Métodos de evaluación, mantenimiento y reutilización de páginas 'wiki' educativas de acceso abierto

El propósito de este proyecto ha sido el desarrollo y la consolidación de la manera en que los docentes gestionamos las denominadas ‘wikis’, páginas web autoeditables que varias asignaturas universitarias utilizan ya como recursos docentes abiertos y colaborativos. Concretamente nos centramos en los tres aspectos más relevantes de dicha gestión: la evaluación de la utilidad de estos recursos, su mantenimiento para que permanezcan funcionales y relevantes para nuestro alumnado, y la reutilización de contenidos entre recursos similares del mismo o de distintos proyectos educativos. Este Proyecto de Innovación y Mejora de la Calidad Docente (PIMCD) aporta continuidad a un proyecto anterior denominado “Implementación de wikis educativas de acceso abierto con amplia diversidad de contenidos en inglés y castellano”, realizado durante el curso 2014-2015, con el identificador 368. Se trata de una iniciativa a largo plazo en la que un grupo amplio de docentes de la Universidad Complutense de Madrid estamos tratando de explorar todo el potencial de las aplicaciones web colaborativas para fomentar el aprendizaje cooperativo y mejorar la participación de los estudiantes en su formación, a la par que aumentar su motivación intrínseca por la generación y transmisión de conocimiento

Notificació d’incidents en la seguretat del pacient en l’hospitalització d’aguts a Catalunya: dades de 2022

Notificació; Seguretat del pacient; Hospitalització d’agutsNotification; Patient safety; Acute hospitalizationNotificación; Seguridad del paciente; Hospitalización de agudosL’objectiu és fer un recull dels incidents que en permeti fer una anàlisi i buscar solucions per tal de reduir-ne el nombre i la freqüència amb la finalitat d’augmentar la seguretat del pacient durant l’assistència sanitària. Les dades que s’analitzen a continuació corresponen a l’any 2022, però cal tenir en compte que les notificacions analitzades en aquest informe corresponen únicament a les que els centres han tancat, una vegada revisades pels gestors de l’eina. I, per tant, el nombre d’incidents anual depèn del moment en què s’extreuen les dades (en aquest cas, el 16 d’agost de 2023)

Notificació d’incidents en la seguretat del pacient a l’atenció primària a Catalunya: dades de 2022

Notificació; Seguretat del pacient; Atenció primàriaNotification; Patient safety; Primary health careNotificación; Seguridad del paciente; Atención primariaL’objectiu és conèixer els resultats agregats dels incidents relacionats amb la seguretat del pacient de cada any per detectar les línies prioritàries en les quals incidir per augmentar la seguretat durant l’assistència sanitària. Les dades que s’analitzen a continuació corresponen a notificacions d’incidents de l’any 2022 i, que, en data 28 d’agost de 2023, els gestors de l’eina dels centres han estudiat, proposat mesures perquè no tornin a succeir i que ja donen per tancades

Notificació d’incidents en la seguretat del pacient en l’hospitalització d’aguts a Catalunya: dades de 2021

Notificació; Seguretat del pacient; Hospitalització d’agutsNotification; Patient safety; Acute hospitalizationNotificación; Seguridad del paciente; Hospitalización de agudosL’objectiu és fer un recull dels incidents que en permeti fer una anàlisi i buscar solucions per tal de reduir-ne el nombre i la freqüència amb la finalitat d’augmentar la seguretat del pacient durant l’assistència sanitària. Les dades que s’analitzen a continuació corresponen a l’any 2021, però cal tenir en compte que les notificacions analitzades en aquest informe corresponen únicament a les que els centres han tancat, una vegada revisades pels gestors de l’eina. Per tant, el nombre d’incidents anual depèn del moment en què s’extreuen les dades (en aquest cas, l’11 d’agost de 2023)

Notificació d’incidents en la seguretat del pacient a l’atenció primària a Catalunya: dades de 2021

Notificació; Seguretat del pacient; Atenció primàriaNotification; Patient safety; Primary health careNotificación; Seguridad del paciente; Atención primariaL’objectiu és conèixer els resultats agregats dels incidents relacionats amb la seguretat del pacient de cada any per detectar les línies prioritàries en les quals incidir per augmentar la seguretat durant l’assistència sanitària. Les dades que s’analitzen a continuació corresponen a notificacions d’incidents de l’any 2021 i, que, en data 30 d’agost de 2023, els gestors de l’eina dels centres han estudiat, proposat mesures perquè no tornin a succeir i que ja donen per tancades

Provirus reactivation is impaired in HIV-1 infected individuals on treatment with dasatinib and antiretroviral therapy

The latent viral reservoir formed by HIV-1, mainly in CD4 + T cells, is responsible for the failure of antiretroviral therapy (ART) to achieve a complete elimination of the virus in infected individuals. We previously determined that CD4 + T cells from individuals with chronic myeloid leukemia (CML) on treatment with dasatinib are resistant to HIV-1 infection ex vivo. The main mechanism for this antiviral effect is the preservation of SAMHD1 activity. In this study, we aimed to evaluate the impact of dasatinib on the viral reservoir of HIV-infected individuals with CML who were on simultaneous treatment with ART and dasatinib. Due to the low estimated incidence of HIV-1 infection and CML (1:65,000), three male individuals were recruited in Spain and Germany. These individuals had been on treatment with standard ART and dasatinib for median 1.3 years (IQR 1.3-5.3 years). Reservoir size and composition in PBMCs from these individuals was analyzed in comparison with HIV-infected individuals on triple ART regimen and undetectable viremia. The frequency of latently infected cells was reduced more than 5-fold in these individuals. The reactivation of proviruses from these cells was reduced more than 4-fold and, upon activation, SAMHD1 phosphorylation was reduced 40-fold. Plasma levels of the homeostatic cytokine IL-7 and CD4 effector subpopulations TEM and TEMRA in peripheral blood were also reduced. Therefore, treatment of HIV-infected individuals with dasatinib as adjuvant of ART could disturb the reservoir reactivation and reseeding, which might have a beneficial impact to reduce its size

Long-Term Real-World Effectiveness and Safety of Ustekinumab in Crohn’s Disease Patients: The SUSTAIN Study

Background Large real-world-evidence studies are required to confirm the durability of response, effectiveness, and safety of ustekinumab in Crohn’s disease (CD) patients in real-world clinical practice. Methods A retrospective, multicentre study was conducted in Spain in patients with active CD who had received ≥1 intravenous dose of ustekinumab for ≥6 months. Primary outcome was ustekinumab retention rate; secondary outcomes were to identify predictive factors for drug retention, short-term remission (week 16), loss of response and predictive factors for short-term efficacy and loss of response, and ustekinumab safety. Results A total of 463 patients were included. Mean baseline Harvey-Bradshaw Index was 8.4. A total of 447 (96.5%) patients had received prior biologic therapy, 141 (30.5%) of whom had received ≥3 agents. In addition, 35.2% received concomitant immunosuppressants, and 47.1% had ≥1 abdominal surgery. At week 16, 56% had remission, 70% had response, and 26.1% required dose escalation or intensification; of these, 24.8% did not subsequently reduce dose. After a median follow-up of 15 months, 356 (77%) patients continued treatment. The incidence rate of ustekinumab discontinuation was 18% per patient-year of follow-up. Previous intestinal surgery and concomitant steroid treatment were associated with higher risk of ustekinumab discontinuation, while a maintenance schedule every 12 weeks had a lower risk; neither concomitant immunosuppressants nor the number of previous biologics were associated with ustekinumab discontinuation risk. Fifty adverse events were reported in 39 (8.4%) patients; 4 of them were severe (2 infections, 1 malignancy, and 1 fever). Conclusions Ustekinumab is effective and safe as short- and long-term treatment in a refractory cohort of CD patients in real-world clinical practice

A facility and community-based assessment of scabies in rural Malawi.

Background Scabies is a neglected tropical disease of the skin, causing severe itching, stigmatizing skin lesions and systemic complications. Since 2015, the DerMalawi project provide an integrated skin diseases clinics and Tele-dermatology care in Malawi. Clinic based data suggested a progressive increase in scabies cases observed. To better identify and treat individuals with scabies in the region, we shifted from a clinic-based model to a community based outreach programme. Methodology/principal findings From May 2015, DerMalawi project provide integrated skin diseases and Tele-dermatological care in the Nkhotakota and Salima health districts in Malawi. Demographic and clinical data of all patients personally attended are recorded. Due to a progressive increase in the number of cases of scabies the project shifted to a community-based outreach programme. For the community outreach activities, we conducted three visits between 2018 to 2019 and undertook screening in schools and villages of Alinafe Hospital catchment area. Treatment was offered for all the cases and school or household contacts. Scabies increased from 2.9% to 39.2% of all cases seen by the DerMalawi project at clinics between 2015 to 2018. During the community-based activities approximately 50% of the population was assessed in each of three visits. The prevalence of scabies was similar in the first two rounds, 15.4% (2392) at the first visit and 17.2% at the second visit. The prevalence of scabies appeared to be lower (2.4%) at the third visit. The prevalence of impetigo appeared unchanged and was 6.7% at the first visit and 5.2% at the final visit. Conclusions/significance Prevalence of scabies in our setting was very high suggesting that scabies is a major public health problem in parts of Malawi. Further work is required to more accurately assess the burden of disease and develop appropriate public health strategies for its control

Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)

Objectives: The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters. Methods: A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs). Results: In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p < 0.001) for tocilizumab, 0.82 (0.71-1.30; p 0.82) for IHDC, 0.61 (0.43-0.86; p 0.006) for PDC, and 1.17 (0.86-1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02-0.17; p < 0.001). Conclusions: Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situatio

re-habitar El Carmen : Un proyecto sobre patrimonio contemporáneo

El proyecto _re-HABITAR suponía para el propio proceder de la institución un avance más allá del reconocimiento, registro, inventario o protección patrimonial de la arquitectura del siglo XX y del Movimiento Moderno para posicionarse en la acción preventiva y conservativa de ese legado contemporáneo. Para ello, la praxis patrimonial se aferraba a un modelo: el de la vivienda social en España en la segunda mitad del siglo XX; a un caso concreto: el de la barriada de Nuestra Señora del Carmen (Recasens Méndez-Queipo de Llano, 1958); y a un requisito fundamental: analizar un objeto vivo y en uso, aún con la presencia de quienes lo vivieron y usaron desde su origen