Identification of new putative driver mutations and predictors of disease evolution in chronic lymphocytic leukemia

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LiDARgrammetry: A New Method for Generating Synthetic Stereoscopic Products from Digital Elevation Models

There are currently several new technologies being used to generate digital elevation models that do not use photogrammetric techniques. For example, LiDAR (Laser Imaging Detection and Ranging) and RADAR (RAdio Detection And Ranging) can generate 3D points and reflectivity information of the surface without using a photogrammetric approach. In the case of LiDAR, the intensity level indicates the amount of energy that the object reflects after a laser pulse is transmitted. This energy mainly depends on the material and the wavelength used by LiDAR. This intensity level can be used to generate a synthetic image colored by this attribute (intensity level), which can be viewed as a RGB (red, green and blue) picture. This work presents the outline of an innovative method, designed by the authors, to generate synthetic pictures from point clouds to use in classical photogrammetric software (digital restitution or stereoscopic vision). This is conducted using available additional information (for example, the intensity level of LiDAR). This allows mapping operators to view the LiDAR as if it were stereo-imagery, so they can manually digitize points, 3D lines, break lines, polygons and so on

A Three-Gene Expression Signature Identifies a Cluster of Patients with Short Survival in Chronic Lymphocytic Leukemia.

Chronic lymphocytic leukemia (CLL) is a lymphoproliferative disorder characterized by its heterogeneous clinical evolution. Despite the discovery of the most frequent cytogenomic drivers of disease during the last decade, new efforts are needed in order to improve prognostication. In this study, we used gene expression data of CLL samples in order to discover novel transcriptomic patterns associated with patient survival. We observed that a 3-gene expression signature composed of SCGB2A1, KLF4, and PPP1R14B differentiate a group of circa 5% of cases with short survival. This effect was independent of the main cytogenetic markers of adverse prognosis. Finally, this finding was reproduced in an independent retrospective cohort. We believe that this small gene expression pattern will be useful for CLL prognostication and its association with CLL response to novel drugs should be explored in the future

LiDARgrammetry: A New Method for Generating Synthetic Stereoscopic Products from Digital Elevation Models

There are currently several new technologies being used to generate digital elevation models that do not use photogrammetric techniques. For example, LiDAR (Laser Imaging Detection and Ranging) and RADAR (RAdio Detection And Ranging) can generate 3D points and reflectivity information of the surface without using a photogrammetric approach. In the case of LiDAR, the intensity level indicates the amount of energy that the object reflects after a laser pulse is transmitted. This energy mainly depends on the material and the wavelength used by LiDAR. This intensity level can be used to generate a synthetic image colored by this attribute (intensity level), which can be viewed as a RGB (red, green and blue) picture. This work presents the outline of an innovative method, designed by the authors, to generate synthetic pictures from point clouds to use in classical photogrammetric software (digital restitution or stereoscopic vision). This is conducted using available additional information (for example, the intensity level of LiDAR). This allows mapping operators to view the LiDAR as if it were stereo-imagery, so they can manually digitize points, 3D lines, break lines, polygons and so on

Alasdair MacIntyre: introducción narrativa a su obra

A raíz de la publicación del último libro del filósofo británico Alasdair MacIntyre, Ethics in the Conflicts of Modernity: An Essay on Desire, Practical Reasoning, and Narrative, este trabajo propone una manera de comprender su producción bibliográfica en el contexto de la narrativa de su trayectoria vital e intelectual. Se elabora una periodización del itinerario de MacIntyre, basada en las referencias que el propio autor ha hecho sobre su vida académica y en las propuestas de varios estudiosos de su pensamiento. Se concluye que el examen narrativo de la obra de Alasdair MacIntyre revela que su proyecto filosófico está marcado básicamente por Aristóteles y Tomás de Aquino, cuyo pensamiento ayudó a nuestro autor a articular una propuesta sólida sobre las principales cuestiones de filosofía moral y la filosofía de la religión, y a elaborar un nuevo marco de interpretación y conocimiento sapiencial de la realidad, también en su aspecto científico. Este trabajo se concibe como introductorio porque se centra solamente en los libros de MacIntyre, pero se espera que sirva como base sólida para realizar un estudio crítico minucioso — sobre todo, desde una perspectiva cronológica— de la práctica totalidad de su obra, que incluye también capítulos de libros, artículos académicos, entrevistas, entre otros.In the wake of the publication of the last book of the British philosopher Alasdair MacIntyre, Ethics in the Conflicts of Modernity: An Essay on Desire, Practical Reasoning, and Narrative, this work proposes a way to understand his bibliographical production in the context of the narrative of his life and his intellectual career. It is elaborated a periodization of the itinerary of MacIntyre, based on the references that the author himself has made of his academic life and in the proposals of several scholars of his thought. It is concluded that the narrative examination of MacIntyre’s work reveals that his philosophical project is basically marked by Aristotle and Aquinas, whose thought helped our author to articulate a solid proposal on the main issues of moral philosophy and philosophy of religion, and to elaborate a new framework of interpretation and sapiential knowledge of reality, including its scientific dimension. This work is conceived as introductory because it focuses only on MacIntyre’s books, but it’s expected to serve as a solid basis for a thorough critical study —especially from a chronological perspective— of his entire work, which includes chapters of books, papers, interviews, among others

Valorization of bottom ash from municipal solid waste incineration: recovery of copper by electrowinning

Postprint (published version

New Recurrent Structural Aberrations in the Genome of Chronic Lymphocytic Leukemia Based on Exome-Sequencing Data

Chronic lymphocytic leukemia (CLL) is the most frequent lymphoproliferative syndrome in Western countries, and it is characterized by recurrent large genomic rearrangements. During the last decades, array techniques have expanded our knowledge about CLL’s karyotypic aberrations. The advent of large sequencing databases expanded our knowledge cancer genomics to an unprecedented resolution and enabled the detection of small-scale structural aberrations in the cancer genome. In this study, we have performed exome-sequencing-based copy number aberration (CNA) and loss of heterozygosity (LOH) analysis in order to detect new recurrent structural aberrations. We describe 54 recurrent focal CNAs enriched in cancer-related pathways, and their association with gene expression and clinical evolution. Furthermore, we discovered recurrent large copy number neutral LOH events affecting key driver genes, and we recapitulate most of the large CNAs that characterize the CLL genome. These results provide “proof-of-concept” evidence supporting the existence of new genes involved in the pathogenesis of CLL.S

Efficiency improvement of HF communications using cognitive radio principles

Cognitive Radio principles can be applied to HF communications to make a more efficient use of the extremely scarce spectrum. In this contribution we focus on analyzing the usage of the available channels done by the legacy users, which are regarded as primary users since they are allowed to transmit without resorting any smart procedure, and consider the possibilities for our stations -over the HFDVL (HF Data+Voice Link) architecture- to participate as secondary users. Our goal is to enhance an efficient use of the HF band by detecting the presence of uncoordinated primary users and avoiding collisions with them while transmitting in different HF channels using our broad-band HF transceiver. A model of the primary user activity dynamics in the HF band is developed in this work. It is based on Hidden Markov Models (HMM) which are a powerful tool for modelling stochastic random processes, and is trained with real measurements from the 14 MHz band