Identifying nonlinear wave interactions in plasmas using two-point measurements: a case study of Short Large Amplitude Magnetic Structures (SLAMS)

A framework is described for estimating Linear growth rates and spectral energy transfers in turbulent wave-fields using two-point measurements. This approach, which is based on Volterra series, is applied to dual satellite data gathered in the vicinity of the Earth's bow shock, where Short Large Amplitude Magnetic Structures (SLAMS) supposedly play a leading role. The analysis attests the dynamic evolution of the SLAMS and reveals an energy cascade toward high-frequency waves.Comment: 26 pages, 13 figure

Effects of cover crops on phosphatase activity in a clay arable soil in the UK

The effect of five cover crop species (radish, buckwheat, vetch, phacelia and oat) alongside an un-cropped control, on the activity and persistence of soil acid and alkaline phosphatase activity was investigated. There was no effect on alkaline phosphatase activity at the time of cover crop incorporation (March), but by the point of maturation of the following oat cash crop (June) significant differences were detected, with the greatest activity following an oat cover crop. Acid phosphatase activity showed species-related significant differences at both sampling dates, with the magnitude increasing by June. Again, plots following an oat cover crop showed the greatest activity, followed by phacelia. This has shown that soil phosphatase enzymes are affected by the presence of a cover crop, that this effect is apparently species-dependent – and not dependent on the amount of biomass from the cover crop – and that cover crops could be a potential means to enhance soil phosphorus cycling

Comprehensive framework for human health risk assessment of nanopesticides

Nanopesticides are not only in an advanced state of research and development but have started to appear on the market. Industry and regulatory agencies need a consolidated and comprehensive framework and guidance for human health risk assessments. In this perspective we develop such a comprehensive framework by exploring two case studies from relevant product types: an active ingredient delivered with a nanocarrier system, and a nanoparticle as an active ingredient. For a nanocarrier system, three entities are tracked during the assessment: the nanocarrier–active ingredient complex, the empty nanocarrier remaining after the complete release of the active ingredient, and the released active ingredient. For the nanoparticle of pure active ingredient, only two entities are relevant: the nanoparticle and the released ions. We suggest important adaptations of the existing pesticide framework to determine the relevant nanopesticide entities and their concentrations for toxicity testing. Depending on the nature of the nanopesticides, additional data requirements, such as those pertaining to durability in biological media and potential for crossing biological barriers, have also been identified. Overall, our framework suggests a tiered approach for human health risk assessment, which is applicable for a range of nanopesticide products to support regulators and industry in making informed decisions on nanopesticide submissions. Brief summaries of suitable methods including references to existing standards (if available) have been included together with an analysis of current knowledge gaps. Our study is an important step towards a harmonized approach accepted by regulatory agencies for assessing nanopesticides

Higgs Bosons and the Indirect Search for WIMPs

We investigated the contribution of the MSSM Higgs bosons produced in the neutralino annihilation in the Earth and Sun to the total WIMPs detection signals. We found that this contribution is very important and results in a lower bound for the muon flux from the Sun of 10^{-7} - 10^{-8} m^{-2} yr^{-1} for neutralinos heavier than 200 GeV. We noticed that due to the SUSY charged Higgs bosons one can expect an energetic tau neutrino flux from the Sun at a level of 10^2 m^{-2} yr^{-1}.Comment: 10 pages, 4 figures. Talk given at Dark2000, Heidelberg, Germany, 10-15 July, 200

Mode regularization of the susy sphaleron and kink: zero modes and discrete gauge symmetry

To obtain the one-loop corrections to the mass of a kink by mode regularization, one may take one-half the result for the mass of a widely separated kink-antikink (or sphaleron) system, where the two bosonic zero modes count as two degrees of freedom, but the two fermionic zero modes as only one degree of freedom in the sums over modes. For a single kink, there is one bosonic zero mode degree of freedom, but it is necessary to average over four sets of fermionic boundary conditions in order (i) to preserve the fermionic Z$_2$ gauge invariance $\psi \to -\psi$, (ii) to satisfy the basic principle of mode regularization that the boundary conditions in the trivial and the kink sector should be the same, (iii) in order that the energy stored at the boundaries cancels and (iv) to avoid obtaining a finite, uniformly distributed energy which would violate cluster decomposition. The average number of fermionic zero-energy degrees of freedom in the presence of the kink is then indeed 1/2. For boundary conditions leading to only one fermionic zero-energy solution, the Z$_2$ gauge invariance identifies two seemingly distinct `vacua' as the same physical ground state, and the single fermionic zero-energy solution does not correspond to a degree of freedom. Other boundary conditions lead to two spatially separated $\omega \sim 0$ solutions, corresponding to one (spatially delocalized) degree of freedom. This nonlocality is consistent with the principle of cluster decomposition for correlators of observables.Comment: 32 pages, 5 figure

Time Asymmetric Quantum Physics

Mathematical and phenomenological arguments in favor of asymmetric time evolution of micro-physical states are presented.Comment: Tex file with 2 figure

Prostaglandin E2 promotes survival of naive UCB T cells via the Wnt/β-catenin pathway and alters immune reconstitution after UCBT

The outcome of umbilical cord blood transplantation (UCBT) is compromised by low hematopoietic stem cell (HSC) doses leading to prolonged time to engraftment, delayed immunological reconstitution and late memory T-cell skewing. Exposure of UCB to dimethyl-prostaglandin E2 (dmPGE2) increases HSC in vivo. We determined that exposure of UCB T lymphocytes to dmPGE2 modified Wnt signaling resulting in T cell factor (TCF)-mediated transcription. Wnt signaling upregulated interleukin (IL)-7R and IL-2Rβ, resulting in enhanced survival mediated by the homeostatic cytokines IL-7 and IL-15. dmPGE2 also induced components of the Wnt pathway and Wnt receptors, thereby priming UCB T cells to receive signals via Wnt ligands in vivo. We observed that the Wnt transcription factor TCF7 and its target EOMES were elevated in the T cells of patients who received PGE2-treated UCBs. Consistent with the role of Wnt/β-catenin signaling to induce and maintain naive, memory precursors and long-lived central memory CD8+ cells, these patients also had increased fractions of CD8+CD45RO-CD62L+ plus CD8+CD45RO+CD62L+ subsets encompassing these T-cell populations. These effects of the PGE2/Wnt/β-catenin axis may have significant implications for harnessing immunity in the context of UCBT, where impaired immune reconstitution is associated with late memory T-cell skewing

Acceptability of new formulations of Corn-Soy Blends and Lipid-based Nutrient Supplements in Province du Passoré, Burkina Faso

The objective of this study was to evaluate the acceptability of new formulations of six corn-soy blended flours (CSB) and six lipid-based nutrient supplements (LNS) with different quantities of milk and qualities of soy to be used for the treatment of moderate acute malnutrition (MAM). Furthermore, we wanted to explore the acceptability of foods currently used for the prevention and treatment of malnutrition in Burkina Faso to identify possible barriers that could affect the acceptability of the new formulations of supplementary foods. The study was carried out prior to a randomized controlled trial evaluating the effectiveness of these new formulations. The study involved an observed test-meal and a three-day take-home ration of the experimental food supplements to 6-30-months-old healthy children, followed by questionnaire-based interviews about the acceptability of these supplements. Interviews and focus group discussions were carried out to explore the acceptability of foods currently used for the prevention and treatment of malnutrition. The results suggest that both LNS and CSB products with different quantities of milk and qualities of soy are equally well accepted among healthy children in rural Burkina Faso based on general appreciation of the supplements and organoleptic properties. All experimental foods received good ratings and there was no significant difference between the foods. However, after the take-home ration, 58% of participants receiving CSB reported having left-overs at the end of the day compared to 37% (n=33) of the participants receiving LNS (p=0.004), suggesting that CSB was not as readily consumed as LNS. Yet, both CSB and LNS products were perceived as easy to administer and the frequency of feeding was estimated to be adequate. The study also found that similar foods, used for the prevention and treatment of malnutrition, were well appreciated in the study location. LNS were to a higher degree associated with medicine or foods with medicinal properties, but both LNS and CSB were perceived as beneficial to child health