21 research outputs found
The impact of dengue illness on social distancing and caregiving behavior
- Author
- Astete-Vega Helvio
- Barker Christopher M.
- Córdova-López Jhonny J.
- Elder John P.
- Elson William H.
- Kitron Uriel
- Morrison Amy C.
- Paz-Soldan Valerie A.
- Perkins T. Alex
- Quiroz Flores W. Lorena
- Rios López Esther Jennifer
- Rothman Alan L.
- Schaber Kathryn L.
- Scott Thomas W.
- Vazquez-Prokopec Gonzalo M.
- Vizcarra Santillan Alfonso S.
- Waller Lance A.
- Publication venue
- DigitalCommons@URI
- Publication date
- 01/01/2021
- Field of study
Background
Human mobility among residential locations can drive dengue virus (DENV) transmission dynamics. Recently, it was shown that individuals with symptomatic DENV infection exhibit significant changes in their mobility patterns, spending more time at home during illness. This change in mobility is predicted to increase the risk of acquiring infection for those living with or visiting the ill individual. It has yet to be considered, however, whether social contacts are also changing their mobility, either by socially distancing themselves from the infectious individual or increasing contact to help care for them. Social, or physical, distancing and caregiving could have diverse yet important impacts on DENV transmission dynamics; therefore, it is necessary to better understand the nature and frequency of these behaviors including their effect on mobility.
Methodology and principal findings
Through community-based febrile illness surveillance and RT-PCR infection confirmation, 67 DENV positive (DENV+) residents were identified in the city of Iquitos, Peru. Using retrospective interviews, data were collected on visitors and home-based care received during the illness. While 15% of participants lost visitors during their illness, 22% gained visitors; overall, 32% of all individuals (particularly females) received visitors while symptomatic. Caregiving was common (90%), particularly caring by housemates (91%) and caring for children (98%). Twenty-eight percent of caregivers changed their behavior enough to have their work (and, likely, mobility patterns) affected. This was significantly more likely when caring for individuals with low “health-related quality of well-being” during illness (Fisher’s Exact, p = 0.01).
Conclusions/Significance
Our study demonstrates that social contacts of individuals with dengue modify their patterns of visitation and caregiving. The observed mobility changes could impact a susceptible individual’s exposure to virus or a presymptomatic/clinically inapparent individual’s contribution to onward transmission. Accounting for changes in social contact mobility is imperative in order to get a more accurate understanding of DENV transmission
Hyperoxemia and excess oxygen use in early acute respiratory distress syndrome : Insights from the LUNG SAFE study
- Author
- Abad Ricardo Diaz
- Abe Toshikazu
- Abroug Fekri
- Adams John C.
- Adamsson Richard O.
- Adolfsson Anne
- Aguilar Ronald Zumaran
- Aguirre Janet S.
- Aguirre-Bermeo Hernan
- Aisa Tharwat M.
- Aisiku Imo
- Ajetunmobi Olaitan O.
- Aker Mustafa
- Akyol Onat O.
- Al Dorzi Hasan M.
- Al Jabbary Ahmed S.
- Albaiceta Guillermo M.
- Albarrak Mohamad M.
- Albiero Daniela
- Alda Rosa S.
- Alejandro Risso V.
- Alexander Peter
- Algaba Ángela
- Aliaga Felipe A.
- Alisasis Alain U.
- Allan Russell M.
- Allue Raquel Montoiro
- Almekhlafi Ghaleb
- Alonso Javier G.
- Altaf Wahid
- Alvarez António M.
- Alvarez Javier
- Amin Pravin
- Amir Fahd
- Amor Abdellatif Benslama Mourad
- An Youzhong
- Andersen Finn H.
- Andoh Kohkichi
- Andruszkiewicz Pawel
- Aneman Anders
- Antonelli Massimo M.
- Antônio Ana Carolina P.
- Aoki Nobumasa
- Appelberg Henrik
- Arabi Yaasen
- Arabi Yaseen M.
- Araujo Ana M.
- Arizmendi Alfons
- Arnal Jean-Michel
- Artiga Maria Jose D.
- Artigas Antonio
- Ascoli Aline
- Au Siu-Ming
- Avila Luis E.
- Azad Raman
- Azevedo Luciano Cesar
- Baboi Loredana
- Badie Julio C.
- Bailey Irene M.
- Bailey Mathew B.
- Bajwa Ed
- Balkhi Hicham
- Baltus Thomas
- Banner-Goodspeed Valerie M.
- Barberet Guillaume
- Baron Rebecca M.
- Baronia Arvind K.
- Barratt-Due Andreas
- Barros Filipa M.
- Barros Nelson C.
- Batra Hitesh
- Battle Ceri E.
- Bauer Philippe R.
- Beck Eduardo
- Beck Oliver
- Bedreag Ovidiu H.
- Beegle Scott H.
- Beitler Jeremy R.
- Bellani Giacomo
- Bellani Giacomo
- Beloncle Francois
- Beraldo Daniel O.
- Berghe Caroline
- Berkelmans Frantz
- Besset Sebastien L.
- Bettini Lisandro R.
- Beuret Pascal
- Bezzi Marco G.
- Bhardwaj Vallish K.
- Bhowmick Kaushik
- Biehler Jerome
- Bigot Charlene
- Bihari Shailesh
- Biondi Rodrigo S.
- Biscione Roberto R.
- Bisso Mariano Carboni
- Black Colin S.
- Blakeman Thomas C.
- Bolon Stefan
- Borello Silvina A.
- Borotto Erika E.
- Botteri Marco
- Bouchoucha Slaheddine
- Boukhazna Messabi
- Bouw Maria J.
- Boyd Owen
- Bramall Jon
- Braschi Antonio
- Brazzi Luca
- Breen Dorothy M.
- Briquet Anais
- Brito Vania A.
- Brizuela Matias
- Brochard Laurent
- Brochard Laurent
- Broman Lars M.
- Brown Samuel M.
- Browne Troy S.
- Bruhn Alejandro R.
- Brunettini Barbara
- Bruns Monique M.
- Buensuseso Juan A.
- Bugedo Guillermo
- Buise Marc P.
- Bulpa Pierre A.
- Bumbasierevic Vesna
- Bumbasirevic Vesna
- Burtenshaw Andrew J.
- Burtin Philippe
- Buzancais Gautier
- Béduneau Gaetan
- Camsooksai Julie
- Canestrini Sergio
- Cani Alma
- Carbayo-Gorriz Cecilia
- Cardonnet Luis P.
- Careless Jon P.
- Carpentier Dorothée
- Carreño Nicolás G.
- Carteaux Guillaume
- Casalena Paolo
- Casement Jonathan
- Castro Alejandro G.
- Castro Silvia
- Catorze Nuno T.
- Cazorla-Barranquero Francisca G.
- Ceniceros-Barros Alexandra
- Cereijo Enrique
- Cerny Vladimir
- Cerrato Valeria I.
- Cervantes Mavy Ramirez
- Cesar Palazon Sanchez
- Ceunen Helga
- Ceylan Ilkay
- Chabanne Russell
- Chapman Rhiannon
- Chau Simon K.
- Chelly Jonathan
- Chen Kai
- Chena Ariel
- Cheng Meisy Perez
- Chiche Jean-Daniel
- Chouchene Imed
- Choudry Shazia
- Christiansen Aage
- Cimic Nedim
- Cinnella Gilda
- Cirone Rob
- Citalán Johanna E.
- Claraco-Vega Luis M.
- Clarkson Kevin
- Clarkson Kevin P.
- Claverias Laura
- Cohen Jason E.
- Cole Jade M.
- Collins Daniel V.
- Collyer Thomas
- Colombo Riccardo
- Combaux Daniele M.
- Combes Alain
- Cooper Raphael
- Coppadoro Andrea
- Corneci Dan E.
- Cortegiani Andrea
- Cortez Cesar A.
- Coxo Cristina M.
- Cracchiolo Andrea N.
- Cranshaw Julius H.
- Crapelli Giulia
- Crouch Daniel R.
- Crova Philippe J.
- Csabi Peter
- Curley Gerard
- Curto Elena Gallego
- Daldin Julio
- Dangers Laurence
- Danin Pierre-Eric
- Daubin C. dric
- Daviaud Fabrice
- Davies Kyle G.
- Dawson Heidi
- de Cima-Iglesias Sara
- de Gordoa Laura Ortiz-Ruiz
- de Haro Candelaria
- de Pablo Raul
- de Prost Nicolas
- Dean Michael N.
- Declercq Pierre-Louis M.
- Dector Dulce
- Dector Dulce M.
- Deicas Alberto
- del Carmen Lorente Maria
- Dellamonica Jean
- Dellera Christian
- Delsing Angela
- Demirkiran Oktay
- Demoule Alexandre
- Dempsey Ged
- Dendane Tarek
- Depuydt P.
- Depuydt Pieter
- Derman Suleyman S.
- di Tomasso Nora N.
- di Yu D.
- Diaz-Rodriguez Esther
- Dive Alain M.
- Dixit Subhal B.
- Do Vale Fernandes Antero
- Dolva Merete S.
- Donnelly Adrian
- Dowling Anna T.
- Doyen Denis
- Dres Martin
- Dreyer Kyle R.
- Dunne Eimhin S.
- Dupont Herve
- Duranteau Jacques
- Dwyer Rory
- Démpaire Gabriel
- Ebeid Alejandro
- Elatrous Souheil
- Elisabet Garcia M.
- Elkhayari Mina
- Ellis Helen E.
- Elmasri Mary
- Erbabacan Emre
- Eriksson Karin E.
- Esteban Andres
- Estenssoro Elisa
- Esteve Francisco
- Estilita Joana M.
- Estrella Claudia R.
- Ezzouine Hanane
- Fan Eddy
- Fan Eddy
- Fartoukh Muriel
- Farías Pamela A.
- Fawkes Danielle A.
- Ferguson Andrew
- Ferguson Niall D.
- Fernandez Adriana M.
- Fernandez Ruben O.
- Fierro Jonathan M.
- Floris Leda
- Follin Arnaud
- Fontenele Danielle C.
- Formenti Paolo
- Forteza Catalina
- Fossali Tommaso
- Foti Giuseppe
- Franco Nieves
- França Ana G.
- Frati Elena
- Frendl Gyorgy
- Frigyik Aniko D.
- Fusari Maurizio
- Futami Satoru
- Gally Josette
- Ganesan Deeban
- Gao Yan
- Gao Yuan N.
- Garcia Patricio H.
- Gattinoni Luciano
- Gazenkampf Andrey A.
- Gelée Bruno
- George Fernando G.
- Ghazi Mohammed
- Gianinetto Hernan
- Giarratano Antonino
- Gillis Sarah
- Girgin Nermin Kelebek
- Gjedsted Jakob
- Glietsch Rita
- Goldgran-Toledano Dany
- Goligher Ewan C.
- Gomaa Dina
- Gomes Rui M.
- Gomez Pablo E.
- Gomez-Flores Saira S.
- Gonz Á Lez Raquel Montiel
- Gonzalez Daniel R.
- Gonzalez Marcos
- González Rojas Manuel A.
- González-Salamanca Ángela
- Gonçalves Claudio H.
- Goodson Jennifer C.
- Gordo Federico
- Gosselin Ryan J.
- Goubaux Bernard
- Graziani Romano
- Grelon Fabien
- Griffin Ruth O.
- Grigoriev Evgeny
- Grijalba Carolina Quintana
- Grissom Colin K.
- Gritsan Alexey I.
- Grubissich Nicolas
- Gueret Renaud M.
- Gurjar Mohan
- Guttormsen Anne B.
- Guérin Claude
- Gómez Pilar Ricart Aroa
- Hacking Danielle J.
- Haddad Youssef
- Hadfield Dan
- Hagan Samantha J.
- Han Hui
- Han Yi
- Hang Ai Y.
- Hanlon Gabrielle C.
- Harasawa Tomofumi
- Harrois Anatole
- Hashemian S. M.
- Hashemian Seyed Mohammadreza
- Hashida Tomoaki
- He Zhenyang
- Hedlund Lars
- Heidari Farshad
- Heines Serge J.
- Helleberg Johan
- Henderson Galen
- Herbrecht Jean-Etienne
- Hermosa Cecilia
- Hessell Robert J.
- Heunks Leo M.
- Higashijima Ushio
- Hirata Akira
- Holzgraefe Bernhard
- Honda Hiroyuki
- Honrubia Teresa
- Hopf Hans-Bernd F.
- Hopkins Phil
- Hormis Anil P.
- Hou Peter C.
- Hou Sen-Kuang
- Hraiech Sami
- Hua Ma X.
- Huang Qing Q.
- Huang Xiao B.
- Huerta Francisco P.
- Huff Nidhi G.
- Humphreys Sally K.
- Hunt Anna
- Hurtado Javier
- Hutchison Robyn A.
- Hutton Paula J.
- Ibañez-Santacruz Marcos
- Ichikado Kazuya
- Ilutovich Santiago
- Imai Hiroshi
- Imma Vallverdu P.
- Imperio María C.
- Insaurralde Carolina S.
- Inskip Deborah M.
- Ioannou Nicholas
- Iotti Giorgio A.
- Irvine Donald A.
- Ismail Dina
- Ismail Mehvish
- Ito Fumihito
- Izawa Masayo
- Jaafar Rola F.
- Jakubowska Karina
- Jamaati Hamidreza
- Jarquin-Badiola Yves D.
- Jassal Mandeep
- Javeed Areej
- Javier-Blanco
- Jhamatthew Thomas Rajeev R.
- Jiang Liangyan
- Jibaja Manuel
- Jimenez Antonio G.
- Jochmans S. bastien
- Jog Sameer A.
- Jovanovic Bojan
- Judy Claine
- Jurado M. . Teresa
- Kadaba Varsha
- Kajtor Istvan
- Kakar Vivek
- Kalaitzis Evangelos
- Kalkoff Michael
- Kamel Ghassan
- Kameyama Yoshinobu
- Kamoun Salma
- Kander Thomas
- Kannan Santhana G.
- Kansuke-Koyama
- Kashiwa Yozo
- Kedelv Hans
- Kennedy Barry
- Khebbeb Samy
- Kheir Fayez
- Kheir Fayez M.
- Kimura Hiroyasu
- Kiourtzieva Ellada V.
- Kitch Barrett T.
- Knapman Karl M.
- Knoll Jenny
- Knowles Serena
- Kol Mark R.
- Kong Jing
- Kraßler Jens
- Krstevski Amanda
- Kulkarni Shreedhar
- Kumar Alek
- Kurahashi Kiyoyasu
- Kusumoto Kohei
- Laake Jon H.
- Laake Jon Henrik
- Labarca Eduardo F.
- Laffey John
- Laffey John G.
- Laffey John G.
- Lamb Keith D.
- Lanspa Michael J.
- Larsson Anders
- Larsson Niklas
- le Moal Charlene
- Lebbinck Herve
- Lee Jarone
- Leemann-Refondini Corinne
- Lemiale Virginie
- Lemus Jordana S.
- Leon Yoshido Hector H.
- Li Bin
- Li Qingdong
- Li Qiong J.
- Li Wenwen
- Li Xiao L.
- Li Xinyu
- Li Yimin
- Li Yuan Y.
- Li-Xin Zhou
- Liew Kong Y.
- Ling Long L.
- Liu Haitao
- Liu Jian
- Liu Jing L.
- Liu Ling
- Llano Miguel
- Llinares Moya David D.
- Lohner Ralph
- Loiacono Flavia A.
- Lombardo Andrea
- Lopez Esther Bermejo
- Lopez-Delgado Juan C.
- Lora Fredy S.
- Lora Pilar
- Lorente Jose A.
- Losada Elena Perez
- Lovazzano Pablo
- Lu Weihua
- Lu Yuanhua
- Luis Palazon Sanchez Eugenio
- Luo Xiaoming
- Lynch Joan M.
- López-Messa Juan B.
- Maazouzi Wajdi
- MacFadyen Rosaleen
- MacFie Caroline C.
- Madotto Fabiana
- Maeyama Hiroki N.
- Maghrabi Khalid A.
- Magret Monica
- Mahto Heera L.
- Mancebo Jordi
- Manoharan Venika
- Marcos Diego Pastor
- Marcu Alexandra
- Maria Villa
- Marin Julien
- Marin Maria C.
- Martinez Felipe T.
- Martinho Aurelia M.
- Marum Susan M.
- Massa Eleni V.
- Mataloun Sergio
- Matamis Dimitrios
- Matsumoto Shuhei
- Mattei Alessia
- May Martin M.
- McArthur Colin
- McAuley Daniel F.
- McAuley Daniel F.
- McAuley Danny
- McCalman Katie H.
- McKechnie Stuart
- McKee Raymond
- McKenna Toni E.
- McLeod Alex
- McNamee Lia
- McNicholas Bairbre
- Meaney Edel A.
- Meco Basak Ceyda
- Meersseman Philippe
- Mehta Sangeeta
- Mejia Francisco Javier Flores
- Mellis Clare
- Memon Mohammedfaruk
- Mercat Alain
- Mesar Tomaz
- Messias António M.
- Messika Jonathan
- Meybohm Patrick
- Michel Philippe
- Millar Rebecca T.
- Miller Jennene J.
- Miller Russel R.
- Mirabella Lucia
- Miryam-Prieto-González
- Mizuguchi Ichiko
- Mochizuki Katsunori
- Mohr Nicholas M.
- Mojoli Francesco
- Moles Silvia Iglesias
- Molin Alexandre
- Montanha Gustavo M.
- Monteiro Jorge M.
- Montero Laura Alvarez
- Montes Oscanoa Fredy A.
- Monti Giacomo
- Montini Luca M.
- Moock Marcelo
- Morin Anna-Karin
- Mortaza Satar
- Morton Alex
- Mouloudi Eleni K.
- Mukkera Satyanarayana Reddy
- Mustafa Ghanem M.
- Muthuchellappan Radhakrishnan
- Myra-Rinia
- Máca Jan
- Nagy Eva O.
- Nakamura Tomoyuki
- Namih Miriam
- Nassar Antonio P.
- Nasu Michitaka
- Navalpotro Miguel Angel Blasco
- Navarra Leanlove
- Navarro Gonzalo
- Neal John
- Negoita Silvius Ioan
- Newby Lynette
- Nichol Alistair
- Nielsen Jonas
- Niimi Daisuke
- Nin Nicolas
- Nin Nicolás
- Nishikawa Erin
- Nitta Kenichi
- Nobrega Danielle
- Noremark Kim Andre L.
- Nunci Lordian
- Nunes Silvia L.
- Nutt Christopher
- Nuñez Edgardo
- Nygren Ingela
- O'Croinin Donall
- O'Kane Sinead C.
- O'Muircheartaigh Aogan C.
- O'Neill Orla
- Occhipinti Giovanna
- Oetting Trevor W.
- Ogino Yasuaki
- Oikonomou Marina A.
- Okuda Nao
- Oldroyd Matthew G.
- Olga Moreno F.
- Oliveira Bruno S.
- Ortiz Claudia A.
- Osman Emilio M.
- Oss Peteris
- Ouanes Islem
- Ourailogloy Vasilis
- Owens Robert L.
- Ozcelik Menekse
- Palaniswamy Vijayanand
- Palma Daniela M.
- Palmese Salvatore
- Palo Jose Emmanuel
- Panarello Giovanna
- Panwar Rakshit
- Papanikolaou Metaxia N.
- Papavasilopoulou Theonymfi G.
- Papazian Laurent
- Papurica Marius
- Para Luis Herrera
- Parhar Ken
- Parotto Matteo
- Pasanting-Lim Rossini Abbie B.
- Patroniti Nicolò
- Pattarino Pierpaolo Terragni Ilaria
- Pecci Elisabetta
- Pellegrini Carlos A.
- Pelletier Nicolas
- Pellicer Ana M.
- Penuelas Oscar
- Pereira Carlos S.
- Perez Cesar P.
- Perez Manuel P.
- Persson Linnea
- Pesenti Antonio
- Pg Hj Ismail Dk Maizatul Aiman B.
- Pham T. i
- Pham T. i
- Pham Tai
- Phan Nga T.
- Piacentini Enrique A.
- Pillai Suresh
- Pintado Maria C.
- Piquilloud Lise
- Piras Claudio
- Pittini Gustavo
- Plotnikow Gustavo A.
- Poblano Manuel
- Poli Michela M.
- Pota Vincenzo
- Pozo Norberto C.
- Pozzi Matteo
- Preez Pieter D.
- Pronovost Antoine
- Protti Alessandro
- Protti Alessandro
- Qin Bingyu
- Qin Junping
- Qin Shu H.
- Qin Tie H.
- Qiu Haibo
- Raaijmakers Monique
- Rafael S. nchez I.
- Raimondi Ferdinando
- Raj Ashok S.
- Ramakrishnan Nagarajan
- Ramesh Venkatapura J.
- Ramirez-Alfaro Christian M.
- Ramirez-Gutierrez Alvaro
- Rampinelli Adenilton M.
- Ranero Jorge Luis
- Ranieri Marco
- Raponi Francesco
- Recio Noelia N.
- Reschreiter Henrik
- Reske Andreas W.
- Reuter Danielle
- Reynolds Claire
- Rezoagli Emanuele
- Rhayakar Rachana V.
- Rialp Gemma
- Richecoeur Jack R.
- Ricome Sylvie
- Rigaud Jean-Philippe
- Rios Fernando
- Riss Katharina C.
- Rittayamai Nuttapol
- Roberts Brigit L.
- Robine Adrien
- Robles Joanne B.
- Roche-Campo Ferran
- Rodgers Helen J.
- Rodriguez Lucia L.
- Rodriguez Ruben
- Rosa Jonas I.
- Roser Tomas P.
- Rossi Anna
- Roux Damien
- Rubenfeld Gordon
- Rugonfalvi Szabolcs
- Ruiz Silvia Rodriguez
- Ruiz-Aguilar Antonio L.
- Rylander Christian C.
- Ryosuke Sekine
- Sabelnikovs Olegs
- Sable Safal D.
- Saenz María G.
- Saez Alejandro A.
- Sagar Sudha V.
- Saito Koji
- Saito Shigeki
- Salahuddin Nawal
- Salas Javier E.
- Sales Vanessa M.
- Samkaoui Nacer
- Sanchez Roberto Jimenez
- Sanchez-Hurtado Luis A.
- Sanchez-Medina Jorge R.
- Sandesc Dorel
- Santoli Francesco L.
- Santos Cristina
- Sauvadet Elise P.
- Savioli Monica
- Scafetti Sergio
- Schiavone Vincenzo
- Schiavoni Lorenzo
- Schiöler Fredrik
- Schlichting Adam B.
- Schmidt Marcello
- Schneider Francis
- Schomer Ashley
- Schouten Jeroen A.
- Schuetz Michael
- Schultz Marcus J.
- Schäfer Susanne
- Scott Christopher J.
- Seasman Colette
- Seethala Raghu
- Sellors Gareth P.
- Seoane-Quiroga Leticia
- Serra Carolina
- Serra Isabel M.
- Setten Mariano G.
- Seven Aylin
- Shah Bhagyesh
- Shao Huanzhang
- Shen Juanhong
- Shenoy Anitha
- Sher Sara
- Shimizu Kazuyoshi
- Shin-Nunomiya
- Shindhe Suresh
- Shinn John O.
- Shiozaki Kyoko
- Silesky Jimenez Juan I.
- Silesky Juan
- Sim Malcolm
- Simon Philipp
- Simonis Fabienne D.
- Sivashanmugavel Mageswaran
- Sjøbø Brit Å.
- Sklienka Peter
- Slutsky Arthur S.
- Smith Mark J.
- Smith Oliver
- Soler Juan Alfonso
- Solis-Quesada Jaime E.
- Sotillo Diaz Juan Carlos J.
- Sottiaux T.
- Souissi Asma Ben
- Spadaro Savino
- Srinivasa Latha
- Stamou Electra E.
- Staudinger Thomas
- Stephenson Lorraine
- Stewart Richard
- Stigler William
- Strauch Ulrich
- Sula Hektor
- Sun Renhua
- Surbatovic Maja
- Susana-Temprano
- Suzuki Hiroyuki
- Symmonds Sophie
- Szakmany Tamas
- Sánchez Rocío Manzano
- Sánchez-Ballesteros Jesús
- Søreide Eldar
- Tabhan Edgardo
- Tabhan Edgardo E.
- Tainter Christopher
- Takaba Akihiro
- Takada Tadaaki
- Takagi Shunsuke
- Tallet Alfonso Alec A.
- Tan Beatriz C.
- Tanaka Hiroyuki
- Tang Rui
- Tapponnier Romain
- Tarantino Fabio
- Terzi Nicolas
- Theresa Uhc Mother
- Thibault Sandrine
- Thompson B. Taylor
- Thompson Marlus M.
- Tibblin Anna Oscarsson
- Tinnirello Andrea
- Tiribelli Norberto
- Todeschini Manuel
- Tomescu Dana R.
- Toribio D. Á Cil Parrilla
- Toth-Tarsoly Piroska
- Treanor Nuala
- Trinder T. John
- Trinidad Olivia A.
- Tulaimat Aiman
- Twohey Linda
- Uchiyama Akinori
- Ueda Takeshi
- Ueno Keiko
- Umbrello Michele
- Unnikrishnan Ramesh
- Uppalapati Aditya
- van Haren Frank
- van Haren Frank
- van Wezel Hellen M.
- Vargas Monica P.
- Vascotto Ettore R.
- Vasquez Daniela N.
- Vega Luis D.
- Veljovic Milic
- Venti Aaron
- Vercueil Andre
- Vermassen Joris
- Verstraete Rik
- Villagomez Asisclo
- Villagomez Asisclo J.
- Villamagua Boris G.
- Villar Veronica
- Vinzio Mauricio
- Virgilio Corcoles G.
- Vitale Michela N.
- Volta Carlo A.
- Wang Chunting
- Wang Hua X.
- Wang Shou H.
- Wang Wei
- Warren Jessica
- Watanabe Eizo
- Watt Philip
- Welters Ingeborg D.
- Wenham Tim
- Wessbergh Joanna
- Whitehead Christina
- Willett Emma L.
- Williams Alexandra J.
- Williams Karen E.
- Wise Matt P.
- Wittebole Xavier
- Wong Helen S.
- Woods Paul W.
- Wrathall David W.
- Wrigge Hermann
- Wu Ya Q.
- Xin-Hua Qiang
- Xu Yonghao
- Yamaguchi Osamu
- Yamaji Yoshihiro
- Yao Qingchun
- Ye Zheng L.
- Yeatts Dale J.
- Yu Rongguo
- Yu Tao
- Yu Wenkui
- Yumha Jacob S.
- Yuste Luis J.
- Zacharas Giannis A.
- Zacharowski Kai D.
- Zani Gianluca
- Zantua Kim S.
- Zazu Alan
- Zeggwagh Amine Ali
- Zein Salem Ould
- Zender Hervé O.
- Zhai Zhe
- Zhang Fan
- Zhang Xing Y.
- Zhao Huiying
- Zhao Jun
- Zhao Xian Y.
- Zheng Ruiqiang
- Zhou Fa C.
- Zhou Suming
- Zhu Bao H.
- Zhu Wei H.
- Zogheib Elie H.
- Ñamendys-Silva Silvio A.
- Ünal Necmettin
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2020
- Field of study
Publisher Copyright: © 2020 The Author(s). Copyright: Copyright 2020 Elsevier B.V., All rights reserved.Background: Concerns exist regarding the prevalence and impact of unnecessary oxygen use in patients with acute respiratory distress syndrome (ARDS). We examined this issue in patients with ARDS enrolled in the Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE (LUNG SAFE) study. Methods: In this secondary analysis of the LUNG SAFE study, we wished to determine the prevalence and the outcomes associated with hyperoxemia on day 1, sustained hyperoxemia, and excessive oxygen use in patients with early ARDS. Patients who fulfilled criteria of ARDS on day 1 and day 2 of acute hypoxemic respiratory failure were categorized based on the presence of hyperoxemia (PaO2 > 100 mmHg) on day 1, sustained (i.e., present on day 1 and day 2) hyperoxemia, or excessive oxygen use (FIO2 ≥ 0.60 during hyperoxemia). Results: Of 2005 patients that met the inclusion criteria, 131 (6.5%) were hypoxemic (PaO2 < 55 mmHg), 607 (30%) had hyperoxemia on day 1, and 250 (12%) had sustained hyperoxemia. Excess FIO2 use occurred in 400 (66%) out of 607 patients with hyperoxemia. Excess FIO2 use decreased from day 1 to day 2 of ARDS, with most hyperoxemic patients on day 2 receiving relatively low FIO2. Multivariate analyses found no independent relationship between day 1 hyperoxemia, sustained hyperoxemia, or excess FIO2 use and adverse clinical outcomes. Mortality was 42% in patients with excess FIO2 use, compared to 39% in a propensity-matched sample of normoxemic (PaO2 55-100 mmHg) patients (P = 0.47). Conclusions: Hyperoxemia and excess oxygen use are both prevalent in early ARDS but are most often non-sustained. No relationship was found between hyperoxemia or excessive oxygen use and patient outcome in this cohort. Trial registration: LUNG-SAFE is registered with ClinicalTrials.gov, NCT02010073publishersversionPeer reviewe
Immunocompromised patients with acute respiratory distress syndrome : Secondary analysis of the LUNG SAFE database
- Author
- Abad R.D.
- Abe Toshikazu
- Abroug Fekri
- Adams J.C.
- Adamsson Richard O.
- Adolfsson Anne
- Aguirre Janet S
- Aguirre-Bermeo Hernan
- Aisa T.M.
- Aisiku Imo
- Ajetunmobi Olaitan O.
- Aker Mustafa
- Akyol Onat O.
- Al Dorzi H.M.
- Al Jabbary A.S.
- Albaiceta G.M.
- Albarrak M.M.
- Albiero Daniela
- Alda R.S.
- Alejandro Risso V.
- Alexander P.
- Alfonso Alec A.Tallet
- Algaba Á.
- Aliaga Felipe A.
- Alisasis A.U.
- Allan R.M.
- Allue R.M.
- Almekhlafi G.
- Alonso J.G.
- Altaf Wahid
- Alvarez A.M.
- Alvarez Javier
- Amin P.
- Amir Fahd
- Amor M.
- An Youzhong
- Andersen F.H.
- Andoh Kohkichi
- Andruszkiewicz P.
- Aneman Anders
- Antonelli Massimo
- Antônio Ana Carolina P.
- Aoki Nobumasa
- Appelberg Henrik
- Arabi Y.M.
- Araujo A.M.
- Arizmendi A.
- Arnal Jean-Michel
- Artiga M.J.D.
- Artigas A.
- Ascoli Aline
- Au Siu-Ming
- Avila Luis E.
- Azad Raman
- Azevedo L.C.
- Baboi Loredana
- Badie Julio C.
- Bailey Irene M.
- Bailey M.B.
- Bajwa E.
- Balkhi H.
- Baltus Thomas
- Banner-Goodspeed V.M.
- Barberet Guillaume
- Baron Rebecca M
- Baronia Arvind K.
- Barratt-Due Andreas
- Barros F.M.
- Barros N.C.
- Batra H.
- Battle C.E.
- Bauer P.R.
- Beck Eduardo
- Beck O.
- Bedreag O.H.
- Beegle S.H.
- Beitler J.R.
- Bellani Giacomo
- Beloncle François
- Benslama A.
- Beraldo Daniel O.
- Berghe Caroline
- Berkelmans Frantz.
- Besset Sebastien L.
- Bettini Lisandro R.
- Beuret Pascal
- Bezzi Marco G.
- Bhardwaj Vallish K.
- Bhowmick Kaushik
- Biehler Jerome
- Bigot Charlene
- Bihari Shailesh
- Binti Pengiran Haji Ismail Dayangku Hajah Maizatul Aiman
- Biondi Rodrigo S.
- Biscione Roberto R.
- Bisso Mariano Carboni
- Black Colin S.
- Blakeman T.C.
- Blanco J.
- Bolon S.
- Borello Silvana A.
- Borotto Erika E.
- Botteri Marco
- Bouchoucha Slaheddiine
- Boukhazna Messabi
- Bouw M.J.
- Boyd O.
- Bramall J.
- Braschi Antonio
- Brazzi Luca
- Breen Dorothy M.
- Briquet Anais
- Brito V.A.
- Brizuela Matias
- Broman Lars M.
- Brown S.M.
- Browne T.S.
- Bruhn Alejandro R.
- Brunettini Barbara
- Bruns M.M.
- Buensuseso J.A.
- Bugedo G.
- Buise M.P.
- Bulpa Pierre Alain
- Bumbasierevic V.
- Bumbasirevic Vesna
- Burtenshaw A.J.
- Burtin Philippe
- Buzancais Gautier
- Béduneau Gaetan
- Camsooksai Julie
- Canestrini Sergio
- Cani Alma
- Carbayo-Gorriz C.
- Cardonnet Luis P.
- Careless J.P.
- Carpentier Dorothée
- Carreño Nicolás G.
- Carteaux Guillaume
- Casalena Paolo
- Casement J.
- Castro A.G.
- Castro S.
- Catorze N.T.
- Cazorla-Barranquero F.G.
- Ceniceros-Barros A.
- Cereijo E.
- Cerny V.
- Cerrato Valeria I.
- Cervantes M.R.
- Cesar Palazon Sanchez
- Ceunen Helga
- Ceylan Ilkay
- Chabanne Russell
- Chapman R.
- Chau S.K.
- Chelly Jonathan
- Chen Kai
- Chena Ariel
- Cheng M.P.
- Chiche Jean-Daniel
- Chouchene Imed
- Choudry S.
- Christiansen Aage
- Cimic N.
- Cinnella Gilda
- Cirone Rob
- Citalán Johanna E.
- Claraco-Vega L.M.
- Clarkson Kevin P.
- Claverias Laura
- Cohen J.E.
- Cole J.M.
- Collins Daniel V.
- Collyer T.
- Colombo Ricardo
- Combaux Daniele M.
- Combes Alain
- Conti S.
- Cooper R.
- Coppadoro Andrea
- Corneci D.E.
- Cortegiani Andrea
- Cortez Cesar A.
- Coxo C.M.
- Cracchiolo Andrea N.
- Cranshaw J.H.
- Crapelli Giulia
- Crouch D.R.
- Crova Philippe J.
- Csabi P.
- Curley Gerard
- Curto Elena Gallego
- Daldin Julio
- Dangers Laurence
- Danin Pierre-Eric.
- Daubin Cédric
- Daviaud Fabrice
- Davies Kyle G.
- Dawson H.
- de Cima-Iglesias S.
- de Gordoa L.O.R.
- de Haro C.
- de Pablo R.
- de Prost Nicolas
- Dean M.N.
- Declercq Pierre-Louis M.
- Dector D.
- Dector D.M.
- Deicas A.
- Dellamonica Jean
- Dellera Christian
- Delsing A.
- Demirkiran Oktay
- Demoule Alexandre
- Dempsey Ged
- Dendane T.
- Depuydt Pieter
- Derman Suleyman S.
- Di Tomasso Nora N.
- Di Yu D.
- Diaz-Rodriguez Esther
- Dive Alain M.
- Dixit Subhal B.
- do Vale Fernandes A.
- Dolva M.S.
- Donnelly A.
- Dowling A.T.
- Doyen Denis
- Dres Martin
- Dreyer K.R.
- Dunne Eimhin S.
- Dupont Herve
- Duranteau Jacques
- Dwyer Rory
- Démpair G.
- Ebeid A.
- Elatrous Souheil
- Elisabet Garcia M.
- Elkhayari M.
- Ellis Helen E.
- Elmasri M.
- Erbabacan Emre
- Eriksson Karin E.
- Estenssoro Elisa
- Esteve F.
- Estilita J.M.
- Estrella C.R.
- Ezzouine Hanane
- Fan E.
- Fartoukh Muriel
- Farías Pamela A.
- Fawkes Danielle A.
- Ferguson Andrew
- Ferguson Niall D.
- Fernandez Adriana M.
- Fernandez Ruben O.
- Fierro J.M.
- Floris Leda
- Follin Arnaud
- Fontenele Danielle C.
- Formenti Paolo
- Forteza Catalina
- Fossali Tommaso
- Foti Giuseppe
- Franco N.
- Francois Guy M.
- França A.G.
- Frati Elena
- Frendl Gyorgy
- Frigyik A.D.
- Fusari Maurizio
- Futami Satoru
- Gally Josette
- Ganesan Deeban
- Gao Yuan N.
- Gao Yuan N.
- Garcia Patricio H.
- Gazenkampf A.A.
- Gelée Bruno
- George F.G.
- Ghazi Mohammed
- Gianinetto Hernan
- Giarratano Antonino
- Gillis S.
- Girgin Nermin Kelebek
- Gjedsted Jakob
- Glietsch Rita
- Goldgran-Toledano Dany
- Goligher Ewan C.
- Gomaa D.
- Gomes R.M.
- Gomez Pablo E.
- Gomez-Flores S.S.
- Gonzalez D.R.
- Gonzalez M.
- González R.M.
- González-Salamanca Ángela
- Gonçalves Claudio H.
- Goodson Jennifer C
- Gordo F.
- Gosselin R.J.
- Goubaux Bernard
- Grasselli Giacomo
- Graziani Romano
- Gregoretti Cesare
- Grelon Fabien
- Griffin Ruth
- Grigoriev E.
- Grijalba C.Q.
- Grissom C.K.
- Gritsan A.I.
- Grubissich Nicolas
- Gueret R.M.
- Gurjar Mohan
- Guttormsen A.B.
- Guérin Claude
- Gómez P.R.A.
- Hacking D.J.
- Haddad Youssef
- Hadfield Dan
- Hagan S.J.
- Han Hui
- Han Yi
- Hang Ai Y.
- Hanlon Gabrielle C.
- Harasawa Tomofumi
- Harrois Anatole
- Hashemian Seyed Mohammadreza
- Hashida Tomoaki
- He Z.
- Hedlund Lars
- Heidari Farshad
- Heines S.J.
- Helleberg Johan
- Henderson Galen
- Herbrecht Jean-Etienne.
- Hermosa C.
- Hessell R.J.
- Heunks L.M.
- Higashijima Ushio
- Hirata Akira
- Holzgraefe Bernhard
- Honda Hiroyuki
- Honrubia T.
- Hopf Hans-Bernd F.
- Hopkins Phil
- Hormis Anil P.
- Hou Peter C.
- Hou Sen-Kuang
- Hraiech Sami
- Hua Ma X.
- Huang Qing Q.
- Huang Xiao B.
- Huerta Francisco P.
- Huff N.G.
- Humphreys Sally K.
- Hunt A.
- Hurtado J.
- Hutchison R.A.
- Hutton Paula J.
- Ibañez-Santacruz M.
- Ichikado Kazuya
- Ilutovich Santiago
- Imai Hiroshi
- Imma Vallverdu P.
- Imperio M.C.
- Insaurralde Carolina S.
- Inskip Deborah M.
- Ioannou N.
- Iotti Giorgio A.
- Irvine Donald A
- Ismail D.
- Ismail Mehvish
- Ito Fumihito
- Izawa Masayo
- Jaafar Rola F.
- Jakubowska K.
- Jamaati Hamidreza
- Jarquin-Badiola Y.D.
- Jassal Mandeep
- Javeed Areej
- Jha Rajeev R.
- Jiang Liangyan
- Jibaja M.
- Jimenez Antonio G.
- Jochmans Sébasien
- Jog Sameer A.
- Jovanovic Bojan
- Judy C.
- Jurado M.T.
- Kadaba Varsha
- Kajtor I.
- Kakar Vivek
- Kalaitzis Evangelos
- Kalkoff M.
- Kamel G.
- Kameyama Yoshinobu
- Kamoun Salma
- Kander Thomas
- Kannan Santhana G.
- Kashiwa Yozo
- Kedelv Hans
- Kennedy Barry
- Khebbeb Samy
- Kheir F.
- Kheir F.M.
- Kimura Hiroyasu
- Kiourtzieva Ellada V.
- Kitch B.T.
- Knapman Karl M.
- Knoll Jenny
- Knowles Serena
- Kol Mark R.
- Kong Jing
- Koyama Kansuke
- Krabler Jens
- Krstevski Amanda
- Kulkarni S.
- Kumar Alek
- Kurahashi K.
- Kusumoto Kohei
- Laake Jon Henrik
- Labarca Eduardo F.
- Laffey John G.
- Lamb K.D.
- Lanspa M.J.
- Larsson A.
- Larsson Niklas
- Lebbinck Herve
- Lee J.
- Leemann-Refondini Corinne
- Lemiale Virginie
- Lemus J.S.
- Leon Yoshido H.H.
- Li Bin
- Li Qingdong
- Li Qiong J.
- Li Wenwen
- Li Xiao L.
- Li Xinyu
- Li Yimin
- Li Yuan Y.
- Li-Xin Zhou
- Liew Kong Y.
- Ling Long L.
- Liu Haitao
- Liu Jian
- Liu Jing L.
- Liu Ling
- Llano Miguel
- Llinares Moya David D.
- Lohner Ralph
- Loiacono Flavia A.
- Lombardo Andrea
- Lopez Esther Bermejo
- Lopez-Delgado J.C.
- Lora F.S.
- Lora Pilar
- Lorente J.A.
- Lorente M.d.C.
- Losada E.P.
- Lovazzano Pablo
- Lu Weihua
- Lu Yuanhua
- Luis Palazon Sanchez Eugenio
- Luo Xiaoming
- Lynch Joan M.
- López-Messa J.B.
- Maazouzi W.
- Macfadyen R.
- MacFie C.C.
- Madotto Fabiana
- Maeyama Hiroki N.
- Maghrabi K.A.
- Magret Monica
- Mahto Heera L.
- Mancebo Jordi
- Manoharan Venika
- Marcos D.P.
- Marcu A.
- Marin Julien
- Marin M.C.
- Martinez Felipe T.
- Marum S.M.
- Massa Eleni V.
- Mataloun Sergio
- Matamis D.
- Matsumoto Shunei
- Mattei Alessia
- May M.M.
- Mcarthur C.
- McAuley Danny
- Mccalman K.H.
- Mckechnie Stuart
- Mckee Raymond
- Mckenna Toni E.
- Mcleod A.
- McNamee Lia
- Meaney Edel A.
- Meco Basak Ceyda
- Meersseman Philippe
- Mehta Sangeeta
- Mejia F.J.F.
- Mellis Clare
- Memon Mohammedfaruk
- Mercat Alain
- Mesar T.
- Messias A.M.
- Messika Jonathan
- Meybohm Patrick
- Michel Philippe
- Millar Rebecca T.
- Miller Jennene J.
- Miller R.R.
- Mirabella Lucia
- Mizuguchi Ichiko
- Moal Charlene Le
- Mochizuki Katsunori
- Mohr N.M.
- Mojoli Francesco
- Moles S.I.
- Molin A.lexandre
- Montanha G.M.
- Monteiro J.M.
- Montero L.A.
- Monti Giacomo
- Montini Luca M.
- Moock Marcelo
- Morin Anna-Karin
- Mortaza Satar
- Morton Alex
- Mouloudi Eleni K.
- Mukkera S.R.
- Mustafa G.M.
- Muthuchellappan Radhakrishnan
- Máca Jan
- Nagy Eva O.
- Nakamura Tomoyuki
- Namih Miriam
- Nassar Antonio P.
- Nasu Michitaka
- Navalpotro M.A.B.
- Navarra L.
- Navarro G.
- Neal John
- Negoita S.I.
- Newby L.
- Nichol Alistair
- Nielsen Jonas
- Niimi Daisuke
- Nin N.
- Nishikawa Erin
- Nitta Kenichi
- Nobrega Danielle
- Noremark K.A.
- Nunci Lordian
- Nunes Silvia L.
- Nunomiya Shin
- Nutt Christopher
- Nuñez E.
- Nygren Ingela
- O'Croinin Donall
- O'Muircheartaigh Aogan C.
- Occhipinti Giovanna
- Oetting T.W.
- Ogino Yasuaki
- Oikonomou Marina A.
- Okane S.C.
- Okuda Nao
- Oldroyd M.G.
- Olga M.F.
- Oliveira B.S.
- Oneill Orla
- Ortiz Claudia A.
- Oscanoa F.A.M.
- Osman Emilio M.
- Oss Peteris
- Ouanes Islem
- Ourailogloy Vasilis
- Owens Robert L.
- Ozcelik Meneske
- Palaniswamy Vijayanand
- Palma Daniela M.
- Palmese Salvatore
- Palo J.E.
- Panarello Giovanna
- Papanikolaou Metaxia N.
- Papavasilopoulou Theonymfi G.
- Papazian Laurent
- Papurica M.
- Para L.H.
- Parhar Ken
- Parotto Matteo
- Pasanting-Lim R.A.
- Patroniti Nicolò
- Pattarino Pierpaolo Terragni Ilaria
- Pecci Elisabetta
- Pellegrini CarlosA.
- Pelletier Nicolas
- Pellicer Ana M.
- Pereira C.S.
- Perez C.P.
- Perez M.P.
- Persson Linnea
- Pesenti Antonio
- Peñuelas Oscar
- Pham Tai
- Phan Nga T.
- Piacentini E.A.
- Pillai S.
- Pintado M.C.
- Piquilloud Lise
- Piras Claudio
- Pittini G.
- Plotnikow Gustavo A.
- Poblano M.
- Poli Michela M.
- Pota Vincenzo
- Pozo Norberto C.
- Pozzi Matteo
- Preez P.D.
- Prieto-González M.
- Pronovost Antoine
- Protti Alessandro
- Qin Bingyu
- Qin Junping
- Qin Shu H.
- Qin Tie H.
- Qiu Haibo
- Raaijmakers M.
- Rabboni Francesca
- Rafael Sanchez I.
- Raimondi Ferdinando
- Raj Ashok S.
- Ramakrishnan Nagarajan
- Ramesh Venkatapura J.
- Ramirez-Alfaro Christian M.
- Ramirez-Gutierrez A.
- Rampinelli Adenilton M.
- Ranero J.L.
- Raponi Francesco
- Recio Noelia N.
- Reschreiter Henrik
- Reske Andreas W.
- Reuter Danielle
- Reynolds Claire.
- Rhayakar Rachana V.
- Rialp G.
- Richecoeur Jack R.
- Ricome Sylvie
- Rigaud Jean-Philippe.
- Rinia M.
- Rios F.
- Riss Katharina C.
- Rittayamai Nuttapol
- Roberts Brigit L.
- Robine Adrien
- Robles J.B.
- Roche-Campo F.
- Rodgers Helen J.
- Rodriguez Lucia L.
- Rodriguez R.
- Rojas Manuel A.González
- Rosa JonasI.
- Roser T.P.
- Rossi Anna
- Roux Damien
- Rugonfalvi Szabolcs
- Ruiz S.R.
- Ruiz-Aguilar A.L.
- Rylander ChristianC.
- Ryosuke Sekine
- Sabelnikovs Olegs
- Sable Safal D.
- Saenz María G.
- Saez Alejandro A.
- Sagar Sudha V.
- Saito Koji
- Saito S.
- Salahuddin N.
- Salas Javier E.
- Sales Brunei Vanessa M.
- Samkaoui N.
- Sanchez R.J.
- Sanchez-Hurtado L.A.
- Sanchez-Medina J.R.
- Sandesc D.
- Santoli Francesco L.
- Santos C.
- Sauvadet Elise P.
- Savioli Monica
- Scafetti Sergio
- Schiavone Vincenzo
- Schiavoni Lorenzo
- Schiöler Fredrik
- Schlichting A.B.
- Schneider Francis
- Schomer Ashley
- Schouten J.A.
- Schuetz Michael
- Schultz M. J.
- Schäfer Susanne
- Scott Christopher J.
- Seasman Colette
- Seethala Raghu
- Sellors G.P.
- Seoane-Quiroga L.
- Serra Aurelia I.M.
- Serra C.
- Setten Mariano G.
- Seven Aylin
- Shah Bhagyesh
- Shao Huanzhang
- Shen Juanhong
- Shenoy Anitha
- Sher Sara
- Shimizu Kazuyoshi
- Shindhe Suresh
- Shinn J.O.
- Shiozaki Kyoko
- Silesky Jimenez Juan I.
- Silesky J.
- Sim M.
- Simon Philipp
- Simonis F.D.
- Sivashanmugavel M.
- Sjøbø B.A.
- Sklienka Peter
- Smith Mark J.
- Smith O.
- Soler J.A.
- Solis-Quesada Jaime E.
- Sotillo Diaz Juan Carlos
- Sottiaux T.
- Souissi Asma Ben
- Spadaro Savino
- Srinivasa Latha
- Stamou Electra E.
- Staudinger Thomas
- Stephenson L.
- Stewart R.
- Stigler W.
- Strauch U.
- Sula Hektor
- Sun Renhua
- Surbatovic Maja
- Suzuki Hiroyuki
- Symmonds S.
- Szakmany T.
- Sánchez Rocio Manzano
- Sánchez-Ballesteros Jesús
- Søreide E.
- Tabhan E.
- Tabhan E.E.
- Tainter C.
- Takaba Akihiro
- Takada Tadaaki
- Takagi Shunsuke
- Tan B.C.
- Tanaka Hroyuki
- Tang Rui
- Tapponnier Romain
- Tarantino Fabio
- Temprano S.
- Terzi Nicolas
- Thibault Sandrine
- Thomas Matthew
- Thompson Marlus M.
- Tibblin Anna Oscarsson
- Tinnirello Andrea
- Tiribelli Norberto
- Todeschini Manuel
- Tomescu D.R.
- Toribio D.P.
- Toth-Tarsoly P.
- Treanor Nuala
- Trinder T.J.
- Trinidad O.A.
- Tulaimat A.
- Twohey Linda
- Uchiyama Akinori
- Ueda Takeshi
- Ueno Keiko
- Umbrello Michele
- Universitat Autònoma de Barcelona
- Unnikrishnan Rammesh
- Uppalapati A.
- Van Haren Frank
- Van Wezel H.M.
- Vargas Monica P.
- Vascotto Ettore R.
- Vasquez Daniela N.
- Vega Luis D.
- Veljovic Milic
- Venti Aaron
- Vercueil Andre
- Vermassen Joris
- Verstraete Rik
- Villagomez A.
- Villagomez A.J.
- Villamagua Boris G.
- Villar Veronica
- Vinzio Mauricio
- Virgilio Corcoles G.
- Vitale Michela N.
- Volta Carlo A.
- Wang Chunting
- Wang Hua X.
- Wang Shou H.
- Wang Wei
- Warren J.
- Watanabe Eizo
- Watt Philip
- Welters I.D.
- Wenham T.
- Wessbergh Joanna
- Whitehead Christina
- Willett E.L.
- Williams A.J.
- Williams K.E.
- Wise M.P.
- Wittebole Xavier
- Wong Helen S.
- Woods Paul W.
- Wrathall D.W.
- Wrigge H.
- Wu Ya Q.
- Xin-Hua Qiang
- Xu Yinghao
- Yamaguchi Osamu
- Yamaji Yoshihiro
- Yao Qingchun
- Ye Zheng L.
- Yeatts D.J.
- Yu Rongguo
- Yu Tao
- Yu Wenkui
- Yumha Jacob S.
- Yuste L.J.
- Zacharas Giannis A.
- Zacharowski Kai D.
- Zani Gianluca
- Zantua K.S.
- Zazu Alan
- Zeggwagh Amine Ali
- Zein Salem Ould
- Zender Hervé O.
- Zhai Zhe
- Zhang Fan
- Zhang Xing Y.
- Zhao H.
- Zhao Jun
- Zhao Xian Y.
- Zheng Ruiqiang
- Zhou Fa C.
- Zhou Suming
- Zhu Bao H.
- Zhu Wei H.
- Zogheib Elie
- Zumaran Aguilar Ronald
- Ñamendys-Silva S.A.
- ünal Necmettin
- Publication venue
- Publication date
- 01/01/2018
- Field of study
The aim of this study was to describe data on epidemiology, ventilatory management, and outcome of acute respiratory distress syndrome (ARDS) in immunocompromised patients. Methods: We performed a post hoc analysis on the cohort of immunocompromised patients enrolled in the Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure (LUNG SAFE) study. The LUNG SAFE study was an international, prospective study including hypoxemic patients in 459 ICUs from 50 countries across 5 continents. Results: Of 2813 patients with ARDS, 584 (20.8%) were immunocompromised, 38.9% of whom had an unspecified cause. Pneumonia, nonpulmonary sepsis, and noncardiogenic shock were their most common risk factors for ARDS. Hospital mortality was higher in immunocompromised than in immunocompetent patients (52.4% vs 36.2%; p < 0.0001), despite similar severity of ARDS. Decisions regarding limiting life-sustaining measures were significantly more frequent in immunocompromised patients (27.1% vs 18.6%; p < 0.0001). Use of noninvasive ventilation (NIV) as first-line treatment was higher in immunocompromised patients (20.9% vs 15.9%; p = 0.0048), and immunodeficiency remained independently associated with the use of NIV after adjustment for confounders. Forty-eight percent of the patients treated with NIV were intubated, and their mortality was not different from that of the patients invasively ventilated ab initio. Conclusions: Immunosuppression is frequent in patients with ARDS, and infections are the main risk factors for ARDS in these immunocompromised patients. Their management differs from that of immunocompetent patients, particularly the greater use of NIV as first-line ventilation strategy. Compared with immunocompetent subjects, they have higher mortality regardless of ARDS severity as well as a higher frequency of limitation of life-sustaining measures. Nonetheless, nearly half of these patients survive to hospital discharge. Trial registration: ClinicalTrials.gov, NCT02010073. Registered on 12 December 2013
Immunocompromised patients with acute respiratory distress syndrome: Secondary analysis of the LUNG SAFE database
- Author
- Abad Ricardo Diaz
- Abe Toshikazu
- Abroug Fekri
- Adams John C.
- Adamsson Richard
- Adolfsson Anne
- Aguilar Ronald Zumaran
- Aguirre Janet S.
- Aguirre-Bermeo Hernan
- Aisa Tharwat
- Aisiku Imo
- Ajetunmobi Olaitan
- Aker Mustafa
- Akyol Onat
- Al Dorzi Hasan M.
- Al Jabbary Ahmed
- Albaiceta Guillermo
- Albarrak Mohamad M.
- Albiero Daniela
- Alda Rosa S.
- Alejandro Risso V.
- Alexander Peter
- Alfonso Alec A. Tallet
- Algaba Ángela
- Aliaga Felipe A.
- Alisasis Alain
- Allan Russell
- Allue Raquel Montoiro
- Almekhlafi Ghaleb
- Alonso Javier
- Altaf Wahid
- Alvarez António
- Alvarez Javier
- Amin Pravin
- Amir Fahd
- Amor Mourad
- An Youzhong
- Andersen Finn
- Andoh Kohkichi
- Andruszkiewicz Pawel
- Aneman Anders
- Antonelli Massimo
- Antonelli Massimo
- Antônio Ana Carolina P.
- Aoki Nobumasa
- Appelberg Henrik
- Arabi Yaasen
- Arabi Yaseen M.
- Araujo Ana
- Arizmendi Alfons
- Arnal Jean-Michel
- Artiga Maria Jose D.
- Artigas Antonio
- Ascoli Aline
- Au Siu-Ming
- Avila Luis
- Azad Raman
- Azevedo Luciano Cesar
- Baboi Loredana
- Badie Julio
- Bailey Irene M.
- Bailey Mathew B.
- Bajwa Ed
- Balkhi Hicham
- Baltus Thomas
- Banner-Goodspeed Valerie
- Barberet Guillaume
- Baron Rebecca
- Baronia Arvind K.
- Barratt-Due Andreas
- Barros Filipa
- Barros Nelson C.
- Batra Hitesh
- Battle Ceri
- Bauer Philippe
- Beck Eduardo
- Beck Oliver
- Bedreag Ovidiu
- Beegle Scott H.
- Beitler Jeremy R.
- Bellani Giacomo
- Beloncle Francois
- Benslama Abdellatif
- Beraldo Daniel O.
- Berghe Caroline
- Berkelmans Frantz
- Besset Sebastien
- Bettini Lisandro R.
- Beuret Pascal
- Bezzi Marco G.
- Bhardwaj Vallish K.
- Bhowmick Kaushik
- Biehler Jerome
- Bigot Charlene
- Bihari Shailesh
- Binti Pengiran Haji Ismail Dayangku Hajah Maizatul Aiman
- Biondi Rodrigo S.
- Biscione Roberto
- Bisso Mariano Carboni
- Black Colin
- Blakeman Thomas C.
- Blanco Javier
- Bolon Stefan
- Borello Silvina A.
- Borotto Erika
- Botteri Marco
- Bouchoucha Slaheddine
- Boukhazna Messabi
- Bouw Maria J.
- Boyd Owen
- Bramall Jon
- Braschi Antonio
- Brazzi Luca
- Breen Dorothy M.
- Briquet Anais
- Brito Vania A.
- Brizuela Matias
- Broman Lars M.
- Brown Samuel M.
- Browne Troy S.
- Bruhn Alejandro R.
- Brunettini Barbara
- Bruns Monique
- Buensuseso Juan
- Bugedo Guillermo
- Buise Marc
- Bulpa Pierre A.
- Bumbasierevic Vesna
- Bumbasirevic Vesna
- Burtenshaw Andrew
- Burtin Philippe
- Buzancais Gautier
- Béduneau Gaetan
- Camsooksai Julie
- Canestrini Sergio
- Cani Alma
- Carbayo-Gorriz Cecilia
- Cardonnet Luis P.
- Careless Jon P.
- Carpentier Dorothée
- Carreño Nicolás G.
- Carteaux Guillaume
- Casalena Paolo
- Casement Jonathan
- Castro Alejandro
- Castro Silvia
- Catorze Nuno T.
- Cazorla-Barranquero Francisca G.
- Ceniceros-Barros Alexandra
- Cereijo Enrique
- Cerny Vladimir
- Cerrato Valeria I.
- Cervantes Mavy Ramirez
- Cesar Palazon Sanchez
- Ceunen Helga
- Ceylan Ilkay
- Chabanne Russell
- Chapman Rhiannon
- Chau Simon
- Chelly Jonathan
- Chen Kai
- Chena Ariel
- Cheng Meisy Perez
- Chiche Jean-Daniel
- Chouchene Imed
- Choudry Shazia
- Christiansen Aage
- Cimic Nedim
- Cinnella Gilda
- Cirone Rob
- Citalán Johanna E.
- Claraco-Vega Luis M.
- Clarkson Kevin
- Clarkson Kevin
- Claverias Laura
- Cohen Jason
- Cole Jade M.
- Collins Daniel
- Collyer Thomas
- Colombo Riccardo
- Combaux Daniele M.
- Combes Alain
- Conti Sara
- Cooper Raphael
- Coppadoro Andrea
- Corneci Dan
- Cortegiani Andrea
- Cortez Cesar
- Coxo Cristina
- Cracchiolo Andrea
- Cranshaw Julius
- Crapelli Giulia
- Crouch Daniel
- Crova Philippe
- Csabi Peter
- Curley Gerard
- Curto Elena Gallego
- Daldin Julio
- Dangers Laurence
- Danin Pierre-Eric
- Daubin Cédric
- Daviaud Fabrice
- Davies Kyle G.
- Dawson Heidi
- de Cima-Iglesias Sara
- de Gordoa Laura Ortiz-Ruiz
- de Haro Candelaria
- de Pablo Raul
- de Prost Nicolas
- Dean Michael N.
- Declercq Pierre-Louis M.
- Dector Dulce
- Dector Dulce M.
- Deicas Alberto
- Dellamonica Jean
- Dellera Christian
- Delsing Angela
- Demirkiran Oktay
- Demoule Alexandre
- Dempsey Ged
- Dendane Tarek
- Depuydt P.
- Depuydt Pieter
- Derman Suleyman S.
- Di Tomasso Nora
- Di Yu
- Diaz-Rodriguez Esther
- Dive Alain M.
- Dixit Subhal
- do Vale Fernandes Antero
- Dolva Merete S.
- Donnelly Adrian
- Dowling Anna T.
- Doyen Denis
- Dres Martin
- Dreyer Kyle
- Dunne Eimhin
- Dupont Herve
- Duranteau Jacques
- Dwyer Rory
- Démpair Gabriel
- Ebeid Alejandro
- Elatrous Souheil
- Elisabet Garcia M.
- Elkhayari Mina
- Ellis Helen E.
- Elmasri Mary
- Erbabacan Emre
- Eriksson Karin
- Estenssoro Elisa
- Esteve Francisco
- Estilita Joana M.
- Estrella Claudia R.
- Ezzouine Hanane
- Fan Eddy
- Fartoukh Muriel
- Farías Pamela A.
- Fawkes Danielle A.
- Ferguson Andrew
- Ferguson Niall D.
- Fernandez Adriana M.
- Fernandez Ruben O.
- Fierro Jonathan M.
- Floris Leda
- Follin Arnaud
- Fontenele Danielle C.
- Formenti Paolo
- Forteza Catalina
- Fossali Tommaso
- Foti Giuseppe
- Franco Nieves
- Francois Guy
- França Ana
- Frati Elena
- Frendl Gyorgy
- Frigyik Aniko
- Fusari Maurizio
- Futami Satoru
- Gally Josette
- Ganesan Deeban
- Gao Yan
- Gao Yuan
- Garcia Patricio H.
- Gazenkampf Andrey A.
- Gelée Bruno
- George Fernando
- Ghazi Mohammed
- Gianinetto Hernan
- Giarratano Antonino
- Gillis Sarah
- Girgin Nermin Kelebek
- Gjedsted Jakob
- Glietsch Rita
- Goldgran-Toledano Dany
- Goligher Ewan C.
- Gomaa Dina
- Gomes Rui
- Gomez Pablo E.
- Gomez-Flores Saira S.
- Gonzalez Daniel
- Gonzalez Marcos
- González Raquel Montiel
- González-Salamanca Ángela
- Gonçalves Claudio H.
- Goodson Jennifer
- Gordo Federico
- Gosselin Ryan
- Goubaux Bernard
- Grasselli Giacomo
- Graziani Romano
- Gregoretti Cesare
- Grelon Fabien
- Griffin Ruth
- Grigoriev Evgeny
- Grijalba Carolina Quintana
- Grissom Colin K.
- Gritsan Alexey
- Grubissich Nicolas
- Gueret Renaud
- Gurjar Mohan
- Guttormsen Anne B.
- Guérin Claude
- Gómez Pilar Ricart Aroa
- Hacking Danielle J.
- Haddad Youssef
- Hadfield Dan
- Hagan Samantha J.
- Han Hui
- Han Yi
- Hang Ai
- Hanlon Gabrielle C.
- Harasawa Tomofumi
- Harrois Anatole
- Hashemian S. M.
- Hashemian Seyed Mohammadreza
- Hashida Tomoaki
- He Zhenyang
- Hedlund Lars
- Heidari Farshad
- Heines Serge
- Helleberg Johan
- Henderson Galen
- Herbrecht Jean-Etienne
- Hermosa Cecilia
- Hessell Robert
- Heunks Leo
- Higashijima Ushio
- Hirata Akira
- Holzgraefe Bernhard
- Honda Hiroyuki
- Honrubia Teresa
- Hopf Hans-Bernd F.
- Hopkins Phil
- Hormis Anil P.
- Hou Peter
- Hou Sen-Kuang
- Hraiech Sami
- Hua Ma X.
- Huang Qing
- Huang Xiao B.
- Huerta Francisco P.
- Huff Nidhi
- Humphreys Sally K.
- Hunt Anna
- Hurtado Javier
- Hutchison Robyn
- Hutton Paula J.
- Ibañez-Santacruz Marco
- Ichikado Kazuya
- Ilutovich Santiago
- Imai Hiroshi
- Imma Vallverdu
- Imperio María C.
- Insaurralde Carolina S.
- Inskip Deborah M.
- Ioannou Nicholas
- Iotti Giorgio
- Irvine Donald A.
- Ismail Dina
- Ismail Mehvish
- Ito Fumihito
- Izawa Masayo
- Jaafar Rola F.
- Jakubowska Karina
- Jamaati Hamidreza
- Jarquin-Badiola Yves D.
- Jassal Mandeep
- Javeed Areej
- Jha Rajeev
- Jiang Liangyan
- Jibaja Manuel
- Jimenez Antonio
- Jochmans Sébastien
- Jog Sameer
- Jovanovic Bojan
- Judy Claine
- Jurado Maria Teresa
- Kadaba Varsha
- Kajtor Istvan
- Kakar Vivek
- Kalaitzis Evangelos
- Kalkoff Michael
- Kamel Ghassan
- Kameyama Yoshinobu
- Kamoun Salma
- Kander Thomas
- Kannan Santhana
- Kashiwa Yozo
- Kedelv Hans
- Kennedy Barry
- Khebbeb Samy
- Kheir Fayez
- Kheir Fayez M.
- Kimura Hiroyasu
- Kiourtzieva Ellada
- Kitch Barrett T.
- Knapman Karl
- Knoll Jenny
- Knowles Serena
- Kol Mark R.
- Kong Jing
- Koyama Kansuke
- Krabler Jens
- Krstevski Amanda
- Kulkarni Shreedhar
- Kumar Alek
- Kurahashi Kiyoyasu
- Kusumoto Kohei
- Laake Jon
- Labarca Eduardo F.
- Laffey John
- Laffey John G.
- Lamb Keith
- Lanspa Michael
- Larsson Anders
- Larsson Niklas
- Lebbinck Herve
- Lee Jarone
- Leemann-Refondini Corinne
- Lemiale Virginie
- Lemus Jordana
- Leon Yoshido Hector
- Li Bin
- Li Qingdong
- Li Qiong
- Li Wenwen
- Li Xiao L.
- Li Xinyu
- Li Yimin
- Li Yuan
- Li-Xin Zhou
- Liew Kong
- Ling Long L.
- Liu Haitao
- Liu Jian
- Liu Jing
- Liu Ling
- Llano Miguel
- Llinares Moya David
- Lohner Ralph
- Loiacono Flavia A.
- Lombardo Andrea
- Lopez Esther Bermejo
- Lopez-Delgado Juan
- Lora Fredy
- Lora Pilar
- Lorente Jose A.
- Lorente Maria del Carmen
- Losada Elena Perez
- Lovazzano Pablo
- Lu Weihua
- Lu Yuanhua
- Luis Palazon Sanchez Eugenio
- Luo Xiaoming
- Lynch Joan M.
- López-Messa Juan B.
- Maazouzi Wajdi
- Macfadyen Rosaleen
- MacFie Caroline
- Madotto Fabiana
- Maeyama Hiroki
- Maghrabi Khalid
- Magret Monica
- Mahto Heera
- Mancebo Jordi
- Manoharan Venika
- Marcos Diego Pastor
- Marcu Alexandra
- Marin Julien
- Marin Maria
- Martinez Felipe T.
- Marum Susan
- Massa Eleni V.
- Mataloun Sergio
- Matamis Dimitrios
- Matsumoto Shuhei
- Mattei Alessia
- May Martin
- Mcarthur Colin
- McAuley Daniel
- McAuley Danny
- Mccalman Katie
- Mckechnie Stuart
- Mckee Raymond
- Mckenna Toni E.
- Mcleod Alex
- McNamee Lia
- Meaney Edel
- Meco Basak Ceyda
- Meersseman Philippe
- Mehta Sangeeta
- Mejia Francisco Javier Flores
- Mellis Clare
- Memon Mohammedfaruk
- Mercat Alain
- Mesar Tomaz
- Messias António M.
- Messika Jonathan
- Meybohm Patrick
- Michel Philippe
- Millar Rebecca T.
- Miller Jennene J.
- Miller Russel R.
- Mirabella Lucia
- Mizuguchi Ichiko
- Moal Charlene Le
- Mochizuki Katsunori
- Mohr Nicholas
- Mojoli Francesco
- Moles Silvia Iglesias
- Molin Alexandre
- Montanha Gustavo
- Monteiro Jorge
- Montero Laura Alvarez
- Monti Giacomo
- Montini Luca M.
- Moock Marcelo
- Morin Anna-Karin
- Mortaza Satar
- Morton Alex
- Mouloudi Eleni
- Mukkera Satyanarayana Reddy
- Mustafa Ghanem M.
- Muthuchellappan Radhakrishnan
- Máca Jan
- Nagy Eva
- Nakamura Tomoyuki
- Namih Miriam
- Nassar Antonio P.
- Nasu Michitaka
- Navalpotro Miguel Angel Blasco
- Navarra Leanlove
- Navarro Gonzalo
- Neal John
- Negoita Silvius Ioan
- Newby Lynette
- Nichol Alistair
- Nielsen Jonas
- Niimi Daisuke
- Nin Nicolás
- Nishikawa Erin
- Nitta Kenichi
- Nobrega Danielle
- Noremark Kim Andre
- Nunci Lordian
- Nunes Silvia
- Nunomiya Shin
- Nutt Christopher
- Nuñez Edgardo
- Nygren Ingela
- O'Croinin Donall
- O'Muircheartaigh Aogan C.
- Occhipinti Giovanna
- Oetting Trevor W.
- Ogino Yasuaki
- Oikonomou Marina A.
- Okane Sinead
- Okuda Nao
- Oldroyd Matthew G.
- Olga Moreno F.
- Oliveira Bruno S.
- Oneill Orla
- Ortiz Claudia A.
- Oscanoa Fredy A. Montes
- Osman Emilio M.
- Oss Peteris
- Ouanes Islem
- Ourailogloy Vasilis
- Owens Robert L.
- Ozcelik Menekse
- Palaniswamy Vijayanand
- Palma Daniela M.
- Palmese Salvatore
- Palo Jose Emmanuel
- Panarello Giovanna
- Papanikolaou Metaxia
- Papavasilopoulou Theonymfi G.
- Papazian Laurent
- Papurica Marius
- Para Luis Herrera
- Parhar Ken
- Parotto Matteo
- Pasanting-Lim Rossini Abbie
- Patroniti Nicolò
- Pattarino Pierpaolo Terragni Ilaria
- Pecci Elisabetta
- Pellegrini Carlos A.
- Pelletier Nicolas
- Pellicer Ana
- Penuelas Oscar
- Pereira Carlos
- Perez Cesar P.
- Perez Manuel
- Persson Linnea
- Pesenti Antonio
- Pham Tai
- Phan Nga T.
- Piacentini Enrique
- Pillai Suresh
- Pintado Maria
- Piquilloud Lise
- Piras Claudio
- Pittini Gustavo
- Plotnikow Gustavo A.
- Poblano Manuel
- Poli Michela M.
- Pota Vincenzo
- Pozo Norberto C.
- Pozzi Matteo
- Preez Pieter
- Prieto-González Miryam
- Pronovost Antoine
- Protti Alessandro
- Qin Bingyu
- Qin Junping
- Qin Shu H.
- Qin Tie
- Qiu Haibo
- Raaijmakers Monique
- Rabboni Francesca
- Rafael Sánchez I.
- Raimondi Ferdinando
- Raj Ashok
- Ramakrishnan Nagarajan
- Ramesh Venkatapura J.
- Ramirez-Alfaro Christian M.
- Ramirez-Gutierrez Alvaro
- Rampinelli Adenilton M.
- Ranero Jorge Luis
- Raponi Francesco
- Recio Noelia
- Reschreiter Henrik
- Reske Andreas
- Reuter Danielle
- Reynolds Claire
- Rhayakar Rachana V.
- Rialp Gemma
- Richecoeur Jack
- Ricome Sylvie
- Rigaud Jean-Philippe
- Rinia Myra
- Rios Fernando
- Riss Katharina C.
- Rittayamai Nuttapol
- Roberts Brigit L.
- Robine Adrien
- Robles Joanne B.
- Roche-Campo Ferran
- Rodgers Helen J.
- Rodriguez Lucia L.
- Rodriguez Ruben
- Rojas Manuel A. González
- Rosa Jonas I.
- Roser Tomas
- Rossi Anna
- Roux Damien
- Rugonfalvi Szabolcs
- Ruiz Silvia Rodriguez
- Ruiz-Aguilar Antonio
- Rylander Christian C.
- Ryosuke Sekine
- Sabelnikovs Olegs
- Sable Safal D.
- Saenz María G.
- Saez Alejandro A.
- Sagar Sudha V.
- Saito Koji
- Saito Shigeki
- Salahuddin Nawal
- Salas Javier E.
- Sales Brunei Vanessa M.
- Samkaoui Nacer
- Sanchez Roberto Jimenez
- Sanchez-Hurtado Luis
- Sanchez-Medina Jorge
- Sandesc Dorel
- Santoli Francesco L.
- Santos Cristina
- Sauvadet Elise
- Savioli Monica
- Scafetti Sergio
- Schiavone Vincenzo
- Schiavoni Lorenzo
- Schiöler Fredrik
- Schlichting Adam
- Schneider Francis
- Schomer Ashley
- Schouten Jeroen A.
- Schuetz Michael
- Schultz Marcus J.
- Schäfer Susanne
- Scott Christopher
- Seasman Colette
- Seethala Raghu
- Sellors Gareth P.
- Seoane-Quiroga Leticia
- Serra Aurelia Isabel
- Serra Carolina
- Setten Mariano G.
- Seven Aylin
- Shah Bhagyesh
- Shao Huanzhang
- Shen Juanhong
- Shenoy Anitha
- Sher Sara
- Shimizu Kazuyoshi
- Shindhe Suresh
- Shinn Iii John O.
- Shiozaki Kyoko
- Silesky Jimenez Juan
- Silesky Juan
- Sim Malcolm
- Simon Philipp
- Simonis Fabienne
- Sivashanmugavel Mageswaran
- Sjøbø Brit A.
- Sklienka Peter
- Smith Mark
- Smith Oliver
- Soler Juan Alfonso
- Solis-Quesada Jaime E.
- Sotillo Diaz Juan Carlos
- Sottiaux T.
- Souissi Asma Ben
- Spadaro Savino
- Srinivasa Latha
- Stamou Electra E.
- Staudinger Thomas
- Stephenson Lorraine
- Stewart Richard
- Stigler William
- Strauch Ulrich
- Sula Hektor
- Sun Renhua
- Surbatovic Maja
- Suzuki Hiroyuki
- Symmonds Sophie
- Szakmany Tamas
- Sánchez Rocío Manzano
- Sánchez-Ballesteros Jesús
- Søreide Eldar
- Tabhan Edgardo
- Tabhan Edgardo E.
- Tainter Christopher
- Takaba Akihiro
- Takada Tadaaki
- Takagi Shunsuke
- Tan Beatriz C.
- Tanaka Hiroyuki
- Tang Rui
- Tapponnier Romain
- Tarantino Fabio
- Temprano Susana
- Terzi Nicolas
- Thibault Sandrine
- Thomas Matthew
- Thompson Marlus M.
- Tibblin Anna Oscarsson
- Tinnirello Andrea
- Tiribelli Norberto
- Todeschini Manuel
- Tomescu Dana
- Toribio Dácil Parrilla
- Toth-Tarsoly Piroska
- Treanor Nuala
- Trinder T. John
- Trinidad Olivia A.
- Tulaimat Aiman
- Twohey Linda
- Uchiyama Akinori
- Ueda Takeshi
- Ueno Keiko
- Umbrello Michele
- Unnikrishnan Ramesh
- Uppalapati Aditya
- Van Haren Frank
- Van Wezel Hellen M.
- Vargas Monica
- Vascotto Ettore
- Vasquez Daniela N.
- Vega Luis D.
- Veljovic Milic
- Venti Aaron
- Vercueil Andre
- Vermassen Joris
- Verstraete Rik
- Villagomez Asisclo
- Villagomez Asisclo J.
- Villamagua Boris
- Villar Veronica
- Vinzio Mauricio
- Virgilio Corcoles G.
- Vitale Michela N.
- Volta Carlo A.
- Wang Chunting
- Wang Hua
- Wang Shou H.
- Wang Wei
- Warren Jessica
- Watanabe Eizo
- Watt Philip
- Welters Ingeborg
- Wenham Tim
- Wessbergh Joanna
- Whitehead Christina
- Willett Emma L.
- Williams Alexandra J.
- Williams Karen E.
- Wise Matt
- Wittebole Xavier
- Wong Helen S.
- Woods Paul W.
- Wrathall David
- Wrigge Hermann
- Wu Ya
- Xin-Hua Qiang
- Xu Yonghao
- Yamaguchi Osamu
- Yamaji Yoshihiro
- Yao Qingchun
- Ye Zheng L.
- Yeatts Dale
- Yu Rongguo
- Yu Tao
- Yu Wenkui
- Yumha Jacob S.
- Yuste Luis J.
- Zacharas Giannis
- Zacharowski Kai
- Zani Gianluca
- Zantua Kim
- Zazu Alan
- Zeggwagh Amine Ali
- Zein Salem Ould
- Zender Hervé
- Zhai Zhe
- Zhang Fan
- Zhang Xing Y.
- Zhao Huiying
- Zhao Jun
- Zhao Xian Y.
- Zheng Ruiqiang
- Zhou Fa C.
- Zhou Suming
- Zhu Bao
- Zhu Wei H.
- Zogheib Elie
- Ñamendys-Silva Silvio A.
- ünal Necmettin
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
Background: The aim of this study was to describe data on epidemiology, ventilatory management, and outcome of acute respiratory distress syndrome (ARDS) in immunocompromised patients. Methods: We performed a post hoc analysis on the cohort of immunocompromised patients enrolled in the Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure (LUNG SAFE) study. The LUNG SAFE study was an international, prospective study including hypoxemic patients in 459 ICUs from 50 countries across 5 continents. Results: Of 2813 patients with ARDS, 584 (20.8%) were immunocompromised, 38.9% of whom had an unspecified cause. Pneumonia, nonpulmonary sepsis, and noncardiogenic shock were their most common risk factors for ARDS. Hospital mortality was higher in immunocompromised than in immunocompetent patients (52.4% vs 36.2%; p < 0.0001), despite similar severity of ARDS. Decisions regarding limiting life-sustaining measures were significantly more frequent in immunocompromised patients (27.1% vs 18.6%; p < 0.0001). Use of noninvasive ventilation (NIV) as first-line treatment was higher in immunocompromised patients (20.9% vs 15.9%; p = 0.0048), and immunodeficiency remained independently associated with the use of NIV after adjustment for confounders. Forty-eight percent of the patients treated with NIV were intubated, and their mortality was not different from that of the patients invasively ventilated ab initio. Conclusions: Immunosuppression is frequent in patients with ARDS, and infections are the main risk factors for ARDS in these immunocompromised patients. Their management differs from that of immunocompetent patients, particularly the greater use of NIV as first-line ventilation strategy. Compared with immunocompetent subjects, they have higher mortality regardless of ARDS severity as well as a higher frequency of limitation of life-sustaining measures. Nonetheless, nearly half of these patients survive to hospital discharge. Trial registration: ClinicalTrials.gov, NCT02010073. Registered on 12 December 2013
Evolution over Time of Ventilatory Management and Outcome of Patients with Neurologic Disease∗
- Author
- Abderrahim Azzouzi
- Abroug F.
- Achille Kouatchet
- Achim Lunkeit
- Adam Mikstacki
- Aguilera García
- Ahmed Sbihi
- Ai-Chin Cheng
- Ainhoa Rosselló
- Alain Mercat
- Alan Javier Zazu
- Alberto Belenguer
- Alberto Deicas
- Alberto Marino
- Alberto Soler
- Alejandro Algora
- Alejandro Arroliga
- Alejandro de la Serna
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- Anzueto A.
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- Ashley Ellis
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- Bas M Kors
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- Bin Du
- Bin Du
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- M Eugenia
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- Maggiore S. M.
- Manoj K Saxena
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- Mourad Amor
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- Nicolás Zamboschi
- Nieves Franco
- Nils Marquardt
- Nin N.
- Norberto Tiribelli
- Norberto Tiribelli
- Norma Beatriz Márquez
- Nuria Alonso
- Oliver Franke
- Olivia Dulfo
- Orla Smith
- Oscar Cluzet
- P Kruska
- P Samaddar
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- Pang Wing Yan
- Paolo Navalesi
- Pascal Beuret
- Pascual Valdez
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- Pedro Rosa
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- Penuelas O.
- Pertsas Evangelos
- Peter van der Voort
- Pham Thi Van Anh
- Phil Alkana
- Philippe Berger
- Pierre-Gildas Guitard
- Prachee Sathe
- Pravin Amin
- Priya Nair
- Qing Song
- Qingyuan Zhan
- Qunmei Yao
- Rachael Parke
- Rachel Whyte
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- Rafael Morales
- Rahul Nanchal
- Raju Pusapati
- Ramiro Puetate
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- Raquel Montoiro
- Raquel Yano
- Raymondos K.
- Raúl de Pablo
- Raúl González
- Raúl Lombardi
- Remzi Iscimen
- Ricardo Buitrago
- Ricardo Martinez Zubieta
- Ricardo Matos
- Rick McAllister
- Rios F.
- Robba C.
- Robert Fowler
- Robyn Klages
- Rodrigo E Gómez-Paz
- Roger Lamoglie
- Rogério de Castro Pereira
- Roland Schneider
- Rolf Dembinski
- Rolf Rossaint
- Rollin Roldán Mori
- Romano Tetamo
- Román Garrido
- Ronald Pairumani
- Ronnie Mantilla
- Rosa Luz López Martínez
- Rosa Sebastián
- Rosa Álvaro
- Rosalba Tufano
- Rosanna Del Giudice
- Rosanna Vaschetto
- Rosario Urbino
- Rovílson Lara
- Rovílson Lara
- Rubens Altair Amaral de Pádua
- Rubén Camargo
- Rui Moreno
- Rupesh Vakil
- Ryan Albert
- Sabriye Guvenc
- Salem Ould Zein
- Salvatore Maurizio Maggiore
- Samer Haj-Bakri
- Samir Abdelhadi
- Samir Sahu
- Samir Vermani
- Sando Chavarria
- Sangeeta Mehta
- Sanjay Dhanuka
- Santiago Ilutovich
- Sara Cabañes
- Schimdt Alejandra
- Sebastian Circo
- Sebastián E Mare
- Serena Azzari
- Serge Heines
- Sergio Cáceres
- Sergio Lasdica
- Seton Henderson
- Shawna Reddie
- Sheila Nainan Myatra
- Shelby Sutton
- Sheree Gare
- Shirley Nelson
- Shouhong Wang
- Silke Frenzel
- Silvia Mareque
- Silvina Borello
- Silvio A Ñamendys-Silva
- Simon J G Hockley
- Simona Beniczky
- Sindhaghatta Venkatram
- Sine Wichman
- Smyth Smith
- Soares M. A.
- Sofía García
- Soraya Puertas
- Srinivas Samavedam
- Stambouli Neji
- Steffen Appel
- Steffen Weber-Carstens
- Stephanie Lubchansky
- Stephen Lapinsky
- Steven Y Chang
- Stevens Salva
- Subhash Kumar Todi
- Sujoy Mukherjee
- Susan Gillen
- Susana Alves Ferreira
- Susana Moradillo
- Susana Temprano
- Susanne Andi Iversen
- Sutherasan Y.
- Sutrisno Gunawan
- Sylvia den Boer
- Tania Caf
- Tarek Dendane
- Tayfun Adanir
- Tejerina E. E.
- Teresa Mut
- Teresa Sánchez de Dios
- Thille A. W.
- Thomas Bein
- Thomas Lipp
- Thomas Moellhoff
- Thomas Steinke
- Thoralf Kerner
- Tiehe Qin
- Tim Coles
- Tim Houlihan
- Timothy D Girard
- Tom Cowlam
- Tony Sutherland
- Tony Williams
- Travis Parry
- Troy Browne
- Tumbass Volker
- Uli Strauch
- Umesh G
- Unase Büyükkoçak
- V J Cardenas Jr
- Valentín Parra
- Valerio Mangani
- Valery Subbotin
- Valle Pinheiro B.
- Valéria de Carvalho Magela
- Vanesa Ramírez
- Vicente Arraez
- Victoria Goñi
- Vincent John Scott
- Vito Marco Ranieri
- Vivek Joshi
- Wajdi Maazouzi
- Walter Brandt
- Walter Seyde
- Wanxia Li
- Wei He
- Wei Yu
- Wei Zhang
- Weihai Yao
- William Rodriguez-Cintron
- Winfried Schubert
- Wolfgang Baier
- Won-Yeon Lee
- Xi Zhu
- Xianyao Wan
- Xiaobo Huang
- Xue Wang
- Yalin Liu
- Yan Kang
- Yangong Chao
- Yaseen Arabi
- Yi Li
- Yi Yang
- Yogeet Kaur
- Yongjie Yin
- Young Suh G.
- Younsuck Koh
- Yu Bai
- Yuan Xu
- Yuhong Guo
- Yun Seong Kim
- Yunxuan Yue
- Zafer Dogan
- Zalatiel Maycotte Luna
- Zaza Cohen
- Zhengxuan Lv
- Zhenjie Hu
- Zhenyang He
- Zhicheng Zhang
- Zhihua Hu
- Zhixiang Li
- Zoltan Szentkereszty
- Zoraida Parra
- Zsolt Molnar
- Ángela Alonso
- Publication venue
- 'Ovid Technologies (Wolters Kluwer Health)'
- Publication date
- 01/11/2021
- Field of study
OBJECTIVES: To describe the changes in ventilator management over time in patients with neurologic disease at ICU admission and to estimate factors associated with 28-day hospital mortality. DESIGN: Secondary analysis of three prospective, observational, multicenter studies. SETTING: Cohort studies conducted in 2004, 2010, and 2016. PATIENTS: Adult patients who received mechanical ventilation for more than 12 hours. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Among the 20,929 patients enrolled, we included 4,152 (20%) mechanically ventilated patients due to different neurologic diseases. Hemorrhagic stroke and brain trauma were the most common pathologies associated with the need for mechanical ventilation. Although volume-cycled ventilation remained the preferred ventilation mode, there was a significant (p < 0.001) increment in the use of pressure support ventilation. The proportion of patients receiving a protective lung ventilation strategy was increased over time: 47% in 2004, 63% in 2010, and 65% in 2016 (p < 0.001), as well as the duration of protective ventilation strategies: 406 days per 1,000 mechanical ventilation days in 2004, 523 days per 1,000 mechanical ventilation days in 2010, and 585 days per 1,000 mechanical ventilation days in 2016 (p < 0.001). There were no differences in the length of stay in the ICU, mortality in the ICU, and mortality in hospital from 2004 to 2016. Independent risk factors for 28-day mortality were age greater than 75 years, Simplified Acute Physiology Score II greater than 50, the occurrence of organ dysfunction within first 48 hours after brain injury, and specific neurologic diseases such as hemorrhagic stroke, ischemic stroke, and brain trauma. CONCLUSIONS: More lung-protective ventilatory strategies have been implemented over years in neurologic patients with no effect on pulmonary complications or on survival. We found several prognostic factors on mortality such as advanced age, the severity of the disease, organ dysfunctions, and the etiology of neurologic disease
New insights into the genetic etiology of Alzheimer’s disease and related dementias
- Author
- Aaltonen Lauri
- Aaltonen Vesa
- Aarsland Dag
- Aavikko Mervi
- Abalos Mariana Sanchez
- Abdelnour Carla
- Abner Erin
- Abraham Richard
- Adams Hieab
- Adams Perrie M.
- Adarmes-Gómez Ad
- Adarmes-Gómez Astrid D.
- Aguilera Nuria
- Aguilera Nuria
- Aguirre Alyssa
- Ahmad Shahzad
- Akinyemi Rufus O.
- Al-Chalabi Ammar
- Alarcón-Martín Emilio
- Albert Marilyn S.
- Albin Roger L.
- Alcolea Daniel
- Alegret Montserrat
- Ali Muhammad
- Allen Mariet
- Allende Irene Rosas
- Alonso María Dolores
- Alonso María Dolores
- Alvarez Ignacio
- Alvarez Lisa
- Amer-Ferrer Guillermo
- Amin Najaf
- Amouyel Philippe
- Anastasiou Anna
- Anastasiou Costas
- Andrade Victor
- Andreassen Ole A.
- Andreoni Simona
- Antequera Martirio
- Antikainen Riitta
- Antonell Anna
- Anttonen Vuokko
- Antúnez Carmen
- Aparicio Hugo J.
- Apostolova Liana G.
- Appollonio Ildebrando
- Arcaro Marina
- Archetti Silvana
- Armstrong Nicola
- Armstrong Nicola J.
- Arnold Steven E.
- Arosio Beatrice
- Arvas Mikko
- Assogna Francesca
- Asthana Sanjay
- Athanasiu Lavinia
- Atwood Craig S.
- Auge Franck
- Auranen Annika
- Auvinen Päivi
- Awaisa Ghazal
- Ayres Gayle
- Bacha Juan Ignacio
- Bahadori Maryam
- Bahrami Shahram
- Bailly Henri
- Baldwin Clinton T.
- Banaj Nerisa
- Baquero Miquel
- Barber Robert C.
- Barnes Lisa L.
- Barral Sandra
- Barral Sandra
- Bass Nicholas J.
- Bass Nick
- Bastiani Patrizia
- Bayer Anthony
- Beach Thomas G.
- Becker James T.
- Becker James T.
- Becker Tim
- Beecham Gary W.
- Beekly Duane
- Behrens Tim
- Beiser Alexa
- Belezhanska Diyana
- Bellenguez Céline
- Below Jennifer E.
- Below Jennifer E.
- Ben-Shlomo Yoav
- Benchek Penelope
- Benchek Penelope
- Benitez Bruno A.
- Bennett David
- Benussi Alberto
- Benussi Luisa
- Bergh Sverre
- Bernardo-Harrington Mateus
- Berr Claudine
- Bertelson John
- Besse Céline
- Bessi Valentina
- Betts Jo
- Bhangale Tushar
- Biessels Geert Jan
- Binetti Giuliano
- Bing Nan
- Bird Thomas D.
- Bis Joshua C.
- Biswas Shameek
- Bizarro Alessandra
- Bjerke Maria
- Blacker Deborah
- Blesa Rafael
- Blomster Timo
- Boada Mercè
- Boecker Henning
- Boerwinkle Eric
- Boeve Bradley F.
- Boland Anne
- Borroni Barbara
- Boschi Silvia
- Bosnes Ingunn
- Bossù Paola
- Bowen James D.
- Bowers Natalie
- Boxer Adam
- Brauer Matt
- Brayne Carol
- Brein Georg
- Bresner Catherine
- Bressler Jan
- Breteler Monique
- Brewer James
- Brice Alexis
- Brodaty Henry
- Broeckhoven Christine Van
- Bronson Paola
- Brookes KJ
- Brown Kristelle
- Brown Kristelle S.
- Brusco Luis Ignacio
- Bråthen Geir
- Buendia Mar
- Buiza-Rueda Dolores
- Bullido María J.
- Burguera Juan Andrés
- Burholt Vanessa
- Burke James R.
- Burns Jeffrey M.
- Bush Will S.
- Bush William S.
- Buxbaum Joseph D.
- Bûrger Katharina
- Cairns Nigel J.
- Calero Miguel
- Caliskan Minal
- Call Katherine
- Call Kathy
- campion Dominique
- Campos-Martin Rafael
- Cano Amanda
- Cantwell Laura B.
- Cao Chuanhai
- Carlson Christopher S.
- Carlsson Cynthia M.
- Carney Regina M.
- Carpén Olli
- Carracedo Ángel
- Carrasquillo Minerva M.
- Carrillo F.
- Carrillo Fátima
- Carrion-Claro M.
- Carrión-Claro Mario
- Casajeros María José
- Castaño Eduardo M.
- Cañabate Pilar
- Cañabate Pilar
- Cecchetti Roberta
- Cervera-Carles Laura
- Challis Ben
- Chang Diana
- Chapuis Julien
- Charbonnier Camille
- Chasman Daniel
- Chasse Scott
- Chatelain Clement
- Chauhan Ganesh
- Chen Chia-Yen
- Chen Hao
- Chen Hubert
- Chen Hung-Hsin
- Chen Xing
- Chene Geneviève
- Chesi Alessandra
- Chesselet Marie-Francoise
- Chhibber Aparna
- Chillotti Caterina
- Chin Nathaniel A.
- Chipi Elena
- Choy David
- Chu Audrey
- Chui Helena C.
- Chung Jaeyoon
- Chung Jaeyoon
- Ciccone Simona
- Ciullo Valentina
- Claassen Jurgen A. H. R.
- Clarimon Jordi
- Clark Christopher
- Clarke Robert
- Close David
- Collinge John
- Comic Hata
- Conti Elisa
- Cores Valeria
- Corma-Gómez Anaïs
- Costa Marcos R.
- Costantini Emanuele
- Cox Simon
- Craft Suzanne
- Craig David
- Crane Paul K.
- Cribbs David H.
- Crocco Elizabeth A.
- Crohns Marika
- Cruchaga Carlos
- Cuccaro Michael L.
- Cuccaro Michael L.
- Cuesta Carolina
- Cullum Munro
- Cummings Beryl
- Cupples Adrienne L.
- Custodero Carlo
- Daian Delphine
- Dalmasso Maria Carolina
- Daly Mark
- Damotte Vincent
- Daniele Antonio
- Darby Eveleen
- Dardiotis Efthimios
- Dartigues Jean-François
- Davies Chloe
- Davies Gail
- Davis Barbara
- Davis Justin Wade
- de Deyn Peter Paul
- De Jager Philip L.
- de Mendonça Alexandre
- de Munain Adolfo Lopez
- de Paiva Lopes Katia
- de Rojas Itziar
- de Witte Lot D.
- Debette Stéphanie
- DeCarli Charles
- DeCarli Charles S.
- Deckert Jürgen
- del Ser Teodoro
- Deleuze Jean-François
- della Briotta Parola Pietro
- della Briotta Parolo Pietro
- Deloukas Panagiotis
- Deloukas Pangiotis
- Denning Nicola
- Deramecourt Vincent
- Deramerourt Vincent
- DeStefano Anita
- DeToledo John
- Dichgans Martin
- Dick Malcolm
- Dickson Dennis W.
- Diego Susana
- Diehl-Schmid Janine
- Diez-Fairen Mónica
- Diogo Dorothee
- Djurovic Srdjan
- Dombroski Beth A.
- Dongen Jasper Van
- Donner Kati
- Doody Rachelle S.
- Dowzell Kimberley
- Drichel Dmitriy
- Duara Ranjan
- Dubois Bruno
- Dufouil Carole
- Duperron Marie-Gabrielle
- Dupuis Josée
- Duron Emmanuelle
- Düzel Emrah
- Eaton Susan
- Ehm Meg
- Eicher John
- Eiriksdottir Gudny
- Eklund Kari
- Elenius Klaus
- Elliott Amanda
- Engelborghs Sebastiaan
- Epelbaum Jacques
- Ertekin-Taner Nilüfer
- Escott-Price Valentina
- Escuela R.
- Escuela Rocío
- Esmaeeli Sahar
- Espinosa Ana
- Espinosa Miguel Angel Labrador
- Etchepareborda Ignacio
- Evans Denis A.
- Evans Tavia
- Ewers Michael
- Faber Kelley M.
- Fabrizio Tagliavini
- Fairchild Thomas J.
- Fallon Kenneth B.
- Fan Frank
- Fardo David W.
- Farlow Martin R.
- Farotti Lucia
- Farrell John J.
- Farrer Lindsay A.
- Fenoglio Chiara
- Fernandez-Hernandez Victoria
- Fernández-Fuertes Marta
- Ferrarese Carlo
- Ferrari Raffaele
- Ferreira Catarina B.
- Ferri Evelyn
- Ferris Steven
- Feulner Thomas
- Fievet Nathalie
- Fin Bertrand
- Fischer Peter
- Fisher Elizabeth
- Fitzpatrick Annette
- Fladby Tormod
- Fließbach Klaus
- Fohner Alison E.
- Fongang Bernard
- Fornage Myriam
- Foroud Tatiana M.
- Forsell Charlotte
- Fortea Juan
- Fostinelli Silvia
- Fox Caroline
- Fox Nick
- Fox Nick C.
- Franco-Macías Emlio
- Frank-García Ana
- Frikke-Schmidt Ruth
- Froelich Lutz
- Frosch Matthew P.
- Frölich Lutz
- Fulton-Howard Brian
- Fulton-Howard Brian
- Färkkilä Martti
- Gailhajenet Anna
- Galasko Douglas R.
- Galeano Pablo
- Galimberti Daniela
- Gamboa Adriana
- Ganguli Mary
- Ganna Andrea
- Garcia-Gonzalez Pablo
- Garcia-Madrona Sebastian
- Garcia-Ribas Guillermo
- Garcia-Tabuenca Javier
- García-Alberca Jose Maria
- García-González Pablo
- Garrote-Espina L.
- Garrote-Espina Lorena
- Gearing Marla
- Geerlings Mirjam
- Georgantas Bob
- George-Hyslop Peter St
- Germani Sandra
- Gerrish Amy
- Geschwind Daniel H.
- Ghanbari Mohsen
- Ghetti Bernardino
- Ghidoni Roberta
- Ghosh Soumitra
- Giedraitis Vilmantas
- Giegling Ina
- Gilbert John R.
- Gill Michael
- Giorgio Giaccone
- Glatt Stephen J.
- Goate Alison M.
- Goldhardt Oliver
- Gomez-Fonseca Duber
- Gonzalez Hector M.
- González-Pérez Antonio
- Gordillo Jorge Esparza
- Gormley Padhraig
- Goss Monica
- Gossel Matthias
- Grabe Hans
- Grabowski Thomas J.
- Gracia-Tabuenca Javier
- Graff Caroline
- Graff-Radford Neill R.
- Graham Robert
- Grand Quentin Le
- Grande Giulia
- Grant Struan F. A.
- Green Emma
- Green Robert C.
- Greenberg Steven
- Grenier-Boley Benjamin
- Grimmer Timo
- Growdon John H.
- Grunin Michelle
- Grünblatt Edna
- Gu Wei
- Gudnason Vilmundur
- Guerreiro Rita
- Guetta-Baranes Tamar
- Guitart Marina
- Gurling Hugh
- Gursoy Ulvi
- Gwilliam Rhian
- Gómez-Garre P.
- Gómez-Garre Pilar
- Haapasalo Annakaisa
- Habes Mohamad
- Hadjigeorgiou Georgios
- Haines Jonathan L.
- Haines Jonathan L.
- Hakonarson Hakon
- Hall James
- Hamilton Ronald L.
- Hamilton-Nelson Kara L.
- Hampel Harald
- Hannequin Didier
- Hannula-Jouppi Katariina
- Hanon Olivier
- Harari Oscar
- Hardy John
- Harju Jarmo
- Harju Terttu
- Harold Denise
- Harrell Lindy E.
- Hartmann Annette M.
- Harvima Ilkka
- Harwood Janet
- Hausner Lucrezia
- Haut Jacob
- Hautala Nina
- Havulinna Aki
- Head Elizabeth
- Heap Graham
- Heckbert Susan R.
- Hedman Åsa
- Heikkinen Sami
- Heilmann-Heimbach Stefanie
- Helisalmi Seppo
- Henderson Victor W.
- Hendolin Minna
- Heneka Michael T.
- Hernandez Michelle
- Hernández Isabel
- Herold Christine
- Heron Samuel
- Herrmann Martin J.
- Heun Reinhard
- Heuser Isabella
- Hevilla Saray
- Heyne Henrike
- Hiekkalinna Tero
- Hiltunen Mikko
- Hinttala Reetta
- Hochfeld Marla
- Hodges Angela
- Hofer Edith
- Hoffman Joshua
- Hoffmann Per
- Hohman Timothy
- Hollingworth Paul
- Holmans Peter A.
- Holmes Clive
- Holstege Henne
- Holzinger Emily
- Hong Elliot
- Honig Lawrence S.
- Hooper Nigel M.
- Hort Jakub
- Hu Xinli
- Huang Yunfeng
- Huebinger Ryan M.
- Huentelman Matthew J.
- Hughes Timothy
- Huhtakangas Johanna
- Huilaja Laura
- Hulette Christine M.
- Hulsman Marc
- Humphrey Jack
- Hunkapiller Julie
- Hyman Bradley T.
- Hynan Linda S.
- Hyvärinen Kati
- Hüll Michael
- Ibanez Laura
- Ibarria Marta
- Ikram M. Arfan
- Ingelsson Martin
- Ingino Carlos
- Iriarte Maite Mendioroz
- Isomäki Pia
- Jacob Howard
- Jalanko Anu
- Jambulingam Dhanaprakash
- Janowitz Daniel
- Jansen Iris E.
- Jarvik Gail P.
- Jayadev Suman
- Jessen Frank
- Jesús S.
- Jesús Silvia
- Jian Xueqiu
- Jiménez Manuel González
- Jin Lee-Way
- Joensuu Heikki
- Johansson Charlotte
- John Sally
- Johnson Kim
- Johnson Leigh
- Johnston Janet A.
- Johnston Jarret A.
- Jones Lesley
- Juan Pascual Sánchez
- Julkunen Valtteri
- Jun Gyungah R.
- Junttila Juhani
- Juonala Markus
- Jussila Airi
- Järvensivu Elina
- Jöckel Karl-Heinz
- Kaarniranta Kai
- Kaarteenaho Riitta
- Kaiharju Essi
- Kaipiainen-Seppänen Oili
- Kajanne Risto
- Kalaoja Marita
- Kalpala Kirsi
- Kamboh M. Ilyas
- Kanai Masahiro
- Kangasniemi Eeva
- Kankaanranta Hannu
- Kaprio Jaakko
- Karihtala Peeter
- Karjalainen Juha
- Karjalainen Minna
- Karlsson Antti
- Karydas Anna M.
- Kastumata Yuriko
- Katz Mindy J.
- Kaunisto Mari
- Kauppi Paula
- Kauppila Saila
- Kautz Tiffany F.
- Kauwe John
- Kaye Jeffrey A.
- Keene C. Dirk
- Kehoe Patrick G.
- Kerchner Geoff
- Kettunen Johannes
- Khaleeq Aisha
- Kiiskinen Tuomo
- Kilander Lena
- Kilpeläinen Elina
- Kilpi Terhi
- Kim Ronald
- King Karen S.
- Kiviniemi Mikko
- Kivipelto Miia
- Kleineidam Luca
- Klinger Kathy
- Klopp Norman
- Knebl Janice
- Knol Maria
- Kochen Silvia
- Kohler Eduardo
- Kohler Matias
- Koivisto Anne
- Kornhuber Johannes
- Koskinen Miika
- Kosma Veli-Matti
- Kosmidis Mary H.
- Koulu Leena
- Kowall Neil W.
- Kramer Joel H.
- Kremen William
- Kristiansson Kati
- Kujala Urho
- Kuksa Pavel P.
- Kuksa Pavel P.
- Kukull Walter A.
- Kulkarni Diptee
- Kunkle Brian W.
- Kurki Mitja
- Kuulasmaa Teemu
- Kuzma Amanda B.
- Kvikstad Erika
- Kähönen Mika
- Kälviäinen Reetta
- Kölsch Heike
- Küçükali Fahri
- Laakkonen Eija
- Laakso Markku
- Laatikainen Tiina
- Labrador Ma
- Lacaze Paul
- Lacidogna Giordano
- Lacour André
- Laczo Jan
- LaFerla Frank M.
- Lafuente Asunción
- Lage Carmen
- Lage Carmen
- Lah James J.
- Lahdenperä Sanni
- Lahti Jari
- Laiho Päivi
- Laitinen Tarja
- Laivuori Hannele
- Lambert Jean-Charles
- Larson Eric B.
- Laske Christoph
- Laukka Erika J.
- Laukkanen Jari
- Laukkanen Markku
- Launer Lenore
- Lauria Alessandra
- Lawlor Brian
- Lee Chien-Yueh
- Lee Chien-Yueh
- Lee Edward B.
- Lee Jiwoo
- Legaz Agustina
- Lehisto Arto
- Lehistö Arto
- Lehtisalo Jenni
- Lehtonen Anne
- Lehtonen Heli
- Lemmelä Susanna
- Lerch Ondrej
- Lerner Alan
- Lertratanakul Apinya
- Leung Yuk Yee
- Leverenz James B.
- Levey Allan I.
- Li Mingyao
- Li Shuo
- Lieberman Andrew P.
- Linden Kari
- Lindström Jaana
- Lipton Richard B.
- Lisso Julieta
- Litkowski Elizabeth
- Liu Dan
- Liu Dongyu
- Liu Jimmy
- Liu Xuan
- Livingston Gill
- Lleó Alberto
- Llorens Vincent
- Loboda Andrey
- Loerch Patrick
- Logue Mark
- Loitfelder Marisa
- Longstreth William
- Loomis Stephanie
- Lopez Oscar
- Lord Jenny
- Loukola Anu
- Love Seth
- Lovestone Simon
- Lu Tim
- Luckcuck Lauren
- Lunetta Kathryn L.
- Luodonpää Marja
- Lupton Michelle
- Lyketsos Constantine G.
- Lynch Aoibhinn
- Lähteenmäki Sini
- López-García Sara
- López-García Sara
- Löwemark Malin
- Ma Yiyi
- Macias Juan
- Macias-García D.
- Macias-García Daniel
- MacLeod Catherine A.
- Macías Juan
- Maier Wolfgang
- Maillard Pauline
- Mains Douglas
- Malamon John
- Malarstig Anders
- Malik Rainer
- Mangialasche Francesca
- Mangone Carlos
- Mann David
- Mannermaa Arto
- Manning Alisa
- Mantere Tuomo
- Manzanares Salvadora
- Maranville Joseph
- Margaret Flanagan E.
- Marioni Riccardo
- Maroñas Olalla
- Marquié Marta
- Mars Nina
- Marshall Catherine
- Marshall Rachel
- Marson Daniel C.
- Martin Eden R.
- Martinez de Pancorbo Marian
- Martiniuk Frank
- Martín Elvira
- Martínez Begoña
- Martínez Victoriana
- Martínez-Lage Álvarez Pablo
- Martínez-Larrad María Teresa
- Marín M.
- Marín Marta
- Marín Tamara
- Marín-Muñoz Juan
- Mash Deborah C.
- Masliah Eliezer
- Massman Paul
- Masullo Carlo
- Masurkar Arjun
- Matakidou Athena
- Mather Karen
- Matoska Vaclav
- Mattson Johanna
- Mattsson Hannele
- Mauleón Ana
- Mayeux Richard
- Mayhaus Manuel
- Mazoyer Bernard
- McCarthy Linda
- McCarthy Mark
- McCormick Wayne C.
- McCurry Susan M.
- McDavid Andrew N.
- McDonough Stefan
- McDonough Stefan
- McGuinness Bernadette
- McKee Ann C.
- McQuillin Andrew
- Mead Simon
- Mecocci Patrizia
- Medel Nancy
- Medina Miguel
- Meggy Alun
- Mehrabian Shima
- Mehta Vinay
- Mei Hao
- Mendoza Silvia
- Menéndez-González Manuel
- Meretoja Tuomo
- Merlín Isabel Sastre
- Mesulam Marsel
- Metsärinne Kaj
- Mez Jesse
- Michon John
- Mihova Kalina Yonkova
- Miller Bruce L.
- Miller Carol A.
- Miller Joshua W.
- Miller Melissa
- Mir Pablo
- Mishra Aniket
- Moebus Susanne
- Mohammed Elhaj
- Mol Merel
- Molina-Porcel Laura
- Montes Angel Martín
- Montine Thomas J.
- Montrreal Laura
- Monuki Edwin S.
- Morales Atahualpa Castillo
- Morelli Laura
- Moreno Fermin
- Moreno Mariona
- Moreno-Grau Sonia
- Morgan Kevin
- Morris John C.
- Mosley Thomas
- Muchnik Carolina
- Mukherjee Shubhabrata
- Mummery Catherine
- Muslin Anthony
- Myers Amanda J.
- Mäkelä Johanna
- Mäkelä Tomi
- Männikkö Lotta
- Mäntylä Päivi
- Nacmias Benedetta
- Naj Adam C.
- Nash William
- Natunen Teemu
- Ngandu Tiia
- Nguyen Trung
- Nicolas Gael
- Nielsen Sune Fallgaard
- Niemi Mari E.
- Nieminen Pekka
- Niiranen Teemu
- Nordestgaard Børge G.
- Novack Gisela
- Nuñez-Llaves Raúl
- Nyquist Paul
- Nöthen Markus M.
- Oh Danny
- Olaso Robert
- Olichney John M.
- Olivar Natividad
- Olivé Clàudia
- Ollila Terhi
- Orellana Adelina
- Orsini Michela
- Ortega Gemma
- Ortiz Cecilia
- Ory Marcia
- Owen Michael
- Owen Michael J.
- O’Bryant Sid
- O’Connell Jeffrey
- O’Donovan Michael
- O’Donovan Michael C.
- Paajanen Teemu
- Padovani Alessandro
- Pakkanen Raimo
- Palacio Dana Lis
- Palin Kimmo
- Palmer Raymond
- Palomäki Antti
- Palotie Aarno
- Palotie Ulla
- Palta Priit
- Pancho Ana
- Paolo Caffarra
- Papenberg Goran
- Parisi Joseph E.
- Parkkinen Jaakko
- Parnetti Lucilla
- Partanen Jukka
- Parveen Kayenat
- Pasquier Florence
- Passmore Peter
- Passmore Peter
- Pastor Alfonso Arias
- Pastor Ana Belén
- Pastor Pau
- Patel Yash
- Patel Yogen
- Paulson Henry L.
- Paus Tomas
- Pausova Zdenka
- Pavlik Valory
- Paydarfar David
- Pelejà Esther
- Pelejá Ester
- Pelkonen Margit
- Peloso Gina
- Peltola Jukka
- Peltonen Markku
- Peltonen Sirkku
- Pendergrass Sarah
- Perez Victoria
- Pericak-Vance Margaret A.
- Pericard Pierre
- Periñán Mt
- Periñán-Tocino María Teresa
- Perneczky Robert
- Perola Markus
- Peskind Elaine
- Peters Oliver
- Petersen Ronald C.
- Peterson Andrew
- Petrovski Slavé
- Phillips-Cremins Jennifer E.
- Pickering-Brown Stuart
- Pierce Aimee
- Pihlajamäki Jussi
- Pijnenburg Yolande A. L.
- Pikkarainen Sampsa
- Pinchler Sabrina
- Pineda Juan A.
- Pineda-Sánchez R.
- Pineda-Sánchez Rocío
- Piras Fabrizio
- Piras Federica
- Pirilä Laura
- Pisanu Claudia
- Pitkäranta Anne
- Piñol-Ripoll Gerard
- Plenge Robert
- Podgornaia Anna
- Polak Thomas
- Politis Daniel G.
- Polk Marsha
- Poon Wayne W.
- Popovic Relja
- Popp Julius
- Posthuma Danielle
- Potter Huntington
- Powell John
- Powell John F.
- Preckler Silvia
- Prestia Federico Ariel
- Priller Josef
- Proitsi Petra
- Prokic Ivana
- Psaty Bruce M.
- Puerta Raquel
- Pulford David
- Pulkki Kari
- Pussinen Pirkko
- Pylkäs Katri
- Pärn Kalle
- Pérez-Cordón Alba
- Pérez-Tur Jordi
- Qu Liming
- Quarless Danjuma
- Quenez Olivier
- Quiceno Mary
- Quinn Joseph F.
- Quintela Inés
- Rahimov Fedik
- Raikkonen-Talvitie Katri
- Rainero Innocenzo
- Raj Ashok
- Raj Towfique
- Rajabli Farid
- Rajpal Deepak
- Rajula Reddy
- Ramakers Inez
- Ramirez Alfredo
- Raskind Murray
- Rathinakannan Venkat Subramaniam
- Real de Asúa Diego
- Real Luis M.
- Reeve Mary Pat
- Reiman Eric M.
- Reinders Marcel J. T.
- Reisberg Barry
- Reisch Joan S.
- Reitz Christiane
- Remes Anne
- Reyes-Dumeyer Dolly
- Riaz Moeen
- Rice David
- Rich Stephen
- Ridge Perry
- Riedel-Heller Steffi
- Riederer Peter
- Riemenschneider Matthias
- Riley-Gillis Bridget
- Ringman John M.
- Rinne Juha
- Rios Mario
- Ripatti Samuli
- Ritari Jarmo
- Rivas Manuel
- Roberson Erik D.
- Roberto Natalia
- Rodrigo Silvia
- Rodrigo-Herrero Silvia
- Rodriguear Monica
- Rodriguez-Rodriguez Eloy
- Rodríguez Carmen Martínez
- Roeck Ellen De
- Rogaeva Ekaterina
- Rojo Matias
- Romero Jose
- Rongve Arvid
- Rosen Howard J.
- Rosenberg Roger N.
- Rosende-Roca Maitée
- Roshchupkin Gena
- Rossi Giacomina
- Rossi Paolo Dionigi
- Rossor Martin
- Rossor Martin
- Rotter Jerome
- Roveta Fausto
- Royall Donald R.
- Royo Jose Luis
- Rubino Elisa
- Rubinsztein David C.
- Ruiz Agustín
- Rujescu Dan
- Runz Heiko
- Ryan Natalie S.
- Ryan Nathalie
- Rábano Alberto
- Rüeger Sina
- Saba Yasaman
- Sachdev Perminder
- Saenz Aldo
- Sager Mark A.
- Sakka Paraskevi
- Sala Gessica
- Salmi Teea
- Salminen Aino
- Salo Tuula
- Salomaa Veikko
- Saltvedt Ingvild
- Salvadori Nicola
- Sanabria Ángela
- Sanchez-Garcia Florentino
- Sando Sigrid B.
- Sano Mary
- Sargurupremraj Murali
- Sarnowski Chloé
- Sastre Isabel
- Satizabal Claudia L.
- Saykin Andrew J.
- Scamosci Michela
- Scarmeas Nikolaos
- Scarpini Elio
- Schellenberg Gerard D.
- Scheltens Philip
- Scherbaum Norbert
- Scherer Martin
- Schleutker Johanna
- Schmid Matthias
- Schmidt Helena
- Schmidt Reinhold
- Schneider Anja
- Schneider Julie A.
- Schneider Lon S.
- Schott Jonathan M.
- Schutzman Jennifer
- Schürmann Britta
- Seeley William W.
- Seitsonen Sanna
- Sekhar Hema
- Selbæk Geir
- Selnes Per
- Seripa Davide
- Serpente Maria
- Serpi Raisa
- Serrano Manuel
- Seshadri Sudha
- Sevillano Zulma
- Sha Jin
- Shadrin Alexey A.
- Shaikho Elmutaz
- Shaw Christopher E.
- Shcherban Anastasia
- Shin Jean
- Shofany Jacob
- Shulman Joshua M.
- Siirtola Harri
- Simino Jeannette
- Sims Rebecca
- Sinisalo Juha
- Sipeky Csilla
- Sipilä Kirsi
- Sipilä Timo P.
- Siponen Maria
- Sistonen Tuuli
- Skrobot Olivia
- Sleegers Kristel
- Slifer Susan
- Slifer Susan H.
- Sliz Eeva
- Small Scott
- Smaoui Nizar
- Smith A. David
- Smith Amanda G.
- Smith Janet P.
- Smith Jennifer
- Snijders Gijsje J. L.
- Soininen Hilkka
- Solfrizzi Vincenzo
- Solis Patricia
- Solomon Alina
- Song Yeunjoo
- Song Yeunjoo E.
- Sonnen Joshua A.
- Sorbi Sandro
- Sotolongo-Grau Oscar
- Spallazzi Marco
- Spalletta Gianfranco
- Spina Salvatore
- Spottke Annika
- Squassina Alessio
- Stern Robert A.
- Stevens Alan B.
- Stordal Eystein
- Strandberg Timo
- Strauss Erich
- Strittmatter Stephen M.
- Ståhlbom Anne Kinhult
- Sultzer David
- Suominen Liisa
- Sussams Rebecca
- Swerdlow Russell H.
- Sáez María Eugenia
- Sánchez-Arjona María Bernal
- Sánchez-Valle Raquel
- Takalo Mari
- Tanzi Rudolph E.
- Tartan Juan Pablo
- Tasanen Kaisa
- Taskinen Marja-Riitta
- Teipel Stefan
- Teng Edmond
- Tesí Niccolo
- Teumer Alexander
- Thalamuthu Anbupalam
- Thomas Alvin
- Thomas Charlene
- Thomas Tegos
- Thomassen Jesper Qvist
- Thonberg Håkan
- Tienari Pentti
- Tilson Jeffrey L.
- Tin Adrienne
- Todd Stephen
- Toso Carlos Reyes
- Tosto Giuseppe
- Traykov Latchezar
- Tremolizzo Lucio
- Trojanowski John Q.
- Troncoso Juan C.
- Tsai Ellen
- Tsolaki Anthoula
- Tsolaki Magda
- Tsuang Debby W.
- Tsuo Kristin
- Tucker-Drob Elliot
- Tukiainen Taru
- Tuomi Tiinamaija
- Tuomilehto Jaakko
- Tuovila Outi
- Turpeinen Miia
- Turton James
- Turunen Joni A.
- Tybjærg-Hansen Anne
- Tzourio Christophe
- Tárraga Lluís
- Uitterlinden Andre
- Ullgren Abbe
- Ulstein Ingun
- Uphill James
- Usiskin Keith
- Uusitalo Hannu
- Uusitalo-Järvinen Hannele
- Vacca Alessandro
- Vainio Seppo
- Valero Sergi
- Valladares Otto
- Valladares Otto
- van Adelsberg Janet
- Van Deerlin Vivianna M.
- van den Bussche Hendrik
- van der Flier Wiesje M.
- van der Lee Sven J.
- van der Lugt Aad
- van Duijn Cornelia M.
- van Eldik Linda J.
- van Lent Debora Melo
- van Rooij Jeroen
- van Swieten John
- Vance Jeffery
- Vandenberghe Rik
- Vardarajan Badri N.
- Vardy Emma
- Vargas Liliana
- Vassar Robert
- Verhey Frans
- Vicente Maria Pilar
- Vidal Jean-Sébastien
- Vigo-Ortega R.
- Vigo-Ortega Rosario
- Vilas Raquel Huerto
- Vinters Harry V.
- Virolainen Petri
- Vivancos Liliana
- Vogelgsang Jonathan
- Vojinovic Dina
- Vonsattel Jean-Paul
- Voutilainen Markku
- Vyhnalek Martin
- Wadhawan Samir
- Wagner Michael
- Wallon David
- Wang Clarence
- Wang Li-San
- Wang Ruiqi
- Wang Yanbing
- Warden Donald
- Waring Jeff
- Waring Jeffrey
- Warner Nick
- Warren Jason D.
- Waterworth Dawn
- Weber Heike
- Weinhold Leonie
- Weinstein Galit
- Weintraub Sandra
- Welsh-Bohmer Kathleen A.
- Whelan Christopher
- Whitehead Patrice L.
- Wichmann H-Erich
- Wigmore Eleonor
- Wijsman Ellen M.
- Wilcock Gordon
- Wilhelmsen Kirk C.
- Williams Amy
- Williams Benjamin
- Williams Dylan
- Williams Julie
- Williamson Jennifer
- Wilms Henrik
- Wiltfang Jens
- Windle Gill
- Wingo Thomas S.
- Wisniewski Thomas
- Wittfeld Katharina
- Woltjer Randall L.
- Wong Regis
- Woods Bob
- Woon Martin
- Wright Clinton B.
- Wu Chuang-Kuo
- Wu Ying
- Xia Tai-he
- Xu Ethan
- Xu Fanli
- Yanek Lisa
- Yang Qiong
- Yang Yunju
- Yannakoulia Mary
- Yaqub Amber
- Younkin Steven G.
- Yu Chang-En
- Yu Lei
- Zare Habil
- Zhang Xiaoling
- Zhang Yuanchao
- Zhao Yi
- Zhao Yi
- Zhou Wei
- Zhu Congcong
- Zhu Xiongwei
- Ziemann Adam
- Zoia Chiara Paola
- Zompo Maria Del
- Zulaica Miren
- Álvarez Victoria
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/04/2022
- Field of study
Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele
Outcome of acute hypoxaemic respiratory failure: insights from the LUNG SAFE Study
- Author
- Aage Christiansen
- Aaron Venti
- Abdellatif Benslama
- Adam B Schlichting
- Adenilton M Rampinelli
- Aditya Uppalapati
- Adrian Donnelly
- Adriana M Fernandez
- Adrien Robine
- Ahmad Yazid Bin Hj Abul Wahab
- Ahmed S Al Jabbary
- Ai Y Hang
- Aiman Tulaimat
- Akihiro Takaba
- Akinori Uchiyama
- Akira Hirata
- Alain Combes
- Alain M Dive
- Alain Mercat
- Alain U Alisasis
- Alan Zazu
- Alberto Deicas
- Alec A Tallet Alfonso
- Alejandro A Saez
- Alejandro Ebeid
- Alejandro G Castro
- Alejandro R Bruhn
- Alejandro Rojas
- Alek Kumar
- Alessandro Protti
- Alessia Mattei
- Alex Mcleod
- Alex Morton
- Alexandra Ceniceros-Barros
- Alexandra J Williams
- Alexandra Marcu
- Alexandre Demoule
- Alexandre Molin
- Alexey I Gritsan
- Alfons Arizmendi
- Aline Ascoli
- Alistair Nichol
- Alma Cani
- Alvaro Ramirez-Gutierrez
- Amanda Krstevski
- Amine Ali Zeggwagh
- Amine Ali Zeggwagh
- Ana Carolina P Antônio
- Ana G França
- Ana M Araujo
- Ana M Pellicer
- Anais Briquet
- Anatole Harrois
- Anders Aneman
- Anders Larsson
- Anders Larsson
- Andre Vercueil
- Andrea Coppadoro
- Andrea Cortegiani
- Andrea Lombardo
- Andrea N Cracchiolo
- Andrea Tinnirello
- Andreas Barratt-Due
- Andreas W Reske
- Andres Esteban
- Andrew Ferguson
- Andrew J Burtenshaw
- Andrey A Gazenkampf
- Angela Delsing
- Aniko D Frigyik
- Anil P Hormis
- Anitha Shenoy
- Anna Hunt
- Anna Oscarsson Tibblin
- Anna T Dowling
- Anna-Karin Morin
- Anne Adolfsson
- Anne B Guttormsen
- Antero do Vale Fernandes
- Antoine Pronovost
- Antonino Giarratano
- Antonio Artigas
- Antonio Braschi
- Antonio G Jimenez
- Antonio L RuizAguilar
- Antonio P Nassar Jr
- Antonio Pesenti
- António M Alvarez
- António M Messias
- Aogan C O'Muircheartaigh
- Areej Javeed
- Ariel Chena
- Arnaud Follin
- Arthur S Slutsky
- Arvind K Baronia
- Ashley Schomer
- Ashok S Raj
- Asisclo J Villagomez
- Asisclo Villagomez
- Asma Ben Souissi
- Aurelia M Martinho
- Aylin Seven
- B Taylor Thompson
- Bao H Zhu
- Barbara Brunettini
- Barrett T Kitch
- Barry Kennedy
- Basak Ceyda Meco
- Beatriz C Tan
- Bellani Giacomo
- Bernard Goubaux
- Bernhard Holzgraefe
- Bhagyesh Shah
- Bin Li
- Bingyu Qin
- Bojan Jovanovic
- Boris G Villamagua
- Brigit L Roberts
- Brit Å Sjøbø
- Brochard Laurent J.
- Bruhn Alejandro
- Bruno Gelée
- Bruno S Oliveira
- Bugedo Guillermo
- Candelaria De Haro
- Carlo A Volta
- Carlos A Pellegrini
- Carlos S Pereira
- Carolina Quintana Grijalba
- Carolina S Insaurralde
- Carolina Serra
- Caroline Berghe
- Caroline C MacFie
- Catalina Forteza
- Cecilia Carbayo-Gorriz
- Cecilia Hermosa
- Ceri E Battle
- Cesar A Cortez
- Cesar P Perez
- Charlene Bigot
- Charlene Le Moal
- Christian C Rylander
- Christian Dellera
- Christian M Ramirez-Alfaro
- Christina Whitehead
- Christopher J Scott
- Christopher Nutt
- Christopher Tainter
- Chunting Wang
- Claine Judy
- Claire Reynolds
- Clare Mellis
- Claude Guérin
- Claudia A Ortiz
- Claudia R Estrella
- Claudio H Gonçalves
- Claudio Piras
- Colette Seasman
- Colin K Grissom
- Colin McArthur
- Colin S Black
- Corcoles G Virgilio
- Corinne Leemann-Refondini
- Cristina M Coxo
- Cristina Santos
- Cédric Daubin
- Daisuke Niimi
- Dale J Yeatts
- Damien Roux
- Dan E Corneci
- Dan Hadfield
- Dana R Tomescu
- Daniel F McAuley
- Daniel F McAuley
- Daniel O Beraldo
- Daniel R Crouch
- Daniel R Crouch
- Daniel R Gonzalez
- Daniel V Collins
- Daniela Albiero
- Daniela M Palma
- Daniela N Vasquez
- Daniele M Combaux
- Danielle A Fawkes
- Danielle C Fontenele
- Danielle J Hacking
- Danielle Nobrega
- Danielle Reuter
- Danny McAuley
- Dany Goldgran-Toledano
- David D Llinares Moya
- David W Wrathall
- Deborah M Inskip
- Deeban Ganesan
- Denis Doyen
- Diego Pastor Marcos
- Dimitrios Matamis
- Dina Gomaa
- Dina Gomaa
- Dina Ismail
- Donald A Irvine
- Donall O'Croinin
- Dorel Sandesc
- Dorothy M Breen
- Dorothée Carpentier
- Dulce Dector
- Dácil Parrilla Toribio
- Ed Bajwa
- Eddy Fan
- Eddy Fan
- Edel A Meaney
- Edgardo E Tabhan
- Edgardo Nuñez
- Edgardo Tabhan
- Eduardo Beck
- Eduardo F Labarca
- Eimhin S Dunne
- Eizo Watanabe
- Eldar Søreide
- Electra E Stamou
- Elena Frati
- Elena Gallego Curto
- Elena Perez Losada
- Eleni K Mouloudi
- Eleni V Massa
- Elie H Zogheib
- Elisa Estenssoro
- Elisabetta Pecci
- Elise P Sauvadet
- Ellada V Kiourtzieva
- Emilio M Osman
- Emma L Willett
- Emre Erbabacan
- Enrique A Piacentini
- Enrique Cereijo
- Erika E Borotto
- Erin Nishikawa
- Esteban Andres
- Esther Bermejo Lopez
- Esther Diaz-Rodriguez
- Ettore R Vascotto
- Eva O Nagy
- Evangelos Kalaitzis
- Evgeny Grigoriev
- Ewan C Goligher
- Fa C Zhou
- Fabien Grelon
- Fabienne D Simonis
- Fabio Tarantino
- Fabrice Daviaud
- Fahd Amir
- Fan Zhang
- Fan Eddy
- Farshad Heidari
- Fayez Kheir
- Fayez M Kheir
- Federico Gordo
- Fekri Abroug
- Felipe A Aliaga
- Felipe T Martinez
- Ferdinando Raimondi
- Fernandes Antero do Vale
- Fernando G George
- Fernando Rios
- Ferran RocheCampo
- Filipa M Barros
- Finn H Andersen
- Flavia A Loiacono
- Francesco L Santoli
- Francesco Mojoli
- Francesco Raponi
- Francis Schneider
- Francisca G Cazorla-Barranquero
- Francisco Esteve
- Francisco Javier Flores Mejia
- Francisco P Huerta
- Francois Beloncle
- Frank van Haren
- Frank van Haren
- Frantz Berkelmans
- Fredrik Schiöler
- Fredy A Montes Oscanoa
- Fredy S Lora
- Fumihito Ito
- Gabriel Démpaire
- Gabrielle C Hanlon
- Gaetan Béduneau
- Galen Henderson
- Garcia M Elisabet
- Gareth P Sellors
- Gattinoni Luciano
- Gautier Buzancais
- Ged Dempsey
- Gemma Rialp
- Gerard Curley
- Ghaleb Almekhlafi
- Ghanem M Mustafa
- Ghassan Kamel
- Giacomo Bellani
- Giacomo Bellani
- Giacomo Monti
- Gianluca Zani
- Giannis A Zacharas
- Gilda Cinnella
- Giorgio A Iotti
- Giovanna Occhipinti
- Giovanna Panarello
- Giulia Crapelli
- Giuseppe Foti
- Gonzalo Navarro
- Gordon Rubenfeld
- Guillaume Barberet
- Guillaume Carteaux
- Guillermo Bugedo
- Guillermo M Albaiceta
- Gustavo A Plotnikow
- Gustavo M Montanha
- Gustavo Pittini
- Gyorgy Frendl
- Haibo Qiu
- Haibo Qiu
- Haitao Liu
- Hamidreza Jamaati
- Hanane Ezzouine
- Hans Kedelv
- HansBernd F Hopf
- Hasan M Al Dorzi
- Hector H Leon Yoshido
- Heera L Mahto
- Heidi Dawson
- Hektor Sula
- Helen E Ellis
- Helen J Rodgers
- Helen S Wong
- Helga Ceunen
- Hellen M van Wezel
- Henrik Appelberg
- Henrik Reschreiter
- Hermann Wrigge
- Hermann Wrigge
- Hernan Aguirre-Bermeo
- Hernan Gianinetto
- Herve Dupont
- Herve Lebbinck
- Hervé O Zender
- Hicham Balkhi
- Hiroki N Maeyama
- Hiroshi Imai
- Hiroyasu Kimura
- Hiroyuki Honda
- Hiroyuki Suzuki
- Hiroyuki Tanaka
- Hitesh Batra
- Hua X Wang
- Huanzhang Shao
- Hui Han
- Huiying Zhao
- Ichiko Mizuguchi
- Iguel Llano
- Ilaria Pattarino
- Ilkay Ceylan
- Imed Chouchene
- Imo Aisiku
- Ingeborg D Welters
- Ingela Nygren
- Irene M Bailey
- Isabel M Serra
- Islem Ouanes
- Istvan Kajtor
- Jack R Richecoeur
- Jacob S Yumha
- Jacques Duranteau
- Jade M Cole
- Jaime E SolisQuesada
- Jakob Gjedsted
- Jan Máca
- Janet S Aguirre
- Jarone Lee
- Jason E Cohen
- Javier Alvarez
- Javier Blanco
- Javier E Salas
- Javier G Alonso
- Javier Hurtado
- Javier Hurtado
- Javier Hurtado
- Jean Dellamonica
- Jean-Daniel Chiche
- Jean-Etienne Herbrecht
- Jean-Michel Arnal
- Jean-Philippe Rigaud
- Jennene J Miller
- Jennifer C Goodson
- Jenny Knoll
- Jens Kraßler
- Jeremy R Beitler
- Jeroen A Schouten
- Jerome Biehler
- Jessica Warren
- Jesús Sánchez-Ballesteros
- Jian Liu
- Jing Kong
- Jing L Liu
- Joan M Lynch
- Joana M Estilita
- Joanna Wessbergh
- Joanne B Robles
- Johan Helleberg
- Johanna E Citalán
- John C Adams
- John G Laffey
- John G Laffey
- John Laffey
- John Neal
- John O Shinn Iii
- Jon Bramall
- Jon H Laake
- Jon Henrik Laake
- Jon P Careless
- Jonas I Rosa
- Jonas Nielsen
- Jonas Nielsen
- Jonathan Casement
- Jonathan Chelly
- Jonathan M Fierro
- Jonathan Messika
- Jordana S Lemus
- Jordi Mancebo
- Jorge Luis Ranero
- Jorge M Monteiro
- Jorge R Sanchez-Medina
- Joris Vermassen
- Jose A Lorente
- Jose Emmanuel Palo
- Josette Gally
- Juan A Buensuseso
- Juan A Buensuseso
- Juan Alfonso Soler
- Juan B López-Messa
- Juan C Lopez-Delgado
- Juan Carlos J Sotillo Diaz
- Juan I Silesky Jimenez
- Juan Silesky
- Juanhong Shen
- Julie Camsooksai
- Julien Marin
- Julio C Badie
- Julio Daldin
- Julius H Cranshaw
- Jun Zhao
- Junping Qin
- Kai Chen
- Kai D Zacharowski
- Kansuke Koyama
- Karen E Williams
- Karin E Eriksson
- Karina Jakubowska
- Karl M Knapman
- Katharina C Riss
- Katie H McCalman
- Katsunori Mochizuki
- Kaushik Bhowmick
- Kazuya Ichikado
- Kazuyoshi Shimizu
- Keiko Ueno
- Keith D Lamb
- Ken Parhar
- Kenichi Nitta
- Kevin Clarkson
- Kevin P Clarkson
- Khalid A Maghrabi
- Kim Andre L Noremark
- Kim S Zantua
- Kiyoyasu Kurahashi
- Kohei Kusumoto
- Kohkichi Andoh
- Koji Saito
- Kong Y Liew
- Kyle G Davies
- Kyle R Dreyer
- Kyoko Shiozaki
- Laffey John G
- Lars Hedlund
- Lars M Broman
- Larsson Anders
- Latha Srinivasa
- Laura Alvarez Montero
- Laura Claverias
- Laura Ortiz-Ruiz de Gordoa
- Laurence Dangers
- Laurent Brochard
- Laurent Papazian
- Leanlove Navarra
- Leda Floris
- Leo M Heunks
- Leo M Heunks
- Leticia Seoane-Quiroga
- Lia McNamee
- Lia McNamee
- Liangyan Jiang
- Linda Twohey
- Ling Liu
- Linnea Persson
- Lisandro R Bettini
- Lise Piquilloud
- Lise Piquilloud
- Long L Ling
- Lordian Nunci
- Loredana Baboi
- Lorente José Angel
- Lorenzo Schiavoni
- Lorraine Stephenson
- Luca Brazzi
- Luca M Montini
- Lucia L Rodriguez
- Lucia Mirabella
- Luciano Cesar Azevedo
- Luciano Gattinoni
- Luis A Sanchez-Hurtado
- Luis D Vega
- Luis E Avila
- Luis Herrera Para
- Luis J Yuste
- Luis M Claraco-Vega
- Luis P Cardonnet
- Lynette Newby
- Ma X Hua
- Mageswaran Sivashanmugavel
- Maizatul Ismail
- Malcolm Sim
- Mandeep Jassal
- Manuel A González Rojas
- Manuel Jibaja
- Manuel P Perez
- Manuel Poblano
- Manuel Poblano
- Manuel Todeschini
- Marc P Buise
- Marcelo Moock
- Marco Botteri
- Marco G Bezzi
- Marco Ranieri
- Marcos Gonzalez
- Marcos Ibañez-Santacruz
- Marcus J Schultz
- Maria C Marin
- Maria C Pintado
- Maria Del Carmen Lorente
- Maria J Bouw
- Maria Jose D Artiga
- Mariano Carboni Bisso
- Mariano G Setten
- Marina A Oikonomou
- Marius Papurica
- Mark J Smith
- Mark R Kol
- Marlus M Thompson
- Martin Dres
- Martin M May
- Mary Elmasri
- María C Imperio
- María G Saenz
- Masayo Izawa
- Massimo M Antonelli
- Mathew B Bailey
- Matias Brizuela
- Matteo Parotto
- Matteo Pozzi
- Matthew G Oldroyd
- Matthew Thomas
- Mauricio Vinzio
- Maurizio Fusari
- Mavy Ramirez Cervantes
- McAuley Daniel F.
- Mehvish Ismail
- Meisy Perez Cheng
- Menekse Ozcelik
- Merete S Dolva
- Messabi Boukhazna
- Metaxia N Papanikolaou
- Michael J Lanspa
- Michael Kalkoff
- Michael N Dean
- Michael Schuetz
- Michela M Poli
- Michela N Vitale
- Michele Umbrello
- Michitaka Nasu
- Miguel Angel Blasco Navalpotro
- Mina Elkhayari
- Miriam Namih
- Miryam PrietoGonzález
- Mohamad M Albarrak
- Mohammed Ghazi
- Mohammedfaruk Memon
- Mohan Gurjar
- Monica Magret
- Monica P Vargas
- Monica Savioli
- Monique M Bruns
- Monique Raaijmakers
- Moreno F Olga
- Mourad Amor
- Muriel Fartoukh
- Mustafa Aker
- Myra Rinia
- Mª Teresa Jurado
- Nacer Samkaoui
- Nagarajan Ramakrishnan
- Nao Okuda
- Nawal Salahuddin
- Necmettin Ünal
- Nedim Cimic
- Nelson C Barros
- Nermin Kelebek Girgin
- Nga T Phan
- Niall D Ferguson
- Nicholas Ioannou
- Nicholas M Mohr
- Nicolas de Prost
- Nicolas Grubissich
- Nicolas Nin
- Nicolas Pelletier
- Nicolas Terzi
- Nicolás G Carreño
- Nicolás Nin
- Nicolò Patroniti
- Nidhi G Huff
- Nieves Franco
- Niklas Larsson
- Nobumasa Aoki
- Noelia N Recio
- Nora N Di Tomasso
- Norberto C Pozo
- Norberto Tiribelli
- Nuala Treanor
- Nuno T Catorze
- Nuttapol Rittayamai
- Oktay Demirkiran
- Olaitan O Ajetunmobi
- Olegs Sabelnikovs
- Oliver Beck
- Oliver Smith
- Olivia A Trinidad
- Onat O Akyol
- Orla Oneill
- Osamu Yamaguchi
- Oscar Penuelas
- Ovidiu H Bedreag
- Owen Boyd
- Pablo E Gomez
- Pablo Lovazzano
- Palazon Sanchez Cesar
- Palazon Sanchez Eugenio Luis
- Pamela A Farías
- Paolo Casalena
- Paolo Formenti
- Pascal Beuret
- Patricio H Garcia
- Patrick Meybohm
- Paul W Woods
- Paula J Hutton
- Pawel Andruszkiewicz
- Pesenti Antonio
- Peter Alexander
- Peter C Hou
- Peter Csabi
- Peter Sklienka
- Peteris Oss
- Pham Tài
- Phil Hopkins
- Philip Watt
- Philipp Simon
- Philippe Burtin
- Philippe J Crova
- Philippe Meersseman
- Philippe Michel
- Philippe R Bauer
- Pierpaolo Terragni
- Pierre A Bulpa
- Pierre-Eric Danin
- PierreLouis M Declercq
- Pieter D Preez
- Pieter Depuydt
- Pieter Depuydt
- Pilar Lora
- Pilar Ricart Aroa Gómez
- Piroska Toth-Tarsoly
- Pravin Amin
- Qiang Xin-Hua
- Qing Q Huang
- Qingchun Yao
- Qingdong Li
- Qiong J Li
- Rachana V Rhayakar
- Radhakrishnan Muthuchellappan
- Raghu Seethala
- Rajeev R Jha
- Ralph Lohner
- Raman Azad
- Ramesh Unnikrishnan
- Ranieri Marco
- Raphael Cooper
- Raquel Montiel González
- Raquel Montoiro Allue
- Raul De Pablo
- Raymond Mckee
- Rebecca M Baro
- Rebecca T Millar
- Renaud M Gueret
- Renhua Sun
- Rhiannon Chapman
- Ricardo Diaz Abad
- Riccardo Colombo
- Richard Stewart
- Rik Verstraete
- Rios Fernando
- Risso V Alejandro
- Rita Glietsch
- Rob Cirone
- Robert J Hessell
- Robert L Owens
- Roberto Jimenez Sanchez
- Roberto R Biscione
- Robyn A Hutchison
- Rocío Manzano Sánchez
- Rodrigo S Biondi
- Rola F Jaafar
- Romain Tapponnier
- Romano Graziani
- Ronald Zumaran Aguilar
- Rongguo Yu
- Rory Dwyer
- Rosa S Alda
- Rosaleen Macfadyen
- Rossini Abbie B Pasanting-Lim
- Ruben O Fernandez
- Ruben Rodriguez
- Rubenfeld Gordon
- Rui M Gomes
- Rui Tang
- Ruiqiang Zheng
- Russel R Miller
- Russell Chabanne
- Russell M Allan
- Ruth O Griffin
- Ryan J Gosselin
- S M Hashemian
- Safal D Sable
- Saira S Gomez-Flores
- Salem Ould Zein
- Sally K Humphreys
- Salma Kamoun
- Salvatore Palmese
- Samantha J Hagan
- Sameer A Jog
- Sami Hraiech
- Samuel M Brown
- Samy Khebbeb
- Sandrine Thibault
- Sangeeta Mehta
- Santhana G Kannan
- Santiago Ilutovich
- Sara De Cima-Iglesias
- Sarah Gillis
- Satar Mortaza
- Satoru Futami
- Satyanarayana Reddy Mukkera
- Savino Spadaro
- Scott H Beegle
- Sebastien L Besset
- Sekine Ryosuke
- Sen-Kuang Hou
- Serena Knowles
- Serge J Heines
- Sergio Canestrini
- Sergio Mataloun
- Sergio Scafetti
- Seyed Mohammadreza Hashemian
- Shailesh Bihari
- Shazia Choudry
- Shigeki Saito
- Shin Nunomiya
- Shou H Wang
- Shreedhar Kulkarni
- Shu H Qin
- Shuhei Matsumoto
- Shunsuke Takagi
- Silvia Castro
- Silvia Iglesias Moles
- Silvia L Nunes
- Silvia Rodriguez Ruiz
- Silvina A Borello
- Silvio A Ñamendys-Silva
- Silvius Ioan Negoita
- Simon K Chau
- Sinead C Okane
- Siu-Ming Au
- Slaheddine Bouchoucha
- Sophie Symmonds
- Souheil Elatrous
- Stefan Bolon
- Stuart Mckechnie
- Subhal B Dixit
- Sudha V Sagar
- Suleyman S Derman
- Suming Zhou
- Suresh Pillai
- Suresh Shindhe
- Susan M Marum
- Susana TempranoSusana
- Susanne Schäfer
- Sylvie Ricome
- Szabolcs Rugonfalvi
- Sánchez I Rafael
- Sébastien Jochmans
- T John Trinder
- Tadaaki Takada
- Takeshi Ueda
- Tamas Szakmany
- Tao Yu
- Tarek Dendane
- Teresa Honrubia
- Tharwat M Aisa
- Theonymfi G Papavasilopoulou
- Thierry Sottiaux
- Thomas Baltus
- Thomas C Blakeman
- Thomas Collyer
- Thomas Kander
- Thomas Staudinger
- Thompson B. Taylor
- Tie H Qin
- Tim Wenham
- Tomas P Roser
- Tomaz MesarJarone Lee
- Tommaso Fossali
- Tomoaki Hashida
- Tomofumi Harasawa
- Tomoyuki Nakamura
- Toni E McKenna
- Toshikazu Abe
- Trevor W Oetting
- Troy S Browne
- Tài Pham
- Tài Pham
- Tài Pham
- Ulrich Strauch
- Ushio Higashijima
- Valeria I Cerrato
- Valerie M Banner-Goodspeed
- Vallish K Bhardwaj
- Vallverdu P Imma
- Van Haren Frank
- Vanessa M Sales
- Vania A Brito
- Varsha Kadaba
- Vasilis Ourailogloy
- Venika Manoharan
- Venkatapura J Ramesh
- Veronica Villar
- Vesna Bumbasierevic
- Vesna Bumbasirevic
- Vijayanand Palaniswamy
- Vincenzo Pota
- Vincenzo Schiavone
- Virginie Lemiale
- Vivek Kakar
- Vladimir Cerny
- Wahid Altaf
- Wajdi Maazouzi
- Wei H Zhu
- Wei Wang
- Weihua Lu
- Wenkui Yu
- Wenwen Li
- William Stigler
- Wrigge Hermann
- Xavier Wittebole
- Xian Y Zhao
- Xiao B Huang
- Xiao L Li
- Xiaoming Luo
- Xing Y Zhang
- Xinyu Li
- Ya Q Wu
- Yaasen Arabi
- Yan Gao
- Yaseen M Arabi
- Yaseen M Arabi
- Yasuaki Ogino
- Yi Han
- Yimin Li
- Yonghao Xu
- Yoshihiro Yamaji
- Yoshinobu Kameyama
- Youssef Haddad
- Youzhong An
- Yozo Kashiwa
- Yu D Di
- Yuan N Gao
- Yuan Y Li
- Yuanhua Lu
- Yves D Jarquin-Badiola
- Zhe Zhai
- Zheng L Ye
- Zhenyang He
- Zhou Li-Xin
- Ángela Algaba
- Ángela González-Salamanca
- Publication venue
- 'European Respiratory Society (ERS)'
- Publication date
- 01/01/2021
- Field of study
Background: Current incidence and outcome of patients with acute hypoxaemic respiratory failure requiring mechanical ventilation in the intensive care unit (ICU) are unknown, especially for patients not meeting criteria for acute respiratory distress syndrome (ARDS).
Methods: An international, multicentre, prospective cohort study of patients presenting with hypoxaemia early in the course of mechanical ventilation, conducted during four consecutive weeks in the winter of 2014 in 459 ICUs from 50 countries (LUNG SAFE). Patients were enrolled with arterial oxygen tension/inspiratory oxygen fraction ratio ≤300 mmHg, new pulmonary infiltrates and need for mechanical ventilation with a positive end-expiratory pressure of ≥5 cmH2O. ICU prevalence, causes of hypoxaemia, hospital survival and factors associated with hospital mortality were measured. Patients with unilateral versus bilateral opacities were compared.
Findings: 12 906 critically ill patients received mechanical ventilation and 34.9% with hypoxaemia and new infiltrates were enrolled, separated into ARDS (69.0%), unilateral infiltrate (22.7%) and congestive heart failure (CHF; 8.2%). The global hospital mortality was 38.6%. CHF patients had a mortality comparable to ARDS (44.1% versus 40.4%). Patients with unilateral-infiltrate had lower unadjusted mortality, but similar adjusted mortality compared to those with ARDS. The number of quadrants on chest imaging was associated with an increased risk of death. There was no difference in mortality comparing patients with unilateral-infiltrate and ARDS with only two quadrants involved.
Interpretation: More than one-third of patients receiving mechanical ventilation have hypoxaemia and new infiltrates with a hospital mortality of 38.6%. Survival is dependent on the degree of pulmonary involvement whether or not ARDS criteria are reached
Mechanical ventilation in patients with cardiogenic pulmonary edema: a sub-analysis of the LUNG SAFE study
- Author
- Abad Ricardo,
- Abe Toshikazu
- Abroug Fekri
- Adams John,
- Adamsson Richard,
- Adolfsson Anne
- Aguilar Ronald,
- Aguirre Janet,
- Aguirre-Bermeo Hernan
- Aisa Tharwat,
- Aisiku Imo
- Ajetunmobi Olaitan,
- Aker Mustafa
- Akyol Onat,
- Al Dorzi Hasan,
- Albaiceta Guillermo,
- Albaiceta Guillermo,
- Albarrak Mohamad,
- Albiero Daniela
- Alda Rosa,
- Alejandro Risso,
- Alexander Peter
- Alfonso Alec,
- Algaba Ángela
- Aliaga Felipe,
- Alisasis Alain,
- Aljabbary Ahmed,
- Allan Russell,
- Allue Raquel,
- Almekhlafi Ghaleb
- Alonso Javier,
- Altaf Wahid
- Alvarez António,
- Alvarez Javier
- Amado-Rodríguez Laura
- Amin Pravin
- Amir Fahd
- Amor Mourad
- An Youzhong
- Andersen Finn,
- Andoh Kohkichi
- Andruszkiewicz Pawel
- Aneman Anders
- Antonelli Massimo,
- Antônio Ana,
- Aoki Nobumasa
- Appelberg Henrik
- Arabi Yaasen
- Arabi Yaseen,
- Arabi Yaseen,
- Araujo Ana,
- Arizmendi Alfons
- Arnal Jean-Michel
- Artiga Maria,
- Artigas Antonio
- Ascoli Aline
- Avila Luis,
- Azad Raman
- Azevedo Luciano,
- Baboi Loredana
- Badie Julio,
- Bailey Irene,
- Bailey Mathew,
- Bajwa Ed
- Balkhi Hicham
- Baltus Thomas
- Bannergoodspeed Valerie,
- Barberet Guillaume
- Baro Rebecca,
- Baronia Arvind,
- Barratt-Due Andreas
- Barros Filipa,
- Barros Nelson,
- Batra Hitesh
- Battle Ceri,
- Bauer Philippe,
- Beck Eduardo
- Beck Oliver
- Bedreag Ovidiu,
- Beegle Scott,
- Beitler Jeremy,
- Bellani Giacomo
- Beloncle Francois
- Benslama Abdellatif
- Beraldo Daniel,
- Berghe Caroline
- Berkelmans Frantz
- Besset Sebastien,
- Bettini Lisandro,
- Beuret Pascal
- Bezzi Marco,
- Bhardwaj Vallish,
- Bhowmick Kaushik
- Biehler Jerome
- Bigot Charlene
- Bihari Shailesh
- Binhjabul Wahab Ahmad,
- Biondi Rodrigo,
- Biscione Roberto,
- Bisso Mariano,
- Black Colin,
- Blakeman Thomas,
- Blanco Javier
- Bolon Stefan
- Borello Silvina,
- Borotto Erika,
- Botteri Marco
- Bouchoucha Slaheddine
- Boukhazna Messabi
- Bouw Maria,
- Boyd Owen
- Bramall Jon
- Braschi Antonio
- Brazzi Luca
- Breen Dorothy,
- Briquet Anais
- Brito Vania,
- Brizuela Matias
- Brochard Laurent
- Broman Lars,
- Brown Samuel,
- Browne Troy,
- Bruhn Alejandro,
- Brunettini Barbara
- Bruns Monique,
- Buensuseso Juan,
- Bugedo Guillermo
- Buise Marc,
- Bulpa Pierre,
- Bumbasierevic Vesna
- Bumbasirevic Vesna
- Burtenshaw Andrew,
- Burtin Philippe
- Buzancais Gautier
- Béduneau Gaetan
- Camsooksai Julie
- Canestrini Sergio
- Cani Alma
- Carbayo-Gorriz Cecilia
- Cardonnet Luis,
- Careless Jon,
- Carpentier Dorothée
- Carreño Nicolás,
- Carteaux Guillaume
- Casalena Paolo
- Casement Jonathan
- Castro Alejandro,
- Castro Silvia
- Catorze Nuno,
- Cazorla-Barranquero Francisca,
- Ceniceros-Barros Alexandra
- Cereijo Enrique
- Cerny Vladimir
- Cerrato Valeria,
- Cervantes Mavy,
- Cesar Palazon,
- Ceunen Helga
- Ceylan Ilkay
- Chabanne Russell
- Chapman Rhiannon
- Chau Simon,
- Chelly Jonathan
- Chen Kai
- Chena Ariel
- Cheng Meisy,
- Chiche Jean-Daniel
- Chouchene Imed
- Choudry Shazia
- Christiansen Aage
- Cimic Nedim
- Cinnella Gilda
- Cirone Rob
- Citalán Johanna,
- Claraco-Vega Luis,
- Clarkson Kevin
- Clarkson Kevin,
- Claverias Laura
- Cohen Jason,
- Cole Jade,
- Collins Daniel,
- Collyer Thomas
- Colombo Riccardo
- Combaux Daniele,
- Combes Alain
- Cooper Raphael
- Coppadoro Andrea
- Corneci Dan,
- Cortegiani Andrea
- Cortez Cesar,
- Coxo Cristina,
- Cracchiolo Andrea,
- Cranshaw Julius,
- Crapelli Giulia
- Crouch Daniel,
- Crouch Daniel,
- Crova Philippe,
- Csabi Peter
- Curley Gerard
- Curto Elena,
- Daldin Julio
- Dangers Laurence
- Danin Pierre-Eric
- Daubin Cédric
- Daviaud Fabrice
- Davies Kyle,
- Dawson Heidi
- de Cima-Iglesias Sara
- de Gordoa Laura Ortiz-Ruiz
- de Haro Candelaria
- de Pablo Raul
- de Prost Nicolas
- Dean Michael,
- Declercq Pierrelouis,
- Dector Dulce
- Deicas Alberto
- del Carmenlorente Maria
- Dellamonica Jean
- Dellera Christian
- Delsing Angela
- Demirkiran Oktay
- Demoule Alexandre
- Dempsey Ged
- Dendane Tarek
- Depuydt Pieter
- Depuydt Pieter
- Derman Suleyman,
- Di Tomasso Nora,
- Di Yu,
- Diaz Juan,
- Diaz-Rodriguez Esther
- Dive Alain,
- Dixit Subhal,
- Do Vale Fernandes Antero
- Dolva Merete,
- Donnelly Adrian
- Dowling Anna,
- Doyen Denis
- Dres Martin
- Dreyer Kyle,
- Dunne Eimhin,
- Dupont Herve
- Duranteau Jacques
- Dwyer Rory
- Démpaire Gabriel
- Ebeid Alejandro
- Elatrous Souheil
- Elisabet Garcia,
- Elkhayari Mina
- Ellis Helen,
- Elmasri Mary
- Erbabacan Emre
- Eriksson Karin,
- Esteban Andres
- Estenssoro Elisa
- Esteve Francisco
- Estilita Joana,
- Estrella Claudia,
- Ezzouine Hanane
- Fan Eddy
- Fartoukh Muriel
- Farías Pamela,
- Fawkes Danielle,
- Ferguson Andrew
- Ferguson Niall,
- Fernandez Adriana,
- Fernandez Ruben,
- Fierro Jonathan,
- Floris Leda
- Follin Arnaud
- Fontenele Danielle,
- Formenti Paolo
- Forteza Catalina
- Fossali Tommaso
- Foti Giuseppe
- Franco Nieves
- França Ana,
- Frati Elena
- Frendl Gyorgy
- Frigyik Aniko,
- Fusari Maurizio
- Futami Satoru
- Gally Josette
- Ganesan Deeban
- Gao Yan
- Gao Yuan,
- Garcia Patricio,
- Gattinoni Luciano
- Gazenkampf Andrey,
- Gelée Bruno
- George Fernando,
- Ghazi Mohammed
- Gianinetto Hernan
- Giarratano Antonino
- Gillis Sarah
- Girgin Nermin,
- Gjedsted Jakob
- Glietsch Rita
- Goldgran-Toledano Dany
- Goligher Ewan,
- Gomaa Dina
- Gomaa Dina
- Gomes Rui,
- Gomez Pablo,
- Gomez-Flores Saira,
- Gonzalez Daniel,
- Gonzalez Marcos
- González Raquel,
- González-Salamanca Ángela
- Gonçalves Claudio,
- Goodson Jennifer,
- Gordo Federico
- Gosselin Ryan,
- Goubaux Bernard
- Graziani Romano
- Grelon Fabien
- Griffin Ruth,
- Grigoriev Evgeny
- Grissom Colin,
- Gritsan Alexey,
- Grubissich Nicolas
- Gueret Renaud,
- Gurjar Mohan
- Guttormsen Anne,
- Guérin Claude
- Gómez Pilar,
- Hacking Danielle,
- Haddad Youssef
- Hadfield Dan
- Hagan Samantha,
- Han Hui
- Han Yi
- Hang Ai,
- Hanlon Gabrielle,
- Harasawa Tomofumi
- Harrois Anatole
- Hashemian S,
- Hashemian Seyed,
- Hashida Tomoaki
- He Zhenyang
- Hedlund Lars
- Heidari Farshad
- Heines Serge,
- Helleberg Johan
- Henderson Galen
- Herbrecht Jean-Etienne
- Hermosa Cecilia
- Hessell Robert,
- Heunks Leo,
- Heunks Leo,
- Higashijima Ushio
- Hirata Akira
- Holzgraefe Bernhard
- Honda Hiroyuki
- Honrubia Teresa
- Hopf Hansbernd,
- Hopkins Phil
- Hormis Anil,
- Hou Peter,
- Hou Sen-Kuang
- Hraiech Sami
- Hua Ma,
- Huang Qing,
- Huang Xiao,
- Huerta Francisco,
- Huff Nidhi,
- Humphreys Sally,
- Hunt Anna
- Hurtado Javier
- Hurtado Javier
- Hurtado Javier
- Hutchison Robyn,
- Hutton Paula,
- Ibañez-Santacruz Marcos
- Ichikado Kazuya
- Ilutovich Santiago
- Imai Hiroshi
- Imma Vallverdu,
- Imperio María,
- Insaurralde Carolina,
- Inskip Deborah,
- Ioannou Nicholas
- Iotti Giorgio,
- Irvine Donald,
- Isidro San
- Ismail Dina
- Ismail Maizatul
- Ismail Mehvish
- Ito Fumihito
- Izawa Masayo
- Jaafar Rola,
- Jakubowska Karina
- Jamaati Hamidreza
- Jarquin-Badiola Yves,
- Jassal Mandeep
- Javeed Areej
- Jha Rajeev,
- Jiang Liangyan
- Jibaja Manuel
- Jimenez Antonio,
- Jimenez Juan,
- Jochmans Sébastien
- Jog Sameer,
- Jovanovic Bojan
- Judy Claine
- Jurado M,
- Kadaba Varsha
- Kajtor Istvan
- Kakar Vivek
- Kalaitzis Evangelos
- Kalkoff Michael
- Kamel Ghassan
- Kameyama Yoshinobu
- Kamoun Salma
- Kander Thomas
- Kannan Santhana,
- Kashiwa Yozo
- Kedelv Hans
- Kennedy Barry
- Khebbeb Samy
- Kheir Fayez
- Kheir Fayez,
- Kimura Hiroyasu
- Kiourtzieva Ellada,
- Kitch Barrett,
- Knapman Karl,
- Knoll Jenny
- Knowles Serena
- Kol Mark,
- Kong Jing
- Koyama Kansuke
- Kraßler Jens
- Krstevski Amanda
- Kulkarni Shreedhar
- Kumar Alek
- Kurahashi Kiyoyasu
- Kusumoto Kohei
- Laake Jon,
- Laake Jon,
- Labarca Eduardo,
- Laffey John,
- Laffey John,
- Lamb Keith,
- Lanspa Michael,
- Larsson Anders
- Larsson Anders
- Larsson Niklas
- Las Lomas Sanatorio
- Le Moal Charlene
- Lebbinck Herve
- Lee Jarone
- Leemann-Refondini Corinne
- Lemiale Virginie
- Lemus Jordana,
- Leonyoshido Hector,
- Li Bin
- Li Qingdong
- Li Qiong,
- Li Wenwen
- Li Xiao,
- Li Xinyu
- Li Yimin
- Li Yuan,
- Li-Xin Zhou
- Liew Kong,
- Ling Long,
- Liu Haitao
- Liu Jian
- Liu Jing,
- Liu Ling
- Llano Iguel
- Lohner Ralph
- Loiacono Flavia,
- Lombardo Andrea
- Lopez Esther,
- Lopez-Delgado Juan,
- Lora Fredy,
- Lora Pilar
- Lorente Jose,
- Losada Elena,
- Lovazzano Pablo
- Lu Weihua
- Lu Yuanhua
- Luis Palazon,
- Luo Xiaoming
- Lynch Joan,
- López-Messa Juan,
- Maazouzi Wajdi
- Macfadyen Rosaleen
- Macfie Caroline,
- Madotto Fabiana
- Maeyama Hiroki,
- Maghrabi Khalid,
- Magret Monica
- Mahto Heera,
- Mancebo Jordi
- Manoharan Venika
- Marcos Diego,
- Marcu Alexandra
- Marin Julien
- Marin Maria,
- Martinez Felipe,
- Martinho Aurelia,
- Marum Susan,
- Massa Eleni,
- Mataloun Sergio
- Matamis Dimitrios
- Matsumoto Shuhei
- Mattei Alessia
- May Martin,
- Mcarthur Colin
- Mcauley Daniel,
- Mcauley Daniel,
- Mcauley Danny
- Mccalman Katie,
- Mckechnie Stuart
- Mckee Raymond
- Mckenna Toni,
- Mcleod Alex
- Mcnamee Lia
- Mcnamee Lia
- Meaney Edel,
- Meco Basak,
- Meersseman Philippe
- Mehta Sangeeta
- Mejia Francisco,
- Mellis Clare
- Memon Mohammedfaruk
- Mercat Alain
- Mesar Tomaz
- Messias António,
- Messika Jonathan
- Meybohm Patrick
- Michel Philippe
- Millar Rebecca,
- Miller Jennene,
- Miller Russel,
- Mirabella Lucia
- Mizuguchi Ichiko
- Mochizuki Katsunori
- Mohr Nicholas,
- Mojoli Francesco
- Moles Silvia,
- Molin Alexandre
- Montanha Gustavo,
- Monteiro Jorge,
- Montero Laura,
- Monti Giacomo
- Montini Luca,
- Moock Marcelo
- Morin Anna-Karin
- Mortaza Satar
- Morton Alex
- Mouloudi Eleni,
- Moya David,
- Mukkera Satyanarayana,
- Mustafa Ghanem,
- Muthuchellappan Radhakrishnan
- Máca Jan
- Nagy Eva,
- Nakamura Tomoyuki
- Namih Miriam
- Nassar Jr Antonio,
- Nasu Michitaka
- Navalpotro Miguel,
- Navarra Leanlove
- Navarro Gonzalo
- Neal John
- Negoita Silvius,
- Newby Lynette
- Nichol Alistair
- Nielsen Jonas
- Nielsen Jonas
- Niimi Daisuke
- Nin Nicolas
- Nin Nicolás
- Nishikawa Erin
- Nitta Kenichi
- Nobrega Danielle
- Noremark Kim,
- Nunci Lordian
- Nunes Silvia,
- Nunomiya Shin
- Nutt Christopher
- Nuñez Edgardo
- Nygren Ingela
- Occhipinti Giovanna
- Oetting Trevor,
- Ogino Yasuaki
- Oikonomou Marina,
- Okane Sinead,
- Okuda Nao
- Oldroyd Matthew,
- Olga Moreno,
- Oliveira Bruno,
- Oneill Orla
- Ortiz Claudia,
- Oscanoa Fredy,
- Osman Emilio,
- Oss Peteris
- Ouanes Islem
- Ourailogloy Vasilis
- Owens Robert,
- Ozcelik Menekse
- O’croinin Donall
- O’muircheartaigh Aogan,
- Palaniswamy Vijayanand
- Palma Daniela,
- Palmese Salvatore
- Palo Jose,
- Panarello Giovanna
- Papanikolaou Metaxia,
- Papavasilopoulou Theonymfi,
- Papazian Laurent
- Papurica Marius
- Para Luis,
- Parhar Ken
- Parotto Matteo
- Pasanting-Lim Rossini,
- Patroniti Nicolò
- Pattarino Ilaria
- Pecci Elisabetta
- Pellegrini Carlos,
- Pelletier Nicolas
- Pellicer Ana,
- Penuelas Oscar
- Pereira Carlos,
- Perez Cesar,
- Perez Manuel,
- Persson Linnea
- Pesenti Antonio
- Pham Tài
- Phan Nga,
- Piacentini Enrique,
- Pillai Suresh
- Pintado Maria,
- Piquilloud Lise
- Piras Claudio
- Pittini Gustavo
- Plotnikow Gustavo,
- Poblano Manuel
- Poli Michela,
- Pota Vincenzo
- Pozo Norberto,
- Pozzi Matteo
- Preez Pieter,
- Prietogonzález Miryam
- Pronovost Antoine
- Protti Alessandro
- Qin Bingyu
- Qin Junping
- Qin Shu,
- Qin Tie,
- Qiu Haibo
- Qiu Haibo
- Raaijmakers Monique
- Rafael Sánchez,
- Raimondi Ferdinando
- Raj Ashok,
- Ramakrishnan Nagarajan
- Ramesh Venkatapura,
- Ramirez-Alfaro Christian,
- Ramirez-Gutierrez Alvaro
- Rampinelli Adenilton,
- Ranero Jorge,
- Ranieri Marco
- Raponi Francesco
- Recio Noelia,
- Reschreiter Henrik
- Reske Andreas,
- Reuter Danielle
- Reynolds Claire
- Rhayakar Rachana,
- Rialp Gemma
- Richecoeur Jack,
- Ricome Sylvie
- Rigaud Jean-Philippe
- Rinia Myra
- Rios Fernando
- Riss Katharina,
- Rittayamai Nuttapol
- Roberts Brigit,
- Robine Adrien
- Robles Joanne,
- Rochecampo Ferran
- Rodgers Helen,
- Rodriguez Lucia,
- Rodriguez Ruben
- Rodríguez-Garcia Raquel
- Rojas Alejandro
- Rojas Manuel,
- Rosa Jonas,
- Roser Tomas,
- Rossi Anna
- Roux Damien
- Rubenfeld Gordon
- Rugonfalvi Szabolcs
- Ruiz Silvia,
- Ruizaguilar Antonio,
- Rylander Christian,
- Ryosuke Sekine
- Sabelnikovs Olegs
- Sable Safal,
- Saenz María,
- Saez Alejandro,
- Sagar Sudha,
- Saito Koji
- Saito Shigeki
- Salahuddin Nawal
- Salas Javier,
- Sales Vanessa,
- Samkaoui Nacer
- Sanchez Roberto,
- Sanchez-Hurtado Luis,
- Sanchez-Medina Jorge,
- Sandesc Dorel
- Santoli Francesco,
- Santos Cristina
- Sauvadet Elise,
- Savioli Monica
- Scafetti Sergio
- Schiavone Vincenzo
- Schiavoni Lorenzo
- Schiöler Fredrik
- Schlichting Adam,
- Schneider Francis
- Schomer Ashley
- Schouten Jeroen,
- Schuetz Michael
- Schultz Marcus,
- Schäfer Susanne
- Scott Christopher,
- Seasman Colette
- Seethala Raghu
- Sellors Gareth,
- Seoane-Quiroga Leticia
- Serra Carolina
- Serra Isabel,
- Setten Mariano,
- Seven Aylin
- Shah Bhagyesh
- Shao Huanzhang
- Shen Juanhong
- Shenoy Anitha
- Sher Sara
- Shimizu Kazuyoshi
- Shindhe Suresh
- Shinn Iii John,
- Shiozaki Kyoko
- Silesky Juan
- Sim Malcolm
- Simon Philipp
- Simonis Fabienne,
- Sivashanmugavel Mageswaran
- Sjøbø Brit,
- Sklienka Peter
- Slutsky Arthur,
- Smith Mark,
- Smith Oliver
- Soler Juan,
- Solisquesada Jaime,
- Sottiaux Thierry
- Souissi Asma,
- Spadaro Savino
- Srinivasa Latha
- Stamou Electra,
- Staudinger Thomas
- Stephenson Lorraine
- Stewart Richard
- Stigler William
- Strauch Ulrich
- Sula Hektor
- Sun Renhua
- Suzuki Hiroyuki
- Symmonds Sophie
- Szakmany Tamas
- Sánchez Rocío,
- Sánchez-Ballesteros Jesús
- Søreide Eldar
- Tabhan Edgardo
- Tabhan Edgardo,
- Tainter Christopher
- Takaba Akihiro
- Takada Tadaaki
- Takagi Shunsuke
- Tan Beatriz,
- Tanaka Hiroyuki
- Tang Rui
- Tapponnier Romain
- Tarantino Fabio
- Taylor Thompson B
- Temprano Susana
- Terragni Pierpaolo
- Terzi Nicolas
- Thibault Sandrine
- Thomas Matthew
- Thompson Marlus,
- Tibblin Anna,
- Tinnirello Andrea
- Tiribelli Norberto
- Todeschini Manuel
- Tomescu Dana,
- Toribio Dácil,
- Toth-Tarsoly Piroska
- Treanor Nuala
- Trinder T,
- Trinidad Olivia,
- Tulaimat Aiman
- Twohey Linda
- Uchiyama Akinori
- Ueda Takeshi
- Ueno Keiko
- Umbrello Michele
- Unnikrishnan Ramesh
- Uppalapati Aditya
- van Haren Frank
- van Haren Frank
- van Wezel Hellen,
- Vargas Monica,
- Vascotto Ettore,
- Vasquez Daniela,
- Vega Luis,
- Venti Aaron
- Vercueil Andre
- Vermassen Joris
- Verstraete Rik
- Villagomez Asisclo
- Villagomez Asisclo,
- Villamagua Boris,
- Villar Veronica
- Vinzio Mauricio
- Virgilio Corcoles,
- Vitale Michela,
- Volta Carlo,
- Wang Chunting
- Wang Hua,
- Wang Shou,
- Wang Wei
- Warren Jessica
- Watanabe Eizo
- Watt Philip
- Welters Ingeborg,
- Wenham Tim
- Wessbergh Joanna
- Whitehead Christina
- Willett Emma,
- Williams Alexandra,
- Williams Karen,
- Wittebole Xavier
- Wong Helen,
- Woods Paul,
- Wrathall David,
- Wrigge Hermann
- Wrigge Hermann
- Wu Ya,
- Xin-Hua Qiang
- Xu Yonghao
- Yamaguchi Osamu
- Yamaji Yoshihiro
- Yao Qingchun
- Ye Zheng,
- Yeatts Dale,
- Yu Rongguo
- Yu Tao
- Yu Wenkui
- Yumha Jacob,
- Yuste Luis,
- Zacharas Giannis,
- Zacharowski Kai,
- Zani Gianluca
- Zantua Charing,
- Zazu Alan
- Zeggwagh Amine,
- Zeggwagh Amine,
- Zein Salem,
- Zender Hervé,
- Zhai Zhe
- Zhang Fan
- Zhang Xing,
- Zhao Huiying
- Zhao Jun
- Zhao Xian,
- Zheng Ruiqiang
- Zhou Fa,
- Zhou Suming
- Zhu Bao,
- Zhu Wei,
- Zogheib Elie,
- Ñamendys-Silva Silvio,
- Ünal Necmettin
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 25/12/2022
- Field of study
International audienceBackground: Patients with acute respiratory failure caused by cardiogenic pulmonary edema (CPE) may require mechanical ventilation that can cause further lung damage. Our aim was to determine the impact of ventilatory settings on CPE mortality. Methods: Patients from the LUNG SAFE cohort, a multicenter prospective cohort study of patients undergoing mechanical ventilation, were studied. Relationships between ventilatory parameters and outcomes (ICU discharge/ hospital mortality) were assessed using latent mixture analysis and a marginal structural model. Results: From 4499 patients, 391 meeting CPE criteria (median age 70 [interquartile range 59-78], 40% female) were included. ICU and hospital mortality were 34% and 40%, respectively. ICU survivors were younger (67 [57-77] vs 74 [64-80] years, p < 0.001) and had lower driving (12 [8-16] vs 15 [11-17] cmH 2 O, p < 0.001), plateau (20 [15-23] vs 22 [19-26] cmH 2 O, p < 0.001) and peak (21 [17-27] vs 26 [20-32] cmH 2 O, p < 0.001) pressures. Latent mixture analysis of patients receiving invasive mechanical ventilation on ICU day 1 revealed a subgroup ventilated with high pressures with lower probability of being discharged alive from the ICU (hazard ratio [HR] 0.79 [95% confidence interval 0.60-1.05], p = 0.103) and increased hospital mortality (HR 1.65 [1.16-2.36], p = 0.005). In a marginal structural model, driving pressures in the first week (HR 1.12 [1.06-1.18], p < 0.001) and tidal volume after day 7 (HR 0.69 [0.52-0.93], p = 0.015) were related to survival. Conclusions: Higher airway pressures in invasively ventilated patients with CPE are related to mortality. These patients may be exposed to an increased risk of ventilator-induced lung injury
Mechanical ventilation in patients with cardiogenic pulmonary edema: a sub-analysis of the LUNG SAFE study
- Author
- Abad Ricardo Diaz
- Abe Toshikazu
- Abroug Fekri
- Adams John C.
- Adamsson Richard O.
- Adolfsson Anne
- Aguilar Ronald Zumaran
- Aguirre Janet S.
- Aguirre-Bermeo Hernan
- Aisa Tharwat M.
- Aisiku Imo
- Ajetunmobi Olaitan O.
- Aker Mustafa
- Akyol OnatO
- Al Dorzi Hasan M.
- Albaiceta
- Albaiceta GuillermoM
- Albarrak Mohamad M.
- Albiero Daniela
- Alda Rosa S.
- Alejandro Risso V.
- Alexander Peter
- Alfonso Alec A. Tallet
- Algaba Ángela
- Aliaga Felipe A.
- Alisasis Alain U.
- AlJabbary AhmedS
- Allan Russell M
- Allue Raquel Montoiro
- Almekhlafi Ghaleb
- Alonso Javier G.
- Altaf Wahid
- Alvarez António M.
- Alvarez Javier
- Amado-Rodríguez Laura
- Amin Pravin
- Amir Fahd
- Amor Mourad
- An Youzhong
- Andersen Finn H.
- Andoh Kohkichi
- Andruszkiewicz Pawel
- Aneman Anders
- Antonelli Massimo M.
- Antônio Ana Carolina P.
- Aoki Nobumasa
- Appelberg Henrik
- Arabi Yaasen
- Arabi Yaseen M.
- Arabi YaseenM
- Araujo AnaM
- Arizmendi Alfons
- Arnal Jean-Michel
- Artiga Maria Jose D.
- Artigas Antonio
- Ascoli Aline
- Avila Luis E.
- Azad Raman
- Azevedo Luciano Cesar
- Baboi Loredana
- Badie Julio C.
- Bailey Irene M.
- Bailey Mathew B.
- Bajwa Ed
- Balkhi Hicham
- Baltus Thomas
- BannerGoodspeed Valerie M.
- Barberet Guillaume
- Baro Rebecca M.
- Baronia Arvind K.
- Barratt-Due Andreas
- Barros Filipa M.
- Barros Nelson C.
- Batra Hitesh
- Battle Ceri E.
- Bauer Philippe R.
- Beck Eduardo
- Beck Oliver
- Bedreag Ovidiu H.
- Beegle Scott H.
- Beitler Jeremy R.
- Bellani Giacomo
- Beloncle Francois
- Benslama Abdellatif
- Beraldo Daniel O.
- Berghe Caroline
- Berkelmans Frantz
- Besset Sebastien L.
- Bettini Lisandro R.
- Beuret Pascal
- Bezzi Marco G.
- Bhardwaj VallishK
- Bhowmick Kaushik
- Biehler Jerome
- Bigot Charlene
- Bihari Shailesh
- BinHJAbul Wahab Ahmad Yazid
- Biondi Rodrigo S.
- Biscione RobertoR
- Bisso Mariano Carboni
- Black ColinS
- Blakeman Thomas C.
- Blanco Javier
- Bolon Stefan
- Borello Silvina A.
- Borotto Erika E.
- Botteri Marco
- Bouchoucha Slaheddine
- Boukhazna Messabi
- Bouw Maria J.
- Boyd Owen
- Bramall Jon
- Braschi Antonio
- Brazzi Luca
- Breen Dorothy M.
- Briquet Anais
- Brito Vania A.
- Brizuela Matias
- Brochard Laurent
- Broman Lars M
- Brown SamuelM
- Browne Troy S.
- Bruhn Alejandro R.
- Brunettini Barbara
- Bruns Monique M.
- Buensuseso Juan A.
- Bugedo Guillermo
- Buise Marc P.
- Bulpa Pierre A.
- Bumbasierevic Vesna
- Bumbasirevic Vesna
- Burtenshaw Andrew J.
- Burtin Philippe
- Buzancais Gautier
- Béduneau Gaetan
- Camsooksai Julie
- Canestrini Sergio
- Cani Alma
- Carbayo-Gorriz Cecilia
- Cardonnet Luis P.
- Careless Jon P.
- Carpentier Dorothée
- Carreño Nicolás G.
- Carteaux Guillaume
- Casalena Paolo
- Casement Jonathan
- Castro Alejandro G.
- Castro Silvia
- Catorze NunoT
- Cazorla-Barranquero Francisca G.
- Ceniceros-Barros Alexandra
- Cereijo Enrique
- Cerny Vladimir
- Cerrato Valeria I.
- Cervantes Mavy Ramirez
- Cesar Palazon Sanchez
- Ceunen Helga
- Ceylan Ilkay
- Chabanne Russell
- Chapman Rhiannon
- Chau SimonK
- Chelly Jonathan
- Chen Kai
- Chena Ariel
- Cheng Meisy Perez
- Chiche Jean-Daniel
- Chouchene Imed
- Choudry Shazia
- Christiansen Aage
- Cimic Nedim
- Cinnella Gilda
- Cirone Rob
- Citalán Johanna E.
- Claraco-Vega LuisM
- Clarkson Kevin
- Clarkson Kevin P.
- Claverias Laura
- Cohen Jason E.
- Cole JadeM
- Collins Daniel V.
- Collyer Thomas
- Colombo Riccardo
- Combaux DanieleM
- Combes Alain
- Cooper Raphael
- Coppadoro Andrea
- Corneci Dan E.
- Cortegiani Andrea
- Cortez Cesar A.
- Coxo Cristina M.
- Cracchiolo Andrea N.
- Cranshaw JuliusH
- Crapelli Giulia
- Crouch Daniel R.
- Crouch Daniel R.
- Crova Philippe J.
- Csabi Peter
- Curley Gerard
- Curto Elena Gallego
- Daldin Julio
- Dangers Laurence
- Danin Pierre-Eric
- Daubin Cédric
- Daviaud Fabrice
- Davies Kyle G.
- Dawson Heidi
- De Cima-Iglesias Sara
- de Gordoa Laura Ortiz-Ruiz
- De Haro Candelaria
- De Pablo Raul
- de Prost Nicolas
- Dean MichaelN
- Declercq PierreLouis M.
- Dector Dulce
- Deicas Alberto
- del CarmenLorente Maria
- Dellamonica Jean
- Dellera Christian
- Delsing Angela
- Demirkiran Oktay
- Demoule Alexandre
- Dempsey Ged
- Dendane Tarek
- Depuydt Pieter
- Depuydt Pieter
- Derman SuleymanS
- Di Tomasso Nora N.
- Di Yu D.
- Diaz Juan Carlos J. Sotillo
- Diaz-Rodriguez Esther
- Dive Alain M.
- Dixit Subhal B.
- do Vale Fernandes Antero
- Dolva Merete S.
- Donnelly Adrian
- Dowling AnnaT
- Doyen Denis
- Dres Martin
- Dreyer Kyle R.
- Dunne EimhinS
- Dupont Herve
- Duranteau Jacques
- Dwyer Rory
- Démpaire Gabriel
- Ebeid Alejandro
- Elatrous Souheil
- Elisabet Garcia M.
- Elkhayari Mina
- Ellis HelenE
- Elmasri Mary
- Erbabacan Emre
- Eriksson KarinE
- Esteban Andres
- Estenssoro Elisa
- Esteve Francisco
- Estilita Joana M.
- Estrella Claudia R.
- Ezzouine Hanane
- Fan Eddy
- Fartoukh Muriel
- Farías Pamela A.
- Fawkes Danielle A.
- Ferguson Andrew
- Ferguson Niall D.
- Fernandez Adriana M.
- Fernandez Ruben O.
- Fierro Jonathan M.
- Floris Leda
- Follin Arnaud
- Fontenele Danielle C.
- Formenti Paolo
- Forteza Catalina
- Fossali Tommaso
- Foti Giuseppe
- Franco Nieves
- França Ana G
- Frati Elena
- Frendl Gyorgy
- Frigyik Aniko D.
- Fusari Maurizio
- Futami Satoru
- Gally Josette
- Ganesan Deeban
- Gao Yan
- Gao Yuan N.
- Garcia Patricio H.
- Gattinoni Luciano
- Gazenkampf Andrey A.
- Gelée Bruno
- George Fernando G.
- Ghazi Mohammed
- Gianinetto Hernan
- Giarratano Antonino
- Gillis Sarah
- Girgin Nermin Kelebek
- Gjedsted Jakob
- Glietsch Rita
- Goldgran-Toledano Dany
- Goligher Ewan C.
- Gomaa Dina
- Gomes Rui M.
- Gomez Pablo E.
- Gomez-Flores Saira S.
- Gonzalez Daniel R.
- Gonzalez Marcos
- González Raquel Montiel
- González-Salamanca Ángela
- Gonçalves Claudio H.
- Goodson Jennifer C.
- Gordo Federico
- Gosselin Ryan J.
- Goubaux Bernard
- Graziani Romano
- Grelon Fabien
- Griffin Ruth O.
- Grigoriev Evgeny
- Grissom ColinK
- Gritsan Alexey I.
- Grubissich Nicolas
- Gueret Renaud M.
- Guillermo M
- Gurjar Mohan
- Guttormsen AnneB
- Guérin Claude
- Gómez Pilar Ricart Aroa
- Hacking DanielleJ
- Haddad Youssef
- Hadfield Dan
- Hagan SamanthaJ
- Han Hui
- Han Yi
- Hang Ai Y.
- Hanlon Gabrielle C.
- Harasawa Tomofumi
- Harrois Anatole
- Hashemian S. M.
- Hashemian Seyed Mohammadreza
- Hashida Tomoaki
- He Zhenyang
- Hedlund Lars
- Heidari Farshad
- Heines SergeJ
- Helleberg Johan
- Henderson Galen
- Herbrecht Jean-Etienne
- Hermosa Cecilia
- Hessell Robert J.
- Heunks Leo M.
- Heunks Leo M.
- Higashijima Ushio
- Hirata Akira
- Holzgraefe Bernhard
- Honda Hiroyuki
- Honrubia Teresa
- Hopf HansBernd F.
- Hopkins Phil
- Hormis Anil P.
- Hou Peter C.
- Hou Sen-Kuang
- Hraiech Sami
- Hua Ma X.
- Huang Qing Q.
- Huang Xiao B.
- Huerta FranciscoP
- Huff Nidhi G.
- Humphreys Sally K.
- Hunt Anna
- Hurtado Javier
- Hurtado Javier
- Hurtado Javier
- Hutchison Robyn A.
- Hutton PaulaJ
- Ibañez-Santacruz Marcos
- Ichikado Kazuya
- Ilutovich Santiago
- Imai Hiroshi
- Imma Vallverdu P.
- Imperio María C.
- Insaurralde Carolina S.
- Inskip Deborah M.
- Ioannou Nicholas
- Iotti Giorgio A.
- Irvine DonaldA
- Isidro San
- Ismail Dina
- Ismail Maizatul
- Ismail Mehvish
- Ito Fumihito
- Izawa Masayo
- Jaafar Rola F.
- Jakubowska Karina
- Jamaati Hamidreza
- Jarquin-Badiola YvesD
- Jassal Mandeep
- Javeed Areej
- Jha Rajeev R.
- Jiang Liangyan
- Jibaja Manuel
- Jimenez AntonioG
- Jimenez Juan I. Silesky
- Jochmans Sébastien
- Jog Sameer A.
- Jovanovic Bojan
- Judy Claine
- Jurado M. Teresa
- Kadaba Varsha
- Kajtor Istvan
- Kakar Vivek
- Kalaitzis Evangelos
- Kalkoff Michael
- Kamel Ghassan
- Kameyama Yoshinobu
- Kamoun Salma
- Kander Thomas
- Kannan Santhana G.
- Kashiwa Yozo
- Kedelv Hans
- Kennedy Barry
- Khebbeb Samy
- Kheir Fayez
- Kheir Fayez M.
- Kimura Hiroyasu
- Kiourtzieva Ellada V.
- Kitch Barrett T.
- Knapman Karl M.
- Knoll Jenny
- Knowles Serena
- Kol Mark R.
- Kong Jing
- Koyama Kansuke
- Kraßler Jens
- Krstevski Amanda
- Kulkarni Shreedhar
- Kumar Alek
- Kurahashi Kiyoyasu
- Kusumoto Kohei
- Laake Jon H.
- Laake Jon Henrik
- Labarca Eduardo F.
- Laffey John
- Laffey John G
- Lamb Keith D.
- Lanspa MichaelJ
- Larsson Anders
- Larsson Anders
- Larsson Niklas
- Las Lomas Sanatorio
- Le Moal Charlene
- Lebbinck Herve
- Lee Jarone
- Leemann-Refondini Corinne
- Lemiale Virginie
- Lemus Jordana S.
- LeonYoshido Hector H.
- Li Bin
- Li Qingdong
- Li Qiong J.
- Li Wenwen
- Li Xiao L.
- Li Xinyu
- Li Yimin
- Li Yuan Y.
- Li-Xin Zhou
- Liew Kong Y.
- Ling Long L.
- Liu Haitao
- Liu Jian
- Liu Jing L.
- Liu Ling
- Llano Iguel
- Lohner Ralph
- Loiacono Flavia A.
- Lombardo Andrea
- Lopez Esther Bermejo
- Lopez-Delgado JuanC
- Lora Fredy S.
- Lora Pilar
- Lorente Jose A.
- Losada Elena Perez
- Lovazzano Pablo
- Lu Weihua
- Lu Yuanhua
- Luis Palazon Sanchez Eugenio
- Luo Xiaoming
- Lynch Joan M.
- López-Messa JuanB
- Maazouzi Wajdi
- Macfadyen Rosaleen
- MacFie Caroline C.
- Madotto Fabiana
- Maeyama Hiroki N.
- Maghrabi Khalid A.
- Magret Monica
- Mahto HeeraL
- Mancebo Jordi
- Manoharan Venika
- Marcos Diego Pastor
- Marcu Alexandra
- Marin Julien
- Marin Maria C.
- Martinez Felipe T.
- Martinho Aurelia M.
- Marum Susan M.
- Massa Eleni V.
- Mataloun Sergio
- Matamis Dimitrios
- Matsumoto Shuhei
- Mattei Alessia
- May Martin M
- McArthur Colin
- McAuley DanielF
- McAuley DanielF
- McAuley Danny
- McCalman KatieH
- Mckechnie Stuart
- Mckee Raymond
- McKenna Toni E.
- Mcleod Alex
- McNamee Lia
- McNamee Lia
- Meaney Edel A.
- Meco Basak Ceyda
- Meersseman Philippe
- Mehta Sangeeta
- Mejia Francisco Javier Flores
- Mellis Clare
- Memon Mohammedfaruk
- Mercat Alain
- Mesar Tomaz
- Messias António M.
- Messika Jonathan
- Meybohm Patrick
- Michel Philippe
- Millar Rebecca T.
- Miller Jennene J.
- Miller Russel R.
- Mirabella Lucia
- Mizuguchi Ichiko
- Mochizuki Katsunori
- Mohr Nicholas M.
- Mojoli Francesco
- Moles Silvia Iglesias
- Molin Alexandre
- Montanha Gustavo M.
- Monteiro Jorge M.
- Montero Laura Alvarez
- Monti Giacomo
- Montini Luca M.
- Moock Marcelo
- Morin Anna-Karin
- Mortaza Satar
- Morton Alex
- Mouloudi Eleni K.
- Moya David D. Llinares
- Mukkera Satyanarayana Reddy
- Mustafa Ghanem M.
- Muthuchellappan Radhakrishnan
- Máca Jan
- Nagy Eva O.
- Nakamura Tomoyuki
- Namih Miriam
- Nassar Jr Antonio P.
- Nasu Michitaka
- Navalpotro Miguel Angel Blasco
- Navarra Leanlove
- Navarro Gonzalo
- Neal John
- Negoita Silvius Ioan
- Newby Lynette
- Nichol Alistair
- Nielsen Jonas
- Nielsen Jonas
- Niimi Daisuke
- Nin Nicolas
- Nin Nicolás
- Nishikawa Erin
- Nitta Kenichi
- Nobrega Danielle
- Noremark Kim Andre L.
- Nunci Lordian
- Nunes SilviaL
- Nunomiya Shin
- Nutt Christopher
- Nuñez Edgardo
- Nygren Ingela
- Occhipinti Giovanna
- Oetting Trevor W.
- Ogino Yasuaki
- Oikonomou Marina A.
- Okane Sinead C.
- Okuda Nao
- Oldroyd Matthew G.
- Olga Moreno F.
- Oliveira Bruno S.
- Oneill Orla
- Ortiz Claudia A.
- Oscanoa Fredy A. Montes
- Osman Emilio M.
- Oss Peteris
- Ouanes Islem
- Ourailogloy Vasilis
- Owens RobertL
- Ozcelik Menekse
- O’Croinin Donall
- O’Muircheartaigh Aogan C.
- Palaniswamy Vijayanand
- Palma Daniela M.
- Palmese Salvatore
- Palo Jose Emmanuel
- Panarello Giovanna
- Papanikolaou Metaxia N.
- Papavasilopoulou Theonymfi G.
- Papazian Laurent
- Papurica Marius
- Para Luis Herrera
- Parhar Ken
- Parotto Matteo
- Pasanting-Lim Rossini Abbie B.
- Patroniti Nicolò
- Pattarino Ilaria
- Pecci Elisabetta
- Pellegrini Carlos A.
- Pelletier Nicolas
- Pellicer Ana M.
- Penuelas Oscar
- Pereira Carlos S.
- Perez CesarP
- Perez ManuelP
- Persson Linnea
- Pesenti Antonio
- Pham Tài
- Phan Nga T.
- Piacentini Enrique A.
- Pillai Suresh
- Pintado Maria C.
- Piquilloud Lise
- Piras Claudio
- Pittini Gustavo
- Plotnikow Gustavo A.
- Poblano Manuel
- Poli Michela M.
- Pota Vincenzo
- Pozo Norberto C.
- Pozzi Matteo
- Preez PieterD
- PrietoGonzález Miryam
- Pronovost Antoine
- Protti Alessandro
- Qin Bingyu
- Qin Junping
- Qin Shu H.
- Qin Tie H.
- Qiu Haibo
- Qiu Haibo
- Raaijmakers Monique
- Rafael Sánchez I.
- Raimondi Ferdinando
- Raj Ashok S.
- Ramakrishnan Nagarajan
- Ramesh Venkatapura J.
- Ramirez-Alfaro ChristianM
- Ramirez-Gutierrez Alvaro
- Rampinelli Adenilton M.
- Ranero Jorge Luis
- Ranieri Marco
- Raponi Francesco
- Recio NoeliaN
- Reschreiter Henrik
- Reske Andreas W.
- Reuter Danielle
- Reynolds Claire
- Rhayakar RachanaV
- Rialp Gemma
- Richecoeur Jack R.
- Ricome Sylvie
- Rigaud Jean-Philippe
- Rinia Myra
- Rios Fernando
- Riss Katharina C
- Rittayamai Nuttapol
- Roberts Brigit L.
- Robine Adrien
- Robles Joanne B.
- RocheCampo Ferran
- Rodgers Helen J.
- Rodriguez Lucia L.
- Rodriguez Ruben
- Rodríguez-Garcia Raquel
- Rojas Alejandro
- Rojas Manuel A. González
- Rosa JonasI
- Roser Tomas P.
- Rossi Anna
- Roux Damien
- Rubenfeld Gordon
- Rugonfalvi Szabolcs
- Ruiz Silvia Rodriguez
- RuizAguilar AntonioL
- Rylander Christian C.
- Ryosuke Sekine
- Sabelnikovs Olegs
- Sable Safal D.
- Saenz María G.
- Saez Alejandro A.
- Sagar Sudha V.
- Saito Koji
- Saito Shigeki
- Salahuddin Nawal
- Salas Javier E.
- Sales Vanessa M.
- Samkaoui Nacer
- Sanchez Roberto Jimenez
- Sanchez-Hurtado Luis A.
- Sanchez-Medina Jorge R.
- Sandesc Dorel
- Santoli FrancescoL
- Santos Cristina
- Sauvadet EliseP
- Savioli Monica
- Scafetti Sergio
- Schiavone Vincenzo
- Schiavoni Lorenzo
- Schiöler Fredrik
- Schlichting Adam B.
- Schneider Francis
- Schomer Ashley
- Schouten Jeroen A.
- Schuetz Michael
- Schultz Marcus J.
- Schäfer Susanne
- Scott ChristopherJ
- Seasman Colette
- Seethala Raghu
- Sellors Gareth P.
- Seoane-Quiroga Leticia
- Serra Carolina
- Serra IsabelM
- Setten Mariano G.
- Seven Aylin
- Shah Bhagyesh
- Shao Huanzhang
- Shen Juanhong
- Shenoy Anitha
- Sher Sara
- Shimizu Kazuyoshi
- Shindhe Suresh
- Shinn III John O.
- Shiozaki Kyoko
- Silesky Juan
- Sim Malcolm
- Simon Philipp
- Simonis Fabienne D.
- Sivashanmugavel Mageswaran
- Sjøbø BritÅ
- Sklienka Peter
- Slutsky Arthur S.
- Smith Mark J.
- Smith Oliver
- Soler Juan Alfonso
- SolisQuesada Jaime E.
- Sottiaux Thierry
- Souissi Asma Ben
- Spadaro Savino
- Srinivasa Latha
- Stamou Electra E.
- Staudinger Thomas
- Stephenson Lorraine
- Stewart Richard
- Stigler William
- Strauch Ulrich
- Sula Hektor
- Sun Renhua
- Suzuki Hiroyuki
- Symmonds Sophie
- Szakmany Tamas
- Sánchez Rocío Manzano
- Sánchez-Ballesteros Jesús
- Søreide Eldar
- Tabhan Edgardo
- Tainter Christopher
- Takaba Akihiro
- Takada Tadaaki
- Takagi Shunsuke
- Tan Beatriz C.
- Tanaka Hiroyuki
- Tang Rui
- Tapponnier Romain
- Tarantino Fabio
- Taylor Thompson B.
- Temprano Susana
- Terragni Pierpaolo
- Terzi Nicolas
- Thibault Sandrine
- Thomas Matthew
- Thompson MarlusM
- Tibblin Anna Oscarsson
- Tinnirello Andrea
- Tiribelli Norberto
- Todeschini Manuel
- Tomescu Dana R.
- Toribio Dácil Parrilla
- Toth-Tarsoly Piroska
- Treanor Nuala
- Trinder T. John
- Trinidad Olivia A.
- Tulaimat Aiman
- Twohey Linda
- Uchiyama Akinori
- Ueda Takeshi
- Ueno Keiko
- Umbrello Michele
- Unnikrishnan Ramesh
- Uppalapati Aditya
- van Haren Frank
- Van Haren Frank
- Van Wezel Hellen M.
- Vargas Monica P.
- Vascotto EttoreR
- Vasquez Daniela N.
- Vega Luis D.
- Venti Aaron
- Vercueil Andre
- Vermassen Joris
- Verstraete Rik
- Villagomez Asisclo
- Villamagua BorisG
- Villar Veronica
- Vinzio Mauricio
- Virgilio CorcolesG
- Vitale Michela N.
- Volta Carlo A.
- Wang Chunting
- Wang Hua X.
- Wang ShouH
- Wang Wei
- Warren Jessica
- Watanabe Eizo
- Watt Philip
- Welters Ingeborg D.
- Wenham Tim
- Wessbergh Joanna
- Whitehead Christina
- Willett EmmaL
- Williams Alexandra J
- Williams Karen E.
- Wittebole Xavier
- Wong Helen S.
- Woods Paul W.
- Wrathall David W
- Wrigge Hermann
- Wrigge Hermann
- Wu Ya Q.
- Xin-Hua Qiang
- Xu Yonghao
- Yamaguchi Osamu
- Yamaji Yoshihiro
- Yao Qingchun
- Ye Zheng L.
- Yeatts DaleJ
- Yu Rongguo
- Yu Tao
- Yu Wenkui
- Yumha Jacob S.
- Yuste Luis J.
- Zacharas Giannis A.
- Zacharowski Kai D.
- Zani Gianluca
- Zantua Charing Kim S.
- Zazu Alan
- Zeggwagh Amine Ali
- Zeggwagh Amine Ali
- Zein Salem Ould
- Zender HervéO
- Zhai Zhe
- Zhang Fan
- Zhang Xing Y
- Zhao Huiying
- Zhao Jun
- Zhao Xian Y.
- Zheng Ruiqiang
- Zhou Fa C.
- Zhou Suming
- Zhu Bao H.
- Zhu Wei H.
- Zogheib Elie H.
- Ñamendys-Silva Silvio A.
- Ünal Necmettin
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
Background: Patients with acute respiratory failure caused by cardiogenic pulmonary edema (CPE) may require mechanical ventilation that can cause further lung damage. Our aim was to determine the impact of ventilatory settings on CPE mortality. Methods: Patients from the LUNG SAFE cohort, a multicenter prospective cohort study of patients undergoing mechanical ventilation, were studied. Relationships between ventilatory parameters and outcomes (ICU discharge/hospital mortality) were assessed using latent mixture analysis and a marginal structural model. Results: From 4499 patients, 391 meeting CPE criteria (median age 70 [interquartile range 59-78], 40% female) were included. ICU and hospital mortality were 34% and 40%, respectively. ICU survivors were younger (67 [57-77] vs 74 [64-80] years, p < 0.001) and had lower driving (12 [8-16] vs 15 [11-17] cmH2O, p < 0.001), plateau (20 [15-23] vs 22 [19-26] cmH2O, p < 0.001) and peak (21 [17-27] vs 26 [20-32] cmH2O, p < 0.001) pressures. Latent mixture analysis of patients receiving invasive mechanical ventilation on ICU day 1 revealed a subgroup ventilated with high pressures with lower probability of being discharged alive from the ICU (hazard ratio [HR] 0.79 [95% confidence interval 0.60-1.05], p = 0.103) and increased hospital mortality (HR 1.65 [1.16-2.36], p = 0.005). In a marginal structural model, driving pressures in the first week (HR 1.12 [1.06-1.18], p < 0.001) and tidal volume after day 7 (HR 0.69 [0.52-0.93], p = 0.015) were related to survival. Conclusions: Higher airway pressures in invasively ventilated patients with CPE are related to mortality. These patients may be exposed to an increased risk of ventilator-induced lung injury. Trial registration Clinicaltrials.gov NCT02010073
Mechanical ventilation in patients with cardiogenic pulmonary edema: a sub-analysis of the LUNG SAFE study
- Author
- Aage Christiansen
- Aaron Venti
- Abdellatif Benslama
- Adam B Schlichting
- Adenilton M Rampinelli
- Aditya Uppalapati
- Adrian Donnelly
- Adriana M Fernandez
- Adrien Robine
- Ahmad Yazid BinHJAbul Wahab
- AhmedS AlJabbary
- Ai Y Hang
- Aiman Tulaimat
- Akihiro Takaba
- Akinori Uchiyama
- Akira Hirata
- Alain Combes
- Alain M Dive
- Alain Mercat
- Alain U Alisasis
- Alan Zazu
- Albaiceta Guillermo M
- Alberto Deicas
- Alec A Tallet Alfonso
- Alejandro A Saez
- Alejandro Ebeid
- Alejandro G Castro
- Alejandro R Bruhn
- Alejandro Rojas
- Alek Kumar
- Alessandro Protti
- Alessia Mattei
- Alex Mcleod
- Alex Morton
- Alexandra Ceniceros-Barros
- Alexandra J Williams
- Alexandra Marcu
- Alexandre Demoule
- Alexandre Molin
- Alexey I Gritsan
- Alfons Arizmendi
- Aline Ascoli
- Alistair Nichol
- Alma Cani
- Alvaro Ramirez-Gutierrez
- Amado-Rodríguez Laura
- Amanda Krstevski
- Amine Ali Zeggwagh
- Amine Ali Zeggwagh
- Ana Carolina P Antônio
- Ana G França
- Ana M Pellicer
- Anais Briquet
- AnaM Araujo
- Anatole Harrois
- Anders Aneman
- Anders Larsson
- Anders Larsson
- Andre Vercueil
- Andrea Coppadoro
- Andrea Cortegiani
- Andrea Lombardo
- Andrea N Cracchiolo
- Andrea Tinnirello
- Andreas Barratt-Due
- Andreas W Reske
- Andres Esteban
- Andrew Ferguson
- Andrew J Burtenshaw
- Andrey A Gazenkampf
- Angela Delsing
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- Anil P Hormis
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- Anna Hunt
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- António M Alvarez
- António M Messias
- Aogan C O'Muircheartaigh
- Areej Javeed
- Ariel Chena
- Arnaud Follin
- Arthur S Slutsky
- Arvind K Baronia
- Ashley Schomer
- Ashok S Raj
- Asisclo Villagomez
- AsiscloJ Villagomez
- Asma Ben Souissi
- Aurelia M Martinho
- Aylin Seven
- B Taylor Thompson
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- Barbara Brunettini
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- Daniel O Beraldo
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- Daniel R Crouch
- Daniel R Gonzalez
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- Elisabetta Pecci
- EliseP Sauvadet
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- Fayez M Kheir
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- Felipe A Aliaga
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- Ferdinando Raimondi
- Fernando G George
- Fernando Rios
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- Finn H Andersen
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- Frank Van Haren
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- Fredy S Lora
- Fumihito Ito
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- Haibo Qiu
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- Hermann Wrigge
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- Imo Aisiku
- Ingeborg D Welters
- Ingela Nygren
- Irene M Bailey
- IsabelM Serra
- Islem Ouanes
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- Jack R Richecoeur
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- Jakob Gjedsted
- Jan Máca
- Janet S Aguirre
- Jarone Lee
- Jason E Cohen
- Javier Alvarez
- Javier Blanco
- Javier E Salas
- Javier G Alonso
- Javier Hurtado
- Javier Hurtado
- Javier Hurtado
- Jean Dellamonica
- Jean-Daniel Chiche
- Jean-Etienne Herbrecht
- Jean-Michel Arnal
- Jean-Philippe Rigaud
- Jennene J Miller
- Jennifer C Goodson
- Jenny Knoll
- Jens Kraßler
- Jeremy R Beitler
- Jeroen A Schouten
- Jerome Biehler
- Jessica Warren
- Jesús Sánchez-Ballesteros
- Jian Liu
- Jing Kong
- Jing L Liu
- Joan M Lynch
- Joana M Estilita
- Joanna Wessbergh
- Joanne B Robles
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- Johanna E Citalán
- John C Adams
- John Laffey
- John Neal
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- Jon Henrik Laake
- Jon P Careless
- Jonas Nielsen
- Jonas Nielsen
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- Joris Vermassen
- Jose A Lorente
- Jose Emmanuel Palo
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- Juan Alfonso Soler
- Juan Carlos J Sotillo Diaz
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- Julie Camsooksai
- Julien Marin
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- Jun Zhao
- Junping Qin
- Kai Chen
- Kai D Zacharowski
- Kansuke Koyama
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- Kazuya Ichikado
- Kazuyoshi Shimizu
- Keiko Ueno
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- Ken Parhar
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- Kevin P Clarkson
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- Luis A Sanchez-Hurtado
- Luis D Vega
- Luis E Avila
- Luis Herrera Para
- Luis J Yuste
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- Maria J Bouw
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- Myra Rinia
- Nacer Samkaoui
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- Nawal Salahuddin
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- OnatO Akyol
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- Owen Boyd
- Pablo E Gomez
- Pablo Lovazzano
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- Palazon Sanchez Eugenio Luis
- Pamela A Farías
- Paolo Casalena
- Paolo Formenti
- Pascal Beuret
- Patricio H Garcia
- Patrick Meybohm
- Paul W Woods
- PaulaJ Hutton
- Pawel Andruszkiewicz
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- Peter C Hou
- Peter Csabi
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- Phil Hopkins
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- Philippe Burtin
- Philippe J Crova
- Philippe Meersseman
- Philippe Michel
- Philippe R Bauer
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- Pierre A Bulpa
- Pierre-Eric Danin
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- Pieter Depuydt
- Pieter Depuydt
- PieterD Preez
- Pilar Lora
- Pilar Ricart Aroa Gómez
- Piroska Toth-Tarsoly
- Pravin Amin
- Qiang Xin-Hua
- Qing Q Huang
- Qingchun Yao
- Qingdong Li
- Qiong J Li
- RachanaV Rhayakar
- Radhakrishnan Muthuchellappan
- Raghu Seethala
- Rajeev R Jha
- Ralph Lohner
- Raman Azad
- Ramesh Unnikrishnan
- Raphael Cooper
- Raquel Montiel González
- Raquel Montoiro Allue
- Raul De Pablo
- Raymond Mckee
- Rebecca M Baro
- Rebecca T Millar
- Renaud M Gueret
- Renhua Sun
- Rhiannon Chapman
- Ricardo Diaz Abad
- Riccardo Colombo
- Richard O Adamsson
- Richard Stewart
- Rik Verstraete
- Risso V Alejandro
- Rita Glietsch
- Rob Cirone
- Robert J Hessell
- RobertL Owens
- Roberto Jimenez Sanchez
- RobertoR Biscione
- Robyn A Hutchison
- Rocío Manzano Sánchez
- Rodrigo S Biondi
- Rodríguez-Garcia Raquel
- Rola F Jaafar
- Romain Tapponnier
- Romano Graziani
- Ronald Zumaran Aguilar
- Rongguo Yu
- Rory Dwyer
- Rosa S Alda
- Rosaleen Macfadyen
- Rossini Abbie B Pasanting-Lim
- Ruben O Fernandez
- Ruben Rodriguez
- Rui M Gomes
- Rui Tang
- Ruiqiang Zheng
- Russel R Miller
- Russell Chabanne
- Russell M Allan
- Ruth O Griffin
- Ryan J Gosselin
- S M Hashemian
- Safal D Sable
- Saira S Gomez-Flores
- Salem Ould Zein
- Sally K Humphreys
- Salma Kamoun
- Salvatore Palmese
- SamanthaJ Hagan
- Sameer A Jog
- Sami Hraiech
- SamuelM Brown
- Samy Khebbeb
- San Isidro
- Sanatorio Las Lomas
- Sandrine Thibault
- Sangeeta Mehta
- Santhana G Kannan
- Santiago Ilutovich
- Sara De Cima-Iglesias
- Sara Sher
- Sarah Gillis
- Satar Mortaza
- Satoru Futami
- Satyanarayana Reddy Mukkera
- Savino Spadaro
- Scott H Beegle
- Sebastien L Besset
- Sekine Ryosuke
- Sen-Kuang Hou
- Serena Knowles
- SergeJ Heines
- Sergio Canestrini
- Sergio Mataloun
- Sergio Scafetti
- Seyed Mohammadreza Hashemian
- Shailesh Bihari
- Shazia Choudry
- Shigeki Saito
- Shin Nunomiya
- ShouH Wang
- Shreedhar Kulkarni
- Shu H Qin
- Shuhei Matsumoto
- Shunsuke Takagi
- Silvia Castro
- Silvia Iglesias Moles
- Silvia Rodriguez Ruiz
- SilviaL Nunes
- Silvina A Borello
- Silvio A Ñamendys-Silva
- Silvius Ioan Negoita
- SimonK Chau
- Sinead C Okane
- Slaheddine Bouchoucha
- Sophie Symmonds
- Souheil Elatrous
- Stefan Bolon
- Stuart Mckechnie
- Subhal B Dixit
- Sudha V Sagar
- SuleymanS Derman
- Suming Zhou
- Suresh Pillai
- Suresh Shindhe
- Susan M Marum
- Susana Temprano
- Susanne Schäfer
- Sylvie Ricome
- Szabolcs Rugonfalvi
- Sánchez I Rafael
- Sébastien Jochmans
- T John Trinder
- Tadaaki Takada
- Takeshi Ueda
- Tamas Szakmany
- Tao Yu
- Tarek Dendane
- Teresa Honrubia
- Tharwat M Aisa
- Theonymfi G Papavasilopoulou
- Thierry Sottiaux
- Thomas Baltus
- Thomas C Blakeman
- Thomas Collyer
- Thomas Kander
- Thomas Staudinger
- Tie H Qin
- Tim Wenham
- Tomas P Roser
- Tomaz Mesar
- Tommaso Fossali
- Tomoaki Hashida
- Tomofumi Harasawa
- Tomoyuki Nakamura
- Toni E McKenna
- Toshikazu Abe
- Trevor W Oetting
- Troy S Browne
- Ulrich Strauch
- Ushio Higashijima
- Valeria I Cerrato
- Valerie M BannerGoodspeed
- VallishK Bhardwaj
- Vallverdu P Imma
- Vanessa M Sales
- Vania A Brito
- Varsha Kadaba
- Vasilis Ourailogloy
- Venika Manoharan
- Venkatapura J Ramesh
- Veronica Villar
- Vesna Bumbasierevic
- Vesna Bumbasirevic
- Vijayanand Palaniswamy
- Vincenzo Pota
- Vincenzo Schiavone
- Virginie Lemiale
- Vivek Kakar
- Vladimir Cerny
- Wahid Altaf
- Wajdi Maazouzi
- Wei H Zhu
- Wei Wang
- Weihua Lu
- Wenkui Yu
- Wenwen Li
- William Stigler
- Xavier Wittebole
- Xian Y Zhao
- Xiao B Huang
- Xiao L Li
- Xiaoming Luo
- Xing Y Zhang
- Xinyu Li
- Ya Q Wu
- Yaasen Arabi
- Yan Gao
- Yaseen M Arabi
- YaseenM Arabi
- Yasuaki Ogino
- Yi Han
- Yimin Li
- Yonghao Xu
- Yoshihiro Yamaji
- Yoshinobu Kameyama
- Youssef Haddad
- Youzhong An
- Yozo Kashiwa
- Yu D Di
- Yuan N Gao
- Yuan Y Li
- Yuanhua Lu
- YvesD Jarquin-Badiola
- Zhe Zhai
- Zheng L Ye
- Zhenyang He
- Zhou Li-Xin
- Ángela Algaba
- Ángela González-Salamanca
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 25/12/2022
- Field of study
Background: Patients with acute respiratory failure caused by cardiogenic pulmonary edema (CPE) may require mechanical ventilation that can cause further lung damage. Our aim was to determine the impact of ventilatory settings on CPE mortality. Methods: Patients from the LUNG SAFE cohort, a multicenter prospective cohort study of patients undergoing mechanical ventilation, were studied. Relationships between ventilatory parameters and outcomes (ICU discharge/hospital mortality) were assessed using latent mixture analysis and a marginal structural model. Results: From 4499 patients, 391 meeting CPE criteria (median age 70 [interquartile range 59-78], 40% female) were included. ICU and hospital mortality were 34% and 40%, respectively. ICU survivors were younger (67 [57-77] vs 74 [64-80] years, p < 0.001) and had lower driving (12 [8-16] vs 15 [11-17] cmH2O, p < 0.001), plateau (20 [15-23] vs 22 [19-26] cmH2O, p < 0.001) and peak (21 [17-27] vs 26 [20-32] cmH2O, p < 0.001) pressures. Latent mixture analysis of patients receiving invasive mechanical ventilation on ICU day 1 revealed a subgroup ventilated with high pressures with lower probability of being discharged alive from the ICU (hazard ratio [HR] 0.79 [95% confidence interval 0.60-1.05], p = 0.103) and increased hospital mortality (HR 1.65 [1.16-2.36], p = 0.005). In a marginal structural model, driving pressures in the first week (HR 1.12 [1.06-1.18], p < 0.001) and tidal volume after day 7 (HR 0.69 [0.52-0.93], p = 0.015) were related to survival. Conclusions: Higher airway pressures in invasively ventilated patients with CPE are related to mortality. These patients may be exposed to an increased risk of ventilator-induced lung injury. Trial registration Clinicaltrials.gov NCT02010073