Public health risks associated with hepatitis E virus (HEV) as a food‐borne pathogen

Hepatitis E virus (HEV) is an important infection in humans in EU/EEA countries, and over the last 10 years more than 21,000 acute clinical cases with 28 fatalities have been notified with an overall 10-fold increase in reported HEV cases; the majority (80%) of cases were reported from France, Germany and the UK. However, as infection in humans is not notifiable in all Member States, and surveillance differs between countries, the number of reported cases is not comparable and the true number of cases would probably be higher. Food-borne transmission of HEV appears to be a major route in Europe; pigs and wild boars are the main source of HEV. Outbreaks and sporadic cases have been identified in immune-competent persons as well as in recognised risk groups such as those with pre-existing liver damage, immunosuppressive illness or receiving immunosuppressive treatments. The opinion reviews current methods for the detection, identification, characterisation and tracing of HEV in food-producing animals and foods, reviews literature on HEV reservoirs and food-borne pathways, examines information on the epidemiology of HEV and its occurrence and persistence in foods, and investigates possible control measures along the food chain. Presently, the only efficient control option for HEV infection from consumption of meat, liver and products derived from animal reservoirs is sufficient heat treatment. The development of validated quantitative and qualitative detection methods, including infectivity assays and consensus molecular typing protocols, is required for the development of quantitative microbial risk assessments and efficient control measures. More research on the epidemiology and control of HEV in pig herds is required in order to minimise the proportion of pigs that remain viraemic or carry high levels of virus in intestinal contents at the time of slaughter. Consumption of raw pig, wild boar and deer meat products should be avoided

Estudio y diseño del programa de implementación del pilar del mantenimiento autónomo, como una estrategia para aumentar la eficiencia global del equipo (OEE), reduciendo las causas de las seis grandes pérdidas para la línea de producción especializada en el principal cliente de la empresa Systempack Ltda.

<p>Hepatitis E virus (HEV) is a common cause of acute hepatitis worldwide. In Europe, HEV is a zoonosis transmitted via contaminated pork meat or other pork food products. Genotype 3 is the most prevalent HEV type in the animal reservoir, as well as in humans. Despite an increased incidence of hepatitis E across Europe, much remains unknown about its spread, sources and transmission routes. A One Health approach is crucial to better understand the (molecular) epidemiology of HEV. HEVnet was established in April 2017 as a network and database for sharing sequences and accompanying metadata collected from human, animal, food and environmental sources. HEVnet members working in the public health, veterinary health, food, environmental and blood safety sectors have submitted 1,615 HEV sequences from nine countries as at January 2019. Most are from humans (89%), and sequences of animal (5%), food (6%) or environmental (0.3%) origin are rare. Metadata for human sequences capture mostly sex (93%), year of birth (92%) and sampling (100%); data on region of sampling (37%) and clinical information (hospitalisation 27%, symptoms 20% or mortality 8%) are limited. HEVnet aims to expand into a global network capable of performing cross-sectoral and supranational studies, with a joint repository of molecular and epidemiological data on HEV.</p

Sachpolitik oder Parteipolitik? Eine Bestimmung des Parteidrucks im Bundesrat mittles bayesianischer Methoden

"In diesem Beitrag untersuchen die Autoren das Abstimmungsverhalten der Länder bei namentlichen Abstimmungen im Bundesrat im Zeitraum von der deutschen Wiedervereinigung 1990 bis zum Ende der Regierung Gerhard Schröders 2005. Sie gehen der Frage nach, ob und wenn ja, wann und in welchem Ausmaß der Bundesrat parteipolitisiert ist. Analytisch geht es um die Frage, wie ein durch originär sachpolitische Interessen motiviertes Verhalten von einem solchen unterschieden werden kann, das sich ausschließlich am strategischen Wettbewerb der Parteien um Wählerstimmen orientiert. Die Autoren entwickeln dazu eine Analysemethode, mit welcher der Zusammenhang zwischen sachpolitischen Länder- respektive Parteiinteressen und parteipolitischer Motivation, also etwa dem Druck, der durch die Parteilager ausgeübt wird, aufgelöst werden kann." (Autorenreferat)"The article analyzes the roll call voting behavior of German Länder governments in the Bundesrat from 1990 to 2005. The authors examine if, when, and to what extent the German Bundesrat is dominated by federal party politics rather than by an appropriate conflict of policy interest between states and state governments. They develop and apply a method to separate the effect of policy preferences and of parties' politics on the voting behavior of Länder governments." (author's abstract

HEVnet: A one health, collaborative, interdisciplinary network and sequence data repository for enhanced hepatitis e virus molecular typing, characterisation and epidemiological investigations

Hepatitis E virus (HEV) is a common cause of acute hepatitis worldwide. In Europe, HEV is a zoonosis transmitted via contaminated pork meat or other pork food products. Genotype 3 is the most prevalent HEV type in the animal reservoir, as well as in humans. Despite an increased incidence of hepatitis E across Europe, much remains unknown about its spread, sources and transmission routes. A One Health approach is crucial to better understand the (molecular) epidemiology of HEV. HEVnet was established in April 2017 as a network and database for sharing sequences and accompanying metadata collected from human, animal, food and environmental sources. HEVnet members working in the public health, veterinary health, food, environmental and blood safety sectors have submitted 1,615 HEV sequences from nine countries as at January 2019. Most are from humans (89%), and sequences of animal (5%), food (6%) or environmental (0.3%) origin are rare. Metadata for human sequences capture mostly sex (93%), year of birth (92%) and sampling (100%); data on region of sampling (37%) and clinical information (hospitalisation 27%, symptoms 20% or mortality 8%) are limited. HEVnet aims to expand into a global network capable of performing cross-sectoral and supranational studies, with a joint repository of molecular and epidemiological data on HEV.</p