Una comunidad de saber con-sentido pedagógico. Experiencia de la Red de Instituciones por la Evaluación: avances, proyecciones, desafíos y recomendaciones

Esta publicación tiene como propósito compartir los avances logrados por la RIE durante sus dos años de funcionamiento. Constituye un material para la reflexión sobre lo que hacen los maestros y maestras de la ciudad para enriquecer la evaluación de los aprendizajes y favorecer el desarrollo social, afectivo, emocional y cognitivo de los estudiantes. En este sentido, se trata de un documento de referencia que se complementa y amplía con elementos académicos, técnicos y didácticos, como la Caja de Herramientas “Ideas compartidas: lo que hacemos cuando evaluamos con-sentido pedagógico”, dispuesto en el Portal Educativo Red Académica de la Secretaría de Educación del Distrito

Infected pancreatic necrosis: outcomes and clinical predictors of mortality. A post hoc analysis of the MANCTRA-1 international study

: The identification of high-risk patients in the early stages of infected pancreatic necrosis (IPN) is critical, because it could help the clinicians to adopt more effective management strategies. We conducted a post hoc analysis of the MANCTRA-1 international study to assess the association between clinical risk factors and mortality among adult patients with IPN. Univariable and multivariable logistic regression models were used to identify prognostic factors of mortality. We identified 247 consecutive patients with IPN hospitalised between January 2019 and December 2020. History of uncontrolled arterial hypertension (p = 0.032; 95% CI 1.135-15.882; aOR 4.245), qSOFA (p = 0.005; 95% CI 1.359-5.879; aOR 2.828), renal failure (p = 0.022; 95% CI 1.138-5.442; aOR 2.489), and haemodynamic failure (p = 0.018; 95% CI 1.184-5.978; aOR 2.661), were identified as independent predictors of mortality in IPN patients. Cholangitis (p = 0.003; 95% CI 1.598-9.930; aOR 3.983), abdominal compartment syndrome (p = 0.032; 95% CI 1.090-6.967; aOR 2.735), and gastrointestinal/intra-abdominal bleeding (p = 0.009; 95% CI 1.286-5.712; aOR 2.710) were independently associated with the risk of mortality. Upfront open surgical necrosectomy was strongly associated with the risk of mortality (p < 0.001; 95% CI 1.912-7.442; aOR 3.772), whereas endoscopic drainage of pancreatic necrosis (p = 0.018; 95% CI 0.138-0.834; aOR 0.339) and enteral nutrition (p = 0.003; 95% CI 0.143-0.716; aOR 0.320) were found as protective factors. Organ failure, acute cholangitis, and upfront open surgical necrosectomy were the most significant predictors of mortality. Our study confirmed that, even in a subgroup of particularly ill patients such as those with IPN, upfront open surgery should be avoided as much as possible. Study protocol registered in ClinicalTrials.Gov (I.D. Number NCT04747990)

Percepción de riesgo de contagio de covid-19: el caso de los estudiantes de la UANL

Se identifican los determinantes de la probabilidad de que los estudiantes de la UANL crean que se pueden contagiar de COVID-19, mediante la estimación de un modelo Logit, utilizando los resultados del Censo UANL 2020 que fue aplicado durante el periodo septiembre-noviembre de 2020. Factores sociodemográficos, experiencias cercanas con la enfermedad, conocimiento del área de salud, el padecimiento de comorbilidades y el medio de transporte explican, de manera significativa, la probabilidad percibida de los estudiantes de contraer COVID-19

Interpreting sperm DNA damage in a diverse range of mammalian sperm by means of the two-tailed comet assay

Sperm DNA damage is associated with fertilization failure, impaired pre-and post- embryo implantation and poor pregnancy outcome. A series of methodologies to assess DNA damage in spermatozoa have been developed but most are unable to differentiate between single-stranded DNA breaks (SSBs) and double-stranded DNA breaks (DSBs) on the same sperm cell. The two-dimensional Two-Tailed Comet assay (TT-comet) protocol highlighted in this review overcomes this limitation and emphasizes the importance in accounting for the difference in sperm protamine composition at a species-specific level for the appropriate preparation of the assay. The TT-comet is a modification of the original comet assay that uses a two dimensional electrophoresis to allow for the simultaneous evaluation of DSBs and SSBs in mammalian spermatozoa. Here we have compiled a retrospective overview of how the TT-comet assay has been used to investigate the structure and function of sperm DNA across a diverse range of mammalian species (eutheria, metatheria, and prototheria). When conducted as part of the TT-comet assay, we illustrate (a) how the alkaline comet single assay has been used to help understand the constitutive and transient changes in DNA structure associated with chromatin packing, (b) the capacity of the TT-comet to differentiate between the presence of SSBs and DSBs (c) and the possible implications of SSBs or DSBs for the assessment of infertility

Diálogos Jurídicos entre España y México 7

Ésta séptima publicación es fruto de la colaboración interinstitucional, con el papel especialmente importante del Dr. Javier Lapiedra Alcamí, Decano de la Universitat Jaume I de Castellón, quien se encargó de la coordinación de los docentes españoles y a quien expresamente manifiesto mi reconocimiento. Estamos ya trabajando en la elaboración de una siguiente publicación (el número ocho de una serie de diez) y deseamos que con el tiempo estas publicaciones se conviertan en el foro de participación de investigadores de otros centros universitarios, siendo especialmente gratificante si entre ellos están quienes en su momento siendo alumnos disfrutaron del intercambio que hizo nacer esta idea.Esta obra cumple una década de vida y ha pretendido ser un lugar de encuentro entre las perspectivas española y mexicana bajo la ordenación jurídica de distintos temas de interés y actualidad. Asimismo, más allá de la inestimable aportación al derecho comparado a través del tiempo ha sido cauce de acercamiento humano entre los académicos de ambos países, manteniendo y ampliando los lazos de amistad entre nuestras universidades.Universidad Autónoma del Estado de México

Culture and indigenous women's health: integrative review

Objetivo: INVESTIGAR A REALIDADE DE SAÚDE DAS MULHERES INDÍGENAS E DO POVO GUARANI E KAINGÀNG, TRAZENDO REFLEXÕES SOBRE AS POLÍTICAS PÚBLICAS DE SAÚDE VOLTADAS PARA A COMUNIDADE INDÍGENA E A INSERÇÃO DA ENFERMAGEM NESTE CONTEXTO. Método: TRATA-SE DE UMA REVISÃO INTEGRATIVA REALIZADA NO PERÍODO DE MARÇO A JULHO DE 2010. Resultados: OS ESTUDOS TRAZEM QUE O ACESSO À SAÚDE DO POVO INDÍGENA AINDA É LIMITADA, QUE AS AÇÕES EM SAÚDE DEVEM CONSIDERAR SUA CULTURA E DEMAIS PARTICULARIDADES E QUE OS PROFISSIONAIS ENVOLVIDOS NESSE PROCESSO NECESSITAM CRIAR VÍNCULOS COM ESSA POPULAÇÃO PARA QUE AS AÇÕES SEJAM EFETIVAS.  Conclusão: AS PESQUISAS SOBRE O TEMA SÃO ESCASSAS, BEM COMO A NECESSIDADE DE UMA ATENÇÃO MAIS AMPLA E QUALIFICADA AOS INDÍGENAS, PRINCIPALMENTE À SAÚDE DA MULHER. Descritores: SAÚDE DA MULHER, POPULAÇÃO INDÍGENA, SAÚDE DE POPULAÇÕES INDÍGENAS, SERVIÇOS DE SAÚDE DO INDÍGENA

Synthesis, Characterization, and Solid State Dynamic Studies of a Hydrogen Bond-Hindered Steroidal Molecular Rotor with a Flexible Axis

A novel steroid molecular rotor was obtained in four steps from the naturally occurring spirostane sapogenin diosgenin. The structural and dynamic characterization was carried out by solution NMR, VT X-ray diffraction, solid state ¹³C CPMAS, and solid state ²H NMR experiments. They allowed the identification of a fast dynamic process with a frequency of 14 MHz at room temperature, featuring a barrier to rotation Ea = 7.87 kcal mol^–1. The gathered experimental evidence indicated the presence of a hydrogen bond that becomes stronger as the temperature lowers. This interaction was characterized using theoretical calculations, based on topological analyses of the electronic density and energies. In addition, combining theoretical calculations with experimental measurements, it was possible to propose a partition to Ea (∼8 kcal/mol) into three contributions, that are the cost of the intrinsic rotation (∼2 kcal/mol), the hydrogen bond interaction (∼2 kcal/mol), and the packing effects (∼2–3 kcal/mol). The findings from the present work highlight the relevance of the individual components in the function of molecular machines in the solid state

Synthesis, Characterization, and Solid State Dynamic Studies of a Hydrogen Bond-Hindered Steroidal Molecular Rotor with a Flexible Axis

A novel steroid molecular rotor was obtained in four steps from the naturally occurring spirostane sapogenin diosgenin. The structural and dynamic characterization was carried out by solution NMR, VT X-ray diffraction, solid state ¹³C CPMAS, and solid state ²H NMR experiments. They allowed the identification of a fast dynamic process with a frequency of 14 MHz at room temperature, featuring a barrier to rotation Ea = 7.87 kcal mol^–1. The gathered experimental evidence indicated the presence of a hydrogen bond that becomes stronger as the temperature lowers. This interaction was characterized using theoretical calculations, based on topological analyses of the electronic density and energies. In addition, combining theoretical calculations with experimental measurements, it was possible to propose a partition to Ea (∼8 kcal/mol) into three contributions, that are the cost of the intrinsic rotation (∼2 kcal/mol), the hydrogen bond interaction (∼2 kcal/mol), and the packing effects (∼2–3 kcal/mol). The findings from the present work highlight the relevance of the individual components in the function of molecular machines in the solid state