The Self-Designing High- Reliability Organization

Recent studies of large, formal organizations that perform complex, inherently hazardous, and highly technical task under conditions of tight coupling and severe time pressure have generally concluded that most will fail spectaculatory at some point, with attendant human and social const of great severity. The notion that accidents in these systems are normal, that is, to be expected given the coditions and risks of operations and risk of operation, appears to be as well grounded in experience as in theory

The Self-Designing High-Reliability Organization: Aircraft Carrier Flight Operations at Sea

Of all activities studied by our research group, flight operations at sea is the closest to the edge of the envelope -operating under the most extreme conditions in the least stable environment, and with the greatest tension between preserving safety and reliability and attaining maximum operational efficiency

Predicting Tenderness in Beef Carcasses by Combining Ultrasound and Mechanical Techniques

• Meat tenderness is a concern today in the beef cattle industry, and it will become an even greater concern in the future. • Tenderness is a complex issue, and it is difficult to predict tenderness after cooking by examining raw beef or carcass beef. Unfortunately, tenderness must be evaluated at the carcass level to be a useful tool in the industry. • A star-shaped probe was attached to an InstronÒ machine. This attachment makes it possible to measure tenderness in both raw and cooked Longissimus dorsi steaks. The correlation between raw and cooked was 0.41. • The correlation between cooked star probe values and Warner Bratzler shear values (the standard tenderness measure) was 0.53. • The star-shaped probe applies pressure to beef tissue. This approach was then combined with ultrasound to evaluate firmness or softness of beef tissue. Ultrasound images were collected as increased pressure was applied (elastography). • A probe has been built that attaches to hot carcasses to evaluate this elastography procedure

Present and historical environmental survey of the Poquoson River, York County, Virginia and the Warwick River; Newport News, Virginia : with special reference to biotic communities and the effects of alum discharge

The objectives of this study were: 1. to determine the areal extent of discharged materials within each of the rivers using the aluminum:silicon ratio as an indicator; 2. to evaluate the benthic invertebrate communities within each of the rivers; 3. to determine whether there are differences in the productivity of the benthic algal and planktonic communities which can be attributed to the discharge of alum sludge in each river; 4. to evaluate the condition of the marsh communities in each river near the filtration plant; 5. to review historical biological data for the Poquoson and Warwick Rivers and to relate the biological communities within these two systems to communities in subestuaries not receiving alum sludge discharges; 6. to evaluate the probable sediment yield from the drainage areas of the two reservoirs in the absence of a dam using the STORM model; 7. to identify mitigation alternatives and evaluate their ecological implications

The Sweetheart Serenade

Illustration of an outline of a girls face on a purple backgroundhttps://scholarsjunction.msstate.edu/cht-sheet-music/10526/thumbnail.jp

RNA-binding protein CPEB1 remodels host and viral RNA landscapes.

Host and virus interactions occurring at the post-transcriptional level are critical for infection but remain poorly understood. Here, we performed comprehensive transcriptome-wide analyses revealing that human cytomegalovirus (HCMV) infection results in widespread alternative splicing (AS), shortening of 3' untranslated regions (3' UTRs) and lengthening of poly(A)-tails in host gene transcripts. We found that the host RNA-binding protein CPEB1 was highly induced after infection, and ectopic expression of CPEB1 in noninfected cells recapitulated infection-related post-transcriptional changes. CPEB1 was also required for poly(A)-tail lengthening of viral RNAs important for productive infection. Strikingly, depletion of CPEB1 reversed infection-related cytopathology and post-transcriptional changes, and decreased productive HCMV titers. Host RNA processing was also altered in herpes simplex virus-2 (HSV-2)-infected cells, thereby indicating that this phenomenon might be a common occurrence during herpesvirus infections. We anticipate that our work may serve as a starting point for therapeutic targeting of host RNA-binding proteins in herpesvirus infections

Infection on a gynecologic oncology service

Little information is available pertaining to infectious morbidity in women with genital malignancy. To define the magnitude of this problem, all patients admitted to the gynecologic oncology services at the University of Michigan Medical Center between January 1, 1986, and December 31, 1986, were followed prospectively for the development of infectious morbidity. One hundred nine bacteriologically confirmed infections occurred in 297 patients during 510 admissions. An additional 31 postoperative patients received empiric therapy for presumed infection. Urinary tract (54) and wound (22) infections were the most commonly confirmed infections. The pathogens isolated from oncology patients were significantly different in frequency of isolation and antibiotic sensitivity when compared with pathogens isolated from women developing infections on the benign gynecology service. Women with genital malignancies are at high risk for the development of a variety of infections by resistant pathogens, emphasizing the importance of obtaining cultures prior to initiation of therapy and carefully selecting the antibiotics to be prescribed.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/28592/1/0000400.pd

A Web Service for Biomedical Term Look-Up

Recent years have seen a huge increase in the amount of biomedical information that is available in electronic format. Consequently, for biomedical researchers wishing to relate their experimental results to relevant data lurking somewhere within this expanding universe of on-line information, the ability to access and navigate biomedical information sources in an efficient manner has become increasingly important. Natural language and text processing techniques can facilitate this task by making the information contained in textual resources such as MEDLINE more readily accessible and amenable to computational processing. Names of biological entities such as genes and proteins provide critical links between different biomedical information sources and researchers' experimental data. Therefore, automatic identification and classification of these terms in text is an essential capability of any natural language processing system aimed at managing the wealth of biomedical information that is available electronically. To support term recognition in the biomedical domain, we have developed Termino, a large-scale terminological resource for text processing applications, which has two main components: first, a database into which very large numbers of terms can be loaded from resources such as UMLS, and stored together with various kinds of relevant information; second, a finite state recognizer, for fast and efficient identification and mark-up of terms within text. Since many biomedical applications require this functionality, we have made Termino available to the community as a web service, which allows for its integration into larger applications as a remotely located component, accessed through a standardized interface over the web

Development of novel adenoviral vectors to overcome challenges observed with HAdV-5 based constructs

Recombinant vectors based on human adenovirus serotype 5 (HAdV-5) have been extensively studied in pre-clinical models and clinical trials over the last two decades. However, the thorough understanding of the HAdV-5 interaction with human subjects has uncovered major concerns about its product applicability. High vector-associated toxicity and widespread pre-existing immunity have been shown to significantly impede the effectiveness of HAdV-5 mediated gene transfer. It is therefore that the in depth knowledge attained working on HAdV-5 is currently being used to develop alternative vectors. Here, we provide a comprehensive overview of data obtained in recent years disqualifying the HAdV-5 vector for systemic gene delivery as well as novel strategies being pursued to overcome the limitations observed with particular emphasis on the ongoing vectorization efforts to obtain vectors based on alternative serotypes

Support for UNRWA's survival

The United Nations Relief and Works Agency for Palestine Refugees in the Near East (UNRWA) provides life-saving humanitarian aid for 5·4 million Palestine refugees now entering their eighth decade of statelessness and conflict. About a third of Palestine refugees still live in 58 recognised camps. UNRWA operates 702 schools and 144 health centres, some of which are affected by the ongoing humanitarian disasters in Syria and the Gaza Strip. It has dramatically reduced the prevalence of infectious diseases, mortality, and illiteracy. Its social services include rebuilding infrastructure and homes that have been destroyed by conflict and providing cash assistance and micro-finance loans for Palestinians whose rights are curtailed and who are denied the right of return to their homeland