Academia de España en Roma.Esta publicación ha sido patrocinada por la Agencia Española de Cooperación Internacional para el Desarroll