The farmhouses of la Garrotxa: Batet de la Serra and Santa Pau: photogrammetric survey of Mas Maçandell

El treball pretén realitzar un estudi previ de les masies de la Garrotxa i aprofundir en les que han quedat en ruïnes per a posteriorment analitzar, estudiar i representar mitjançant diverses tècniques gràfiques Mas Maçandell, per poder donar una eina útil per la seva posterior intervenció i no arribi a l'estat de ruïna.The work aims to do is to conduct a preliminary study of the farmhouses of the Garrotxa and delve into those that have been left in ruins and then analyze, study and represent through various graphic techniques the pathologies and intervention of more Mas Maçandell, so that it does not reach the state of ruin

Fifth Siglo de Oro Drama Festival

Fifth Siglo de Oro Drama Festiva

Spinocerebellar Ataxia Type 2

1. Introduction: The autosomal dominant cerebellar ataxias (ADCA) are a clinically, pathologically and genetically heterogeneous group of neurodegenerative disorders caused by degeneration of cerebellum and its afferent and efferent connections. The degenerative process may additionally involves the ponto- medullar systems, pyramidal tracts, basal ganglia, cerebral cortex, peripheral nerves (ADCA I) and the retina (ADCA II), or can be limited to the cerebellum (ADCA III) (Harding et al., 1993). The most common of these dominantly inherited autosomal ataxias, ADCA I, includes many Spinocerebellar Ataxias (SCA) subtypes, some of which are caused by pathological CAG trinucleotide repeat expansion in the coding region on the mutated gene. Such is the case for SCA1, SCA2, SCA3/MJD, SCA6, SCA7, SCA17 and Dentatorubral-pallidoluysian atrophy (DRPLA) (Matilla et al., 2006). Among the almost 30 SCAs, the variant SCA2 is the second most prevalent subtype worldwide, only surpassed by SCA3 (Schöls et al., 2004; Matilla et al., 2006; Auburger, 2011)..

Plinio y la minería aurífera romana: nueva traducción e interpretación de PLIN.Nat.33.66-78

Readers are presented with a new translation and an original interpretation of PLIN.Nat.33.66-78, text about the gold-bearing Roman mining in the Iberian Peninsula. This work is the result of an interdisciplinary focus, in which the knowledge of the Latin language and the techniques of the Roman mining have come together and have been extremely respected, given that the authors´ main aim has been to get as close as possible to what Pliny the Elder wanted to express, as well as to determine exactly his knowledge about the true dimension of the techniques used in the exploitation of the gold mines in the Roman Empire.El lector tiene ante sí una nueva traducción y una novedosa interpretación de PLIN.Nat.33.66-78, texto dedicado a la minería aurífera romana de la Península Ibérica. Este trabajo es el resultado de un enfoque interdisciplinar, en el que el conocimiento de la lengua latina y las técnicas de minería romana han confluido y se han respetado en grado sumo, pues el objetivo principal de los autores ha sido acercarse lo más posible a lo que Plinio el Viejo quiso expresar, así como matizar con precisión su grado de conocimiento sobre la verdadera dimensión de las técnicas utilizadas en la explotación de las minas de oro en el Imperio Romano

The use of ITC resources and language acquisition

Trabajo Fin de Máste

Eye Movement Abnormalities in Neurodegenerative Diseases

Neurodegenerative disorders consist in heterogeneous group of neurological conditions characterized by a wide spectrum of clinical features resulting from a progressive involvement of distinct neuron populations. Oculomotor abnormalities take a key place in the clinical picture of these disorders because the neurodegenerative processes involve the brain circuits of eye movements. The most common abnormalities include the saccadic dysfunction, fixation instability, and abnormal smooth pursuit. The clinical assessment of oculomotor function can help to differentiate diagnosis, while electrophysiological measures provide useful biomarkers for the understanding of disease physiopathology and progression. In this chapter, we review the state of the art of the eye movement’s deficits in some neurodegenerative diseases, such as Parkinson’s disease, Alzheimer’s disease, amyotrophic lateral sclerosis, Huntington’s disease, and the hereditary ataxias

La Geografía en la Universidad Cubana: logros, dificultades y desafíos de la enseñanza de una ciencia comprometida con el desarrollo económico y social de una sociedad en transformación

Sin resume

Application of miRNA-seq in neuropsychiatry: A methodological perspective

MiRNAs are emerging as key molecules to study neuropsychiatric diseases. However, despite the large number of methodologies and software for miRNA-seq analyses, there is little supporting literature for researchers in this area. This review focuses on evaluating how miRNA-seq has been used to study neuropsychiatric diseases to date, analyzing both the main findings discovered and the bioinformatics workflows and tools used from a methodological perspective. The objective of this review is two-fold: first, to evaluate current miRNA-seq procedures used in neuropsychiatry; and second, to offer comprehensive information that can serve as a guide to new researchers in bioinformatics. After conducting a systematic search (from 2016 to June 30, 2020) of articles using miRNA-seq in neuropsychiatry, we have seen that it has already been used for different types of studies in three main categories: diagnosis, prognosis, and mechanism. We carefully analyzed the bioinformatics workflows of each study, observing a high degree of variability with respect to the tools and methods used and several methodological complexities that are identified and discussed in this reviewInstituto de Salud Carlos III | Ref. PI18/01311Ministerio de Economía y Competitividad | Ref. RYC2014-15246Xunta de Galicia | Ref. ED431C2018/55-GR