A new route to trihydroxamate-containing artificial siderophores and synthesis of a new fluorescent probe.

A fluorescent labelled artificial siderophore 1 was synthesized by coupling a 7-nitrobenz-2-oxa-1,3-diazole (NBD) derivative to the terminal amino group of a new trihydroxamate-containing amine 2, a ferrichrome-type siderophore that was obtained from tris(hydroxymethyl) amino methane. Compound I was shown to be a suitable tool for experiments on siderophore transport and uptake processes in various organisms cells and particularly in Candida albicans cells

Chronic recurrent multifocal osteomyelitis in children with hypophosphatasia explained by anti-inflammatory nucleotidase activity of tissue nonspecific alkaline phosphatase in mesenchymal and hematopoietic cells

International audienc

Le clerc séculier au Moyen Âge

Qu'on n'attende pas ici une étude exhaustive d'un groupe social émietté et diversifié, tant par ses origines, sa formation intellectuelle que par les fonctions exercées par ses membres. Le rapport introductif en souligne les clivages, tout en notant quelques traits communs : la jouissance d'un statut apportant immunité judiciaire et fiscale, mais qui suscite plus de critiques que de considération, en raison de l'écart entre l'idéal évangélique, souvent recherché, et la conduite des clercs, trop souvent relâchée. Du royaume de France à la Scandinavie, de la péninsule ibérique à Constantinople. surgissent les images contrastées des clergeons de cathédrales, des prêtres-filleuls formant une véritable plèbe ecclésiastique, des curés ruraux mal instruits, des dignitaires de chapitres et des évêques qui s'efforcent, tant bien que mal, de veiller au bon fonctionnement des institutions, de contrôler les mœurs du clergé et de lui assurer une médiocre formation continue, afin qu'il puisse mieux répondre à l'idéal sacerdotal. Les diverses communications qui suivent cherchent donc à préciser l'image du clerc dans la société médiévale, le recrutement, la formation, le ministère pastoral, à comprendre aussi comment, par delà la diversité des fonctions et les distances sociales, les clercs séculiers forment un corps, le cœtus clericorum, qui se regroupe dans des confréries ou dans des quartiers urbains spécifiques, étudiés par notre regretté collègue, Jean-Charles Picard, dont ce fut l'une des dernières interventions parmi nous. Si un ouvrage d'ensemble sur le clergé séculier au Moyen Âge est encore prématuré, il faut souhaiter que les contributions ici réunies permettent au lecteur de mieux comprendre la vie foisonnante d'un groupe essentiel de la société médiévale, dans ses idéaux comme dans ses contradictions

Data quality control considerations in multivariate environmental monitoring: experience of the French coastal network SOMLIT

International audienceIntroduction While crucial to ensuring the production of accurate and high-quality data—and to avoid erroneous conclusions—data quality control (QC) in environmental monitoring datasets is still poorly documented. Methods With a focus on annual inter-laboratory comparison (ILC) exercises performed in the context of the French coastal monitoring SOMLIT network, we share here a pragmatic approach to QC, which allows the calculation of systematic and random errors, measurement uncertainty, and individual performance. After an overview of the different QC actions applied to fulfill requirements for quality and competence, we report equipment, accommodation, design of the ILC exercises, and statistical methodology specially adapted to small environmental networks (<20 laboratories) and multivariate datasets. Finally, the expanded uncertainty of measurement for 20 environmental variables routinely measured by SOMLIT from discrete sampling—including Essential Ocean Variables—is provided. Results, Discussion, Conclusion The examination of the temporal variations (2001–2021) in the repeatability, reproducibility, and trueness of the SOMLIT network over time confirms the essential role of ILC exercises as a tool for the continuous improvement of data quality in environmental monitoring datasets

DataSheet_1_Data quality control considerations in multivariate environmental monitoring: experience of the French coastal network SOMLIT.docx

IntroductionWhile crucial to ensuring the production of accurate and high-quality data—and to avoid erroneous conclusions—data quality control (QC) in environmental monitoring datasets is still poorly documented.MethodsWith a focus on annual inter-laboratory comparison (ILC) exercises performed in the context of the French coastal monitoring SOMLIT network, we share here a pragmatic approach to QC, which allows the calculation of systematic and random errors, measurement uncertainty, and individual performance. After an overview of the different QC actions applied to fulfill requirements for quality and competence, we report equipment, accommodation, design of the ILC exercises, and statistical methodology specially adapted to small environmental networks (Results, Discussion, ConclusionThe examination of the temporal variations (2001–2021) in the repeatability, reproducibility, and trueness of the SOMLIT network over time confirms the essential role of ILC exercises as a tool for the continuous improvement of data quality in environmental monitoring datasets.</p