102 research outputs found
Época de preparo de área e plantio de milho no sistema de corte e trituração no municĂpio de IgarapĂ©-Açu, Pará.
bitstream/item/27976/1/com.tec.64.pd
Cutis Laxa
Introdução:A cutis laxa é uma doença rara do tecido conjuntivo provocada por alterações da elastina. Caracteriza-se por pele sem elasticidade, flácida, mole e enrugada, dando aos doentes um aspecto envelhecido; o envolvimento sistémico é variável. Existem formas hereditárias e adquiridas.
Relato de Caso: Lactente do sexo masculino, de seis meses de idade, no qual na sequência de internamento por bronquiolite é notado fenótipo muito sugestivo de cutis laxa, tendo o exame histopatológico cutâneo confirmado o diagnóstico.
DiscussĂŁo ClĂnica: O caso parece relevante, pela raridade da doença e por apresentar fenĂłtipo sugestivo de cutis laxa do
tipo autossĂłmico recessivo, mas com evolução clĂnica mais caracterĂstica da forma dominante, com melhor prognĂłstico
Genótipos de milho para plantio em sistema de corte e trituração.
bitstream/item/27998/1/com.tec.65.pd
Fat intake impairs the recovery of endothelial function following mental stress in young healthy adults
An adaptive management proposal for optimizing the performance of a virtualized computing environment
The number of virtualized servers is overtaking, by a large amount, the number of physical servers. One of the drawbacks of this new scenario is a much more complex computing infrastructure to manage. In this way, the current paper proposes a adaptive management prototype that controls a virtualized environment. This prototype guarantees an adaptive and automatic solution that efficiently supervises and controls any virtualized environment, without almost any human intervention. In addition, it manages the relevant physical computing resources allocated to each virtual machine, like memory and processing power. The results from our prototype suggest that it is possible to balance memory among various machines and perform an effective control of each machine's workload, with a simple and low cost solution for our initial problem.info:eu-repo/semantics/acceptedVersio
Fat Consumption Attenuates Cortical Oxygenation during Mental Stress in Young Healthy Adults
Mental stress has been associated with cardiovascular events and stroke, and has also been linked with poorer brain function, likely due to its impact on cerebral vasculature. During periods of stress, individuals often increase their consumption of unhealthy foods, especially high-fat foods. Both high-fat intake and mental stress are known to impair endothelial function, yet few studies have investigated the effects of fat consumption on cerebrovascular outcomes during periods of mental stress. Therefore, this study examined whether a high-fat breakfast prior to a mental stress task would alter cortical oxygenation and carotid blood flow in young healthy adults. In a randomised, counterbalanced, cross-over, postprandial intervention study, 21 healthy males and females ingested a high-fat (56.5 g fat) or a low-fat (11.4 g fat) breakfast 1.5 h before an 8-min mental stress task. Common carotid artery (CCA) diameter and blood flow were assessed at pre-meal baseline, 1 h 15 min post-meal at rest, and 10, 30, and 90 min following stress. Pre-frontal cortex (PFC) tissue oxygenation (near-infrared spectroscopy, NIRS) and cardiovascular activity were assessed post-meal at rest and during stress. Mental stress increased heart rate, systolic and diastolic blood pressure, and PFC tissue oxygenation. Importantly, the high-fat breakfast reduced the stress-induced increase in PFC tissue oxygenation, despite no differences in cardiovascular responses between high- and low-fat meals. Fat and stress had no effect on resting CCA blood flow, whilst CCA diameter increased following consumption of both meals. This is the first study to show that fat consumption may impair PFC perfusion during episodes of stress in young healthy adults. Given the prevalence of consuming high-fat foods during stressful periods, these findings have important implications for future research to explore the relationship between food choices and cerebral haemodynamics during mental stress
Chromatin accessibility maps of chronic lymphocytic leukemia identify subtypespecific epigenome signatures and associated transcription regulatory networks
Chronic lymphocytic leukemia (CLL) is characterized by substantial clinical heterogeneity, despite relatively few genetic alterations. To provide a basis for studying epigenome deregulation in CLL, we established genome-wide chromatin accessibility maps for 88 CLL samples from 55 patients using the ATAC-seq assay. These data were further complemented by ChIPmentation and RNA-seq profiling in ten samples. Based on this dataset, we devised and applied a bioinformatic method that links chromatin profiles to clinical annotations. Our analysis identified sample-specific variation on top of a shared core of CLL regulatory regions. IGHV mutation status – which distinguishes the two major subtypes of CLL – was accurately predicted by the chromatin profiles, and gene regulatory networks inferred for IGHV-mutated vs. IGHV-unmutated samples identified characteristic regulatory differences between these two disease subtypes. In summary, we found widespread heterogeneity in the CLL chromatin landscape, established a community resource for studying epigenome deregulation in leukemia, and demonstrated the feasibility of chromatin accessibility mapping in cancer cohorts and clinical research
Efeito da época de preparo de área sem queima, na abundância e diversidade da fauna do solo.
Chromatin mapping and single-cell immune profiling define the temporal dynamics of ibrutinib response in CLL
The Bruton tyrosine kinase (BTK) inhibitor ibrutinib provides effective treatment for patients with chronic lymphocytic leukemia (CLL), despite extensive heterogeneity in this disease. To define the underlining regulatory dynamics, we analyze high-resolution time courses of ibrutinib treatment in patients with CLL, combining immune-phenotyping, single-cell transcriptome profiling, and chromatin mapping. We identify a consistent regulatory program starting with a sharp decrease of NF-kappa B binding in CLL cells, which is followed by reduced activity of lineage-defining transcription factors, erosion of CLL cell identity, and acquisition of a quiescence-like gene signature. We observe patient-to-patient variation in the speed of execution of this program, which we exploit to predict patient-specific dynamics in the response to ibrutinib based on the pre-treatment patient samples. In aggregate, our study describes time-dependent cellular, molecular, and regulatory effects for therapeutic inhibition of B cell receptor signaling in CLL, and it establishes a broadly applicable method for epigenome/transcriptome-based treatment monitoring
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A role for hippocampal PSA-NCAM and NMDA-NR2B receptor function in flavonoid-induced spatial memory improvements in young rats
The increase in incidence and prevalence of neurodegenerative diseases highlights the need for a more comprehensive understanding of how food components may affect neural systems. In particular, flavonoids have been recognized as promising agents capable of influencing different aspects of synaptic plasticity resulting in improvements in memory and learning in both animals and humans. Our previous studies highlight the efficacy of flavonoids in reversing memory impairments in aged rats, yet little is known about the effects of these compounds in healthy animals, particularly with respect to the molecular mechanisms by which flavonoids might alter the underlying synaptic modifications responsible for behavioral changes. We demonstrate that a 3-week intervention with two dietary doses of flavonoids (Dose I: 8.7Â mg/day and Dose II: 17.4Â mg/day) facilitates spatial memory acquisition and consolidation (24 recall) (
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