The resonant state at filling factor ν = 1/2 in chiral fermionic ladders

Helical liquids have been experimentally realized in both nanowires and ultracold atomic chains as the result of strong spin–orbit interactions. In both cases the inner degrees of freedom can be considered as an additional space dimension, providing an interpretation of these systems as chiral synthetic ladders, with artificial magnetic fluxes determined by the spin–orbit terms. In this work, we characterize the helical state which appears at filling ν = 1/2: this state is generated by a gap arising in the spin sector of the corresponding Luttinger liquid and it can be interpreted as the one-dimensional (1D) limit of a fractional quantum Hall state of bosonic pairs of fermions. We study its main features, focusing on entanglement properties and correlation functions. The techniques developed here provide a key example for the study of similar quasi-1D systems beyond the semiclassical approximation commonly adopted in the description of the Laughlin-like states

Accelerating ILP solvers for Minimum Flow Decompositions through search space and dimensionality reductions

Given a flow network, the Minimum Flow Decomposition (MFD) problem is finding the smallest possible set of weighted paths whose superposition equals the flow. It is a classical, strongly NP-hard problem that is proven to be useful in RNA transcript assembly and applications outside of Bioinformatics. We improve an existing ILP (Integer Linear Programming) model by Dias et al. [RECOMB 2022] for DAGs by decreasing the solver's search space using solution safety and several other optimizations. This results in a significant speedup compared to the original ILP, of up to 55-90x on average on the hardest instances. Moreover, we show that our optimizations apply also to MFD problem variants, resulting in similar speedups, going up to 123x on the hardest instances. We also developed an ILP model of reduced dimensionality for an MFD variant in which the solution path weights are restricted to a given set. This model can find an optimal MFD solution for most instances, and overall, its accuracy significantly outperforms that of previous greedy algorithms while being up to an order of magnitude faster than our optimized ILP

Width Helps and Hinders Splitting Flows

Peer reviewe

Width Helps and Hinders Splitting Flows

Peer reviewe

Exploring helical phases of matter in bosonic ladders

Ladder models of ultracold atoms offer a versatile platform for the experimental and theoretical study of different phenomena and phases of matter linked to the interplay between artificial gauge fields and interactions. Strongly correlated helical states are known to appear for specific ratios of the particle and magnetic flux densities and they can often be interpreted as a one-dimensional limit of fractional quantum Hall states, thus being called pretopological. Their signatures, however, are typically hard to observe due to the small gaps characterizing these states. Here we investigate bosonic ladder models at filling factor 1. Based on bosonization, renormalization group and matrix product state simulations we pinpoint two strongly correlated helical phases appearing at this resonance. We show that one of them can be accessed in systems with two-species hardcore bosons and on-site repulsions only, thus amenable for optical lattice experiments. Its signatures are sizable and stable over a broad range of parameters for realistic system sizes.Comment: 22 pages, 10 figures, replaced with revised versio

Aktive Studierende - kompetenzorientierte Ausbildung: Fallbeispiele lernender Lehrender

Hohe studentische Aktivität ist ein Hauptanliegen der Bologna-Reform, die Kompetenzorientierung der Ausbildung ein anderes. Effektivem Beurteilen von studentischen Aktivitäten wie Vorträgen, mündlichen Examen und schriftlichen Produkten kommt somit eine besondere Bedeutung zu. Die Effekte der Benotungsmethode sollen sein: Es ist allen klar, welche Kompetenzen benotet werden und wie sie gestellt werden. Die Beurteilungsmethode soll schon im Voraus die methodische und fachliche Qualität der Arbeit stimulieren. Die Beurteilung soll mit allfälligen Begleitfunktionen nicht in Konflikt treten und für alle nachvollziehbar sein. Bei schriftlichen Arbeiten ist eine zuverlässige Selbstbeurteilung möglich. Anhand von Beispielen aus verschiedenen Fachbereichen wird der Gestaltungsspielraum deutlich, in dem sich die genannten Kriterien umsetzen lassen

International nonproprietary names for monoclonal antibodies: an evolving nomenclature system

Appropriate nomenclature for all pharmaceutical substances is important for clinical development, licensing, prescribing, pharmacovigilance, and identification of counterfeits. Nonproprietary names that are unique and globally recognized for all pharmaceutical substances are assigned by the International Nonproprietary Names (INN) Programme of the World Health Organization (WHO). In 1991, the INN Programme implemented the first nomenclature scheme for monoclonal antibodies. To accompany biotechnological development, this nomenclature scheme has evolved over the years; however, since the scheme was introduced, all pharmacological substances that contained an immunoglobulin variable domain were coined with the stem -mab. To date, there are 879 INN with the stem -mab. Owing to this high number of names ending in -mab, devising new and distinguishable INN has become a challenge. The WHO INN Expert Group therefore decided to revise the system to ease this situation. The revised system was approved and adopted by the WHO at the 73rd INN Consultation held in October 2021, and the radical decision was made to discontinue the use of the well-known stem -mab in naming new antibody-based drugs and going forward, to replace it with four new stems: -tug, -bart, -mig, and -ment

International nonproprietary names for monoclonal antibodies: an evolving nomenclature system

Appropriate nomenclature for all pharmaceutical substances is important for clinical development, licensing, prescribing, pharmacovigilance, and identification of counterfeits. Nonproprietary names that are unique and globally recognized for all pharmaceutical substances are assigned by the International Nonproprietary Names (INN) Programme of the World Health Organization (WHO). In 1991, the INN Programme implemented the first nomenclature scheme for monoclonal antibodies. To accompany biotechnological development, this nomenclature scheme has evolved over the years; however, since the scheme was introduced, all pharmacological substances that contained an immunoglobulin variable domain were coined with the stem -mab. To date, there are 879 INN with the stem -mab. Owing to this high number of names ending in -mab, devising new and distinguishable INN has become a challenge. The WHO INN Expert Group therefore decided to revise the system to ease this situation. The revised system was approved and adopted by the WHO at the 73rd INN Consultation held in October 2021, and the radical decision was made to discontinue the use of the well-known stem -mab in naming new antibody-based drugs and going forward, to replace it with four new stems: -tug, -bart, -mig, and -ment. Keywords: International Nonproprietary Name (INN); antibodies; antibody-based drugs; antibody-drug conjugates; biological drugs; biologics; nomenclature scheme; pharmaceuticals; safety; therapeutic antibodies

Upper limits on the strength of periodic gravitational waves from PSR J1939+2134

The first science run of the LIGO and GEO gravitational wave detectors presented the opportunity to test methods of searching for gravitational waves from known pulsars. Here we present new direct upper limits on the strength of waves from the pulsar PSR J1939+2134 using two independent analysis methods, one in the frequency domain using frequentist statistics and one in the time domain using Bayesian inference. Both methods show that the strain amplitude at Earth from this pulsar is less than a few times $10^{-22}$.Comment: 7 pages, 1 figure, to appear in the Proceedings of the 5th Edoardo Amaldi Conference on Gravitational Waves, Tirrenia, Pisa, Italy, 6-11 July 200