The tidally disturbed luminous compact blue galaxy Mkn 1087 and its surroundings

We present new broad-band optical and near-infrared CCD imaging together with deep optical intermediate-resolution spectroscopy of Mkn 1087 and its surrounding objects. We analyze the morphology and colors of the stellar populations of the brightest objects, some of them star-formation areas, as well as the kinematics, physical conditions and chemical composition of the ionized gas associated with them. Mkn 1087 does not host an Active Galactic Nucleus, but it could be a Luminous Compact Blue Galaxy. Although it was classified as a suspected Wolf-Rayet galaxy, we do not detect the spectral features of these sort of massive stars. Mkn 1087 shows morphological and kinematical features that can be explained assuming that it is in interaction with two nearby galaxies: the bright KPG 103a and a dwarf ($M_B\sim-18$) star-forming companion. We argue that this dwarf companion is not a tidal object but an external galaxy because of its low metallicity [12+log(O/H) = 8.24] with respect to the one derived for Mkn 1087 [12+log(O/H) = 8.57] and its kinematics. Some of the non-stellar objects surrounding Mkn 1087 are connected by bridges of matter with the main body, host star-formation events and show similar abundances despite their different angular distances. These facts, together their kinematics, suggest that they are tidal dwarf galaxies formed from material stripped from Mkn 1087. A bright star-forming region at the south of Mkn 1087 (knot #7) does not show indications of being a tidal galaxy or the product of a merging process as suggested in previous works. We argue that Mkn 1087 and its surroundings should be considered a group of galaxies.Comment: Accepted by A&A, 21 pages, 13 figures, 8 table

THE EFQM EXCELLENCE MODEL AS ENABLER OF E-PROCUREMENT ADOPTION AND THE EFFECT ON PERFORMANCE

The objective of this paper is to examine the EFQM Excellence Model as an enabler of E-procurement adoption and the effect on purchasing performance. The study utilized a cross-sectional telephone survey of a sample of Spanish manufacturing companies using multiple informants. A total of 200 firms responded making a total of 800 responses. Data was analyzed using structural equations modelling. The results indicate that the Business Excellence Enablers (Leadership, Strategy, People, Resources, and Processes) act as enablers of E-procurement and help to realize gains in purchasing performance

Nobody expects selfishness

Mechanisms supporting human ultra-cooperativeness are very much subject to debate. One psychological feature likely to be relevant is the formation of expectations, particularly about receiving cooperative or generous behavior from others. Without such expectations, social life will be seriously impeded and, in turn, expectations leading to satisfactory interactions can become norms and institutionalize cooperation. In this paper, we assess people's expectations of generosity in a series of controlled experiments using the dictator game. Despite differences in respective roles, involvement in the game, degree of social distance or variation of stakes, the results are conclusive: subjects seldom predict that dictators will behave selfishly (by choosing the Nash equilibrium action, namely giving nothing). The majority of subjects expect that dictators will choose the equal split. This implies that generous behavior is not only observed in the lab, but also expected by subjects. In addition, expectations are accurate, matching closely the donations observed and showing that as a society we have a good grasp of how we interact. Finally, correlation between expectations and actual behavior suggests that expectations can be an important ingredient of generous or cooperative behavior

Programa de formación e iniciación deportiva en la práctica del atletismo, dirigido a niños entre los 8 y 12 años de la institución educativa Abraham Reyes

La práctica deportiva busca complementar el desarrollo integral del ser humano ofreciendo diferentes alternativas con la variedad de deportes que no solo se enfocan en la parte física sino que van más allá: la formación integrar del ser; así mismo la educación física contribuye desde la pedagogía utilizando herramientas para fomentar la motivación y el entusiasmo en los participantes facilitando el proceso de aprendizaje – enseñanza y del mismo modo genera enseñanzas significativas para mejorar las condiciones físicas del niño. Con este trabajo se pretende diseñar una propuesta para un programa de iniciación deportiva en atletismo para niños de 8 a 12 años en la institución educativa Abraham Reyes, con el fin de enseñar el atletismo de una forma lúdica, generando alegría y goce en su práctica y, al mismo tiempo, como una alternativa de crear espacios para que los niños ocupen su tiempo libre.Sports practice seeks to complement the integral development of the human being by offering different alternatives with the variety of sports that not only focus on the physical part but go further: integrating training of the being; Likewise, physical education contributes from pedagogy using tools to promote motivation and enthusiasm in the participants, facilitating the learning-teaching process and, in the same way, generates significant lessons to improve the physical conditions of the child. This work aims to design a proposal for a sports initiation program in athletics for children from 8 to 12 years old at the Abraham Reyes educational institution, in order to teach athletics in a playful way, generating joy and enjoyment in their practice and At the same time, as an alternative to create spaces for children to occupy their free time

Unraveling the mechanism of TTL genes in cellulose biosynthesis

As sessile organisms, plants require mechanisms to sense and respond to the challenging environment, that encompass both biotic and abiotic factors that results in differential development. In these conditions is essential to balance growth and stress responses. As cell walls shape plant growth, this differential growth response cause alterations to the plant cell wall where cellulose is the major component. Therefore, understanding the mechanisms that regulate cellulose biosynthesis is essential to develop strategies to improve plant production. In Arabidopsis, the TETRATRICOPEPTIDE THIOREDOXIN-LIKE (TTL) gene family is composed by four members (TTL1 to TTL4) and mutations in TTL1, TTL3, and TTL4 genes cause reduced growth under salt and osmotic stress due to defects in plant cell wall integrity. We observe association of TTL3 with most core components in traducing BR signalling, such as LRR-RLK BRI1 or GSK3 BIN2 that modulate cellulose biosynthesis through phosphorylating cellulose synthases. Here, we show that ttl mutants present defects in the plant cell wall, particularly in Isoxaben, salt or sucrose stress. Spinning disk microscopy in etiolated hypocotyls reveals that, TTL proteins are responsible for the cellulose synthase complex (CSC) stability in plasma membrane (PM) upon sucrose stress. Moreover, TTL3 associates with LRR-RLKs that have been shown to be important for cellulose biosynthesis such as FEI1 in the FEI1/FEI2/SOS5 pathway. We aim to investigate the mechanisms by which TTL proteins regulate CesA stability in PM under stress, using a combination of genetics, biochemical, and molecular and cell biology approaches.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech. This work was supported by grants from: (1) Ministerio de Ciencia e Innovación BIO2014-55380-R, BIO2014-56153-REDT; (2) Ministerio de Economía, Industria y Competitividad (BES-2015-071256

Molecular simulation of methane hydrate growth confined into a silica pore

Financiaciado para publicación en acceso aberto: Universidade de Vigo/CISUGThe growth of a methane hydrate seed within a silica slit pore of fixed width has been studied using All- Atom Molecular Dynamics (AA-MD). An AA force field has been used to describe the molecules of the solid silica substrate, with a-quartz crystalline structure. The crystallisation of hydrates in confined geometries is not well understood yet, and the objective of this work is to study the hydrate growth inside a silica pore using molecular simulation. Both NVT and NpT ensembles were used in the AA-MD simulations to analyse the hydrate growth from an initial seed. Results showed that the boundary conditions imposed by the nanometric slit pore yielded a hydrate with structural defects, filling the accessible space between the silica walls. The water molecules which were not incorporated to the initial seed hydrate formed a high density water layer trapped between the silica walls and the crystallised hydrate. These results provide an interesting insight into the hydrate crystallisation process in confined geometries, resembling those found in natural hydrate deposits.Ministerio de Ciencia e Innovación | Ref. PID2021-125081NB-I00FEDER | Ref. SOE2/P1/P0823Xunta de Galicia | Ref. FSE-GALICIA 2014–2020Fundação para a Ciência e a Tecnologia | Ref. UIDB/50011/2020Fundação para a Ciência e a Tecnologia | Ref. UIDP/50011/2020Fundação para a Ciência e a Tecnologia | Ref. LA/ P/0006/2020Ministerio de Ciencia e Innovación | Ref. PID2019-105898GA-C22Comunidad de Madrid | Ref. APOYOJOVENES- 01HQ1S-129-B5E4M

Criterios para la implementación de la norma ISO 14001:2015 en la empresa "ALEGUAMA" del municipio de Castilla La Nueva, Departamento del Meta - caso estudio -

Como un primer paso para cumplir el objeto del presente estudio se realiza un estudio de caso con la empresa ALEGUAMA ubicada en el Municipio de Castilla la Nueva, en el Departamento del Meta; la cual desarrollará una aproximación a las medidas de manejo técnica y ambiental definidos en la Norma ISO 14001:2015; en el desarrollo del proceso, se indaga información importante que hace parte de ALEGUAMA, se revisa sus condiciones actuales en cuanto a temas de legalización y licencias; es necesario revisar el proceso de producción y evaluar cualitativa y cuantitativamente los impactos ambientales que se generan en cada uno de los procesos y finalmente se diseñará un programa ambiental dirigido a alcanzar el certificado ISO 14001 así como todos los beneficios que este representa. Los resultados obtenidos en el presente estudio de caso, son positivos; ya que se demuestra la viabilidad de que ALEGUAMA alcance su certificado ISO 14001:2015; ésta empresa como actividad comercial contempla la producción y comercialización de alevinos de distintas especies como: Tilapia, Mojarra, Bocachico y Yamú, desde hace aproximadamente 14 años. Esta empresa cuenta con un área física de tres hectáreas y media laborables, administrados por su propietario y trabajadores a cargo. En la actualidad tiene documentos legales en regla: cuenta con Código CIIU de la actividad 0322, el cual lo define como Acuicultura de agua dulce (DIAN, 2020), Cámara de Comercio, permiso de Cormacarena para uso de aguas de lagos, permiso de cultivos de la AUNAP y registro ICA, pero no aplica la norma ISO 14001:2015 la cual regula los procesos referentes al SGA. Palabras clave: Acuicultura, Manejo ambiental, Gestión ambiental, Impacto ambiental.As a first step to fulfill the purpose of this study, a case study is carried out with the company ALEGUAMA located in the Municipality of Castilla la Nueva, in the Department of Meta; which will develop an approach to the technical and environmental management measures defined in the ISO 14001: 2015 Standard; During the development of the process, important information that is part of ALEGUAMA is investigated, its current conditions regarding legalization and licensing issues are reviewed; It is necessary to review the production process and qualitatively and quantitatively evaluate the environmental impacts that are generated in each of the processes and finally an environmental program will be designed aimed at achieving the ISO 14001 certificate as well as all the benefits that it represents. The results obtained in the present case study are positive; since the viability of ALEGUAMA achieving its ISO 14001: 2015 certificate is demonstrated; This company as a commercial activity contemplates the production and commercialization of fingerlings of different species such as: Tilapia, Mojarra, Bocachico and Yamú, for approximately 14 years. This company has a physical area of ​​three and a half hectares, managed by its owner and workers in charge. It currently has legal documents in order: it has an ISIC Code for activity 0322, which defines it as Freshwater Aquaculture (DIAN, 2020), Chamber of Commerce, Cormacarena permit for the use of lake waters, cultivation permit of the AUNAP and ICA registration, but the ISO 14001: 2015 standard which regulates the processes related to the EMS does not apply. Keywords: Aquaculture, Environmental management, Environmental management, Environmental impact

Bioinspired design of triboceramics: Learning from the anisotropic microfracture response of dental enamel under sliding contact

[EN] In the quest for novel ceramics for tribological applications via bioinspired design, the differences in the fracture modes that arise upon scratching relevant locations of ceramic-like tooth enamel are investigated. It is found that fracture initiates from weak rod-sheath interfaces at relatively low loads, independent of the sliding direction. However, the geometry and propagation of the cracks depends on the orientation of the interfaces relative to the maximum tensile stress: scratching along the occlusal surface propagates approximately sinusoidal cracks, parallel to the sliding direction, while scratching along the cross-section produces straight cracks that propagate normal (scratch parallel to occlusal surface) or parallel (scratch perpendicular to occlusal surface) to the sliding direction. The formation of cracks is hindered in scratching near the enamel-dentine junction. Implications for the microstructural design of triboceramics (bulks and coatings) with improved durability are discussed.The authors wish to thank Dr Florencio Monje Gil for kindly providing tooth specimens from his clinic (CICOM, Centro de Implantologia Cirugia Oral y Maxilofacial, Badajoz, Spain). This study was supported by Junta de Extremadura, Spain, and FEDER/ERDF funds (grants IB16139 and GR18149), and the Spanish Ministry of Science and Innovation (grant PID2019-105377RB-I00). E. P.-C. gratefully acknowledges support from the Spanish Ministry of Economy and Competitiveness (MINECO) under grant FJCI-2015-27228.Sanchez-Gonzalez, E.; Rodriguez-Rojas, F.; Pinilla-Cienfuegos, E.; Borrero-Lopez, O.; Ortiz, AL.; Guiberteau, F. (2020). Bioinspired design of triboceramics: Learning from the anisotropic microfracture response of dental enamel under sliding contact. Ceramics International. 46(18):27983-27989. https://doi.org/10.1016/j.ceramint.2020.07.2922798327989461

Combinatory effect of BRCA1 and HERC2 expression on outcome in advanced non-small-cell lung cancer

BACKGROUND: BRCA1 is a main component of homologous recombination and induces resistance to platinum in preclinical models. It has been studied as a potential predictive marker in lung cancer. Several proteins modulate the function of BRCA1. The E3 ubiquitin ligase HERC2 facilitates the assembly of the RNF8-UBC13 complex to recruit BRCA1 to DNA damage sites. The combined analysis of multiple components of the pathway leading to the recruitment of BRCA1 at DNA damage sites has the potentiality to improve the BRCA1 predictive model. METHODS: We retrospectively analyzed 71 paraffin-embedded tumor samples from advanced non-small-cell lung cancer patients treated with first-line platinum based chemotherapy and measured the mRNA expression levels of BRCA1, RNF8, UBC13 and HERC2 using real-time PCR. The mRNA expression was categorized using median value as cut-off point. RESULTS: The median progression-free survival of all 71 patients was 7.2 months whereas the median overall survival of the study population was 10.7 months. Among patients with low BRCA1 expression, the median PFS was 7.4 months in the presence of low HERC2 levels and 5.9 months for patients expressing high HERC2 levels (p\u2009=\u20090.01). The median OS was 15.3 months for patients expressing low levels of both genes and 7.4 months for those with low BRCA1 but high HERC2 (p\u2009=\u20090.008). The multivariate analysis showed that among patients with Eastern Cooperative Oncology Group performance status 0-1, the combined low expression of both BRCA1 and HERC2 clearly reduced the risk of progression (p\u2009=\u20090.03) and of death (p\u2009=\u20090.004). CONCLUSIONS: These findings confirm the potentiality of integrated DNA repair components analysis in predicting the sensitivity to platinum in lung cancer. The study indicates a predictive role for HERC2 mRNA expression and paves the way for further refinement of the BRCA1 predictive model