Crustal structure between the Knipovich Ridge and the Van Mijenfjorden (Svalbard)

The Alfred Wegener Institute of Polar and Marine Research, the University of Bergenand the Hokkaido University acquired new seismic refraction data along a transect fromthe Knipovich Ridge to the inner Van Mijenfjorden in southern Svalbard. A close spacing ofon- and offshore receivers and a dense marine shot pattern provide the data for a high resolutionp-wave velocity model for geological interpretation. Additional new seismic reflection data(University of Bergen) yield structural information for a more reliable analysis.Crustal thickness along the Van Mijenfjorden is 33 to 34 km. Seismic velocities of 5.0 km/sare observed within the upper crustal section of the Tertiary Central Spitsbergen Basin.A Paleozoic sedimentary basin with a depth of 8 to 10 km is associated with the Nordfjorden Block.The seismic velocities are up to 6.0 km/s. Paleozoic sedimentary rocks are expected furtherto the west of the Hornsund Lineament since seismic velocities reveal a similar range here.West of the Bellsund the continental crust thins gradually over a 90 km wide rifted zone.The velocity structure within this section is very complex and comprises zones of decreasedvelocities below the West Spitsbergen Fold Belt (down to 20 km depth) and slightly elevatedvelocities (7.2 km/s) at the crust-mantle transition. The first structure is interpreted as intensivelyfractured rocks linked to post-Late Paleocene transpressive orogenic activity and subsequentlyaffected by transtension during break-up from Greenland. The faster deep-crustal velocities aresupposed to express magmatic intrusions of an unidentified origin. Melts could either be channelled by theSpitsbergen Shear Zone from more distant sources, or originate in magmatic interaction between the northern Knipovich Ridgeand the neighbouring young rifted crust.Oceanic crust each side of the Knipovich Ridge is thin (~3.5 km) and is characterised by theabsence of oceanic layer 3 (3.5/4.1 to 4.7 km/s). The oceanic section exhibits zones of verythin crust (~1 km) that are interpreted as fracture zones. Beneath these we observed decreasedmantle velocities (~7.3 km/s) indicating probable serpentinization of peridotites along thesefracture zones. Thickness variations further provide information about the segmentationand magma supply along the northern Knipovich Ridge

Ciclos en sistemas de hornos rotativos

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Sensitive dependence of the motion of a legged robot on granular media

Legged locomotion on flowing ground ({\em e.g.} granular media) is unlike locomotion on hard ground because feet experience both solid- and fluid-like forces during surface penetration. Recent bio-inspired legged robots display speed relative to body size on hard ground comparable to high performing organisms like cockroaches but suffer significant performance loss on flowing materials like sand. In laboratory experiments we study the performance (speed) of a small (2.3 kg) six-legged robot, SandBot, as it runs on a bed of granular media (1 mm poppy seeds). For an alternating tripod gait on the granular bed, standard gait control parameters achieve speeds at best two orders of magnitude smaller than the 2 body lengths/s ($\approx 60$ cm/s) for motion on hard ground. However, empirical adjustment of these control parameters away from the hard ground settings, restores good performance, yielding top speeds of 30 cm/s. Robot speed depends sensitively on the packing fraction $\phi$ and the limb frequency $\omega$, and a dramatic transition from rotary walking to slow swimming occurs when $\phi$ becomes small enough and/or $\omega$ large enough. We propose a kinematic model of the rotary walking mode based on generic features of penetration and slip of a curved limb in granular media. The model captures the dependence of robot speed on limb frequency and the transition between walking and swimming modes but highlights the need for a deeper understanding of the physics of granular media.Comment: 4 figure

Biochemical and transcriptomic evaluation of a 3D lung organoid platform for pre-clinical testing of active substances targeting senescence

Chronic lung diseases such as chronic obstructive pulmonary disease and cystic fibrosis are incurable. Epithelial senescence, a state of dysfunctional cell cycle arrest, contributes to the progression of such diseases. Therefore, lung epithelial cells are a valuable target for therapeutic intervention. Here, we present a 3D airway lung organoid platform for the preclinical testing of active substances with regard to senescence, toxicity, and inflammation under standardized conditions in a 96 well format. Senescence was induced with doxorubicin and measured by activity of senescence associated galactosidase. Pharmaceutical compounds such as quercetin antagonized doxorubicininduced senescence without compromising organoid integrity. Using single cell sequencing, we identified a subset of cells expressing senescence markers which was decreased by quercetin. Doxorubicin induced the expression of detoxification factors specifically in goblet cells independent of quercetin. In conclusion, our platform enables for the analysis of senescence-related processes and will allow the pre-selection of a wide range of compounds (e.g. natural products) in preclinical studies, thus reducing the need for animal testing

A computational study of the electronic properties, ionic conduction, and thermal expansion of Sm1−xAxCoO3 and Sm1−xAxCoO3−x/2 (A = Ba2+, Ca2+, Sr2+, and x = 0.25, 0.5) as intermediate temperature SOFC cathodes

The substitutional doping of Ca2+, Sr2+, and Ba2+ on the Sm-site in the cubic perovskite SmCoO3 is reported to improve both electronic and ionic conductivities for applications as solid oxide fuel cell (SOFC) cathodes. Hence, in this study we have used density functional theory (DFT) calculations to investigate dopant configurations at two different dopant concentrations: 25 and 50%. To preserve the electroneutrality of the system, we have studied two different charge compensation mechanisms: the creation of oxygen vacancies, and electronic holes. After examining the electronic structure, charge density difference, and oxygen vacancy formation energies, we concluded that oxygen vacancy charge compensation is the preferred mechanism to maintain the electroneutrality of the system. Furthermore, we found that the improvement of the electronic conduction is not a direct consequence of the appearance of electron holes, but a result of the distortion of the material, more specifically, the distortion of the Co–O bonds. Finally, molecular dynamics were employed to model ionic conduction and thermal expansion coefficients. It was found that all dopants at both concentrations showed high ionic conduction comparable to experimental results

Local anesthesia in piglets undergoing castration-A comparative study to investigate the analgesic effects of four local anesthetics on the basis of acute physiological responses and limb movements

Surgical castration of male piglets without analgesia is a painful procedure. This prospective, randomized and double-blinded study aimed to evaluate the analgesic effects of four different local anesthetics for piglet castration during the first week of life. In total, 54 piglets aged 3 to 7 days were distributed into 6 treatment groups: handling (H);castration without pain relief (sodium chloride, NaCl);and castration with a local anesthetic: 4% procaine (P), 2% lidocaine (L), 0.5% bupivacaine (B) or 20 mg/ml mepivacaine (M). By excluding stress and fear as disruptive factors via a minimum anesthesia model, all piglets received individual minimum alveolar concentration (MAC) isoflurane anesthesia. Twenty minutes before castration, all treatment groups except group H received one injection per testis. Then, 0.5 ml of a local anesthetic or NaCl was injected intratesticularly (i.t.), and 0.5 ml was administered subscrotally. Acute physiological responses to noxious stimuli at injection and castration were evaluated by measuring blood pressure (BP), heart rate (HR), cortisol, epinephrine, norepinephrine and chromogranin A (CgA);limb movements were quantified. The results confirm that castration without analgesia is highly painful. Surgical castration without pain relief revealed significant changes in mean arterial blood pressure (MAP) and HR. Local anesthetic administration significantly reduced changes in BP and HR associated with castration. Piglets receiving a preoperative local anesthetic exhibited the fewest limb movements during castration, while the NaCl group exhibited the most. Injection itself was not associated with significant changes in MAP or HR. However, many piglets exhibited limb movements during injection, indicating that the injection itself causes nociceptive pain. No significant differences were found between groups regarding parameters of plasma cortisol, catecholamines and CgA. In conclusion, all four local anesthetics administered are highly effective at reducing signs of nociception during castration under light isoflurane anesthesia. However, injection of a local anesthetic seems to be painful

Coordination of opposing sex-specific and core muscle groups regulates male tail posture during Caenorhabditis elegans male mating behavior

Background To survive and reproduce, animals must be able to modify their motor behavior in response to changes in the environment. We studied a complex behavior of Caenorhabditis elegans, male mating behavior, which provided a model for understanding motor behaviors at the genetic, molecular as well as circuit level. C. elegans male mating behavior consists of a series of six sub-steps: response to contact, backing, turning, vulva location, spicule insertion, and sperm transfer. The male tail contains most of the sensory structures required for mating, in addition to the copulatory structures, and thus to carry out the steps of mating behavior, the male must keep his tail in contact with the hermaphrodite. However, because the hermaphrodite does not play an active role in mating and continues moving, the male must modify his tail posture to maintain contact. We provide a better understanding of the molecular and neuro-muscular pathways that regulate male tail posture during mating. Results Genetic and laser ablation analysis, in conjunction with behavioral assays were used to determine neurotransmitters, receptors, neurons and muscles required for the regulation of male tail posture. We showed that proper male tail posture is maintained by the coordinated activity of opposing muscle groups that curl the tail ventrally and dorsally. Specifically, acetylcholine regulates both ventral and dorsal curling of the male tail, partially through anthelmintic levamisole-sensitive, nicotinic receptor subunits. Male-specific muscles are required for acetylcholine-driven ventral curling of the male tail but dorsal curling requires the dorsal body wall muscles shared by males and hermaphrodites. Gamma-aminobutyric acid activity is required for both dorsal and ventral acetylcholine-induced curling of the male tail and an inhibitory gamma-aminobutyric acid receptor, UNC-49, prevents over-curling of the male tail during mating, suggesting that cross-inhibition of muscle groups helps maintain proper tail posture. Conclusion Our results demonstrated that coordination of opposing sex-specific and core muscle groups, through the activity of multiple neurotransmitters, is required for regulation of male tail posture during mating. We have provided a simple model for regulation of male tail posture that provides a foundation for studies of how genes, molecular pathways, and neural circuits contribute to sensory regulation of this motor behavior

Sunda-Banda arc transition: incipient continent-island arc collision (Northwest Australia)

The eastern Sunda arc represents one of the few regions globally where the early stages of continent-arc collision can be studied. We studied along the western limit of the collision zone at the Sunda-Banda arc transition, where the Australian margin collides with the Banda island arc, causing widespread back arc thrusting. We present integrated results of a refraction/wide-angle reflection tomography, gravity modeling, and multichannel reflection seismic imaging using data acquired in 2006 southeast of Sumba Island. The composite structural model reveals the previously unresolved deep geometry of the collision zone. Changes in crustal structure encompass the 10 - 12 km thick Australian basement in the south and the 22 - 24 kmthick Sumba ridge in the north, where backthrusting of the 130 km wide accretionary prism is documented. The structural diversity along this transect could be characteristic of young collisional systems at the transition from oceanic subduction to continent-arc collision. Citation: Shulgin, A., H. Kopp, C. Mueller, E. Lueschen, L. Planert, M. Engels, E. R. Flueh, A. Krabbenhoeft, and Y. Djajadihardja (2009), Sunda-Banda arc transition: Incipient continent-island arc collision (northwest Australia), Geophys. Res. Lett., 36, L10304, doi: 10.1029/2009GL037533

Wafer-Scale Epitaxial Modulation of Quantum Dot Density

Precise control of the properties of semiconductor quantum dots (QDs) is vital for creating novel devices for quantum photonics and advanced opto-electronics. Suitable low QD-density for single QD devices and experiments are challenging to control during epitaxy and are typically found only in limited regions of the wafer. Here, we demonstrate how conventional molecular beam epitaxy (MBE) can be used to modulate the density of optically active QDs in one- and two- dimensional patterns, while still retaining excellent quality. We find that material thickness gradients during layer-by-layer growth result in surface roughness modulations across the whole wafer. Growth on such templates strongly influences the QD nucleation probability. We obtain density modulations between 1 and 10 QDs/${\mu}m^{2}$ and periods ranging from several millimeters down to at least a few hundred microns. This novel method is universal and expected to be applicable to a wide variety of different semiconductor material systems. We apply the method to enable growth of ultra-low noise QDs across an entire 3-inch semiconductor wafer