Hydrostatic Stokes Equations With Non-smooth Date For Mixed Boundary Conditions

The main subject of this work is to study the concept of very weak solution for the hydrostatic Stokes system with mixed boundary conditions (non-smooth Neumann conditions on the rigid surface and homogeneous Dirichlet conditions elsewhere on the boundary). In the Stokes framework, this concept has been studied by Conca [Rev. Mat. Apl. 10 (1989)] imposing non-smooth Dirichlet boundary conditions. In this paper, we introduce the dual problem that turns out to be a hydrostatic Stokes system with non-free divergence condition. First, we obtain strong regularity for this dual problem (which can be viewed as a generalisation of the regularity results for the hydrostatic Stokes system with free divergence condition obtained by Ziane [Appl. Anal. 58 (1995)]). Afterwards, we prove existence and uniqueness of very weak solution for the (primal) problem. As a consequence of this result, the existence of strong solution for the non-stationary hydrostatic Navier-Stokes equations is proved, weakening the hypothesis over the time derivative of the wind stress tensor imposed by Guillén-González, Masmoudi and Rodríguez-Bellido [Differential Integral Equations 50 (2001)]. © 2004 Elsevier SAS. All rights reserved.216807826Amrouche, C., Girault, V., Decomposition of vector spaces and application to the Stokes problem in arbitrary dimension (1994) Czechoslovak Math. J., 44 (119), pp. 109-140Azérad, P., Guillén, F., Mathematical justification of the hydrostatic approximation in the Primitive Equations of qeophysical fluid dynamics (2001) SIAM J. Math. Anal., 33 (4), pp. 847-859Besson, O., Laydi, M.R., Some estimates for the anisotropic Navier-Stokes equations and for the hydrostatic approximation (1992) M2AN-Mod. Math. Ana. Nume., 7, pp. 855-865Cattabriga, L., Sur un problema al contorno relativo al sistema di equazioni di Stokes (1961) Rend. Mat. Sem. Univ. Padova, 31, pp. 308-340Chacón, T., Guillén, F., An intrinsic analysis of existence of solutions for the hydrostatic approximation of the Navier-Stokes equations (2000) C. R. Acad. Sci. Paris, Série I, 330, pp. 841-846Conca, C., Stokes equations with non-smooth data (1989) Revista de Matemáticas Aplicadas, 10, pp. 115-122Girault, V., Raviart, P.A., (1986) Finite Element Methods for Navier-Stokes Equations, , Berlin: Springer-VerlagGuillén-González, F., Rodríguez-Bellido, M.A., On the strong solutions of the Primitive Equations in 2D domains (2002) Nonlin. Anal., 50, pp. 621-646Guillén-González, F., Masmoudi, N., Rodríguez-Bellido, M.A., Anisotropic estimates and strong solutions of the Primitive Equations (2001) Differential Integral Equations, 14 (11), pp. 1381-1408Lewandowski, R., (1997) Analyse Mathématique et Océanographie, , MassonLions, J.L., Magenes, E., (1969) Problèmes aux Limites Non Homogènes et Applications, 1. , Paris: DunodLions, J.L., Temam, R., Wang, S., New formulation of the primitive equations of the atmosphere and applications (1992) Nonlinearity, 5, pp. 237-288Lions, J.L., Temam, R., Wang, S., On the equations of the large scale ocean (1992) Nonlinearity, 5, pp. 1007-1053Pedlosky, J., (1987) Geophysical Fluid Dynamics, , Berlin: Springer-VerlagTemam, R., (1977) Navier-Stokes Equations: Theory and Numerical Analysis, , Amsterdam: North HollandZiane, M., Regularity results for Stokes type systems (1995) Appl. Anal., 58, pp. 263-29

A low-mass planet candidate orbiting Proxima Centauri at a distance of 1.5 AU

Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).Our nearest neighbor, Proxima Centauri, hosts a temperate terrestrial planet. We detected in radial velocities evidence of a possible second planet with minimum mass m c sin i c = 5.8 ± 1.9 M ⊕ and orbital period P c = 5.21 - 0.22 + 0.26 years. The analysis of photometric data and spectro-scopic activity diagnostics does not explain the signal in terms of a stellar activity cycle, but follow-up is required in the coming years for confirming its planetary origin. We show that the existence of the planet can be ascertained, and its true mass can be determined with high accuracy, by combining Gaia astrometry and radial velocities. Proxima c could become a prime target for follow-up and characterization with next-generation direct imaging instrumentation due to the large maximum angular separation of ~1 arc second from the parent star. The candidate planet represents a challenge for the models of super-Earth formation and evolution.Peer reviewedFinal Published versio

Immunization With Bovine Herpesvirus-4-Based Vector Delivering PPRV-H Protein Protects Sheep From PPRV Challenge

The Morbillivirus peste des petits ruminants virus (PPRV) is the causal agent of a highly contagious disease that mostly affects sheep and goats and produces considerable losses in developing countries. Current PPRV control strategies rely on live-attenuated vaccines, which are not ideal, as they cannot differentiate infected from vaccinated animals (DIVA). Recombinant vector-based vaccines expressing viral subunits can provide an alternative to conventional vaccines, as they can be easily paired with DIVA diagnostic tools. In the present work, we used the bovine herpesvirus-4-based vector (BoHV-4-A) to deliver PPRV hemagglutinin H antigen (BoHV-4-A-PPRV-H-ΔTK). Vaccination with BoHV-4-A-PPRV-H-ΔTK protected sheep from virulent PPRV challenge and prevented virus shedding. Protection correlated with anti-PPRV IgGs, neutralizing antibodies and IFN-γ-producing cells induced by the vaccine. Detection of antibodies exclusively against H-PPRV in animal sera and not against other PPRV viral proteins such as F or N could serve as a DIVA diagnostic test when using BoHV-4-A-PPRV-H-ΔTK as vaccine. Our data indicate that BoHV-4-A-PPRV-H-ΔTK could be a promising new approach for PPRV eradication programs

Water retentivity and environmental impact assessment in the headwaters of the Chambira micro-watershed, San Martin region

The study found that maximum precipitation and water retention occur in February for the Cacao sector and in October and February for the Caliza sector, with minimum values in July. The correlation between precipitation and temperature is −0.43 for both sectors, while the negative correlation between retentivity and temperature is stronger in the Caliza sector (−0.467) than in the Cacao sector (−0.096). Precipitation explains 82.07% and 89.92% of the variability in retentivity for the Cacao and Caliza sectors, respectively, according to the R2 coefficients. The environmental impact analysis indicates a medium impact with a value of 5.6

Teaching DBT Skills to DACA Recipients and their Families: Findings from an ECHO Program

Deferred Action for Childhood Arrivals (DACA) offers temporary administrative relief from deportation for undocumented immigrant adolescents and young adults who were brought as children to the United States. Accordingly, DACA has contributed to creating a different landscape of opportunities for this group. However, DACA has been and continues to be highly contested in the national political climate. Threats to DACA give rise to considerable anxiety, fear, and distress among its recipients, who face significant barriers to accessing mental health care services. Thus, a group of psychologists partnered with a leading immigrant rights advocacy organization and formed a reciprocal collaboration to understand and meet the mental health needs of undocumented communities. A major focus of the collaboration is to foster learning and support members of the immigrant community in contributing to their own well-being. The collaborative developed and delivered a stand-alone web-based mental health education session to DACA recipients and their families and practitioners serving this population. The session presented the use of dialectical behavioral therapy skills, three emotion regulation and four distress tolerance skills, as a strength-based approach to managing painful emotions and distress. Session content was adapted to include culturally informed examples for each skill. Quantitative and qualitative findings show that those who participated in the web-based program benefited from the education received. Findings also underscored participants’ need for learning culturally sensitive coping strategies for managing stress. We provide recommendations on the delivery of culturally congruent healing interventions for immigrants with a focus on enhancing access among immigrant communities

USE OF MORINGA SEED (Moringa oleifera Lam.) AS A BIOCOAGULANT TO IMPROVE SURFACE WATER QUALITY

Using Moringa oleifera (Moringa oleifera Lam.) seed as a biocoagulant to enhance surface water's physical and chemical quality was the goal of this study. The methodology applied for the generation of experimental data was through the use of the Jar Test equipment, in a dose of 40 mg/L to 140 mg/L, then a fast mixing of 100 rpm for 1 minute and a slow mixing of 40 rpm for 10 minutes was performed, and sedimentation was left for 5 to 30 minutes, with 5 minutes intervals between each dose. The results show that an optimal biocoagulant dose of 100 mg/L at 20 minutes produced a turbidity reduction effectiveness of 97.06%. Hardness fell by 12% of its starting value, conductivity and total dissolved solids increased dramatically, and there was a 92.3% reduction in perceived colour, which showed that the use of Moringa seeds as a coagulant had a favourable effect on reducing the concentration of turbidity and colour. Because of this, Moringa (Moringa oleifera Lam.) can be used as a natural source to purify drinking water. The Tukey HSD test applied to the turbidity removal percentages, indicates that the means are not significantly different. However, the experimental evaluation indicates that after 20 minutes, the best results are obtained

Draft Genome Sequence of a Multi-Metal Resistant Bacterium Pseudomonas putida ATH-43 Isolated from Greenwich Island, Antarctica

Indexación: Web of Science; Scopus.In this report we present the first draft genome sequence of a P. putida strain isolated from the Antarctic continent. The shotgun sequencing strategy, assembly, and subsequent annotation showed that the ATH-43 strain possesses a wide spectrum of genetic determinants involved in heavy metal and antibiotic resistance, apparently to cope with extreme oxidative stress conditions. P. putida ATH-43 genome now forms part of the 65 genomes of this species registered at the NCBI database (September, 2016) and it is highly related with the endophytic strain P. putida W619, which is also resistant to several heavy metals. Further characterization of multi-metal resistant psychrotrophic bacteria such as P. putida ATH-43 will be promising to develop novel strategies for heavy metal bioremediation in low temperature environments. All genome data has been submitted to NCBI.http://journal.frontiersin.org/article/10.3389/fmicb.2016.01777/ful

Adipose Tissue Therapeutics for Scar Rehabilitation after Thermal Injury

Background: Burn injuries are common and in the long term can lead to hypertrophic or keloid scars, pain and pruritus, limited mobility across joints, and disfigurement. Numerous reports suggest adipose derived tissues, including adipose derived stem cells (ADSCs) and processed lipoaspirate, can improve acutely healing wounds from a variety of etiologies including excisional, thermal, and radiation injuries by both secretion of growth factors and direct differentiation. There are many options for scar treatment, including laser therapy, silicone sheets, steroid injection, and even skin grafting however these techniques either lack optimal efficacy or involve significant cost and morbidity. Clinical case series suggest a beneficial effect of adipose tissues in improving scarred tissues, however this phenomenon has not been extensively studied in animal models especially in a thermal scar model. Objectives: (1) Determine if adipose tissue can accelerate and improve scar remodeling subacutely after acute wound healing has occurred. (2) Determine if the effect is related to adipose derived stem cells or other components of lipoaspirate. Methods: 50 CD1 nu/nu athymic mice received a standardized 70°C 10 second burn with a brass rod to the dorsal skin. Digital photographs and hyperspectral images were taken immediately following injury and serially over the study’s entirety. Burned skin reliably progressed through normal stages of wound healing to a scarred and granulating state. At six weeks post-burn animals received subcutaneous injection immediately beneath the scar with fresh human lipoaspirate (n=10), high dose hADSCs in matrigel (n=10), low dose hADSCs in matrigel (n=10), matrigel control (n=10), or were not injected (n=10). At 4 weeks post-injection (10 weeks post-burn) animals were sacrificed and tissue samples were harvested for histological molecular analysis. Results: Oxygenation and perfusion profiles from hyperspectral imaging and scar wound area correlated between groups suggesting methodological consistency of burns prior to any intervention. Oxygenated hemoglobin at 10 weeks in scars treated with lipoaspirate increased significantly more compared to 6-week pre-treatment baseline than all other groups (1.57x vs. 0.85x, p Conclusion: A consistent model of burn injury and scar maturation is described. Preliminary HSI and scar area data suggest scar improvement in lipoaspirate treated scars compared to ADSCs and controls

Lipoaspirate and Adipose Stem Cells as Potential Therapeutics for Chronic Scars

Introduction: Burn injuries can lead to hypertrophic or keloid scars, causing pain and long lasting mobility issues. Current therapies are often unsatisfactory, costly, or morbid. Prior studies suggest adipose derived stem cells (ADSCs) and lipoaspirate can improve scar outcomes of acute thermal wounds. Clinical reports suggest lipoaspirate and ADSCs can improve chronic burn scar remodeling. However, this has not been extensively studied in animal models. We sought to determine if adipose tissue can improve chronic scar remodeling and to compare the effects of ADSCs and processed lipoaspirate. Methods: 50 CD1 nu/nu athymic mice received a standardized deep partial-thickness thermal burn. Scars matured for 6 weeks. Photographs and perfusion measurements by hyperspectral imaging (HSI) were taken over the entire study. Lipoaspirate and ADSCs (SVF and ex-vivo culture with flow cytometry confirmation) were obtained from a discarded human pannus specimen. After 6 weeks, animals received a 0.6cc subcutaneous graft beneath the scar of either: human lipoaspirate processed with the Coleman technique, high-dose (106) hADSCs in Matrigel, low-dose (104) hADSCs in Matrigel, Matrigel only, or not injected (n=10 per group). At 10 weeks, animals were sacrificed and scar tissue was harvested for histological and molecular analysis. Results: HSI oxygenated hemoglobin values in lipoaspirate treated scars increased significantly more compared to 6-week pre-treatment baseline than all other groups (p \u3c 0.05). Planimetry analysis showed reduction in wound area in lipoaspirate treated mice compared to control groups (p \u3c 0.01). Blood vessel density quantification on Masson’s trichrome stains suggests increased density in lipoaspirate treated scars versus controls (p \u3c 0.01). Conclusion: HSI, blood vessel density, and scar analysis suggest improvement in lipoaspirate treated scars compared to controls. Preliminary molecular data offers some insight to this trend. No effect was seen with ADSCs at either concentration at the analyzed timepoints. Molecular analyses are ongoing to investigate cellular mechanisms in regulating scar remodeling

CARGO: a web portal to integrate customized biological information

There is a huge quantity of information generated in Life Sciences, and it is dispersed in many databases and repositories. Despite the broad availability of the information, there is a great demand for methods that are able to look for, gather and display distributed data in a standardized and friendly way. CARGO (Cancer And Related Genes Online) is a configurable biological web portal designed as a tool to facilitate, integrate and visualize results from Internet resources, independently of their native format or access method. Through the use of small agents, called widgets, supported by a Rich Internet Application (RIA) paradigm based on AJAX, CARGO provides pieces of minimal, relevant and descriptive biological information. The tool is designed to be used by experimental biologists with no training in bioinformatics. In the current state, the system presents a list of human cancer genes. Available at http://cargo.bioinfo.cnio.e