Partly standing internal tides in a dendritic submarine canyon observed by an ocean glider

An autonomous ocean glider is used to make the first direct measurements of internal tides within Whittard Canyon, a large, dendritic submarine canyon system that incises the Celtic Sea continental slope and a site of high benthic biodiversity. This is the first time a glider has been used for targeted observations of internal tides in a submarine canyon. Vertical isopycnal displacement observations at different stations fit a one-dimensional model of partly standing semidiurnal internal tides – comprised of a major, incident wave propagating up the canyon limbs and a minor wave reflected back down-canyon by steep, supercritical bathymetry near the canyon heads. The up-canyon internal tide energy flux in the primary study limb decreases from 9.2 to 2.0 kW m−1 over 28 km (a dissipation rate of View the MathML source), comparable to elevated energy fluxes and internal tide driven mixing measured in other canyon systems. Within Whittard Canyon, enhanced mixing is inferred from collapsed temperature-salinity curves and weakened dissolved oxygen concentration gradients near the canyon heads. It has previously been hypothesised that internal tides impact benthic fauna through elevated near-bottom current velocities and particle resuspension. In support of this, we infer order 20 cm s−1 near-bottom current velocities in the canyon and observe high concentrations of suspended particulate matter. The glider observations are also used to estimate a 1 °C temperature range and 12 μmol kg−1 dissolved oxygen concentration range, experienced twice a day by organisms on the canyon walls, due to the presence of internal tides. This study highlights how a well-designed glider mission, incorporating a series of tide-resolving stations at key locations, can be used to understand internal tide dynamics in a region of complex topography, a sampling strategy that is applicable to continental shelves and slopes worldwide

Ares I Flight Control System Overview

This paper describes the control challenges posed by the Ares I vehicle, the flight control system design and performance analyses used to test and verify the design. The major challenges in developing the control system are structural dynamics, dynamic effects from the powerful first stage booster, aerodynamics, first stage separation and large uncertainties in the dynamic models for all these. Classical control techniques were employed using innovative methods for structural mode filter design and an anti-drift feature to compensate for translational and rotational disturbances. This design was coded into an integrated vehicle flight simulation and tested by Monte Carlo methods. The product of this effort is a linear, robust controller design that is easy to implement, verify and test

In vitro efficacy of tavaborole topical solution, 5% after penetration through nail polish on ex vivo human fingernails

This document is the Accepted Manuscript of the following article: Aditya K. Gupta, et al, 'In vitro efficacy of tavaborole topical solution, 5% after penetration through nail polish on ex vivo human fingernails', Journal of Dermatological Treatment, Jan 2018. Under embargo until 10 January 2019. The final, published version is available online at doi: https://doi.org/10.1080/09546634.2017.1422078.Background: Topical antifungal treatments for onychomycosis are applied to clean, unpolished nails for 48 weeks or longer. Patients often wish to mask their infection with nail polish yet there is no evidence to suggest antifungal efficacy in the presence of nail polish. Objective: To determine if tavaborole retains the ability to penetrate the nail plate and inhibit fungal growth in the presence of nail polish. Method: Tavaborole was applied to human fingernails painted with 2 or 4 coats of nail polish, and unpainted nails in an ex vivo model. Nails were mounted on TurChub ® chambers seeded with Trichophyton rubrum and allowed to incubate for 7 days. Antifungal activity was assessed by measuring zones of inhibition. Results and conclusion: Tavaborole exhibited antifungal activity in all experimental groups. The zones of inhibition of T. rubrum for all experimental groups (2 or 4 coats of polish, unpolished) were greater than infected controls (polished and unpolished), p s <.001. Tavaborole penetrates polished nails and kills T. rubrum in this ex vivo model.Peer reviewe

Glider observations of thermohaline staircases in the tropical North Atlantic using an automated classifier

Thermohaline staircases are stepped structures of alternating thick mixed layers and thin high-gradient interfaces. These structures can be up to several tens of metres thick and are associated with double-diffusive mixing. Thermohaline staircases occur across broad swathes of the Arctic and tropical and subtropical oceans and can increase rates of diapycnal mixing by up to 5 times the background rate, driving substantial nutrient fluxes to the upper ocean. In this study, we present an improved classification algorithm to detect thermohaline staircases in ocean glider profiles. We use a dataset of 1162 glider profiles from the tropical North Atlantic collected in early 2020 at the edge of a known thermohaline staircase region. The algorithm identifies thermohaline staircases in 97.7 % of profiles that extend deeper than 300 m. We validate our algorithm against previous results obtained from algorithmic classification of Argo float profiles. Using fine-resolution temperature data from a fast-response thermistor on one of the gliders, we explore the effect of varying vertical bin sizes on detected thermohaline staircases. Our algorithm builds on previous work by adding improved flexibility and the ability to classify staircases from profiles with noisy salinity data. Using our results, we propose that the incidence of thermohaline staircases is limited by strong background vertical gradients in conservative temperature and absolute salinity.</p

Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases.

Inflammatory bowel diseases, which include Crohn's disease and ulcerative colitis, affect several million individuals worldwide. Crohn's disease and ulcerative colitis are complex diseases that are heterogeneous at the clinical, immunological, molecular, genetic, and microbial levels. Individual contributing factors have been the focus of extensive research. As part of the Integrative Human Microbiome Project (HMP2 or iHMP), we followed 132 subjects for one year each to generate integrated longitudinal molecular profiles of host and microbial activity during disease (up to 24 time points each; in total 2,965 stool, biopsy, and blood specimens). Here we present the results, which provide a comprehensive view of functional dysbiosis in the gut microbiome during inflammatory bowel disease activity. We demonstrate a characteristic increase in facultative anaerobes at the expense of obligate anaerobes, as well as molecular disruptions in microbial transcription (for example, among clostridia), metabolite pools (acylcarnitines, bile acids, and short-chain fatty acids), and levels of antibodies in host serum. Periods of disease activity were also marked by increases in temporal variability, with characteristic taxonomic, functional, and biochemical shifts. Finally, integrative analysis identified microbial, biochemical, and host factors central to this dysregulation. The study's infrastructure resources, results, and data, which are available through the Inflammatory Bowel Disease Multi'omics Database ( http://ibdmdb.org ), provide the most comprehensive description to date of host and microbial activities in inflammatory bowel diseases

Thermohaline forcing and interannual variability of northwestern inflows into the northern North Sea

A long-established, 127 km-long hydrographic section in the northern North Sea at 59.28°N that runs from the eastern coast of Orkney (2.23°W) to the central North Sea (0°) crosses the path of the main inflows of Atlantic water. Data from 122 occupations between 1989 and 2015 are examined to determine the annual cycle and long-term trends of temperature, salinity and depth-varying geostrophic flow across the section. In an average year, the geostrophic flow referenced to the seafloor is at its narrowest (40 km) in winter, during which time it is driven by the strong horizontal salinity gradient; the horizontal temperature gradient is very weak. Velocity exceeds 4 cm s−1, but transport is at a minimum (0.11 Sv). In the deeper water in the east of the section, thermal stratification develops throughout summer and persists until October, whereas the west is tidally mixed all year. The bottom temperature gradient becomes the primary driver of the geostrophic flow, which is fastest (9 cm s−1) in September and broadest (100 km) in October. Maximum transport (0.36 Sv) occurs in October. Throughout the summer, the horizontal salinity gradient weakens, as does its contribution to the flow. However, it nevertheless acts to broaden the flow west of the location of the strongest horizontal temperature gradient. Section-mean de-seasoned temperature is found to be positively correlated to the Atlantic Multidecadal Oscillation and negatively correlated to the North Atlantic Oscillation. These results refine our understanding of the thermohaline forcing of Atlantic inflow into the northern North Sea, particularly in relation to the salinity distribution. Understanding the variability of this inflow is important for understanding the dynamics of the North Sea ecosystem

Catastrophic Decline of World's Largest Primate: 80% Loss of Grauer's Gorilla (Gorilla beringei graueri) Population Justifies Critically Endangered Status

Grauer's gorilla (Gorilla beringei graueri), the World's largest primate, is confined to eastern Democratic Republic of Congo (DRC) and is threatened by civil war and insecurity. During the war, armed groups in mining camps relied on hunting bushmeat, including gorillas. Insecurity and the presence of several militia groups across Grauer's gorilla's range made it very difficult to assess their population size. Here we use a novel method that enables rigorous assessment of local community and ranger-collected data on gorilla occupancy to evaluate the impacts of civil war on Grauer's gorilla, which prior to the war was estimated to number 16,900 individuals. We show that gorilla numbers in their stronghold of Kahuzi- Biega National Park have declined by 87%. Encounter rate data of gorilla nests at 10 sites across its range indicate declines of 82-100% at six of these sites. Spatial occupancy analysis identifies three key areas as the most critical sites for the remaining populations of this ape and that the range of this taxon is around 19,700 km2. We estimate that only 3,800 Grauer's gorillas remain in the wild, a 77% decline in one generation, justifying its elevation to Critically Endangered status on the IUCN Red List of Threatened Species

Glider Observations of the Northwestern Iberian Margin During an Exceptional Summer Upwelling Season

Glider observations from the Northwestern Iberian Margin during the exceptionally strong 2010 summer upwelling season resolved the evolution of physical and biogeochemical variables during two upwelling events. Upwelling brought low-oxygen Eastern North Atlantic Central Water from 190 m depth onto the shelf up to a depth of 50 m. During the two observed periods of upwelling, a poleward jet developed over the shelf break. The persistent upwelling favorable winds maintained equatorward flow on the outer shelf for 2 months with no reversals during relaxation periods, a phenomenon not previously observed. During upwelling, near-surface chlorophyll a concentration increased by more than 6 mg m −3. Oxygen supersaturation in the near surface increased by more than 20%, 6 days after the chlorophyll a maximum

Internal tide energy flux over a ridge measured by a co-located ocean glider and moored Acoustic Doppler Current Profiler

Internal tide energy flux is an important diagnostic for the study of energy pathways in the ocean, from large-scale input by the surface tide, to small-scale dissipation by turbulent mixing. Accurate calculation of energy flux requires repeated full-depth measurements of both potential density (ρ) and horizontal current velocity (u) over at least a tidal cycle and over several weeks to resolve the internal spring-neap cycle. Typically, these observations are made using full-depth oceanographic moorings that are vulnerable to being ‘fished-out’ by commercial trawlers when deployed on continental shelves and slopes. Here we test an alternative approach to minimise these risks, with u measured by a low-frequency ADCP moored near the seabed and ρ measured by an autonomous ocean glider holding station by the ADCP. The method is used to measure the semidiurnal internal tide radiating from the Wyville Thompson Ridge in the North Atlantic. The observed energy flux (4.2±0.2 kW m-1) compares favourably with historic observations and a previous numerical model study. Error in the energy flux calculation due to imperfect co-location of the glider and ADCP is estimated by sub-sampling potential density in an idealised internal tide field along pseudorandomly distributed glider paths. The error is considered acceptable (<10%) if all the glider data is contained within a ‘watch circle’ with a diameter smaller than 1/8 the mode-1 horizontal wavelength of the internal tide. Energy flux is biased low because the glider samples density with a broad range of phase shifts, resulting in underestimation of vertical isopycnal displacement and available potential energy. The negative bias increases with increasing watch circle diameter. If watch circle diameter is larger than 1/8 the mode-1 horizontal wavelength, the negative bias is more than 3% and all realisations within the 95% confidence interval are underestimates. Over the Wyville Thompson Ridge, where the semidiurnal mode-1 horizontal wavelength is ≈100 km and all the glider dives are within a 5 km diameter watch circle, the observed energy flux is estimated to have a negative bias of only 0.4% and an error of less than 3% at the 95% confidence limit. With typical glider performance, we expect energy flux error due to imperfect co-location to be <10% in most mid-latitude shelf slope regions