Evaluación “in vitro” de la Actividad Antifungica del Aceite Esencial de Canela (Cinnamomum zeynalicum) Sobre Botrytis sp Aislado de Mora de Castilla (Rubus glaucus)

Cinnamon is one of the most studied natural agents with antimicrobial powers in recent years whose main component is the cinnamic aldehyde that has antibacterial, antifungal activity and inhibits the production of mycotoxins. For this reason, this research uses Cinnamon essential oil (Cinnamomum zeynalicum) as a potential bioconservative against the microorganisms that cause castor mulberry rot. For this, Botritys sp was isolated, as the main microbiological factor causing the deterioration in arrears of Castilla, after which an in vitro procedure was carried out in Papa Dextrose Agar (PDA) culture medium in a completely randomized design, with different Concentrations of essential oil of cinnamon in which it was demonstrated that the treatments with greater antifungal activity were at concentrations of 250 and 500 ppm. Finally, the antifungal activity of the cinnamon essential oil in situ was evaluated on fresh fruit at different concentrations, time and temperature, through the analysis of color, texture, taste, smell, pH, acidity and count of fungi and yeasts. The in situ experiments showed that the essential oil of cinnamon at 500 ppm combined with the storage of the fruit at refrigeration temperature (5ºC) was the most effective treatment to reduce the deterioration and loss of the quality of the fruits.La canela es uno de los agentes naturales con poderes antimicrobianos más estudiados en los últimos años cuyo principal componente es el aldehído cinámico que posee actividad antibacterial, antifungica e inhibe la producción de micotoxinas. Por tal motivo esta investigación utiliza aceite esencial de Canela (Cinnamomum zeynalicum) como un potencial bioconservador frente a los microorganismos causantes de la pudrición de mora de castilla. Para ello se aisló al Botritys sp, como el principal factor microbiológico causante del deterioro en mora de castilla, luego de lo cual se realizó un procedimiento in vitro en medio de cultivo Papa Dextrosa Agar (PDA) en un diseño completamente al azar, con diferentes concentraciones de aceite esencial de canela en los que se demostró que los tratamientos con mayor actividad anti fúngica fueron a concentraciones de 250 y 500 ppm. Finalmente se evaluó la actividad anti fúngica del aceite esencial de canela in situ sobre fruta fresca a diferentes concentraciones, tiempo y temperatura, mediante el análisis de color, textura, sabor, olor, pH, acidez y recuento de hongos y levaduras. Los experimentos in situ mostraron que el aceite esencial de canela a 500 ppm combinado con el almacenamiento de la fruta a temperatura de refrigeración (5ºC) fue el tratamiento más efectivo para reducir el deterioro y pérdida de la calidad de los frutos

Quality Management System and Quality Assurance Programs in Radiotherapy in the Light of Regulations Applicable in México

Radiotherapy Quality Management Systems (qms) and Quality Assurance (qa) Programs have been proposed as an effective tool to ensure consistency between medical prescription and safe delivery of treatment to patients with minimal exposure to staff. In recent years in Mexico, there has been an increase in the acquisition of modern medical linear accelerators for the delivery of highly sophisticated radiotherapy treatments with specific qa requirements.This makes it necessary to review the current regulatory framework on Quality Management, to know if regulatory requirements are sufficient for the establishment, implementation and development of Comprehensive Quality Systems (qs) in radiotherapy centres. The objective of this work is to review the current national regulations in radiotherapy qms, in particular those referring to standard procedures, human and physical infrastructure, and the implementation of qs in the practice of health care institutions. Results show a first approach to the implementation of quality management systems and quality assurance programs in radiotherapy centres

Quality Management System and Quality Assurance Programs in Radiotherapy in the Light of Regulations Applicable in México

Radiotherapy Quality Management Systems (qms) and Quality Assurance (qa) Programs have been proposed as an effective tool to ensure consistency between medical prescription and safe delivery of treatment to patients with minimal exposure to staff. In recent years in Mexico, there has been an increase in the acquisition of modern medical linear accelerators for the delivery of highly sophisticated radiotherapy treatments with specific qa requirements.This makes it necessary to review the current regulatory framework on Quality Management, to know if regulatory requirements are sufficient for the establishment, implementation and development of Comprehensive Quality Systems (qs) in radiotherapy centres. The objective of this work is to review the current national regulations in radiotherapy qms, in particular those referring to standard procedures, human and physical infrastructure, and the implementation of qs in the practice of health care institutions. Results show a first approach to the implementation of quality management systems and quality assurance programs in radiotherapy centres

Challenges in Diabetic Macular Edema Management: An Expert Consensus Report

Purpose: This paper aimed to present daily-practice recommendations for the management of diabetic macular edema (DME) patients based on available scientific evidence and the clinical experience of the consensus panel. Methods: A group of Spanish retina experts agreed to discuss different aspects related with the clinical management of DME patients. Results: Panel was mainly focused on therapeutic objectives in DME management; defini-tion terms; and role of biomarkers as prognostic and predictive factors to intravitreal treatment response. The panel recommends to start DME treatment as soon as possible in those eyes with a visual acuity less than 20/25 (always according to the retina unit capacity). Naive patient was defined, in a strict manner, as a patient who, up to that moment, had never received any treatment. A refractory DME patient may be defined as the one who did not achieve a complete resolution of the disease, regardless of the treatment administered. Different optical coherence tomography biomarkers, such as disorganization of the retinal inner layers, hyperreflective dots, and cysts, have been identified as prognostic factors. Conclusion: This document has sought to lay down a set of recommendations and to identify key issues that may be useful for the daily management of DME patients

Biomarkers of Venous Thromboembolism Recurrence after Discontinuation of Low Molecular Weight Heparin Treatment for Cancer-Associated Thrombosis (HISPALIS-Study)

The most appropriate duration of anticoagulant treatment for cancer-associated venous thromboembolism (CAT) remains unclear. We have conducted a prospective multicenter study in CAT patients with more than 6 months of anticoagulant treatment to predict the risk of venous thromboembolism (VTE) recurrence after anticoagulation discontinuation. Blood samples were obtained when patients stopped the anticoagulation, at 21 days and at 90 days. In each sample we assessed different coagulation-related biomarkers: D-dimer (DD), high-sensitivity C-reactive protein (hs-CRP), P-selectin (PS), phospholipids, soluble tissue factor, factor VIII and the thrombin generation test. It was evaluated 325 CAT patients and 166 patients were included in the study, mean age 64 ± 17 years. VTE recurrence until 6 months after stopping anticoagulation treatment was 9.87% [95% confidence interval (CI): 6–15]. The biomarkers sub-distribution hazard ratios were 6.32 for ratio DD basal/DD 21 days > 2 (95% CI: 1.82–21.90), 6.36 for hs-CRP > 4.5 (95% CI: 1.73–23.40) and 5.58 for PS > 40 (95% CI: 1.46–21.30) after 21 days of stopping anticoagulation. This is the first study that has identified the DD ratio, hs-CRP and PS as potential biomarkers of VTE recurrence in cancer patients after the discontinuation of anticoagulation treatment. A risk-adapted strategy may allow the identification of the optimal time to withdraw the anticoagulation in each CAT patientmThis research was funded by Instituto de Salud Carlos III, grant number (PI15/01085; PI18/01640, PI20/00075), Sociedad Española de Trombosis y Hemostasia; Fundación Respira, grant number (140/2013), Fundación Neumosur, grant number (5/2013) and the LEO Pharma Research Foundation. Partial funding for open access charge: Universidad de Málaga

Comunidad del organopónico “Simón Bolívar I” en Caracas: una experiencia agroproductiva vinculada a la transformación de la educación universitaria

En el año 2003 el presidente Hugo Rafael Chávez Frías fundó en Caracas el espacio socioproductivo denominado Organopónico Simón Bolívar I, es así como la ciudad dejó de ser sólo un espacio donde se agrupan y viven los consumidores y empezó a contribuir significativamente con la estratégica producción de alimentos y con la soberanía alimentaria. En la actualidad un grupo de 20 estudiantes de Agroecología de la Universidad Bolivariana de Venezuela llevan a cabo su proyecto socio-comunitario en el mencionado espacio y es por ello que participan en jornadas de formación y de trabajo voluntario, junto a diversos movimientos sociales, colectivos organizados e instituciones del Estado que hacen vida en este lugar. Entre los principales logros obtenidos, se encuentra el reconocimiento y respeto hacia los saberes populares que se vinculan con la actividad agrícola, también los niveles de integración de los estudiantes de agroecología con cada una de las actividades socioproductivas que organiza la comunidad y el haber experimentado los innumerables beneficios que aporta el trabajo solidario, organizado y siempre en equipo (cayapas), que ahora garantizan un verdadero y continuo intercambio de saberes, la creación e innovación continua y colectiva, y lo que quizás resulte ser mucho más importante, un afianzado cúmulo de valores socialistas que comienzan a desarrollarse en cada persona que se ha circunscrito en el marco del aprender haciendo.Eje: B6 Desarrollo rural, movimientos sociales, Estado y agroecología (Relatos de experiencias)Facultad de Ciencias Agrarias y Forestale

Type 2 Diabetes-Related Variants Influence the Risk of Developing Prostate Cancer: A Population-Based Case-Control Study and Meta-Analysis

This study was supported by grants from the FIBAO foundation (Granada, Spain) and from the Instituto de Salud Carlos III (PI12/02688, PI17/02256 and PI20/01845; Madrid, Spain).In this study, we have evaluated whether 57 genome-wide association studies (GWAS)-identified common variants for type 2 diabetes (T2D) influence the risk of developing prostate cancer (PCa) in a population of 304 Caucasian PCa patients and 686 controls. The association of selected single nucleotide polymorphisms (SNPs) with the risk of PCa was validated through meta-analysis of our data with those from the UKBiobank and FinnGen cohorts, but also previously published genetic studies. We also evaluated whether T2D SNPs associated with PCa risk could influence host immune responses by analysing their correlation with absolute numbers of 91 blood-derived cell populations and circulating levels of 103 immunological proteins and 7 steroid hormones. We also investigated the correlation of the most interesting SNPs with cytokine levels after in vitro stimulation of whole blood, peripheral mononuclear cells (PBMCs), and monocyte-derived macrophages with LPS, PHA, Pam3Cys, and Staphylococcus Aureus. The meta-analysis of our data with those from six large cohorts confirmed that each copy of the FTOrs9939609A, HNF1B(rs7501939T), HNF1B(rs75721T), HNF1B(rs4430796G), and JAZF1(rs10486567A) alleles significantly decreased risk of developing PCa (p = 3.70 x 10(-5), p = 9.39 x 10(-54), p = 5.04 x 10(-54), p = 1.19 x 10(-71), and p = 1.66 x 10(-18), respectively). Although it was not statistically significant after correction for multiple testing, we also found that the NOTCH2(rs10923931T) and RBMS1(rs7593730) SNPs associated with the risk of developing PCa (p = 8.49 x 10(-4) and 0.004). Interestingly, we found that the protective effect attributed to the HFN1B locus could be mediated by the SULT1A1 protein (p = 0.00030), an arylsulfotransferase that catalyzes the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. In addition to these results, eQTL analysis revealed that the HNF1B(rs7501939), HNF1B(rs757210), HNF1B(rs4430796), NOTCH2(rs10923931), and RBMS1(rs7593730) SNPs influence the risk of PCa through the modulation of mRNA levels of their respective genes in whole blood and/or liver. These results confirm that functional TD2-related variants influence the risk of developing PCa, but also highlight the need of additional experiments to validate our functional results in a tumoral tissue context.FIBAO foundation (Granada, Spain)Instituto de Salud Carlos III PI12/02688 PI17/02256 PI20/0184

Comunidad del organopónico “Simón Bolívar I” en Caracas: una experiencia agroproductiva vinculada a la transformación de la educación universitaria

En el año 2003 el presidente Hugo Rafael Chávez Frías fundó en Caracas el espacio socioproductivo denominado Organopónico Simón Bolívar I, es así como la ciudad dejó de ser sólo un espacio donde se agrupan y viven los consumidores y empezó a contribuir significativamente con la estratégica producción de alimentos y con la soberanía alimentaria. En la actualidad un grupo de 20 estudiantes de Agroecología de la Universidad Bolivariana de Venezuela llevan a cabo su proyecto socio-comunitario en el mencionado espacio y es por ello que participan en jornadas de formación y de trabajo voluntario, junto a diversos movimientos sociales, colectivos organizados e instituciones del Estado que hacen vida en este lugar. Entre los principales logros obtenidos, se encuentra el reconocimiento y respeto hacia los saberes populares que se vinculan con la actividad agrícola, también los niveles de integración de los estudiantes de agroecología con cada una de las actividades socioproductivas que organiza la comunidad y el haber experimentado los innumerables beneficios que aporta el trabajo solidario, organizado y siempre en equipo (cayapas), que ahora garantizan un verdadero y continuo intercambio de saberes, la creación e innovación continua y colectiva, y lo que quizás resulte ser mucho más importante, un afianzado cúmulo de valores socialistas que comienzan a desarrollarse en cada persona que se ha circunscrito en el marco del aprender haciendo.Eje: B6 Desarrollo rural, movimientos sociales, Estado y agroecología (Relatos de experiencias)Facultad de Ciencias Agrarias y Forestale

Usos del e‐learning en las Universidades Andaluzas: estado de la situación y análisis de buenas prácticas. (Resumen ejecutivo).

Secretaría General de Universidades, Investigación y Tecnología P07-SE-J.0267

Usos del e-learning en las Universidades Andaluzas: Estado de la situación y análisis de buenas prácticas. (Versión completa)

Secretaría General de Universidades, Investigación y Tecnología P07-SE-J.0267