El ambiente escolar y sus implicaciones en el desempe?o acad?mico y pedag?gico en el Colegio San Bonifacio de las Lanzas - Ibagu?

71 p. Recurso Electr?nicoEl ambiente escolar es un factor fundamental dentro de las instituciones educativas, motivo por el cual hoy en d?a se habla de calidad educativa y este hecho implica no solo revisar y mantener actualizado el modelo pedag?gico si no por el contrario incluir elementos que ayuden a una buena y sana convivencia escolar, ya que afecta a toda la comunidad educativa en los distintos procesos que se llevan a cabo. En este sentido el presente trabajo se ha centrado en comprender cuales son las implicaciones del ambiente escolar en los desempe?os acad?micos y pedag?gicos en el colegio San Bonifacio de las lanzas. Para lo cual se ha realizado una investigaci?n de enfoque cualitativo y de tipo descriptivo, para la recolecci?n de la informaci?n se utilizaron una encuesta y cuestionario aplicados a docentes (4), y un cuestionario a estudiantes (24). Dentro de los hallazgos se destaca que seg?n los estudiantes el ambiente se ve alterado por estudiantes que tienen comportamientos inadecuados por un lado y por el otro, las condiciones del aula puesto que son calurosas. Los docentes, estos aseguran que las condiciones en general son adecuadas, de gran tama?o y herramientas tecnol?gicas que brindan elementos que mejoran el ambiente escolar. Se recomienda implementar estrategias en las cuales se den capacitaciones o charlas en las cuales se escuchen los conflictos y las dificultades que tienen los estudiantes entre pares, generar espacios y horarios en los cuales se promueva que los docentes puedan dialogar con otros. Palabras Clave: Ambiente escolar, docentes, estudiantes, gesti?n.The school environment is a fundamental factor in educational institutions, which is why today we talk about educational quality and this fact implies not only reviewing and keeping the pedagogical model up to date, but instead include elements that help a good And healthy school coexistence, as it affects the entire educational community in the various processes that are carried out. In this sense the present work has centered in understanding what are the implications of the school environment in the academic and pedagogical performances in the school San Bonifacio of the spears. For which a qualitative and descriptive research was carried out, a survey and questionnaire applied to teachers (4) and a questionnaire were used for data collection (24 students). Among the findings it is highlighted that according to students the environment is altered by students who have inappropriate behavior on the one hand and on the other, the conditions of the classroom since they are hot. Teachers, these ensure that the conditions in general are adequate, large and technological tools that provide elements that improve the school environment. It is recommended to implement strategies in which there are trainings or talks in which the conflicts and difficulties that the students have between peers are heard, generating spaces and schedules in which teachers are encouraged to be able to dialogue with others. Keywords: School environment, teachers, students, management

Effects of polylinker uATGs on the function of grass HKT1 transporters expressed in yeast cells

HvHKT1 mediates K+ or Na+ uniport in yeast cells if the expression promoter is joined directly to the HvHKT1 cDNA, and Na+-K+ symport if a 59-nt polylinker is inserted. Our results show that three ATG triplets in the polylinker decreased the synthesis of the transporter and that the lower amount of transporter caused the functional change. With the rice HKT1 cDNA, the 59-nt polylinker changed the mode of Na+ uptake from K+-insensitive to K+-inhibitable. These two modes of Na+ uptake also occurred in rice plant

Novel CYP4F22 mutations associated with autosomal recessive congenital ichthyosis (ARCI). Study of the CYP4F22 c.1303C>T founder mutation

Mutations in CYP4F22 cause autosomal recessive congenital ichthyosis (ARCI). However, less than 10% of all ARCI patients carry a mutation in CYP4F22. In order to identify the molecular basis of ARCI among our patients (a cohort of ninety-two Spanish individuals) we performed a mutational analysis using direct Sanger sequencing in combination with a multigene targeted NGS panel. From these, eight ARCI families (three of them with Moroccan origin) were found to carry five different CYP4F22 mutations, of which two were novel. Computational analysis showed that the mutations found were present in highly conserved residues of the protein and may affect its structure and function. Seven of the eight families were carriers of a highly recurrent CYP4F22 variant, c.1303C>T; p.(His435Tyr). A 12Mb haplotype was reconstructed in all c.1303C>T carriers by genotyping ten microsatellite markers flanking the CYP4F22 gene. A prevalent 2.52Mb haplotype was observed among Spanish carrier patients suggesting a recent common ancestor. A smaller core haplotype of 1.2Mb was shared by Spanish and Moroccan families. Different approaches were applied to estimate the time to the most recent common ancestor (TMRCA) of carrier patients with Spanish origin. The age of the mutation was calculated by using DMLE and BDMC2. The algorithms estimated that the c.1303C>T variant arose approximately 2925 to 4925 years ago, while Spanish carrier families derived from a common ancestor who lived in the XIII century. The present study reports five CYP4F22 mutations, two of them novel, increasing the number of CYP4F22 mutations currently listed. Additionally, our results suggest that the recurrent c.1303C>T change has a founder effect in Spanish population and c.1303C>T carrier families originated from a single ancestor with probable African ancestry

Impact of cardiovascular risk factors on the clinical presentation and survival of pulmonary embolism without identifiable risk factor

Background: The nature of pulmonary embolism (PE) without identifiable risk factor (IRF) remains unclear. The objective of this study is to investigate the potential relationship between cardiovascular risk factors (CVRFs) and PE without IRF (unprovoked) and assess their role as markers of disease severity and prognosis. Methods: A case-control study was performed of patients with PE admitted to our hospital [2010-2019]. Subjects with PE without IRF were included in the cohort of cases, whereas patients with PE with IRF were allocated to the control group. Variables of interest included age, active smoking, obesity, and diagnosis of arterial hypertension, dyslipidemia or diabetes mellitus. Results: A total of 1,166 patients were included in the study, of whom 64.2% had PE without IRF. The risk for PE without IRF increased with age [odds ratio (OR): 2.68; 95% confidence interval (CI): 1.95-3.68], arterial hypertension (OR: 1.63; 95% CI: 1.27-2.07), and dyslipidemia (OR: 1.63; 95% CI: 1.24-2.15). The risk for PE without IRF was higher as the number of CVRF increased, being 3.99 (95% CI: 2.02-7.90) for subjects with >/=3 CVRF. The percentage of high-risk unprovoked PE increased significantly as the number of CVRF rose [0.6% for no CVRF; 23.8% for a CRF, P/=3, P<0.001 (OR: 14.1; 95% CI: 4.06-49.4)]. No significant differences were observed in 1-month survival between cases and controls, whereas differences in 24-month survival reached significance. Conclusions: A relationship was observed between CVRF and PE without IRF, as the risk for unprovoked PE increased with the number of CVRF. In addition, the number of CVRF was associated with PE without IRF severity, but not with prognosis

Stress tolerance mechanisms in Juncus: responses to salinity and drought in three Juncus species adapted to different natural environments

[EN] Comparative studies on the responses to salinity and drought were carried out in three Juncus species, two halophytes (Juncus maritimus Lam. and Juncus acutus L.) and one more salt-sensitive (Juncus articulatus L.). Salt tolerance in Juncus depends on the inhibition of transport of toxic ions to the aerial part. In the three taxa studied Na+ and Cl accumulated to the same extent in the roots of salt treated plants; however, ion contents were lower in the shoots and correlated with the relative salt sensitivity of the species, with the lowest levels measured in the halophytes. Activation of K+ transport at high salt concentration could also contribute to salt tolerance in the halophytes. Maintenance of cellular osmotic balance is mostly based on the accumulation of sucrose in the three species. Yet, neither the relative salt-induced increase in sugar content nor the absolute concentrations reached can explain the observed differences in salt tolerance. In contrast, proline increased significantly in the presence of salt only in the salt-tolerant J. maritimus and J. acutus, but not in J. articulatus. Similar patterns of osmolyte accumulation were observed in response to water stress, supporting a functional role of proline in stress tolerance mechanisms in JuncusThis work was partly funded by a grant to O.V. from the Spanish Ministry of Science and Innovation (Project CGL2008-00438/BOS), with contribution by the European Regional Development Fund. Mohamad Al Hassan was a recipient of an Erasmus Mundus pre-doctoral scholarship financed by the European Commission (Welcome Consortium)Al Hassan, M.; López Gresa, MP.; Boscaiu Neagu, MT.; Vicente Meana, Ó. (2016). Stress tolerance mechanisms in Juncus: responses to salinity and drought in three Juncus species adapted to different natural environments. FUNCTIONAL PLANT BIOLOGY. 43:949-960. https://doi.org/10.1071/FP16007S94996043Al Hassan, M., Chaura, J., López-Gresa, M. P., Borsai, O., Daniso, E., Donat-Torres, M. P., … Boscaiu, M. (2016). Native-Invasive Plants vs. Halophytes in Mediterranean Salt Marshes: Stress Tolerance Mechanisms in Two Related Species. Frontiers in Plant Science, 7. doi:10.3389/fpls.2016.00473Albert, R., & Popp, M. (1977). Chemical composition of halophytes from the Neusiedler Lake region in Austria. Oecologia, 27(2), 157-170. doi:10.1007/bf00345820Ashraf, M., & Foolad, M. R. (2007). Roles of glycine betaine and proline in improving plant abiotic stress resistance. Environmental and Experimental Botany, 59(2), 206-216. doi:10.1016/j.envexpbot.2005.12.006Bartels, D., & Sunkar, R. (2005). Drought and Salt Tolerance in Plants. Critical Reviews in Plant Sciences, 24(1), 23-58. doi:10.1080/07352680590910410Bates, L. S., Waldren, R. P., & Teare, I. D. (1973). Rapid determination of free proline for water-stress studies. Plant and Soil, 39(1), 205-207. doi:10.1007/bf00018060Boscaiu, M., Ballesteros, G., Naranjo, M. A., Vicente, O., & Boira, H. (2011). Responses to salt stress in Juncus acutus and J. maritimus during seed germination and vegetative plant growth. Plant Biosystems - An International Journal Dealing with all Aspects of Plant Biology, 145(4), 770-777. doi:10.1080/11263504.2011.628446Boscaiu, M., Lull, C., Llinares, J., Vicente, O., & Boira, H. (2012). Proline as a biochemical marker in relation to the ecology of two halophytic Juncus species. Journal of Plant Ecology, 6(2), 177-186. doi:10.1093/jpe/rts017Bose, J., Rodrigo-Moreno, A., & Shabala, S. (2013). ROS homeostasis in halophytes in the context of salinity stress tolerance. Journal of Experimental Botany, 65(5), 1241-1257. doi:10.1093/jxb/ert430Boyer, J. S. (1982). Plant Productivity and Environment. Science, 218(4571), 443-448. doi:10.1126/science.218.4571.443Chen, T. H. H., & Murata, N. (2008). Glycinebetaine: an effective protectant against abiotic stress in plants. 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American Journal of Botany, 92(7), 1094-1101. doi:10.3732/ajb.92.7.1094Espinar, J. L., García, L. V., Figuerola, J., Green, A. J., & Clemente, L. (2006). Effects of salinity and ingestion by ducks on germination patterns of Juncus subulatus seeds. Journal of Arid Environments, 66(2), 376-383. doi:10.1016/j.jaridenv.2005.11.001Fita, A., Rodríguez-Burruezo, A., Boscaiu, M., Prohens, J., & Vicente, O. (2015). Breeding and Domesticating Crops Adapted to Drought and Salinity: A New Paradigm for Increasing Food Production. Frontiers in Plant Science, 6. doi:10.3389/fpls.2015.00978Flowers, T. J., & Colmer, T. D. (2008). Salinity tolerance in halophytes*. New Phytologist, 179(4), 945-963. doi:10.1111/j.1469-8137.2008.02531.xFlowers, T. J., Hajibagheri, M. A., & Clipson, N. J. W. (1986). Halophytes. The Quarterly Review of Biology, 61(3), 313-337. doi:10.1086/415032Flowers, T. J., Munns, R., & Colmer, T. D. (2014). Sodium chloride toxicity and the cellular basis of salt tolerance in halophytes. Annals of Botany, 115(3), 419-431. doi:10.1093/aob/mcu217Gagneul, D., Aïnouche, A., Duhazé, C., Lugan, R., Larher, F. R., & Bouchereau, A. (2007). A Reassessment of the Function of the So-Called Compatible Solutes in the Halophytic Plumbaginaceae Limonium latifolium. Plant Physiology, 144(3), 1598-1611. doi:10.1104/pp.107.099820GIL, R., LULL, C., BOSCAIU, M., BAUTISTA, I., LIDÓN, A., & VICENTE, O. (2011). Soluble Carbohydrates as Osmolytes in Several Halophytes from a Mediterranean Salt Marsh. Notulae Botanicae Horti Agrobotanici Cluj-Napoca, 39(2), 09. doi:10.15835/nbha3927176Gil, R., Boscaiu, M., Lull, C., Bautista, I., Lidón, A., & Vicente, O. (2013). Are soluble carbohydrates ecologically relevant for salt tolerance in halophytes? Functional Plant Biology, 40(9), 805. doi:10.1071/fp12359Gil, R., Bautista, I., Boscaiu, M., Lidon, A., Wankhade, S., Sanchez, H., … Vicente, O. (2014). 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HKT transporters mediate salt stress resistance in plants: from structure and function to the field. Current Opinion in Biotechnology, 32, 113-120. doi:10.1016/j.copbio.2014.11.025Hariadi, Y., Marandon, K., Tian, Y., Jacobsen, S.-E., & Shabala, S. (2010). Ionic and osmotic relations in quinoa (Chenopodium quinoa Willd.) plants grown at various salinity levels. Journal of Experimental Botany, 62(1), 185-193. doi:10.1093/jxb/erq257Jones, E., Simpson, D., Hodkinson, T., Chase, M., & Parnell, J. (2007). The Juncaceae-Cyperaceae Interface: A Combined Plastid Sequence Analysis. Aliso, 23(1), 55-61. doi:10.5642/aliso.20072301.07Kumari, A., Das, P., Parida, A. K., & Agarwal, P. K. (2015). Proteomics, metabolomics, and ionomics perspectives of salinity tolerance in halophytes. Frontiers in Plant Science, 6. doi:10.3389/fpls.2015.00537Munns, R., & Termaat, A. (1986). Whole-Plant Responses to Salinity. Functional Plant Biology, 13(1), 143. doi:10.1071/pp9860143Munns, R., & Tester, M. (2008). 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New Zealand Journal of Botany, 25(4), 559-566. doi:10.1080/0028825x.1987.10410086RAVEN, J. A. (1985). TANSLEY REVIEW No. 2. REGULATION OF PH AND GENERATION OF OSMOLARITY IN VASCULAR PLANTS: A COST-BENEFIT ANALYSIS IN RELATION TO EFFICIENCY OF USE OF ENERGY, NITROGEN AND WATER. New Phytologist, 101(1), 25-77. doi:10.1111/j.1469-8137.1985.tb02816.xRodrı́guez-Navarro, A. (2000). Potassium transport in fungi and plants. Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes, 1469(1), 1-30. doi:10.1016/s0304-4157(99)00013-1Rozema, J. (1976). An Ecophysiological Study on the Response to Salt of Four Halophytic and Glycophytic Juncus Species. Flora, 165(2), 197-209. doi:10.1016/s0367-2530(17)31845-5Rozema, J. (1991). Growth, water and ion relationships of halophytic monocotyledonae and dicotyledonae; a unified concept. Aquatic Botany, 39(1-2), 17-33. doi:10.1016/0304-3770(91)90019-2Smirnoff, N., & Cumbes, Q. J. (1989). Hydroxyl radical scavenging activity of compatible solutes. 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Responses of five Mediterranean halophytes to seasonal changes in environmental conditions

In their natural habitats, different mechanisms may contribute to the tolerance of halophytes to high soil salinity and other abiotic stresses, but their relative contribution and ecological relevance, for a given species, remain largely unknown. We studied the responses to changing environmental conditions of five halophytes (Sarcocornia fruticosa, Inula crithmoides, Plantago crassifolia, Juncus maritimus and J. acutus) in a Mediterranean salt marsh, from summer 2009 to autumn 2010. A principal component analysis was used to correlate soil and climatic data with changes in the plants contents of chemical markers associated with stress responses: ions, osmolytes, malondialdehyde (MDA, a marker of oxidative stress) and antioxidant systems. Stress tolerance in S. fruticosa, I. crithmoides and P. crassifolia (all succulent dicots) seemed to depend mostly on the transport of ions to aerial parts and the biosynthesis of specific osmolytes, whereas both Juncus species (monocots)were able to avoid accumulation of toxic ions, maintaining relatively high K+/Na+ ratios. For the most salt-tolerant taxa (S. fruticosa and I. crithmoides), seasonal variations of Na+, Cl2, K+ and glycine betaine, their major osmolyte, did not correlate with environmental parameters associated with salt or water stress, suggesting that their tolerance mechanisms are constitutive and relatively independent of external conditions, although they could be mediated by changes in the subcellular compartmentalization of ions and compatible osmolytes. Proline levels were too low in all the species to possibly have any effect on osmotic adjustment. However except for P. crassifolia proline may play a role in stress tolerance based on its osmoprotectant functions. No correlation was observed between the degree of environmental stress and the levels of MDA or enzymatic and non-enzymatic antioxidants, indicating that the investigated halophytes are not subjected to oxidative stress under natural conditions and do not, therefore, need to activate antioxidant defence mechanismsThis work was funded by a grant to O.V. from the Spanish Ministry of Science and Innovation (Project CGL2008-00438/BOS), with contribution from the European Regional Development Fund.Gil Ortiz, R.; Bautista Carrascosa, I.; Boscaiu Neagu, MT.; Lidón Cerezuela, AL.; Wankhade, SD.; Sánchez Rodríguez, H.; Llinares Palacios, JV.... (2014). Responses of five Mediterranean halophytes to seasonal changes in environmental conditions. AoB PLANTS. 6:1-18. https://doi.org/10.1093/aobpla/plu049S1186Adrian-Romero, M., Wilson, S. J., Blunden, G., Yang, M.-H., Carabot-Cuervo, A., & Bashir, A. K. (1998). Betaines in coastal plants. Biochemical Systematics and Ecology, 26(5), 535-543. doi:10.1016/s0305-1978(98)00013-1Aebi, H. (1984). [13] Catalase in vitro. Oxygen Radicals in Biological Systems, 121-126. doi:10.1016/s0076-6879(84)05016-3Aghaleh, M., Niknam, V., Ebrahimzadeh, H., & Razavi, K. (2009). Salt stress effects on growth, pigments, proteins and lipid peroxidation in Salicornia persica and S. europaea. Biologia Plantarum, 53(2), 243-248. doi:10.1007/s10535-009-0046-7Aghaleh, M., Niknam, V., Ebrahimzadeh, H., & Razavi, K. (2010). Effect of salt stress on physiological and antioxidative responses in two species of Salicornia (S. persica and S. europaea). Acta Physiologiae Plantarum, 33(4), 1261-1270. doi:10.1007/s11738-010-0656-xAlbert, A., Yenush, L., Gil-Mascarell, M. ., Rodriguez, P. ., Patel, S., Martı́nez-Ripoll, M., … Serrano, R. (2000). X-ray structure of yeast hal2p, a major target of lithium and sodium toxicity, and identification of framework interactions determining cation sensitivity. Journal of Molecular Biology, 295(4), 927-938. doi:10.1006/jmbi.1999.3408Albert, R., & Popp, M. (1977). Chemical composition of halophytes from the Neusiedler Lake region in Austria. Oecologia, 27(2), 157-170. doi:10.1007/bf00345820Apel, K., & Hirt, H. (2004). REACTIVE OXYGEN SPECIES: Metabolism, Oxidative Stress, and Signal Transduction. Annual Review of Plant Biology, 55(1), 373-399. doi:10.1146/annurev.arplant.55.031903.141701Ashraf, M. (2009). Biotechnological approach of improving plant salt tolerance using antioxidants as markers. Biotechnology Advances, 27(1), 84-93. doi:10.1016/j.biotechadv.2008.09.003Ashraf, M., & Foolad, M. R. (2007). Roles of glycine betaine and proline in improving plant abiotic stress resistance. Environmental and Experimental Botany, 59(2), 206-216. doi:10.1016/j.envexpbot.2005.12.006Bartels, D., & Sunkar, R. (2005). Drought and Salt Tolerance in Plants. Critical Reviews in Plant Sciences, 24(1), 23-58. doi:10.1080/07352680590910410Bates, L. S., Waldren, R. P., & Teare, I. D. (1973). Rapid determination of free proline for water-stress studies. Plant and Soil, 39(1), 205-207. doi:10.1007/bf00018060Bazihizina, N., Barrett-Lennard, E. G., & Colmer, T. D. (2012). Plant growth and physiology under heterogeneous salinity. Plant and Soil, 354(1-2), 1-19. doi:10.1007/s11104-012-1193-8Amor, N. B., Jimenez, A., Megdiche, W., Lundqvist, M., Sevilla, F., & Abdelly, C. (2006). Response of antioxidant systems to NaCl stress in the halophyte Cakile maritima. Physiologia Plantarum, 126(3), 446-457. doi:10.1111/j.1399-3054.2006.00620.xHamed, K. B., Ellouzi, H., Talbi, O. Z., Hessini, K., Slama, I., Ghnaya, T., … Abdelly, C. (2013). Physiological response of halophytes to multiple stresses. 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Anti-tumour necrosis factor discontinuation in inflammatory bowel disease patients in remission: study protocol of a prospective, multicentre, randomized clinical trial

Background: Patients with inflammatory bowel disease who achieve remission with anti-tumour necrosis factor (anti-TNF) drugs may have treatment withdrawn due to safety concerns and cost considerations, but there is a lack of prospective, controlled data investigating this strategy. The primary study aim is to compare the rates of clinical remission at 1?year in patients who discontinue anti-TNF treatment versus those who continue treatment. Methods: This is an ongoing, prospective, double-blind, multicentre, randomized, placebo-controlled study in patients with Crohn?s disease or ulcerative colitis who have achieved clinical remission for ?6?months with an anti-TNF treatment and an immunosuppressant. Patients are being randomized 1:1 to discontinue anti-TNF therapy or continue therapy. Randomization stratifies patients by the type of inflammatory bowel disease and drug (infliximab versus adalimumab) at study inclusion. The primary endpoint of the study is sustained clinical remission at 1?year. Other endpoints include endoscopic and radiological activity, patient-reported outcomes (quality of life, work productivity), safety and predictive factors for relapse. The required sample size is 194 patients. In addition to the main analysis (discontinuation versus continuation), subanalyses will include stratification by type of inflammatory bowel disease, phenotype and previous treatment. Biological samples will be obtained to identify factors predictive of relapse after treatment withdrawal. Results: Enrolment began in 2016, and the study is expected to end in 2020. Conclusions: This study will contribute prospective, controlled data on outcomes and predictors of relapse in patients with inflammatory bowel disease after withdrawal of anti-TNF agents following achievement of clinical remission. Clinical trial reference number: EudraCT 2015-001410-1

Measurement of the nuclear modification factor for muons from charm and bottom hadrons in Pb+Pb collisions at 5.02 TeV with the ATLAS detector

Heavy-flavour hadron production provides information about the transport properties and microscopic structure of the quark-gluon plasma created in ultra-relativistic heavy-ion collisions. A measurement of the muons from semileptonic decays of charm and bottom hadrons produced in Pb+Pb and pp collisions at a nucleon-nucleon centre-of-mass energy of 5.02 TeV with the ATLAS detector at the Large Hadron Collider is presented. The Pb+Pb data were collected in 2015 and 2018 with sampled integrated luminosities of 208 mu b(-1) and 38 mu b(-1), respectively, and pp data with a sampled integrated luminosity of 1.17 pb(-1) were collected in 2017. Muons from heavy-flavour semileptonic decays are separated from the light-flavour hadronic background using the momentum imbalance between the inner detector and muon spectrometer measurements, and muons originating from charm and bottom decays are further separated via the muon track's transverse impact parameter. Differential yields in Pb+Pb collisions and differential cross sections in pp collisions for such muons are measured as a function of muon transverse momentum from 4 GeV to 30 GeV in the absolute pseudorapidity interval vertical bar eta vertical bar &lt; 2. Nuclear modification factors for charm and bottom muons are presented as a function of muon transverse momentum in intervals of Pb+Pb collision centrality. The bottom muon results are the most precise measurement of b quark nuclear modification at low transverse momentum where reconstruction of B hadrons is challenging. The measured nuclear modification factors quantify a significant suppression of the yields of muons from decays of charm and bottom hadrons, with stronger effects for muons from charm hadron decays

A search for an unexpected asymmetry in the production of e+μ− and e−μ+ pairs in proton-proton collisions recorded by the ATLAS detector at root s = 13 TeV

This search, a type not previously performed at ATLAS, uses a comparison of the production cross sections for e(+)mu(-) and e(-)mu(+) pairs to constrain physics processes beyond the Standard Model. It uses 139 fb(-1) of proton-proton collision data recorded at root s = 13 TeV at the LHC. Targeting sources of new physics which prefer final states containing e(+)mu(-) and e(-)mu(+), the search contains two broad signal regions which are used to provide model-independent constraints on the ratio of cross sections at the 2% level. The search also has two special selections targeting supersymmetric models and leptoquark signatures. Observations using one of these selections are able to exclude, at 95% confidence level, singly produced smuons with masses up to 640 GeV in a model in which the only other light sparticle is a neutralino when the R-parity-violating coupling lambda(23)(1)' is close to unity. Observations using the other selection exclude scalar leptoquarks with masses below 1880 GeV when g(1R)(eu) = g(1R)(mu c) = 1, at 95% confidence level. The limit on the coupling reduces to g(1R)(eu) = g(1R)(mu c) = 0.46 for a mass of 1420 GeV