39 research outputs found

    COBERTURA DE BASES DE DATOS CIENTÍFICAS SOBRE EL TEMA DE LA CARRERA DUAL EN EL DEPORTE

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    La Carrera Dual es un campo de estudio emergente que centra su objeto en la conciliación entre la vida del deportista y las exigencias derivadas de la académica y/o laboral, siendo um tema de interés para diferentes áreas del saber involucradas en el deporte. El objetivo de este estudio fue analizar la cobertura de las bases de datos científicas sobre el tema “carrera dual deportiva” e identificar las bases de datos más importantes para el área. La metodología implementada consistió en realizar una revisión bibliométrica a seis bases de datos científicas, basados en los criterios de búsqueda establecidos en idioma inglés, español y portugués. Como resultado se encontró que dos bases de datos concentran en 90% de la producción total sobre el “Carrera Dual Deportiva”; así mismo tres bases de datos concentran el 50% de los artículos que no se encuentran publicados en las bases de datos anteriormente mencionadas, convietiendose en un espacio útil para indagar sobre estudios en Latinoamérica y el Caribe

    Genome of the Avirulent Human-Infective Trypanosome—Trypanosoma rangeli

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    Background: Trypanosoma rangeli is a hemoflagellate protozoan parasite infecting humans and other wild and domestic mammals across Central and South America. It does not cause human disease, but it can be mistaken for the etiologic agent of Chagas disease, Trypanosoma cruzi. We have sequenced the T. rangeli genome to provide new tools for elucidating the distinct and intriguing biology of this species and the key pathways related to interaction with its arthropod and mammalian hosts.  Methodology/Principal Findings: The T. rangeli haploid genome is ,24 Mb in length, and is the smallest and least repetitive trypanosomatid genome sequenced thus far. This parasite genome has shorter subtelomeric sequences compared to those of T. cruzi and T. brucei; displays intraspecific karyotype variability and lacks minichromosomes. Of the predicted 7,613 protein coding sequences, functional annotations could be determined for 2,415, while 5,043 are hypothetical proteins, some with evidence of protein expression. 7,101 genes (93%) are shared with other trypanosomatids that infect humans. An ortholog of the dcl2 gene involved in the T. brucei RNAi pathway was found in T. rangeli, but the RNAi machinery is non-functional since the other genes in this pathway are pseudogenized. T. rangeli is highly susceptible to oxidative stress, a phenotype that may be explained by a smaller number of anti-oxidant defense enzymes and heatshock proteins.  Conclusions/Significance: Phylogenetic comparison of nuclear and mitochondrial genes indicates that T. rangeli and T. cruzi are equidistant from T. brucei. In addition to revealing new aspects of trypanosome co-evolution within the vertebrate and invertebrate hosts, comparative genomic analysis with pathogenic trypanosomatids provides valuable new information that can be further explored with the aim of developing better diagnostic tools and/or therapeutic targets

    A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)

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