Monitoring guidance for patients with hypophosphatasia treated with asfotase alfa.

Hypophosphatasia (HPP) is a rare, inherited, systemic, metabolic disorder caused by autosomal recessive mutations or a single dominant-negative mutation in the gene encoding tissue-nonspecific alkaline phosphatase (TNSALP). The disease is associated with a broad range of signs, symptoms, and complications, including impaired skeletal mineralization, altered calcium and phosphate metabolism, recurrent fractures, pain, respiratory problems, impaired growth and mobility, premature tooth loss, developmental delay, and seizures. Asfotase alfa is a human, recombinant enzyme replacement therapy that is approved in many countries for the treatment of patients with HPP. To address the unmet need for guidance in the monitoring of patients receiving asfotase alfa, an international panel of physicians with experience in diagnosing and managing HPP convened in May 2016 to discuss treatment monitoring parameters. The panel discussions focused on recommendations for assessing and monitoring patients after the decision to treat with asfotase alfa had been made and did not include recommendations for whom to treat. Based on the consensus of panel members, this review provides guidance on the monitoring of patients with HPP during treatment with asfotase alfa, including recommendations for laboratory, efficacy, and safety assessments and the frequency with which these should be performed during the course of treatment. Recommended assessments are based on patient age and include regular monitoring of biochemistry, skeletal radiographs, respiratory function, growth, pain, mobility and motor function, and quality of life. Because of the systemic presentation of HPP, a coordinated, multidisciplinary, team-based, patient-focused approach is recommended in the management of patients receiving asfotase alfa. Monitoring of efficacy and safety outcomes must be tailored to the individual patient, depending on medical history, clinical manifestations, availability of resources in the clinical setting, and the clinician's professional judgment

Neonatal Incidence of Hip Dysplasia: Ten Years of Experience

The advantages of sonographic examination are well known, but its main disadvantage is that it might lead to overdiagnosis, which might cause overtreatment. Variations in the incidence of developmental dysplasia of the hip are well known. We ascertained the incidence of neonatal sonographic developmental dysplasia of the hip without considering the development of those joints during followup. All 45,497 neonates (90,994 hips) born in our institute between January 1992 and December 2001 were examined clinically and sonographically during the first 48 hours of life. Sonography was performed according to Graf’s method, which considers mild hip sonographic abnormalities as Type IIa. We evaluated the different severity type incidence pattern and its influence on the total incidence during and between the investigated years. According to our study, sonographic Type IIa has major effects on the incidence of overall developmental dysplasia of the hip with a correlation coefficient of 0.95, whereas more severe sonographic abnormalities show relatively stable incidence patterns

Global Warming and Community Outreach (Semester Unknown) IPRO 331: Global Warming IPRO 331 Final Report F08

The main goal of the fall semester of IPRO 331 is to build off the previous two IPROs in terms of scientific and global data while further enhancing the knowledge of the general public throughout Chicago and the greater Chicago area. The team plans on utilizing the past data (which is presented on iGroups) and creating a more streamlined presentation that covers all of the main topics while enabling the group to add more relevant and interesting information. It is the group’s philosophy that there is no reason to re-do what past groups have done in terms of research when it is already made available. This will allow the group to focus more heavily on the main goal of community outreach. In terms of the community outreach, it is still the same goal as the previous IPROs to reach as many possible candidates as the semester allows. Another one of the group’s philosophies is that reaching as many people as possible is the key to making this semester’s IPRO successful.Deliverable

Global Warming and Community Outreach (Semester Unknown) IPRO 331: Global Warming IPRO 331 Final Presentation F08

The main goal of the fall semester of IPRO 331 is to build off the previous two IPROs in terms of scientific and global data while further enhancing the knowledge of the general public throughout Chicago and the greater Chicago area. The team plans on utilizing the past data (which is presented on iGroups) and creating a more streamlined presentation that covers all of the main topics while enabling the group to add more relevant and interesting information. It is the group’s philosophy that there is no reason to re-do what past groups have done in terms of research when it is already made available. This will allow the group to focus more heavily on the main goal of community outreach. In terms of the community outreach, it is still the same goal as the previous IPROs to reach as many possible candidates as the semester allows. Another one of the group’s philosophies is that reaching as many people as possible is the key to making this semester’s IPRO successful.Deliverable

Global Warming and Community Outreach (Semester Unknown) IPRO 331: Global Warming IPRO 331 Brochure F08

The main goal of the fall semester of IPRO 331 is to build off the previous two IPROs in terms of scientific and global data while further enhancing the knowledge of the general public throughout Chicago and the greater Chicago area. The team plans on utilizing the past data (which is presented on iGroups) and creating a more streamlined presentation that covers all of the main topics while enabling the group to add more relevant and interesting information. It is the group’s philosophy that there is no reason to re-do what past groups have done in terms of research when it is already made available. This will allow the group to focus more heavily on the main goal of community outreach. In terms of the community outreach, it is still the same goal as the previous IPROs to reach as many possible candidates as the semester allows. Another one of the group’s philosophies is that reaching as many people as possible is the key to making this semester’s IPRO successful.Deliverable

Global Warming and Community Outreach (Semester Unknown) IPRO 331: Global Warming IPRO 331 Ethics F08

The main goal of the fall semester of IPRO 331 is to build off the previous two IPROs in terms of scientific and global data while further enhancing the knowledge of the general public throughout Chicago and the greater Chicago area. The team plans on utilizing the past data (which is presented on iGroups) and creating a more streamlined presentation that covers all of the main topics while enabling the group to add more relevant and interesting information. It is the group’s philosophy that there is no reason to re-do what past groups have done in terms of research when it is already made available. This will allow the group to focus more heavily on the main goal of community outreach. In terms of the community outreach, it is still the same goal as the previous IPROs to reach as many possible candidates as the semester allows. Another one of the group’s philosophies is that reaching as many people as possible is the key to making this semester’s IPRO successful.Deliverable

Human Orthotic and Prosthetic Education (Semester Unknown) IPRO 309: Human Orthotic and Prosthetic Education IPRO309 Ethics Sp09

Inter-professional Project 309 is an ongoing venture spanning seven semesters at Illinois Institute of Technology working constantly toward the goal of developing and supporting the first Category III Orthotics and Prosthetics educational program in Latin America to be accredited by the International Society of Prosthetics and Orthotics (ISPO).Deliverable