Estilos de vida asociados al riesgo cardiovascular global en trabajadores universitarios del Estado de México

Objetivo. Evaluar la asociación del estilo de vida con el riesgo cardiovascular (RCV) en trabajadores universitarios del Estado de México. Material y métodos. Estudio de casos y controles anidado en una cohorte. Se evaluaron variables del estilo de vida, sociodemográficas, antropométricas y antecedentes familiares. El análisis estimó razones de momios pareadas crudas y ajustadas a través de regresión logística condicional. Resultados. Se estudiaron 342 casos con RCV y 684 controles. En los trabajadores con sobrepeso u obesidad, el RCV superó al de aquéllos con peso normal. Los antecedentes familiares de infarto del miocardio se asociaron directamente, y la actividad física moderada-vigorosa inversamente con el RCV, en modelos con interacciones entre género y actividad física; esta relación se mantuvo sólo en los hombres. Conclusiones. Los resultados muestran el papel preponderante de la actividad física moderada-vigorosa como factor del estilo de vida asociado con menor RCV

Algarrobos en la Puna

En este escrito presentamos y discutimos los hallazgos del género Prosopissp. efectuados en la microrregión de Antofagasta de la Sierra que corresponden al lapso comprendido entre ca. 7500 - 500 años AP. Estos hallazgos dan cuenta de la interacción de los grupos humanos que habitaron el área con ambientes muy diferentes al puneño, hecho que nos permitió obtener conclusiones acerca de su movilidad, sus interacciones con grupos de otras regiones y modos de vida, así como también la posibilidad de plantearnos preguntas a resolver en futuras investigacionesFil: Rodriguez Maria Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Aguirre, María Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Tucumán; Argentin

The creation of touristic cities as an update of the indigenous dispossession in the Andean area of Neuquén: Villa Pehuenia-Moquehue y Villa La Angostura (Argentina)

Este trabajo se propone analizar el impacto de la creación de municipios sobre territorio indígena mapuce. El artículo se centra en dos estudios de caso ubicados en la zona andina de la provincia de Neuquén, en la que actualmente se desarrollan actividades turísticas de notoriedad nacional e internacional. Se tendrá en cuenta los procesos de desterritorialización indígena en favor del desarrollo del turismo, las consecuencias de la creación de municipios en las comunidades mapuce, los conflictos territoriales y los modos -propiciados por el Estado- de integración o exclusión indígena de los circuitos turísticos. Para analizar estos factores, se ha acudido a documentación estatal administrativa y judicial, prensa escrita y trabajo de campo etnográfico. Las conclusiones del trabajo se vinculan a las desterritorializaciones comprendidas como un despojo actualizado en el presente. De esta forma, se expresan dos procesos asociados a la creación de municipios, la heterogeneidad presente en las formas de “inclusión” indígena en la actividad turística y el crecimiento de la conflictividad territorial.This paper aims to analyze the impact of the creation of cities on Mapuce indigenous territory. The study focuses on two case studies located in the Andean area of ​​the province of Neuquén, Argentina, in which touristic activities of national and international relevance take place. It will take into account the processes of indigenous deterritorialization in favor of touristic development, the consequences of the creation of cities in two Mapuce communities, the territorial conflicts and the ways of indigenous integration or exclusion from tourist circuits promoted by the State. To analyze these factors, we have resorted to administrative and judicial state documentation, written press and ethnographic field work. The conclusions of the work are linked to the deterritorializations understood as an updated dispossession in the present. All in all, the paper portrays two processes associated with the creation of cities, the heterogeneity present in the forms of indigenous “inclusion” in touristic activities and the increase of territorial conflict

La causalidad entre el crecimiento económico y la expansión del transporte aéreo: un análisis empírico para Chile

Este trabajo analiza los efectos a largo plazo entre la demanda de transporte aéreo y el crecimiento económico en Chile. Utilizando datos trimestrales de 1986 (T1) a 2014 (T29), el estudio investiga la posible relación de causalidad entre el pib real y el número de pasajeros aéreos que llegan y salen de los aeropuertos chilenos. Por medio de la cointegración de Johansen, se muestra la existencia de un vector de cointegración en el que las correspondientes elasticidades son positivas. El estudio muestra que la relación de causalidad es positiva y bidireccional. A su vez, el análisis de impulso-respuesta, muestra que un incremento en la magnitud del movimiento de pasajeros produce un efecto positivo en el crecimiento económico en el país

Anthracology of an residential unit at El Pichao (Yucumán - Argentina)

El sitio arqueológico El Pichao ha sido estudiado desde diversos aspectos, sin embargo, hasta la actualidad no se había llevado a cabo el análisis antracológico de las muestras recuperadas en unidades residenciales del período de Desarrollos Regionales (1000-535 AP). Este tema se aborda mediante el estudio de carbones obtenidos en la unidad STucTav5 - 100. La identificación taxonómica de los macro restos se realizó mediante la comparación de los carbones arqueológicos con una colección de referencia de cortes histológicos que incluye ejemplares de la flora del área de estudio; los carbones se examinaron observando las secciones transversal, longitudinal tangencial y longitudinal radial del leño bajo lupa binocular, microscopio óptico con luz incidente y se tomaron fotografías con microscopio electrónico de barrido. En el conjunto de carbones se identificaron a los siguientes taxa: Prosopis sp., P. torquata, Geoffroea decorticans, Acacia sp. Nicotiana glauca, Bulnesia schickendantzii, Larrea divaricata y un taxón quedó en la categoría de No Identificado. Los mismos forman parte de la flora local del área y habrían sido usados durante ocupaciones correspondientes al período de Desarrollos Regionales y posteriores. Los datos generados alientan al desarrollo de esta línea de trabajo en el área.he archaeological site El Pichao has been studied from various aspects, however, the anthracological analysis of samples recovered in residential units of the Regional Development period (1000-535 AP) had not yet been carried out. This topic is addressed by studying carbon obtained from the STucTav5 - 100 unit. The taxonomic identification of the macro remains was made by comparing the archaeological carbons with a reference collection of histological cuts that includes specimens of the flora of the study area; the carbons were examined by observing the transverse, longitudinal tangential and longitudinal radial sections of the log under a binocular magnifier, optical microscope with incident light and photographs were taken with microscope. In the set of carbons, the following taxa were identified: Prosopis sp., P. torquata, Geoffroea decorticans, Acacia sp., Nicotiana glauca, Bulnesia schickendantzii, Larrea divaricata and one taxon remained in the category of Unidentified. They are part of the local flora of the area and would have been used during occupations corresponding to the period of Regional and subsequent Developments. The data generated encourages the development of this line of work in the area.Fil: Aguirre, María Gabriela. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo. Laboratorio de Geoarqueología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán; ArgentinaFil: Sampietro Vattuone, Maria Marta. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo. Laboratorio de Geoarqueología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán; ArgentinaFil: Rodriguez, Maia del Rosario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Estudios Sociales. Universidad Nacional de Tucumán. Instituto Superior de Estudios Sociales; ArgentinaFil: Cano, Sergio Fabian. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo; Argentin

Graphene derivative scaffolds facilitate in vitro cell survival and maturation of dopaminergic SN4741 cells

The emerging carbon nanomaterial Graphene (G), in the form of scaffold structure, has an efficient bioconjugation with common biomolecules and activates cell differentiation of neuronal stem cells, providing a promising approach for neural regeneration. We propose the use of G as a scaffold to re-address the dopaminergic (DA) neurons and the residual axons from dead or apoptotic DA neurons in Parkinson´s disease (PD). G could act as a physical support to promote the axonal sprout as a “deceleration” support for the DA cells derived from neural stem cells or DA direct cell conversion, allowing the propagation of nerve impulses. We cultured a clonal substantia nigra (SN) DA neuronal progenitor cell line (SN4741) in presence of G as scaffold. This cell line derived from mouse embryos was cultured in Dulbecco’s modified Eagle’s medium/10% FCS to about 80% confluence. Cells were incubated in three chemically different G derivatives and two different presentation matrixes as powder and films: 1) G oxide (GO); 2) partially reduced GO (PRGO) which is hydrophobic; and 3) fully reduced GO (FRGO). Cell viability was determined using the MTT assay after adding the following G concentrations: 1mg/ml; 0.1mg/ml; 0.05mg/ml; 0.02mg/ml and 0.01mg/ml, in each type of GO. To study cellular morphology and assessment of cell engraftment into GO films (GO film, PRGO film, FRGO film), we analyzed the immunostaining of the anti-rabbit neuron-specific DNA-binding protein (NeuN) antibody, the anti-rat Beta-3-tubulin antibody in combination with the mitochondrial marker mouse anti-ATP synthase antibody, and the anti-rabbit DCX as immature neuronal marker. Hoechst label was used as nuclei marker. Reactive oxidative species (ROS) were measured by flow cytometry to study the influence of G on the cell redox-state. With this purpose, cells were loaded with dihydroethidium. The mitochondrial membrane potential after JC-1 incubation was studied by flow cytometry. Our results show an increase of survival and metabolism (30-40%) at low concentrations of PRGO and FRGO (0.05-0.01 mg/ml) respect to the higher concentration (1 mg/ml), while no changes were seen in the GO group. LDH concentration was measured in the supernatant using a COBAS analyzer showing a neuroprotective action at low concentrations. Furthermore, either PRGO film or FRGO film show an increase in the effective anchorage capacity to nest into the G matrix and in the maturation of the SN 4741 cells. We conclude that the use of G scaffolds in the research of neurological diseases like PD could offer a powerful platform for neural stem cells, direct cell conversion techniques and neural tissue engineering.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech. Norwegian Research Council (grant nº 215086

Aprovechamiento de residuos, descartes y subproductos agroalimentarios y agropecuarios: tecnologías para la obtención de alimentos y bioproductos para cadenas productivas. Resultados obtenidos 2019-2022.

Las actividades agropecuarias y agroindustriales generan constantemente grandes volúmenes de residuos, descartes y subproductos (RDS), los cuales constituyen un gran problema debido al impacto ambiental que generan y por las dificultades vinculadas a la logística de su disposición y los costos asociados a esta. Los RDS generados conducen a su vez a grandes pérdidas de alimentos. Según cifras de la FAO (2011) se desperdicia aproximadamente un tercio de los alimentos que se producen. Estas pérdidas varían, de acuerdo a la cadena considerada. Por ejemplo, en las frutas y verduras procesadas se pierden alrededor del 30% antes de llegar a los consumidores. En algunos casos, ciertos parámetros de calidad, como los asociados a estética y tamaño, conducen a pérdidas por descarte previas a la industrialización, ya que los productos no son atractivos para los consumidores. A su vez, la agroindustria genera residuos y subproductos propios de la industrialización, tales como piel, semillas, carozos, bagazos, sueros, etc. Así́, la producción de RDS es una parte inevitable de la cadena de elaboración y suministro de alimentos. Sin embargo, pueden minimizarse y valorizarse mediante la aplicación de tecnologías adecuadas. En este contexto, el objetivo del proyecto fue desarrollar y adaptar tecnologías, proponer soluciones tecnológicas, aportar a la generación de conocimientos y consolidar una red de RRHH capacitados que permitan dar respuesta a problemas concretos del Sistema Agro Alimentario Argentino (SAAA) contribuyendo con su sostenibilidad ambiental y competitividad. El proyecto se caracterizó por una amplia distribución geográfica a lo largo de todo el país, abarcando una diversidad de cadena productivas: Cultivos Industriales, Frutales, Hortalizas, Flores y Aromáticas, Carnes, Leche, Cereales y Oleaginosas, Forestales y Miel. Luego de 3 años de ejecución del proyecto queremos compartir con la comunidad algunos de los resultados obtenidos. Es así como presentamos este libro con el objetivo de comunicar y difundir los avances del equipo de investigadores que han ejecutado actividades de I&D en el marco del citado proyecto. Los resultados presentados corresponden al período septiembre 2019 a marzo 2022. Cabe mencionar que las actividades han sido financiadas por fondos correspondientes al proyecto pero, en su mayoría, también han recibido aportes de otros organismos. Se destaca también la cooperación y articulación con otros organismos académicos, entidades locales, organizaciones de productores, industrias, etc. para poder llevar adelante cada una de las actividades.Agricultural and agro-industrial activities constantly generate large volumes of waste, discards and by-products (RDS), which constitute a major problem due to the environmental impact they generate and the difficulties related to the logistics of their disposal and the costs associated with it. The RDS generated in turn lead to large food losses. According to figures from the FAO (2011), approximately one third of the food produced is wasted. These losses vary, according to the considered chain. For example, processed fruits and vegetables lose about 30% before reaching consumers. In some cases, certain quality parameters, such as those associated with aesthetics and size, lead to discard losses prior to industrialization, since the products are not attractive to consumers. In turn, the agro-industry generates waste and by-products typical of industrialization, such as leather, seeds, pits, bagasse, serum, etc. Thus, the production of RDS is an unavoidable part of the food processing and supply chain. However, they can be minimized and valued through the application of appropriate technologies. In this context, the objective of the project was to develop and adapt technologies, propose technological solutions, contribute to the generation of knowledge and consolidate a network of trained human resources that allow responding to specific problems of the Argentine Agro-Food System (SAAA) contributing to its sustainability. environment and competitiveness. The project was characterized by a wide geographical distribution throughout the country, covering a diversity of production chains: Industrial Crops, Fruit Trees, Vegetables, Flowers and Aromatics, Meat, Milk, Cereals and Oilseeds, Forestry and Honey. After 3 years of execution of the project we want to share with the community some of the results obtained. This is how we present this book with the aim of communicating and disseminating the advances of the team of researchers who have carried out R&D activities within the framework of the aforementioned project. The results presented correspond to the period September 2019 to March 2022. It is worth mentioning that the activities have been financed by funds corresponding to the project but, for the most part, they have also received contributions from other organizations. Cooperation and articulation with other academic bodies, local entities, producer organizations, industries, etc. is also highlighted. to carry out each of the activities.Instituto de Investigación de Tecnología de Alimentos (ITA)Fil: Negri Rodriguez, Livia Mari. Instituto Nacional de Tecnología Agropecuaria (INTA). CIA. Instituto de Investigación Tecnología de Alimentos (ITA); Argentina.Fil: Urfalino, Delia Paola. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rama Caída; Argentina.Fil: Aimaretti, Nora Rosa. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela. Agencia De Extensión Rural Monte Vera; Argentina.Fil: Albe Aguirre, Rolando Gustavo. Instituto Nacional de Tecnología Agropecuaria (INTA). Investigación y Desarrollo Tecnológico para la Agricultura Familiar (IPAF).Laguna Naineck. Región NEA. Área de Laboratorio; Argentina.Fil: Monetta, Pablo Miguel. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria San Juan; Argentina

Single-cell transcriptional profile of CD34+ hematopoietic progenitor cells from del(5q) myelodysplastic syndromes and impact of lenalidomide

While myelodysplastic syndromes with del(5q) (del(5q) MDS) comprises a well-defined hematological subgroup, the molecular basis underlying its origin remains unknown. Using single cell RNA-seq (scRNA-seq) on CD34 + progenitors from del(5q) MDS patients, we have identified cells harboring the deletion, characterizing the transcriptional impact of this genetic insult on disease pathogenesis and treatment response. Interestingly, both del(5q) and non-del(5q) cells present similar transcriptional lesions, indicating that all cells, and not only those harboring the deletion, may contribute to aberrant hematopoietic differentiation. However, gene regulatory network (GRN) analyses reveal a group of regulons showing aberrant activity that could trigger altered hematopoiesis exclusively in del(5q) cells, pointing to a more prominent role of these cells in disease phenotype. In del(5q) MDS patients achieving hematological response upon lenalidomide treatment, the drug reverts several transcriptional alterations in both del(5q) and non-del(5q) cells, but other lesions remain, which may be responsible for potential future relapses. Moreover, lack of hematological response is associated with the inability of lenalidomide to reverse transcriptional alterations. Collectively, this study reveals transcriptional alterations that could contribute to the pathogenesis and treatment response of del(5q) MDS. The hematopoiesis of patients with del(5q) Myelodysplastic Syndromes is composed of a mixture of cells with and without the deletion. Here, the authors show that del(5q) and non-del(5q) cells share similar transcriptional alterations, with del(5q) cells presenting additional lesions. Moreover, hematological response to lenalidomide is associated with the reversal of some transcriptional lesions in both del(5q) and non-del(5q) cells

Thirty-day outcomes in frail older patients discharged home from the emergency department with acute heart failure: effects of high-risk criteria identified by the DEED FRAIL-AHF trial

Objectives: To study the effect of high-risk criteria on 30-day outcomes in frail older patients with acute heart failure (AHF) discharged from an emergency department (ED) or an ED's observation and short-stay areas. Material and methods: Secondary analysis of discharge records in the Older AHF Key Data registry. We selected frail patients (aged > 70 years) discharged with AHF from EDs. Risk factors were categorized as modifiable or nonmodifiable. The outcomes were a composite endpoint for a cardiovascular event (revisits for AHF, hospitalization for AHF, or cardiovascular death) and the number of days alive out-of-hospital (DAOH) within 30 days of discharge. Results: We included 380 patients with a mean (SD) age of 86 (5.5) years (61.2% women). Modifiable risk factors were identified in 65.1%, nonmodifiable ones in 47.8%, and both types in 81.6%. The 30-day cardiovascular composite endpoint occurred in 83 patients (21.8%). The mean 30-day DAOH observed was 27.6 (6.1) days. Highrisk factors were present more often in patients who developed the cardiovascular event composite endpoint: the rates for patients with modifiable, nonmodifiable, or both types of risk were, respectively, as follows in comparison with patients not at high risk: 25.0% vs 17.2%, P = .092; 27.6% vs 16.7%, P = .010; and 24.7% vs 15.2%, P = .098). The 30-day DAOH outcome was also lower for at-risk patients, according to type of risk factor present: modifiable, 26.9 (7.0) vs 28.4 (4.4) days, P = .011; nonmodifiable, 27.1 (7.0) vs 28.0 (5.0) days, P = .127; and both, 27.1 (6.7) vs 28.8 (3.4) days, P = .005). After multivariate analysis, modifiable risk remained independently associated with fewer days alive (adjusted absolute difference in 30-day DAOH, -1.3 days (95% CI, -2.7 to -0.1 days). Nonmodifiable factors were associated with increased risk for the 30-day cardiovascular composite endpoint (adjusted absolute difference, 10.4%; 95% CI, -2.1% to 18.7%). Conclusion: Risk factors are common in frail elderly patients with AHF discharged home from hospital ED areas. Their presence is associated with a worse 30-day prognosis

The ocean sampling day consortium.

Ocean Sampling Day was initiated by the EU-funded Micro B3 (Marine Microbial Biodiversity, Bioinformatics, Biotechnology) project to obtain a snapshot of the marine microbial biodiversity and function of the world's oceans. It is a simultaneous global mega-sequencing campaign aiming to generate the largest standardized microbial data set in a single day. This will be achievable only through the coordinated efforts of an Ocean Sampling Day Consortium, supportive partnerships and networks between sites. This commentary outlines the establishment, function and aims of the Consortium and describes our vision for a sustainable study of marine microbial communities and their embedded functional traits