Wave Characteristics of Falling Film on Inclination Plate at Moderate Reynolds Number

Falling water film on an inclined plane is studied by shadowgraphy. The ranges of inclination angle and the film Reynolds number are, respectively, up to 21° and 60. Water is used as working fluid. The scenario of wave regime evolution is identified as three distinctive regimes, namely, initial quiescent smooth film flow, two-dimensional regular solitary wave pattern riding on film flow, and three-dimensional irregular wave pattern. Three characteristic parameters of two-dimensional solitary wave pattern, namely, inception length, primary pulse spacing, and propagation velocity, are examined, which are significant in engineering applications for estimation of heat and mass transfer on film flow. The present experimental data are well in agreement with the Koizumi correlations, the deviation from which is limited to 20% and 15%, respectively, for primary pulse spacing and propagation velocity. Through the scrutiny of the present experimental observation, it is concluded that wave evolution on film flow at the moderate Reynolds number is controlled by gravity and drag and the Rayleigh-Taylor instability that occurred on the steep front of primary pulse triggers the disintegration of continuous two-dimensional regular solitary wave pattern into three-dimensional irregular wave pattern

Genome Sequencing and Comparative Transcriptomics of the Model Entomopathogenic Fungi Metarhizium anisopliae and M. acridum

Metarhizium spp. are being used as environmentally friendly alternatives to chemical insecticides, as model systems for studying insect-fungus interactions, and as a resource of genes for biotechnology. We present a comparative analysis of the genome sequences of the broad-spectrum insect pathogen Metarhizium anisopliae and the acridid-specific M. acridum. Whole-genome analyses indicate that the genome structures of these two species are highly syntenic and suggest that the genus Metarhizium evolved from plant endophytes or pathogens. Both M. anisopliae and M. acridum have a strikingly larger proportion of genes encoding secreted proteins than other fungi, while ∼30% of these have no functionally characterized homologs, suggesting hitherto unsuspected interactions between fungal pathogens and insects. The analysis of transposase genes provided evidence of repeat-induced point mutations occurring in M. acridum but not in M. anisopliae. With the help of pathogen-host interaction gene database, ∼16% of Metarhizium genes were identified that are similar to experimentally verified genes involved in pathogenicity in other fungi, particularly plant pathogens. However, relative to M. acridum, M. anisopliae has evolved with many expanded gene families of proteases, chitinases, cytochrome P450s, polyketide synthases, and nonribosomal peptide synthetases for cuticle-degradation, detoxification, and toxin biosynthesis that may facilitate its ability to adapt to heterogenous environments. Transcriptional analysis of both fungi during early infection processes provided further insights into the genes and pathways involved in infectivity and specificity. Of particular note, M. acridum transcribed distinct G-protein coupled receptors on cuticles from locusts (the natural hosts) and cockroaches, whereas M. anisopliae transcribed the same receptor on both hosts. This study will facilitate the identification of virulence genes and the development of improved biocontrol strains with customized properties

Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes

publisher: Elsevier articletitle: Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes journaltitle: Cell articlelink: https://doi.org/10.1016/j.cell.2018.05.046 content_type: article copyright: © 2018 Elsevier Inc

Effect of Lateral End Plates on Flow Crossing a Yawed Circular Cylinder

Numerical simulation is carried out to investigate the effect of the boundary condition of two lateral end-plate walls on the flow structure in the wake of a flow crossing a yawed circular cylinder. Two typical boundary conditions, nonslip and periodic, are investigated. It is revealed that the boundary condition of the two end-plates has a significant effect on the flow behaviors in the wake. Under the nonslip boundary condition, the vortex structure in the wake exhibits a tapering shape to the tip end. The flow pattern is formed in the wake as the streamlines on the tip side are becoming denser while the streamlines on the base end are becoming sparser. Spectral power analysis of the local lift coefficient shows that the frequency distribution exhibits axial variation. On the base side, the frequency distribution is broadband. On the tip side, there are two peak frequencies: the larger one corresponds to the value predicted by the independence principle, and the smaller one is generated by the secondary axial flow separation from the rear cylinder wall. Under the periodic condition, the numerical results show that organized Strouhal vortex is shed in the wake in the same way as to the flow orthogonally passing a cylinder and the independence principle is still applicable