First Nesting Record of the Caspian Tern in North Dakota

On June 28, 1977, we observed a single pair of Caspian terns (Sterna caspia) with two young on an island in Lake Williams in central North Dakota. This is the first confirmation of actual nesting by the Caspian tern in the State. Previously, breeding records had been postulated from sightings during the breeding season (Kantrud 1973; Robert Randall, personal communication; and Rohrt Stewart, personal communication). Lake Williams is a shallow, saline, 420-hectare lake located near the town of Turtle Lake in east-central Mclean County. Mean depth during the breeding season (May-June) can range from 0 to 50 centimeters. The island consists of a gravel base covered by sand and is approximately 75 meters long with a tapering width of 33 meters to 66 meters. It covers an approximate area of .4 hectare. The closest point of land is 480 meters from the island. The only vegetation noted was Russian thistle (Salsola kali), which was 30 to 60 centimeters high and covered roughly 60 percent of the island

SN Refsdal: Classification as a Luminous and Blue SN 1987A-like Type II Supernova

We have acquired Hubble Space Telescope (HST) and Very Large Telescope near-infrared spectra and images of supernova (SN) Refsdal after its discovery as an Einstein cross in Fall 2014. The HST light curve of SN Refsdal matches the distinctive, slowly rising light curves of SN 1987A-like supernovae (SNe), and we find strong evidence for a broad H-alpha P-Cygni profile in the HST grism spectrum at the redshift (z = 1.49) of the spiral host galaxy. SNe IIn, powered by circumstellar interaction, could provide a good match to the light curve of SN Refsdal, but the spectrum of a SN IIn would not show broad and strong H-alpha absorption. From the grism spectrum, we measure an H-alpha expansion velocity consistent with those of SN 1987A-like SNe at a similar phase. The luminosity, evolution, and Gaussian profile of the H-alpha emission of the WFC3 and X-shooter spectra, separated by ~2.5 months in the rest frame, provide additional evidence that supports the SN 1987A-like classification. In comparison with other examples of SN 1987A-like SNe, SN Refsdal has a blue B-V color and a high luminosity for the assumed range of potential magnifications. If SN Refsdal can be modeled as a scaled version of SN 1987A, we estimate it would have an ejecta mass of 20+-5 solar masses. The evolution of the light curve at late times will provide additional evidence about the potential existence of any substantial circumstellar material (CSM). Using MOSFIRE and X-shooter spectra, we estimate a subsolar host-galaxy metallicity (8.3+-0.1 dex and <8.4 dex, respectively) near the explosion site.Comment: Submitted to ApJ; 26 page

Have the roles of two functional polymorphisms in breast cancer, R72P in P53 and MDM2-309 in MDM2, become clearer?

Genetic differences between individuals have been predicted to account for disparate outcomes in patients diagnosed with cancer. The search for genetic determinants has been ongoing for a considerable amount of time and it is only now that insights have been gained into which polymorphisms are most likely to be important in determining not only disease likelihood but also outcome. The quest to be able to accurately predict patient outcomes in breast cancer may now be a step closer as increased sample size is leading to more robust statistical analysis and a better understanding of molecular mechanisms of disease are forthcoming

A Chandra Observation of the Obscured Star-Forming Complex W40

The young stellar cluster illuminating the W40 H II region, one of the nearest massive star forming regions, has been observed with the ACIS detector on board the Chandra X-ray Observatory. Due to its high obscuration, this is a poorly-studied stellar cluster with only a handful of bright stars visible in the optical band, including three OB stars identified as primary excitation sources. We detect 225 X-ray sources, of which 85% are confidently identified as young stellar members of the region. Two potential distances of the cluster, 260 pc and 600 pc, are used in the paper. Supposing the X-ray luminosity function to be universal, it supports a 600 pc distance as a lower limit for W40 and a total population of at least 600 stars down to 0.1 Mo under the assumption of a coeval population with a uniform obscuration. In fact, there is strong spatial variation in Ks-band-excess disk fraction and non-uniform obscuration due to a dust lane that is identified in absorption in optical, infrared and X-ray. The dust lane is likely part of a ring of material which includes the molecular core within W40. In contrast to the likely ongoing star formation in the dust lane, the molecular core is inactive. The star cluster has a spherical morphology, an isothermal sphere density profile, and mass segregation down to 1.5 Mo. However, other cluster properties, including a \leq{1} Myr age estimate and ongoing star formation, indicate that the cluster is not dynamically relaxed. X-ray diffuse emission and a powerful flare from a young stellar object are also reported.Comment: Accepted for publication in The Astrophysical Journal. 60 pages, 16 figure

Enhancer Sequence Variants and Transcription-Factor Deregulation Synergize to Construct Pathogenic Regulatory Circuits in B-Cell Lymphoma

SummaryMost B-cell lymphomas arise in the germinal center (GC), where humoral immune responses evolve from potentially oncogenic cycles of mutation, proliferation, and clonal selection. Although lymphoma gene expression diverges significantly from GC B cells, underlying mechanisms that alter the activities of corresponding regulatory elements (REs) remain elusive. Here we define the complete pathogenic circuitry of human follicular lymphoma (FL), which activates or decommissions REs from normal GC B cells and commandeers enhancers from other lineages. Moreover, independent sets of transcription factors, whose expression was deregulated in FL, targeted commandeered versus decommissioned REs. Our approach revealed two distinct subtypes of low-grade FL, whose pathogenic circuitries resembled GC B or activated B cells. FL-altered enhancers also were enriched for sequence variants, including somatic mutations, which disrupt transcription-factor binding and expression of circuit-linked genes. Thus, the pathogenic regulatory circuitry of FL reveals distinct genetic and epigenetic etiologies for GC B-cell transformation

SN Refsdal : Photometry and Time Delay Measurements of the First Einstein Cross Supernova

We present the first year of Hubble Space Telescope imaging of the unique supernova (SN) "Refsdal," a gravitationally lensed SN at z = 1.488 ± 0.001 with multiple images behind the galaxy cluster MACS J1149.6+2223. The first four observed images of SN Refsdal (images S1–S4) exhibited a slow rise (over ~150 days) to reach a broad peak brightness around 2015 April 20. Using a set of light curve templates constructed from SN 1987A-like peculiar Type II SNe, we measure time delays for the four images relative to S1 of 4 ± 4 (for S2), 2 ± 5 (S3), and 24 ± 7 days (S4). The measured magnification ratios relative to S1 are 1.15 ± 0.05 (S2), 1.01 ± 0.04 (S3), and 0.34 ± 0.02 (S4). None of the template light curves fully captures the photometric behavior of SN Refsdal, so we also derive complementary measurements for these parameters using polynomials to represent the intrinsic light curve shape. These more flexible fits deliver fully consistent time delays of 7 ± 2 (S2), 0.6 ± 3 (S3), and 27 ± 8 days (S4). The lensing magnification ratios are similarly consistent, measured as 1.17 ± 0.02 (S2), 1.00 ± 0.01 (S3), and 0.38 ± 0.02 (S4). We compare these measurements against published predictions from lens models, and find that the majority of model predictions are in very good agreement with our measurements. Finally, we discuss avenues for future improvement of time delay measurements—both for SN Refsdal and for other strongly lensed SNe yet to come

Loss of synergistic transcriptional feedback loops drives diverse B-cell cancers

BACKGROUND: The most common B-cell cancers, chronic lymphocytic leukemia/lymphoma (CLL), follicular and diffuse large B-cell (FL, DLBCL) lymphomas, have distinct clinical courses, yet overlapping cell-of-origin . Dynamic changes to the epigenome are essential regulators of B-cell differentiation. Therefore, we reasoned that these distinct cancers may be driven by shared mechanisms of disruption in transcriptional circuitry. METHODS: We compared purified malignant B-cells from 52 patients with normal B-cell subsets (germinal center centrocytes and centroblasts, naïve and memory B-cells) from 36 donor tonsils using \u3e325 high-resolution molecular profiling assays for histone modifications, open chromatin (ChIP-, FAIRE-seq), transcriptome (RNA-seq), transcription factor (TF) binding, and genome copy number (microarrays). FINDINGS: From the resulting data, we identified gains in active chromatin in enhancers/super-enhancers that likely promote unchecked B-cell receptor signaling, including one we validated near the immunoglobulin superfamily receptors FCMR and PIGR. More striking and pervasive was the profound loss of key B-cell identity TFs, tumor suppressors and their super-enhancers, including EBF1, OCT2(POU2F2), and RUNX3. Using a novel approach to identify transcriptional feedback, we showed that these core transcriptional circuitries are self-regulating. Their selective gain and loss form a complex, iterative, and interactive process that likely curbs B-cell maturation and spurs proliferation. INTERPRETATION: Our study is the first to map the transcriptional circuitry of the most common blood cancers. We demonstrate that a critical subset of B-cell TFs and their cognate enhancers form self-regulatory transcriptional feedback loops whose disruption is a shared mechanism underlying these diverse subtypes of B-cell lymphoma. FUNDING: National Institute of Health, Siteman Cancer Center, Barnes-Jewish Hospital Foundation, Doris Duke Foundation

SN Refsdal: Classification as a Luminous and Blue SN 1987A-like Type II Supernova

We have acquired Hubble Space Telescope (HST) and Very Large Telescope near-infrared spectra and images of supernova (SN) Refsdal after its discovery as an Einstein cross in fall 2014. The HST light curve of SN Refsdal has a shape consistent with the distinctive, slowly rising light curves of SN 1987A-like SNe, and we find strong evidence for a broad Hα P-Cygni profile and Na I D absorption in the HST grism spectrum at the redshift (z = 1.49) of the spiral host galaxy. SNe IIn, largely powered by circumstellar interaction, could provide a good match to the light curve of SN Refsdal, but the spectrum of a SN IIn would not show broad and strong Hα and Na I D absorption. From the grism spectrum, we measure an Hα expansion velocity consistent with those of SN 1987A-like SNe at a similar phase. The luminosity, evolution, and Gaussian profile of the Hα emission of the WFC3 and X-shooter spectra, separated by ~2.5 months in the rest frame, provide additional evidence that supports the SN 1987A-like classification. In comparison with other examples of SN 1987A-like SNe, photometry of SN Refsdal favors bluer B − V and V − R colors and one of the largest luminosities for the assumed range of potential magnifications. The evolution of the light curve at late times will provide additional evidence about the potential existence of any substantial circumstellar material. Using MOSFIRE and X-shooter spectra, we estimate a subsolar host-galaxy metallicity (8.3 ± 0.1 dex and <8.4 dex, respectively) near the explosion site

Core-collapse supernovae missed by optical surveys

We estimate the fraction of core-collapse supernovae (CCSNe) that remain undetected by optical SN searches due to obscuration by large amounts of dust in their host galaxies. This effect is especially important in luminous and ultraluminous infrared galaxies, which are locally rare but dominate the star formation at redshifts of z~1-2. We perform a detailed investigation of the SN activity in the nearby luminous infrared galaxy Arp 299 and estimate that up to 83% of the SNe in Arp 299 and in similar galaxies in the local Universe are missed by observations at optical wavelengths. For rest-frame optical surveys we find the fraction of SNe missed due to high dust extinction to increase from the average local value of ~19% to ~38% at z~1.2 and then stay roughly constant up to z~2. It is therefore crucial to take into account the effects of obscuration by dust when determining SN rates at high redshift and when predicting the number of CCSNe detectable by future high-z surveys such as LSST, JWST, and Euclid. For a sample of nearby CCSNe (distances 6-15 Mpc) detected during the last 12 yr, we find a lower limit for the local CCSN rate of 1.5 +0.4/-0.3 x 10^-4 yr^-1 Mpc^-3, consistent with that expected from the star formation rate. Even closer, at distances less than ~6 Mpc, we find a significant increase in the CCSN rate, indicating a local overdensity of star formation caused by a small number of galaxies that have each hosted multiple SNe.Comment: 16 pages, 5 figures, 11 tables, minor changes to match the published versio

Deja Vu All Over Again: The Reappearance of Supernova Refsdal

In Hubble Space Telescope (HST) imaging taken on 2014 November 10, four images of supernova (SN) "Refsdal" (redshift z = 1.49) appeared in an Einstein-cross-like configuration (images S1–S4) around an early-type galaxy in the cluster MACS J1149.5+2223 (z = 0.54). Almost all lens models of the cluster have predicted that the SN should reappear within a year in a second host-galaxy image created by the cluster's potential. In HST observations taken on 2015 December 11, we find a new source at the predicted position of the new image of SN Refsdal approximately $8^{\prime\prime}$ from the previous images S1–S4. This marks the first time the appearance of a SN at a particular time and location in the sky was successfully predicted in advance! We use these data and the light curve from the first four observed images of SN Refsdal to place constraints on the relative time delay and magnification of the new image (SX) compared to images S1–S4. This enables us, for the first time, to test "blind" lens model predictions of both magnifications and time delays for a lensed SN. We find that the timing and brightness of the new image are consistent with the blind predictions of a fraction of the models. The reappearance illustrates the discriminatory power of this blind test and its utility to uncover sources of systematic uncertainty. From planned HST photometry, we expect to reach a precision of 1%–2% on the time delay between S1–S4 and SX