Assessing the Impact of Cowpea and Sorghum Research and Extension in Northern Cameroon

Crop Production/Industries, Research and Development/Tech Change/Emerging Technologies, Teaching/Communication/Extension/Profession, Downloads July 2008 - July 2009: 7,

Assessing the Impact of Cowpea and Sorghum Research and Extension in Northern Cameroon

Throughout Africa, per capita food production has been declining since the early 1960s. Cameroon has sought to counter this trend by increasing agricultural productivity through research and extension. In order to establish future investment priorities, policy makers need to know if past agricultural research investments have earned sufficient returns to justify continued funding. Further, national experiences need to be compared to see if returns varied across programs, and in cases where they did, explanations need to be sought to discover why these variations exist. To address these issues, data were collected in Cameroon and analyzed in order to estimate the benefits and costs of investments in sorghum and cowpea research and extension in northern Cameroon. Specific data that were needed to construct benefit and cost streams included the following: yields of traditional and introduced technologies, area harvested, adoption rates of technological innovations, prices of both inputs and outputs, climatic factors influencing both the research agenda and the returns to this research, and the costs of research and extension efforts. Focusing on the period 1979-87, the analysis addressed three questions: What were the returns to past investments? What factors explained the estimated returns and any variability in returns between the sorghum and cowpea programs? And how did institutions influence these returns and the distribution of their benefits?food security, food policy, cowpea, sorghum, Crop Production/Industries, Research and Development/Tech Change/Emerging Technologies, Downloads July 2008 - June 2009: 17, Q16,

Complementary Approaches or Conflicting Strategies? Examining CISA and New York\u27s DFS Cybersecurity Regulations as a Harmonizing Framework for a Bilateral Approach to Cybersecurity

The question of whether more aggressive approaches to the enforcement of cybersecurity standards can survive in a time where sharing threat information is crucial to protecting privacy has been ongoing for some time. This paper argues that this is not an either-or proposition and that enforcement frameworks like New York’s DFS Cybersecurity Regulations and information sharing frameworks such as CISA can exist in harmony, and that their divergent approaches actually strengthen American cybersecurity law as a whole

Overcorrection of hyponatremia is a medical emergency

Overcorrection of hyponatremia is a medical emergency. Excessive correction usually results from the unexpected emergence of a water diuresis after resolution of the cause of water retention. The concurrent administration of desmopressin and 5% dextrose in water can be given to cautiously re-lower the serum sodium concentration when therapeutic limits have been exceeded. Nephrologists should be equally aggressive in correcting hyponatremia and in un-correcting it when their patients get too much of a good thing

Brain dehydration and neurologic deterioration after rapid correction of hyponatremia

Brain dehydration and neurologic deterioration after rapid correction of hyponatremia. We made rats severely hyponatremia varying the rate of onset and duration of the disturbance, and then compared rapid correction to slow correction. An acute fall in the plasma Na to 106 mEq/liter within seven hours caused seizures and coma, but these findings resolved and survival was 100%after either rapid or slow correction. A more gradual fall in plasma Na to 95 mEq/liter in three days caused neither seizures nor coma. Measurements of brain water and electrolytes showed that adaptive losses of brain Na and K (maximally depleted within seven hours) and slower losses of non-electrolyte solutes progressively reduced brain edema. After three days of hyponatremia, rapid correction to 119 mEq/liter with 1m NaCl or to 129 mEq/liter by withdrawing DDAVP caused brain dehydration because lost brain K and non-electrolyte solutes were recovered slowly. This treatment was followed by a delayed onset of severe neurologic findings, demyelinating brain lesions and a mortality rate of over 40%. Slow correction (0.3 mEq/liter/hr) avoided these complications and permitted 100%survival. We conclude that the rat adapts quickly to hyponatremia and can survive with extremely low plasma sodium concentrations for prolonged periods. Although rapid correction is well tolerated when hyponatremia is of brief duration, it may cause brain damage in animals that have had time to more fully adapt to the disturbance

Ablation of atrial fibrillation after the retirement age: considerations on safety and outcome

Background: Although the incidence of atrial fibrillation (AF) progressively increases with age, the vast majority of AF ablation is done in middle-aged patients. We evaluated the feasibility and safety of catheter ablation in patients older than 65years of age with paroxysmal and persistent AF. Methods: Out of a total of 230 consecutive AF ablation procedures, 45 patients were older than 65years of age and underwent 53 procedures. The ablation strategy consisted of wide-area circumferential lines around both ipsilateral pulmonary veins using a three-dimensional mapping system. Results: The mean age was 69 ± 3.5years (35 males). The mean duration for AF was 8.7 ± 6.5years. Thirty-nine had paroxysmal and six persistent AF despite use of 1.38 ± 0.77 antiarrhythmic drugs. All patients had a structurally normal heart. Eleven had systemic hypertension. Mean procedure time was 187 ± 33min. Acute procedural success rate with abolition of all pulmonary vein potentials was achieved in all patients. Pericardial tamponade requiring percutaneous drainage occurred in one (1.9%) patient. There were no cardioembolic events. Among the 43 patients whose clinical outcome was assessed at 6months, 34 (79%) had a significant reduction (>90%) of the total symptomatic AF burden, compared to pre-ablation, with a complete lack of symptomatic AF in 32 (74%) patients. The success rate was higher for patients with paroxysmal versus persistent AF (81 vs. 67%). Six patients (11%) underwent repeat procedures. Conclusions: Catheter ablation is a safe and effective treatment for patients over the age of 65years with symptomatic, drug-refractory AF. Therefore, patients should not be excluded from undergoing AF catheter ablation on the basis of age alon

The Role of Device Diagnostic Algorithms in the Assessment and Management of Patients with Systolic Heart Failure: A Review

Hospitalization due to heart failure (HF) exacerbation represents a major burden in health care and portends a poor long-term prognosis for patients. As a result, there is considerable interest to develop novel tools and strategies to better detect onset of volume overload, as HF hospitalizations may be reduced if appropriate interventions can be promptly delivered. One such innovation is the use of device-based diagnostic parameters in HF patients with implantable cardioverter defibrillators (ICD) and/or cardiac resynchronization therapy (CRT) devices. These diagnostic algorithms can effectively monitor and detect changes in patients' HF status, as well as predict one's risk of HF hospitalization. This paper will review the role of these device diagnostics parameters in the assessment and management of HF patients in ambulatory settings. In addition, the integration of these novel algorithms in existing HF disease management models will be discussed

Treatment Guidelines for Hyponatremia Stay the Course

International guidelines designed to minimize the risk of complications that can occur when correcting severe hyponatremia have been widely accepted for a decade. On the basis of the results of a recent large retrospective study of patients hospitalized with hyponatremia, it has been suggested that hyponatremia guidelines have gone too far in limiting the rate of rise of the serum sodium concentration; the need for therapeutic caution and frequent monitoring of the serum sodium concentration has been questioned. These assertions are reminiscent of a controversy that began many years ago. After reviewing the history of that controversy, the evidence supporting the guidelines, and the validity of data challenging them, we conclude that current safeguards should not be abandoned. To do so would be akin to discarding your umbrella because you remained dry in a rainstorm. The authors of this review, who represent 20 medical centers in nine countries, have all contributed significantly to the literature on the subject. We urge clinicians to continue to treat severe hyponatremia cautiously and to wait for better evidence before adopting less stringent therapeutic limits.</p

Governmental Institutions as Agents of Change: Rethinking American Political Development in the Early Republic, 1787-1835

During the past few years, a new generation of historians have turned their attention to the influence of law, public policy, and public administration in American life in the period between 1787 and 1835. The purpose of this essay is to highlight the contributions of these scholars in the hope that such an inquiry can further the ongoing interdisciplinary dialogue on American political development between historians, political scientists, and historical sociologists