AdS/QCD Modified Soft Wall Model and Light Meson Spectra

We analyze here the mass spectrum of light vector and scalar mesons applying a novel approach where a modified soft wall model that includes a UV-cutoff at a finite $z$-position in the AdS space is used, thus introducing an extra energy scale. For this model, we found that the masses for the scalar and vector spectra are well fitted within $\delta_{RMS}=7.64\%$ for these states, with non-linear trajectories given by two common parameters, the UV locus $z_{0}$ and the quadratic dilaton profile slope $\kappa$. We also conclude that in this model, the $f_{0}(500)$ scalar resonance cannot be fitted holographycally as a $q\overline{q}$ state since we cannot find a trajectory that include this pole. This result is in agreement with the most recent phenomenological and theoretical methods.Comment: 4 pages, no figures, conference pape

Feasibility Study of a Proton Irradiation Facility for Radiobiological Measurements at an 18 MeV Cyclotron

A feasibility study of an experimental setup for the irradiation of biological samples at the cyclotron facility installed at the National Centre of Accelerators (Seville, Spain) is presented. This cyclotron, which counts on an external beam line for interdisciplinary research purposes, produces an 18 MeV proton beam, which is suitable for the irradiation of mono-layer cultures for the measurement of proton cell damages and Relative Biological Effectiveness (RBE) at energies below the beam nominal value. Measurements of this kind are of interest for proton therapy, since the variation of proton RBE at the distal edge of the Bragg curve may have implications in clinical proton therapy treatments. In the following, the characteristics of the beam line and the solutions implemented for the irradiation of biological samples are described. When dealing with the irradiation of cell cultures, low beam intensities and broad homogeneous irradiation fields are required, in order to assure that all the cells receive the same dose with a suitable dose rate. At the cyclotron, these constraints have been achieved by completely defocusing the beam, intercepting the beam path with tungsten scattering foils and varying the exit-window-to-sample distance. The properties of the proton beam thus obtained have been analysed and compared with Monte Carlo simulations. The results of this comparison, as well as the experimental measurement of the lateral dose profiles expected at the position of samples are presented. Meaningful dose rates of about 2–3 Gy/min have been obtained. Homogeneous lateral dose profiles, with maximum deviations of 5%, have been measured at a distance of approximately 50 cm in air from the exit window, placing a tungsten scattering foil of 200 μm in the beam path

Ion Beam Experiments to Emulate Nuclear Fusion Environment on Structural Materials at CMAM

One of the major problems not only in nuclear fusion but in all the fields that have to face irradiation damage is to predict the microstructural evolution of all the features that are involved in the good response of the material. In the case of nuclear fusion, it is well known that structural materials that will be a fundamental piece in the future reactor must withstand severe neutron irradiation damage, high temperatures, and cyclic stresses which will result in a reduction of the lifetime of the component. For that reason, a big effort is being done for the scientific community in order to understand the complex mechanisms that lie in the relationship between irradiation damage, microstructure, temperature, stresses, etc. However, neutron irradiation brings inherently transmutation and nuclear activation, which makes extremely hard to study those samples. Therefore, the scientific community is using since long time ago ion beam facilities to emulate the neutron damage, without the worst inconvenience. In this chapter, the authors described briefly the facility located at Centro de MicroAnálisis de Materiales (CMAM), Madrid, and presented afterward some examples of experiments that Spanish Nuclear Fusion Laboratory at CIEMAT has been carrying out related to this matter

Differences in immunoreactive trypsin values between type of feeding and ethnicity in neonatal cystic fibrosis screening: a cross-sectional study

Background: We studied the differences in immunoreactive trypsin (IRT) in neonatal screening for cystic fibrosis (CF) associated individually with the age of the newborn, ethnicity and environmental temperature. In this study, we determine the overall influence of environmental temperature at birth, gender, feeding, gestational age, maternal age and ethnic origin on an abnormal IRT result. Methods: Cross-sectional observational study. A sample was selected of newborns from Alicante (Spain) who underwent neonatal CF screening in 2012–2013. Primary variable: abnormal IRT levels (≥65 ng/ml). Secondary variables: gender, maternal origin, maternal age (years) (40), gestational age (weeks) (37), type of feeding (natural, formula, mixed and special nutrition), >20 days from birth to blood collection, and average temperature during the month of birth (in°C). Using a multivariate logistic regression model the adjusted odds ratios (ORs) were estimated to analyze the association between atypical IRT levels and the study variables. The α error was 5% and confidence intervals (CI) were calculated for the most relevant parameters. Results: Of a total of 13,310 samples, 199 were abnormal (1.34%). Significant associated factors: feeding method (natural → OR = 1; mixed → OR = 0.53, 95% CI: 0.31-0.89; formula → OR = 0.72, 95% CI: 0.48-1.07; special → OR = 21.88, 95% CI: 6.92-69.14; p 40), semanas de gestación (37), tipo de lactancia (natural, artificial, mixta y nutrición especial), >20 días desde el nacimiento a la extracción de sangre y temperatura media del mes de nacimiento (en°C). Con un modelo multivariante de regresión logística se estimaron las odds ratio ajustadas (ORs) para analizar la relación entre la TIR atípica y las variables del estudio. El error α fue del 5% y se calcularon intervalos de confianza (IC) para los parámetros más relevantes. Resultados: De un total de 13,310 muestras, 199 estuvieron alteradas (1.34%). Factores asociados significativos: tipo alimentación (Materna → OR = 1; Mixta → OR = 0.53, IC 95%: 0.31-0.89; Fórmula → OR = 0.72, IC 95%: 0.48-1.07; Especial → OR = 21.88, IC 95%: 6.92-69.14; p < 0.001). Conclusiones: Los recién nacidos con nutrición especial tienen 20 veces más riesgo de TIR alterada, siendo aconsejable cribarlos una vez inicien alimentación normalizada. Es aconsejable tener presente la variabilidad étnica. La estacionalidad no fue importante

Fisioterapia, psicología y enfermería en músico cornetista

Cartel presentado en el 3er Congreso Internacional de Comunicación en Salud (3ICHC), celebrado los días 19 y 20 de octubre de 2017 en la Universidad Carlos III de Madrid.Los objetivos de este trabajo son prevenir lesiones de cintura escapular, columna vertebral y musculatura facial del músico, potenciar musculatura postural global, optimizar capacidad respiratoria diafragmática y maximizar los volúmenes de aire del cornetista, indicar ayudas técnicas para la marcha y material ortésico de descarga funcional y capacitar psicológicamente

Atención temprana en fisioterapia, enfermería y salud mental

Cartel presentado en el 3er Congreso Internacional de Comunicación en Salud (3ICHC), celebrado los días 19 y 20 de octubre de 2017 en la Universidad Carlos III de Madrid.El objetivo de este trabajo es evaluar y tratar la salud mental infantil y los problemas de desarrollo con Fisioterapia en Atención Temprana. Maximizar la funcionalidad psíquica y cognitiva del infante

Hepatitis fulminante en paciente con amiloidosis primaria con respuesta hematológica completa

Primary amyloidosis is a systemic disease that results from abnormal kappa or lambda protein misfolding. The prognosis is poor, and the treatment includes chemotherapy. Hepatic disorders related to primary amyloidosis are found in at least 70% of autopsies. They have a bad prognosis factor, but their clinical manifestations are rare. We report a patient aged 41 with an initial diagnosis of nephrotic syndrome. Renal biopsy showed amyloid deposition. The treatment included quimiotherapy, reaching a complete hematological response. Even though the patient developed a hepatic failure dying.La amiloidosis primaria es una enfermedad multisistémica debida al mal plegamiento de proteínas kappa o lambda. El pronóstico es infausto y el tratamiento emplea quimioterapia. La afectación hepática se describe en el 70% de las autopsias de pacientes con amiloidosis sistémica y se asocia a peor pronóstico. Presentamos el caso de un varón de 41 años de edad que debuta con edemas en miembros inferiores y bolsa escrotal y síndrome nefrótico clínico y bioquímico. La biopsia renal es compatible con una amiloidosis primaria. Inicia tratamiento quimioterápico logrando respuesta hematológica completa, pero, a pesar de ello, sufre un fallo hepático fulminante de origen colestásico, y fallece

Formalization of gene regulation knowledge using ontologies and gene ontology causal activity models

Gene regulation computational research requires handling and integrating large amounts of heterogeneous data. The Gene Ontology has demonstrated that ontologies play a fundamental role in biological data interoperability and integration. Ontologies help to express data and knowledge in a machine processable way, which enables complex querying and advanced exploitation of distributed data. Contributing to improve data interoperability in gene regulation is a major objective of the GREEKC Consortium, which aims to develop a standardized gene regulation knowledge commons. GREEKC proposes the use of ontologies and semantic tools for developing interoperable gene regulation knowledge models, which should support data annotation. In this work, we study how such knowledge models can be generated from cartoons of gene regulation scenarios. The proposed method consists of generating descriptions in natural language of the cartoons; extracting the entities from the texts; finding those entities in existing ontologies to reuse as much content as possible, especially from well known and maintained ontologies such as the Gene Ontology, the Sequence Ontology, the Relations Ontology and ChEBI; and implementation of the knowledge models. The models have been implemented using Protégé, a general ontology editor, and Noctua, the tool developed by the Gene Ontology Consortium for the development of causal activity models to capture more comprehensive annotations of genes and link their activities in a causal framework for Gene Ontology Annotations. We applied the method to two gene regulation scenarios and illustrate how to apply the models generated to support the annotation of data from research articles

Significados del autocuidado bucal para los escolares de instituciones educativas oficiales de Medellín

Introduction: This research was sponsored by the Secretary of Health of Medellin and udea by an Inter-administrative Agreement No. 4800001581, whose objective is to describe oral health status of school children in Medellin and explore meanings and practices of oral health and disease for this population in 2006 to contribute to a strategy design in order to promote health and trying to outrange the predominant instrumental technical guidance in teaching programs. Materials and methods: A hermeneutic, qualitative approach focused on understanding students’ texts as an expression of their sense world built by their own experiences; included 12-and-13 year children (120). Depth interview and storytelling in a workshop context were used for data collection. We constructed a category matrix for analysis, so meanings were taken as a main reference. Results: Two trends emerged, one related to self-care meanings determined by a health biological conception and a body trivial relationship. The other trend is related to lacking basic concepts which affects practices. Conclusions: To generate teaching processes in order to outrange the instructional model and enable the health experience in everyday life, so they allow a deep meaning development which in turn will lead to a careful behavior by themselves and each other.&nbsp;Introducción: este estudio fue financiado por la Secretaría de Salud de Medellín y la Universidad de Antioquia mediante Con­venio Interadministrativo N° 4800001581, cuyo objeto fue describir el estado de salud bucal de escolares de Medellín y explorar los significados y prácticas de la salud y la enfermedad bucal para este grupo poblacional, año 2006, esto como aporte para el diseño de estrategias de promoción de la salud, que permitan trascender la orientación técnico-instrumental predominante. Materiales y métodos: estudio cualitativo de enfoque hermenéutico, centrado en la interpretación de los textos de los escolares como expresión del mundo de sentidos construido a partir de sus vivencias. Participaron 120 niños y niñas con edades entre 12 y 13 años. Para la recolección de los datos se utilizaron la entrevista en profundidad y los relatos construidos en contextos de taller. El análisis se realizó mediante ejercicio de codificación abierta y axial que dio origen a una matriz categorial. Resultados: aunque emergieron varias categorías y tendencias, en este texto sólo se retoma lo relacionado con los significados del autocuidado, determinados por la concepción biologista de la salud y por la relación superficial con el cuerpo, y respecto a las prácticas, se retoma el desconocimiento de conceptos básicos. Conclusión: se recomienda generar procesos educativos que trasciendan el carácter transmisionista y posibiliten la construcción social y vivencia de la salud en la cotidianidad, lo que permitirá el desarrollo de sentidos profundos que, a su vez, se traducirán en comportamientos cuidadosos de sí y de los otros(as)