Differential regulation of innate and adaptive immune responses in viral encephalitis.

Viral encephalitis is a global health concern. The ability of a virus to modulate the immune response can have a pivotal effect on the course of disease and the fate of the infected host. In this study, we sought to understand the immunological basis for the fatal encephalitis following infection with the murine coronavirus, mouse hepatitis virus (MHV)-JHM, in contrast with the more attenuated MHV-A59. Distinct glial cell cytokine and chemokine response patterns were observed within 3 days after infection, became progressively more polarized during the course of infection and with the infiltration of leukocytes. In the brain, MHV-JHM infection induced strong accumulation of IFNbeta mRNA relative to IFNgamma mRNA. This trend was reversed in MHV-A59 infection and was accompanied by increased CD8 T cell infiltration into brain compared to MHV-JHM infection. Increased apoptosis appeared to contribute to the diminished presence of CD8 T cells in MHV-JHM-infected brain with the consequence of a lower potential for IFNgamma production and antiviral activity. MHV-JHM infection also induced sustained mRNA accumulation of the innate immune response products interleukin (IL)-6 and IL-1. Furthermore, high levels of macrophage-inflammatory protein (MIP)-1alpha, MIP-1beta, and MIP-2 mRNA were observed at the onset of MHV-JHM infection and correlated with a marked elevation in the number of macrophages in the brain on day 7 compared to MHV-A59 infection. These observations indicate that differences in the severity of viral encephalitis may reflect the differential ability of viruses to stimulate innate immune responses within the CNS and subsequently the character of infiltrating leukocyte populations

Observation and Modeling of the Solar-Cycle Variation of the Meridional Flow

We present independent observations of the solar-cycle variation of flows near the solar surface and at a depth of about 60 Mm, in the latitude range $\pm45^\circ$. We show that the time-varying components of the meridional flow at these two depths have opposite sign, while the time-varying components of the zonal flow are in phase. This is in agreement with previous results. We then investigate whether the observations are consistent with a theoretical model of solar-cycle dependent meridional circulation based on a flux-transport dynamo combined with a geostrophic flow caused by increased radiative loss in the active region belt (the only existing quantitative model). We find that the model and the data are in qualitative agreement, although the amplitude of the solar-cycle variation of the meridional flow at 60 Mm is underestimated by the model.Comment: To be published in Solar Physcis Topical Issue "Helioseismology, Asteroseismology, and MHD Connections

Solar differential rotation and meridional flow: The role of a subadiabatic tachocline for the Taylor-Proudman balance

We present a simple model for the solar differential rotation and meridional circulation based on a mean field parameterization of the Reynolds stresses that drive the differential rotation. We include the subadiabatic part of the tachocline and show that this, in conjunction with turbulent heat conductivity within the convection zone and overshoot region, provides the key physics to break the Taylor-Proudman constraint, which dictates differential rotation with contour lines parallel to the axis of rotation in case of an isentropic stratification. We show that differential rotation with contour lines inclined by 10 - 30 degrees with respect to the axis of rotation is a robust result of the model, which does not depend on the details of the Reynolds stress and the assumed viscosity, as long as the Reynolds stress transports angular momentum toward the equator. The meridional flow is more sensitive with respect to the details of the assumed Reynolds stress, but a flow cell, equatorward at the base of the convection zone and poleward in the upper half of the convection zone, is the preferred flow pattern.Comment: 15 pages, 7 figure

Are Split Tablet Keyboards Better? A Study of Soft Keyboard Layout and Hand Posture

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2021-2022 Statewide Utah Angler Survey Report

Continuing an effort that dates to 1967, we collected data through a statewide survey of licensed anglers in an effort to understand their preference and behaviors. Anglers were surveyed across the state of Utah, as well as nonresident anglers who purchased a Utah fishing license. This research was guided by objectives developed by the Division of Wildlife Resources (DWR) as and our research team at the Institute of Outdoor Recreation and Tourism at Utah State University. In the report, we provide statewide statistics and comparisons between the DWRs five management regions. The objectives and key findings are:Objective 1. Define the characteristics of Utah anglersObjective 2. Produce a snapshot of angling in Utah over a 12-month periodObjective 3. Identify what motivates Utah anglersObjective 4. Identify what fish species anglers expected to catch, caught, and prefer to catchObjective 5. Gauge anglers’ perceptions and knowledge of native and nonnative fish species in UtahObjective 6. Explore Utah anglers’ perceptions of, and experiences with, crowdingObjective 7. Identify potential areas where managers can create or promote opportunities for Utah anglers to combine recreational activities to enhance the angling experienceThe report provides tables and figures and explanations pertaining to each of the research objectives outlined above. In addition, statewide and regional statistics are provided to showcase the unique trends associated with Utah anglers and angling resources in Utah

Resolving the role of carbonaceous material in gold precipitation in metasediment-hosted orogenic gold deposits

Carbonaceous material (CM) is commonly associated with gold and sulfides in metasediment-hosted orogenic gold deposits. The role of CM in Au deposition is controversial; CM has been proposed to contribute to gold deposition by reducing Au bisulfide complexes, or by facilitating sulfidation, which destabilizes Au in bisulfide complexes with resultant Au deposition. Integration of petrographic observations, thermodynamic models, and geochemical data from metasediment-hosted orogenic gold deposits in New Zealand, Australia, Canada, and West Africa reveals genetic links between sulfides, CM, and mineralization. The results are consistent with the coexistence of CM and pyrite as a consequence of their codeposition from ore fluids, with a minor proportion of CM originally in situ in the host rocks. Au is deposited when pyrite and CM deposition decreases H2S concentration in ore fluids, destabilizing Au(HS)2-complexes. Most CM in gold deposits is deposited from CO2 and CH4 in ore fluids. These findings are applicable to similar deposits worldwide

Chaotic saddles in nonlinear modulational interactions in a plasma

A nonlinear model of modulational processes in the subsonic regime involving a linearly unstable wave and two linearly damped waves with different damping rates in a plasma is studied numerically. We compute the maximum Lyapunov exponent as a function of the damping rates in a two-parameter space, and identify shrimp-shaped self-similar structures in the parameter space. By varying the damping rate of the low-frequency wave, we construct bifurcation diagrams and focus on a saddle-node bifurcation and an interior crisis associated with a periodic window. We detect chaotic saddles and their stable and unstable manifolds, and demonstrate how the connection between two chaotic saddles via coupling unstable periodic orbits can result in a crisis-induced intermittency. The relevance of this work for the understanding of modulational processes observed in plasmas and fluids is discussed.Comment: Physics of Plasmas, in pres

Mouse hepatitis virus neurovirulence: evidence of a linkage between S glycoprotein expression and immunopathology.

Differences in disease outcome between the highly neurovirulent MHV-JHM and mildly neurovirulent MHV-A59 have been attributed to variations within the spike (S) glycoprotein. Previously, we found that MHV-JHM neurovirulence was marked by diminished expression of interferon-gamma (IFN-gamma) mRNA and a reduced presence of CD8 T cells in the CNS concomitant with heightened macrophage inflammatory protein (MIP)-1 transcript levels and greater macrophage infiltration relative to MHV-A59 infection. Here, the ability of the S and non-spike genes to regulate these immune responses was evaluated using chimeric viruses. Chimeric viruses WTR13 and S4R22 were made on MHV-A59 variant backgrounds and, respectively, contained the S gene of MHV-A59 and MHV-JHM. Unexpectedly, genes other than S appeared to modulate events critical to viral replication and survival. Unlike unresolving MHV-JHM infections, the clearance of WTR13 and S4R22 infections coincided with strong IFN-gamma transcription and an increase in the number of CD8 T cells infiltrating into the CNS. However, despite the absence of detectable viral titers, approximately 40% of S4R22-infected mice succumbed within 3 weeks, indicating that the enhanced mortality following S4R22 infection was not associated with high viral titers. Instead, similar to the MHV-JHM infection, reduced survival following S4R22 infection was observed in the presence of elevated MIP-1alpha and MIP-1beta mRNA accumulation and enhanced macrophage numbers within infected brains. These observations suggest that the S protein of MHV-JHM influences neurovirulence through the induction of MIP-1alpha- and MIP-1beta-driven macrophage immunopathology

Lower solar atmosphere and magnetism at ultra-high spatial resolution

We present the scientific case for a future space-based telescope aimed at very high spatial and temporal resolution imaging of the solar photosphere and chromosphere. Previous missions (e.g., HINODE, SUNRISE) have demonstrated the power of observing the solar photosphere and chromosphere at high spatial resolution without contamination from Earth's atmosphere. We argue here that increased spatial resolution (from currently 70 km to 25 km in the future) and high temporal cadence of the observations will vastly improve our understanding of the physical processes controlling solar magnetism and its characteristic scales. This is particularly important as the Sun's magnetic field drives solar activity and can significantly influence the Sun-Earth system. At the same time a better knowledge of solar magnetism can greatly improve our understanding of other astrophysical objects