Elliptic solutions of generalized Brans-Dicke gravity with a non-universal coupling

We study a model of the generalized Brans-Dicke gravity presented in both the Jordan and in the Einstein frames, which are conformally related. We show that the scalar field equations in the Einstein frame are reduced to the geodesics equations on the target space of the nonlinear sigma-model. The analytical solutions in elliptical functions are obtained when the conformal couplings are given by reciprocal exponential functions. The behavior of the scale factor in the Jordan frame is studied using numerical computations. For certain parameters the solutions can describe an accelerated expansion. We also derive an analytical approximation in exponential functions.Comment: 24 pages, 3 figures; v2: typos fixed, few remarks and references added; version to appear in EPJ

On the origin of subvisible cirrus clouds in the tropical upper troposphere

Spaceborne lidar observations have recently revealed a previously undetected significant population of Subvisible Cirrus (SVC). We show them to be colder than −74 °, with an optical depth below 0.0015 on average. The formation and persistence over time of this new cloud population could be related to several atmospheric phenomena. In this paper, we investigate if these clouds follow the same formation mechanisms as the general tropical cirrus population (including convection and in-situ ice nucleation), or if specific nucleation sites and trace species play a role in their formation. The importance of three scenarios in the formation of the global SVC population is investigated through different approaches that include comparisons with data imaging from several spaceborne instruments and back-trajectories that document the history and behavior of air masses leading to the point in time and space where subvisible cirrus were detected. In order to simplify the study of their formation, we singled out SVC with coherent temperature histories (mean variance lower than 4 K) according to back-trajectories along 5, 10 or 15 days (respectively 58, 25 and 11% of SVC). Our results suggest that external processes, including local increases in liquid and hygroscopic aerosol concentration (either through biomass burning or volcanic injection forming sulfate-based aerosols in the troposphere or the stratosphere) have very limited short-term or mid-term impact on the SVC population. On the other hand, we find that ~20% of air masses leading to SVC formation interacted with convective activity 5 days before they led to cloud formation and detection, a number that climbs to 60% over 15 days. SVC formation appears especially linked to convection over Africa and Central America, more so during JJA than DJF. These results support the view that the SVC population observed by CALIOP is an extension of the general upper tropospheric ice clouds population with its extreme thinness as its only differentiating factor

Capillary origami: spontaneous wrapping of a droplet with an elastic sheet

The interaction between elasticity and capillarity is used to produce three dimensional structures, through the wrapping of a liquid droplet by a planar sheet. The final encapsulated 3D shape is controlled by tayloring the initial geometry of the flat membrane. A 2D model shows the evolution of open sheets to closed structures and predicts a critical length scale below which encapsulation cannot occur, which is verified experimentally. This {\it elastocapillary length} is found to depend on the thickness as $h^{3/2}$, a scaling favorable to miniaturization which suggests a new way of mass production of 3D micro- or nano-scale objects.Comment: 5 pages, 5 figure

Effects of solar activity on noise in CALIOP profiles above the South Atlantic Anomaly

We show that nighttime dark noise measurements from the spaceborne lidar CALIOP contain valuable information about the evolution of upwelling high-energy radiation levels. Above the South Atlantic Anomaly (SAA), CALIOP dark noise levels fluctuate by ±6% between 2006 and 2013, and follow the known anticorrelation of local particle flux with the 11-year cycle of solar activity (with a 1-year lag). By analyzing the geographic distribution of noisy profiles, we are able to reproduce known findings about the SAA region. Over the considered period, it shifts westward by 0.3° year⁻¹, and changes in size by 6° meridionally and 2° zonally, becoming larger with weaker solar activity. All results are in strong agreement with previous works. We predict SAA noise levels will increase anew after 2014, and will affect future spaceborne lidar missions most near 2020

Effect of antibiotics, alone and in combination, on Panton–Valentine leukocidin production by a Staphylococcus aureus reference strain

AbstractThe capacity of Staphylococcus aureus strain LUG855 to release Panton–Valentine leukocidin (PVL) in the presence of sub-inhibitory concentrations of anti-staphylococcal drugs was examined. Oxacillin enhanced PVL release 2.5-fold, while clindamycin, linezolid, fusidic acid and rifampicin were inhibitory, and vancomycin, pristinamycin, tetracycline, ofloxacin and co-trimoxazole had no effect. In combination with oxacillin, sub-inhibitory concentrations of clindamycin or rifampicin inhibited PVL induction significantly, linezolid was less inhibitory, and fusidic acid did not inhibit PVL induction by oxacillin. These data support the use of oxacillin in combination with clindamycin, rifampicin or linezolid for the treatment of PVL-positive S. aureus infections

Ground robotic measurement of aeolian processes

Models of aeolian processes rely on accurate measurements of the rates of sediment transport by wind, and careful evaluation of the environmental controls of these processes. Existing field approaches typically require intensive, event-based experiments involving dense arrays of instruments. These devices are often cumbersome and logistically difficult to set up and maintain, especially near steep or vegetated dune surfaces. Significant advances in instrumentation are needed to provide the datasets that are required to validate and improve mechanistic models of aeolian sediment transport. Recent advances in robotics show great promise for assisting and amplifying scientists’ efforts to increase the spatial and temporal resolution of many environmental measurements governing sediment transport. The emergence of cheap, agile, human-scale robotic platforms endowed with increasingly sophisticated sensor and motor suites opens up the prospect of deploying programmable, reactive sensor payloads across complex terrain in the service of aeolian science. This paper surveys the need and assesses the opportunities and challenges for amassing novel, highly resolved spatiotemporal datasets for aeolian research using partially-automated ground mobility. We review the limitations of existing measurement approaches for aeolian processes, and discuss how they may be transformed by ground-based robotic platforms, using examples from our initial field experiments. We then review how the need to traverse challenging aeolian terrains and simultaneously make high-resolution measurements of critical variables requires enhanced robotic capability. Finally, we conclude with a look to the future, in which robotic platforms may operate with increasing autonomy in harsh conditions. Besides expanding the completeness of terrestrial datasets, bringing ground-based robots to the aeolian research community may lead to unexpected discoveries that generate new hypotheses to expand the science itself. For more information: Kod*lab (http://kodlab.seas.upenn.edu/

Screening of DUB activity and specificity by MALDI-TOF mass spectrometry

Deubiquitylases (DUBs) are key regulators of the ubiquitin system which cleave ubiquitin moieties from proteins and polyubiquitin chains. Several DUBs have been implicated in various diseases and are attractive drug targets. We have developed a sensitive and fast assay to quantify in vitro DUB enzyme activity using matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry. Unlike other current assays, this method uses unmodified substrates, such as diubiquitin topoisomers. By analyzing 42 human DUBs against all diubiquitin topoisomers we provide an extensive characterization of DUB activity and specificity. Our results confirm the high specificity of many members of the OTU and JAMM DUB families and highlight that all USPs tested display low linkage selectivity. We also demonstrate that this assay can be deployed to assess the potency and specificity of DUB inhibitors by profiling 11 compounds against a panel of 32 DUBs

Alcaligenes xylosoxidans Bloodstream Infections in Outpatient Oncology Office

Gaps in infection control led to biofilm production in central venous catheters and resultant bloodstream infection

Using in-situ airborne measurements to evaluate three cloud phase products derived from CALIPSO

International audienceWe compare the cloud detection and cloud phase determination of three independent climatologies based on Cloud-Aerosol Lidar and Infrared Pathfinder Satellite Observation (CALIPSO) to airborne in situ measurements. Our analysis of the cloud detection shows that the differences between the satellite and in situ measurements mainly arise from three factors. First, averaging CALIPSO Level l data along track before cloud detection increases the estimate of high-and low-level cloud fractions. Second, the vertical averaging of Level 1 data before cloud detection tends to artificially increase the cloud vertical extent. Third, the differences in classification of fully attenuated pixels among the CALIPSO climatologies lead to differences in the low-level Arctic cloud fractions. In another section, we compare the cloudy pixels detected by colocated in situ and satellite observations to study the cloud phase determination. At midlatitudes, retrievals of homogeneous high ice clouds by CALIPSO data sets are very robust (more than 94.6% of agreement with in situ). In the Arctic, where the cloud phase vertical variability is larger within a 480 m pixel, all climatologies show disagreements with the in situ measurements and CALIPSO-General Circulation Models-Oriented Cloud Product (GOCCP) report significant undefined-phase clouds, which likely correspond to mixed-phase clouds. In all CALIPSO products, the phase determination is dominated by the cloud top phase. Finally, we use global statistics to demonstrate that main differences between the CALIPSO cloud phase products stem from the cloud detection (horizontal averaging, fully attenuated pixels) rather than the cloud phase determination procedures