Generationengerechtigkeit in der Wirtschaftspolitik.: Eine finanzwissenschaftliche Analyse staatlicher Haushalts- und Rentenpolitik

The new red-green government in Germany follows in economic policy the neoliberal aim of forced public debt reduction. Also the system of public pensions plans (with costs shared by employers and employees) will be reorganised, giving private pension funds payed by employees alone more weight. Both measures shall improve inter-generational justice. This claim is criticized as well in a fundamental manner as in consideration of the german situation

Die Arbeitszeitfrage im Kontext von Wachstum, Ökologie und Wohlstand

Wirtschaftliches Wachstum und wachsender Wohlstand galten lange Zeit als zwei Seiten einer Medaille. Doch geringes Wachstum verschärft die Situation am Arbeitsmarkt. Arbeitszeitverkürzung erscheint als Königsweg, den Wohlstand der Menschen weiter zu steigern, ohne die Umwelt weiter zu belasten

Non-primate hepacivirus infection with apparent hepatitis in a horse — Short communication

Non-primate hepacivirus (NPHV) is a recently identified hepacivirus (family Flaviviridae) in dog and horse; however, the disease associations remain unknown. This study reports the detection of natural NPHV infection in a horse with apparent hepatitis, liver damage and high-level viraemia. NPHV could be hepatotropic and associated with hepatitis in horses

Erneuerungsbedarf und -möglichkeiten der Sozialen Marktwirtschaft

Vom 28. bis 30. Juni 2002 veranstaltete die Akademie für politische Bildung Tutzing unter der Leitung von Prof. Dr. Peter Hampe (Akademie Tutzing) und Prof. Dr. Dr. Karl Homann (Universität München) eine Konferenz zu dem Thema »Ethos oder Ellbogen? Zu den Wertgrundlagen der Sozialen Marktwirtschaft«. Im Mittelpunkt des zweiten Tages stand die Frage nach dem Reformbedarf und den -möglichkeiten der Sozialen Marktwirtschaft. Prof. Dr. Winfried Schlaffke, International School of Management, Dortmund, und Institut der deutschen Wirtschaft, Köln, stellt in seinem Referat die von der Metall- und Elektro-Industrie und weiteren Wirtschaftsverbänden getragene »Initiative Neue Soziale Marktwirtschaft« vor, die »die Menschen für das marktwirtschaftliche Ordnungssystem und für notwendige Reformen gewinnen« möchte. Mit diesen Thesen setzen sich im Anschluss daran Dr. Norbert Reuter, Fachhochschule Aachen, und Dr. Karen Horn, Frankfurter Allgemeine Zeitung, kritisch auseinander. Für Randolf Rodenstock, Vereinigung der Bayerischen Wirtschaft, sollten die Reformen der Sozialen Marktwirtschaft vor allem mehr Subsidiarität, neben der notwendigen Solidarität, bringen: »Der Staat oder die Gemeinschaft springen nur da ein, wo das Individuum es allein nicht schafft.« Prof. Dr. Henning Klodt, Institut für Weltwirtschaft, Kiel, beschäftigt sich in seinem Beitrag ausführlich mit der Frage, ob die Globalisierung »unsozial« sei und Dr. Eberhard von Koerber, Club of Rome und Wittenberg-Zentrum für Globale Ethik, Zürich, unterstreicht die Veränderungen unternehmerischen Handelns in einer globalisierten Welt, die von den Unternehmen »ganzheitliche Verantwortung« verlangt.Soziale Marktwirtschaft, Globalisierung, Sozialer Wandel, Wirtschaftsreform

Identifying CBT non-response among OCD outpatients: A machine-learning approach

Objectives: Machine learning models predicting treatment outcomes for individual patients may yield high clinical utility. However, few studies tested the utility of easy to acquire and low-cost sociodemographic and clinical data. In previous work, we reported significant predictions still insufficient for immediate clinical use in a sample with broad diagnostic spectrum. We here examined whether predictions will improve in a diagnostically more homogeneous yet large and naturalistic obsessive-compulsive disorder (OCD) sample. Methods: We used sociodemographic and clinical data routinely acquired during CBT treatment of n = 533 OCD subjects in a specialized outpatient clinic. Results: Remission was predicted with 65% (p = 0.001) balanced accuracy on unseen data for the best model. Higher OCD symptom severity predicted non-remission, while higher age of onset of first OCD symptoms and higher socioeconomic status predicted remission. For dimensional change, prediction achieved r = 0.31 (p = 0.001) between predicted and actual values. Conclusions: The comparison with our previous work suggests that predictions within a diagnostically homogeneous sample, here OCD, are not per se superior to a more diverse sample including several diagnostic groups. Using refined psychological predictors associated with disorder etiology and maintenance or adding further data modalities as neuroimaging or ecological momentary assessments are promising in order to further increase prediction accuracy.Peer Reviewe

Error-related activity of the sensorimotor network contributes to the prediction of response to cognitive-behavioral therapy in obsessive–compulsive disorder

Background Although cognitive behavioral therapy is a highly effective treatment for obsessive–compulsive disorder (OCD), yielding large symptom reductions on the group level, individual treatment response varies considerably. Identification of treatment response predictors may provide important information for maximizing individual treatment response and thus achieving efficient treatment resource allocation. Here, we investigated the predictive value of previously identified biomarkers of OCD, namely the error-related activity of the supplementary motor area (SMA) and the sensorimotor network (SMN, postcentral gyrus/precuneus). Methods Seventy-two participants with a primary diagnosis of OCD underwent functional magnetic resonance imaging (fMRI) scanning while performing a flanker task prior to receiving routine-care CBT. Results Error-related BOLD response of the SMN significantly contributed to the prediction of treatment response beyond the variance accounted for by clinical and sociodemographic variables. Stronger error-related SMN activity at baseline was associated with a higher likelihood of treatment response. Conclusions The present results illustrate that the inclusion of error-related SMN activity can significantly increase treatment response prediction quality in OCD. Stronger error-related activity of the SMN may reflect the ability to activate symptom-relevant processing networks and may thus facilitate response to exposure-based CBT interventions

Influence of Antipodally Coupled Iodine and Carbon Atoms on the Cage Structure of 9,12-I2-closo-1,2-C2B10H10 : An Electron Diffraction and Computational Study

Because of the comparable electron scattering abilities of carbon and boron, the electron diffraction structure of the C2v-symmetric molecule closo-1,2-C2B10H12 (1), one of the building blocks of boron cluster chemistry, is not as accurate as it could be. On that basis, we have prepared the known diiodo derivative of 1, 9,12-I2-closo-1,2-C2B10H10 (2), which has the same point-group symmetry as 1 but in which the presence of iodine atoms, with their much stronger ability to scatter electrons, ensures much better structural characterization of the C2B10 icosahedral core. Furthermore, the influence on the C2B10 geometry in 2 of the antipodally positioned iodine substituents with respect to both carbon atoms has been examined using the concerted application of gas electron diffraction and quantum chemical calculations at the MP2 and density functional theory (DFT) levels. The experimental and computed molecular geometries are in good overall agreement. Molecular dynamics simulations used to obtain vibrational parameters, which are needed for analyzing the electron diffraction data, have been performed for the first time for this class of compound. According to DFT calculations at the ZORA-SO/BP86 level, the 11B chemical shifts of the boron atoms to which the iodine substituents are bonded are dominated by spin-orbit coupling. Magnetically induced currents within 2 have been calculated and compared to those for [B12H12]2-, the latter adopting a regular icosahedral structure with Ih point-group symmetry. Similar total current strengths are found but with a certain anisotropy, suggesting that spherical aromaticity is present; electron delocalization in the plane of the hetero atoms in 2 is slightly hindered compared to that for [B12H12]2-, presumably because of the departure from ideal icosahedral symmetry

InfoStrom: Learning information infrastructures for crisis management in case of medium to large electrical power breakdowns

One of the most important infrastructures in modern industrialized societies is the electricity network. Due to its fundamental role for many aspects of our everyday life, power infrastructures manifest a strong dependence between power suppliers and customers. Customers take the infrastructure for granted; it appears mostly invisible to them as long as it works, but in the case of breakdowns in power supply customers become aware of the dependence on electricity. They join professional actors in the recovery and coping work with regard to the electricity breakdown: Maintenance workers of the power provider, police, firefighters, red cross, etc. These institutions are professionalized for dealing with such situations, but the people affected by a power outage also need to be considered as actors

Treatment outcomes 24 months after initiating short, all-oral bedaquiline-containing or injectable-containing rifampicin-resistant tuberculosis treatment regimens in South Africa : a retrospective cohort study

DATA SHARING : The data used for this analysis in the form of deidentified participant data and a data dictionary will be made available after publication. Investigators wishing to access these data will need to have an approved research proposal and complete a data access agreement. All inquiries should be sent to the corresponding author ([email protected] or [email protected]).SUPPLEMENTARY MATERIAL 1 : French translation of the abstract. SUPPLEMENTARY MATERIAL 2 : Appendices.BACKGROUND : There is a need for short and safe all-oral treatment of rifampicin-resistant tuberculosis. We compared outcomes up to 24 months after treatment initiation for patients with rifampicin-resistant tuberculosis in South Africa treated with a short, all-oral bedaquiline-containing regimen (bedaquiline group), or a short, injectable-containing regimen (injectable group). METHODS : Patients with rifampicin-resistant tuberculosis, aged 18 years or older, eligible for a short regimen starting treatment between Jan 1 and Dec 31, 2017, with a bedaquiline-containing or WHO recommended injectable-containing treatment regimen of 9–12 months, registered in the drug-resistant tuberculosis database (EDRWeb), and with known age, sex, HIV status, and national identification number were eligible for study inclusion; patients receiving linezolid, carbapenems, terizidone or cycloserine, delamanid, or para-aminosalicylic acid were excluded. Bedaquiline was given at a dose of 400 mg once daily for two weeks followed by 200 mg three times a week for 22 weeks. To compare regimens, patients were exactly matched on HIV and ART status, previous tuberculosis treatment history, and baseline acid-fast bacilli smear and culture result, while propensity score matched on age, sex, province of treatment, and isoniazid-susceptibility status. We did binomial linear regression to estimate adjusted risk differences (aRD) and 95% CIs for 24-month outcomes, which included: treatment success (ie, cure or treatment completion without evidence of recurrence) versus all other outcomes, survival versus death, disease free survival versus survival with treatment failure or recurrence, and loss to follow-up versus all other outcomes. FINDINGS : Overall, 1387 (14%) of 10152 patients with rifampicin-resistant tuberculosis treated during 2017 met inclusion criteria; 688 in the bedaquiline group and 699 in the injectable group. Four patients (1%) had treatment failure or recurrence, 44 (6%) were lost to follow-up, and 162 (24%) died in the bedaquiline group, compared with 17 (2%), 87 (12%), and 199 (28%), respectively, in the injectable group. In adjusted analyses, treatment success was 14% (95% CI 8–20) higher in the bedaquiline group than in the injectable group (70% vs 57%); loss to follow-up was 4% (1–8) lower in the bedaquiline group (6% vs 12%); and disease-free survival was 2% (0–5) higher in the bedaquiline group (99% vs 97%). The bedaquiline group had 8% (4–11) lower risk of mortality during treatment (17·0% vs 22·4%), but there was no difference in mortality post-treatment. INTERPRETATION : Patients in the bedaquiline group experienced significantly higher rates of treatment success at 24 months. This finding supports the use of short bedaquiline-containing regimens in eligible patients.WHO Global TB Programme.http://www.thelancet.com/infectionhj2023Medical Microbiolog