Network centrality: an introduction

Centrality is a key property of complex networks that influences the behavior of dynamical processes, like synchronization and epidemic spreading, and can bring important information about the organization of complex systems, like our brain and society. There are many metrics to quantify the node centrality in networks. Here, we review the main centrality measures and discuss their main features and limitations. The influence of network centrality on epidemic spreading and synchronization is also pointed out in this chapter. Moreover, we present the application of centrality measures to understand the function of complex systems, including biological and cortical networks. Finally, we discuss some perspectives and challenges to generalize centrality measures for multilayer and temporal networks.Comment: Book Chapter in "From nonlinear dynamics to complex systems: A Mathematical modeling approach" by Springe

Matrix gla protein in xenopus laevis: molecular cloning, tissue distribution, and evolutionary considerations

Matrix Gla protein (MGP) belongs to the family of vitamin K-dependent, Gla-containing proteins and in higher vertebrates, is found in the extracellular matrix of mineralized tissues and soft tissues. MGP synthesis is highly regulated at the transcription and posttranscription levels and is now known to be involved in the regulation of extracellular matrix calcification and maintenance of cartilage and soft tissue integrity during growth and development. However, its mode of action at the molecular level remains unknown. Because there is a large degree of conservation between amino,acid sequences of shark and human MGP, the function of MGP probably has been conserved throughout evolution. Given the complexity of the mammalian system, the study of MGP in a lower vertebrate might be advantageous to relate the onset of MGP expression with specific events during development. Toward this goal, MGP was purified from Xenopus long bones and its N-terminal amino acid sequence was determined and used to clone the Xenopus MGP complementary DNA (cDNA) by a mixture of reverse-transcription (RT)- and 5'- rapid amplification of cDNA ends (RACE)-polymerase chain reaction (PCR). MGP messenger RNA (mRNA) was present in all tissues analyzed although predominantly expressed in Xenopus bone and heart and its presence was detected early in development at the onset of chondrocranium development and long before the appearance of the first calcified structures and metamorphosis. These results show that in this system, as in mammals, MGP may be required to delay or prevent mineralization of cartilage and soft tissues during the early stages of development and indicate that Xenopus is an adequate model organism to further study MGP function during growth and development.NATO/CRG940751/SA5.2.05, Praxis XXI/BIA 469/94, (NIH; grant AR 25921) (Praxis XXI/BPD/18816) (Praxis XXI/BICJ-2985

Measurement of the mass difference m(D-s(+))-m(D+) at CDF II

We present a measurement of the mass difference m(D-s(+))-m(D+), where both the D-s(+) and D+ are reconstructed in the phipi(+) decay channel. This measurement uses 11.6 pb(-1) of data collected by CDF II using the new displaced-track trigger. The mass difference is found to be m(D-s(+))-m(D+)=99.41+/-0.38(stat)+/-0.21(syst) MeV/c(2)

Effects of hospital facilities on patient outcomes after cancer surgery: an international, prospective, observational study

Background Early death after cancer surgery is higher in low-income and middle-income countries (LMICs) compared with in high-income countries, yet the impact of facility characteristics on early postoperative outcomes is unknown. The aim of this study was to examine the association between hospital infrastructure, resource availability, and processes on early outcomes after cancer surgery worldwide.Methods A multimethods analysis was performed as part of the GlobalSurg 3 study-a multicentre, international, prospective cohort study of patients who had surgery for breast, colorectal, or gastric cancer. The primary outcomes were 30-day mortality and 30-day major complication rates. Potentially beneficial hospital facilities were identified by variable selection to select those associated with 30-day mortality. Adjusted outcomes were determined using generalised estimating equations to account for patient characteristics and country-income group, with population stratification by hospital.Findings Between April 1, 2018, and April 23, 2019, facility-level data were collected for 9685 patients across 238 hospitals in 66 countries (91 hospitals in 20 high-income countries; 57 hospitals in 19 upper-middle-income countries; and 90 hospitals in 27 low-income to lower-middle-income countries). The availability of five hospital facilities was inversely associated with mortality: ultrasound, CT scanner, critical care unit, opioid analgesia, and oncologist. After adjustment for case-mix and country income group, hospitals with three or fewer of these facilities (62 hospitals, 1294 patients) had higher mortality compared with those with four or five (adjusted odds ratio [OR] 3.85 [95% CI 2.58-5.75]; p<0.0001), with excess mortality predominantly explained by a limited capacity to rescue following the development of major complications (63.0% vs 82.7%; OR 0.35 [0.23-0.53]; p<0.0001). Across LMICs, improvements in hospital facilities would prevent one to three deaths for every 100 patients undergoing surgery for cancer.Interpretation Hospitals with higher levels of infrastructure and resources have better outcomes after cancer surgery, independent of country income. Without urgent strengthening of hospital infrastructure and resources, the reductions in cancer-associated mortality associated with improved access will not be realised

Petrology of the eclogites from western Tasmania : Insights into the Cambro-Ordovician evolution of the paleo-Pacific margin of Gondwana

Eclogite facies rocks along the Paleozoic active margin of Gondwana are rare. They are limited to isolated segments of Northern Victoria Land (Antarctica), western Tasmania, and southeastern Australia. New petrological data for mafic rocks and their host garnet-kyanite schists from the Franklin Metamorphic Complex (western Tasmania) permit reconstruction of six main stages of mineral growth for the eclogite. Stages I and II occurred at greenschist/ amphibolite-facies conditions (ca. 500–600 °C; 0.55–0.7 GPa for stage II) before attaining high-pressure conditions (at≈600–650 °C; N1.5GPa for stage III). The following stages, IV and V, record the decompression from high-pressure conditions to amphibolite-facies (ca. 500–600 °C; 0.4–1.0 GPa). Finally, stage VI represents the late greenschist-facies retrogression. However, the pelitic schist surrounding the eclogite records only the medium pressure amphibolite- facies stage. The P–T evolution over time outlines a clockwise path that is quite steep in both the prograde and retrograde segments. The latter shows a nearly isothermal decompression between the eclogite and the high-pressure amphibolite-facies stage IV, which was achieved at deep crustal levels (≈30 km), and a final decrease in both pressure and temperature from deep/intermediate to shallow crustal levels, with a typical cooling-unloading path. The lack of a complete re-equilibration during the different stages and the high dP/dT for both the prograde and retrograde paths are indicative of a rapid burial and initially rapid exhumation. The similarity of the mafic whole-rock chemical composition, including N, T to E-MORB and of the peak metamorphic age (≈500Ma) between the Tasmanian eclogites and the UHP rocks from Northern Victoria Land, supports the idea that they formed in the context of the same contractional event. However, the different P–T conditions and dP/dT point to different tectono-metamorphic settings for the two sectors of the paleo-Pacific margin of Gondwana during the Ross/Tyennan orogeny.Upprättat; 2009; 20111123 (ysko

New species of Neoplecostomus (Neoplecostomini: Loricariidae) lacking adipose fin from upper Rio Paraná basin, central Brazil

Silva, Gabriel S. C., Reia, Lais, Zawadzki, Cláudio H., Roxo, Fabio F. (2019): New species of Neoplecostomus (Neoplecostomini: Loricariidae) lacking adipose fin from upper Rio Paraná basin, central Brazil. Zootaxa 4544 (1): 93-102, DOI: https://doi.org/10.11646/zootaxa.4544.1.