Diseño y desarrollo del hardware para el control de un DC-DC Modular Multi- Level Converter (DC-DC-MMC) en aplicaciones de redes HVDC

Treball Final de Grau en Enginyeria Elèctrica. Codi: EE1045. Curs acadèmic: 2016/201

EVALUATING FUNGI INDOOR PRESENCE IN HOMES THROUGH VIABLE AND NON-VIABLE SAMPLING

Moulds are common and important allergens. They are more abundant outdoors but patients affected by mould allergy stay indoors much longer than outdoors. So, indoor sampling could help to assess the influence of the concentration of allergens in allergic symptoms. The aim of this study was to assess the relative efficiencies of two air sampling methods, viable and non viable, for the quantification of airborne indoor fungi in the homes of patients sensitized to Alternaria. Furthermore, outdoor sampling was carried out to compare results. Samples were taken over six months in Badajoz (SW Spain). Two houses were selected according to the presence of allergic patients to Alternaria. They were sampled once a month using both viable and non viable personal samplers at solar noon. A Burkard personal sampler was used to record spores and a Sampl’air AES Chemunex sampler was used for colonies. Three rooms were selected in each home: living room, kitchen and bathroom. Temperature and relative humidity were registered at each sample. Outdoor sampling was performed one day per week at the Faculty of Science, using a seven day Burkard sampler for spores and the same personal sampler for colonies. On average, 200-300 CFU/ m3 were found from more than 40 taxa identified. The highest number of colonies was recorded in the kitchen, then in the bathroom and finally in the living room. Nevertheless, there were minor differences between rooms. The houses studied showed a similar temporal pattern, with maximum values in December and minimum in January. Cladosporium colonies showed statistical differences between homes, but these differences were not found with Alternaria, Aspergillus or Penicillium colonies. Differences between rooms appeared for Alternaria colonies and Cladosporium herbarium spores. Temperature was positively correlated in most cases and relative humidity negatively with Alternaria spores. The number of spores collected was as twice as that of colonies, with an average concentration between 600-700 colonies/m3 , and nearly 1400 spores/m3 as maximum concentration. The temporal pattern of spores was similar to that found for colonies. Comparing colonies to spores, Alternaria and AspergillusPenicillium showed similar values. Notwithstanding, Cladosporium spores were nearly five times more abundant than colonies. The advantage of viable methods is the identification to species level, but they have the disadvantage that spores from some ubiquitous species, as Cladosporium, do not always grow in those media, which raises the interest to use additional non-viable methods

The evolution of the ventilatory ratio is a prognostic factor in mechanically ventilated COVID-19 ARDS patients

Background: Mortality due to COVID-19 is high, especially in patients requiring mechanical ventilation. The purpose of the study is to investigate associations between mortality and variables measured during the first three days of mechanical ventilation in patients with COVID-19 intubated at ICU admission. Methods: Multicenter, observational, cohort study includes consecutive patients with COVID-19 admitted to 44 Spanish ICUs between February 25 and July 31, 2020, who required intubation at ICU admission and mechanical ventilation for more than three days. We collected demographic and clinical data prior to admission; information about clinical evolution at days 1 and 3 of mechanical ventilation; and outcomes. Results: Of the 2,095 patients with COVID-19 admitted to the ICU, 1,118 (53.3%) were intubated at day 1 and remained under mechanical ventilation at day three. From days 1 to 3, PaO2/FiO2 increased from 115.6 [80.0-171.2] to 180.0 [135.4-227.9] mmHg and the ventilatory ratio from 1.73 [1.33-2.25] to 1.96 [1.61-2.40]. In-hospital mortality was 38.7%. A higher increase between ICU admission and day 3 in the ventilatory ratio (OR 1.04 [CI 1.01-1.07], p = 0.030) and creatinine levels (OR 1.05 [CI 1.01-1.09], p = 0.005) and a lower increase in platelet counts (OR 0.96 [CI 0.93-1.00], p = 0.037) were independently associated with a higher risk of death. No association between mortality and the PaO2/FiO2 variation was observed (OR 0.99 [CI 0.95 to 1.02], p = 0.47). Conclusions: Higher ventilatory ratio and its increase at day 3 is associated with mortality in patients with COVID-19 receiving mechanical ventilation at ICU admission. No association was found in the PaO2/FiO2 variation

Clustering COVID-19 ARDS patients through the first days of ICU admission. An analysis of the CIBERESUCICOVID Cohort

Background Acute respiratory distress syndrome (ARDS) can be classified into sub-phenotypes according to different inflammatory/clinical status. Prognostic enrichment was achieved by grouping patients into hypoinflammatory or hyperinflammatory sub-phenotypes, even though the time of analysis may change the classification according to treatment response or disease evolution. We aimed to evaluate when patients can be clustered in more than 1 group, and how they may change the clustering of patients using data of baseline or day 3, and the prognosis of patients according to their evolution by changing or not the cluster.Methods Multicenter, observational prospective, and retrospective study of patients admitted due to ARDS related to COVID-19 infection in Spain. Patients were grouped according to a clustering mixed-type data algorithm (k-prototypes) using continuous and categorical readily available variables at baseline and day 3.Results Of 6205 patients, 3743 (60%) were included in the study. According to silhouette analysis, patients were grouped in two clusters. At baseline, 1402 (37%) patients were included in cluster 1 and 2341(63%) in cluster 2. On day 3, 1557(42%) patients were included in cluster 1 and 2086 (57%) in cluster 2. The patients included in cluster 2 were older and more frequently hypertensive and had a higher prevalence of shock, organ dysfunction, inflammatory biomarkers, and worst respiratory indexes at both time points. The 90-day mortality was higher in cluster 2 at both clustering processes (43.8% [n = 1025] versus 27.3% [n = 383] at baseline, and 49% [n = 1023] versus 20.6% [n = 321] on day 3). Four hundred and fifty-eight (33%) patients clustered in the first group were clustered in the second group on day 3. In contrast, 638 (27%) patients clustered in the second group were clustered in the first group on day 3.Conclusions During the first days, patients can be clustered into two groups and the process of clustering patients may change as they continue to evolve. This means that despite a vast majority of patients remaining in the same cluster, a minority reaching 33% of patients analyzed may be re-categorized into different clusters based on their progress. Such changes can significantly impact their prognosis

Elaboración de una rúbrica para la evaluación por parte de tutores y tribunales de los TFG y TFM de la Facultad de Ciencias Matemáticas

Diseño de rúbricas destinadas a la evaluación de los trabajos de fin de grado y de fin de máster en la Facultad de Ciencias Matemáticas de la Universidad Complutense de Madrid. Se presentan modelos tanto para el tutor que dirige el trabajo como para el tribunal que debe evaluar la memoria realizada y su presentación.Depto. de Álgebra, Geometría y TopologíaDepto. de Análisis Matemático y Matemática AplicadaDepto. de Estadística e Investigación OperativaUnidad Deptal. de Astronomía y GeodesiaFac. de Ciencias MatemáticasFALSEsubmitte

Actas de las II Jornadas ScienCity 2019: Fomento de la Cultura Científica, Tecnológica y de Innovación en Ciudades Inteligentes

TecnOlivo: Aplicación de Redes de Sensores en la Agricultura de Precisión / Auditoría y Certificación en Seguridad de Vehículos Autónomos y Conectados / Detección de Vehículos en Pasos de Peatones Inteligentes Mediante Machine Learning / Conteo Automático de Olivos mediante Análisis de Imagen a partir de Capturas Aéreas Multiespectrales / Blockchain en el Mundo Sanitario / Seguridad en Redes Cableadas / Evaluación de la Normativa Actual para la Medida de la Transmitancia Térmica / Overtourism: A Challenge for Smart Cities / Iconos Artísticos y Turismo Sostenible en Ciudades Inteligentes Europeas / Muelle de Levante en Huelva. Revitalización Sostenible de un Muelle Histórico Ligado al Uso Circular de la Energía / Proyecto “Badajoz es Más” / Estudio de Viabilidad de Instalación de Microturbinas en Sistemas de Abastecimiento Urbanos de Agua / Aprendizaje Basado en Proyectos para Educación en Sostenibilidad A User Experience Study for Smart Mobility System with Bikes / MPPT por Estimación de la Resistencia del Punto de Máxima Potencia en Base a Modelo Hiperbólico vs Método Clásico “P&O” / Medición de la Difusividad Térmica de Terrenos (Parámetro αz) Mediante Sondas de Temperatura Low Cost, Enterrada con Método Artesanal I / Medición de la Difusividad Térmica de Terrenos (Parámetro αz) Mediante Sondas de Temperatura Low Cost, Enterrada con Método Artesanal II / Redes DC Bipolares: Mejora en Redes de Distribución con Sistemas de Generación Distribuida- Medio Ambiente y Planificación UrbanaActualmente, nuestras ciudades están experimentando una verdadera transformación digital que requiere una atención inmediata en energía, transporte, movilidad, comunicación, seguridad, educación, turismo y aspectos sociales, así como fomentar todas aquellas actuaciones que persigan mejorar la calidad de vida y el desarrollo económico-ambiental sostenible.ScienCity 2019 es un foro científico-tecnológico que pretende dar a conocer las tecnologías emergentes siendo actualmente investigadas en las universidades, informar de experiencias, servicios e iniciativas puestas ya en marcha por instituciones y empresas, gestar una red temática que garantice la continuación de futuras acciones para el fomento de la cultura científica, tecnológica y de innovación en ciudades inteligentes, llegar a las entidades y decisores políticos para generar sinergias que incentiven líneas de negocio y el desarrollo de la región, así como implicar a los ciudadanos en el desarrollo, gestión y toma de decisiones de sus municipios.Universidad de Huelva Escuela Técnica Superior de Ingeniería Departamento de Ingeniería Electrónica, de Sistemas Informáticos y Automática Cátedra AIQBE Centro Científico-Tecnológico de Huelva Departamento de Tecnologías de la Información Diputación de Huelva Gonzalo Clemente Ariza, Seguros Ax

Switching TNF antagonists in patients with chronic arthritis: An observational study of 488 patients over a four-year period

The objective of this work is to analyze the survival of infliximab, etanercept and adalimumab in patients who have switched among tumor necrosis factor (TNF) antagonists for the treatment of chronic arthritis. BIOBADASER is a national registry of patients with different forms of chronic arthritis who are treated with biologics. Using this registry, we have analyzed patient switching of TNF antagonists. The cumulative discontinuation rate was calculated using the actuarial method. The log-rank test was used to compare survival curves, and Cox regression models were used to assess independent factors associated with discontinuing medication. Between February 2000 and September 2004, 4,706 patients were registered in BIOBADASER, of whom 68% had rheumatoid arthritis, 11% ankylosing spondylitis, 10% psoriatic arthritis, and 11% other forms of chronic arthritis. One- and two-year drug survival rates of the TNF antagonist were 0.83 and 0.75, respectively. There were 488 patients treated with more than one TNF antagonist. In this situation, survival of the second TNF antagonist decreased to 0.68 and 0.60 at 1 and 2 years, respectively. Survival was better in patients replacing the first TNF antagonist because of adverse events (hazard ratio (HR) for discontinuation 0.55 (95% confidence interval (CI), 0.34-0.84)), and worse in patients older than 60 years (HR 1.10 (95% CI 0.97-2.49)) or who were treated with infliximab (HR 3.22 (95% CI 2.13-4.87)). In summary, in patients who require continuous therapy and have failed to respond to a TNF antagonist, replacement with a different TNF antagonist may be of use under certain situations. This issue will deserve continuous reassessment with the arrival of new medications. © 2006 Gomez-Reino and Loreto Carmona; licensee BioMed Central Ltd

The DUNE Far Detector Vertical Drift Technology, Technical Design Report

International audienceDUNE is an international experiment dedicated to addressing some of the questions at the forefront of particle physics and astrophysics, including the mystifying preponderance of matter over antimatter in the early universe. The dual-site experiment will employ an intense neutrino beam focused on a near and a far detector as it aims to determine the neutrino mass hierarchy and to make high-precision measurements of the PMNS matrix parameters, including the CP-violating phase. It will also stand ready to observe supernova neutrino bursts, and seeks to observe nucleon decay as a signature of a grand unified theory underlying the standard model. The DUNE far detector implements liquid argon time-projection chamber (LArTPC) technology, and combines the many tens-of-kiloton fiducial mass necessary for rare event searches with the sub-centimeter spatial resolution required to image those events with high precision. The addition of a photon detection system enhances physics capabilities for all DUNE physics drivers and opens prospects for further physics explorations. Given its size, the far detector will be implemented as a set of modules, with LArTPC designs that differ from one another as newer technologies arise. In the vertical drift LArTPC design, a horizontal cathode bisects the detector, creating two stacked drift volumes in which ionization charges drift towards anodes at either the top or bottom. The anodes are composed of perforated PCB layers with conductive strips, enabling reconstruction in 3D. Light-trap-style photon detection modules are placed both on the cryostat's side walls and on the central cathode where they are optically powered. This Technical Design Report describes in detail the technical implementations of each subsystem of this LArTPC that, together with the other far detector modules and the near detector, will enable DUNE to achieve its physics goals