53 research outputs found
Pro-survival responses to the dual inhibition of anti-apoptotic Bcl-2 family proteins and mTOR-mediated signaling in hypoxic colorectal carcinoma cells
Evolutionary history of Serpulaceae (Basidiomycota): molecular phylogeny, historical biogeography and evidence for a single transition of nutritional mode
<p>Abstract</p> <p>Background</p> <p>The fungal genus <it>Serpula </it>(Serpulaceae, Boletales) comprises several saprotrophic (brown rot) taxa, including the aggressive house-infecting dry rot fungus <it>Serpula lacrymans</it>. Recent phylogenetic analyses have indicated that the ectomycorrhiza forming genera <it>Austropaxillus </it>and <it>Gymnopaxillus </it>cluster within <it>Serpula</it>. In this study we use DNA sequence data to investigate phylogenetic relationships, historical biogeography of, and nutritional mode transitions in Serpulaceae.</p> <p>Results</p> <p>Our results corroborate that the two ectomycorrhiza-forming genera, <it>Austropaxillus </it>and <it>Gymnopaxillus</it>, form a monophyletic group nested within the saprotrophic genus <it>Serpula</it>, and that the <it>Serpula </it>species <it>S. lacrymans </it>and <it>S. himantioides </it>constitute the sister group to the <it>Austropaxillus</it>-<it>Gymnopaxillus </it>clade. We found that both vicariance (Beringian) and long distance dispersal events are needed to explain the phylogeny and current distributions of taxa within Serpulaceae. Our results also show that the transition from brown rot to mycorrhiza has happened only once in a monophyletic Serpulaceae, probably between 50 and 22 million years before present.</p> <p>Conclusions</p> <p>This study supports the growing understanding that the same geographical barriers that limit plant- and animal dispersal also limit the spread of fungi, as a combination of vicariance and long distance dispersal events are needed to explain the present patterns of distribution in Serpulaceae. Our results verify the transition from brown rot to ECM within Serpulaceae between 50 and 22 MyBP.</p
Gender differences in the use of cardiovascular interventions in HIV-positive persons; the D:A:D Study
Peer reviewe
Inter-individual variability of stone marten behavioral responses to a highway
Efforts to reduce the negative impacts of roads on wildlife may be hindered if individuals within the population vary widely
in their responses to roads and mitigation strategies ignore this variability. This knowledge is particularly important for
medium-sized carnivores as they are vulnerable to road mortality, while also known to use available road passages (e.g.,
drainage culverts) for safely crossing highways. Our goal in this study was to assess whether this apparently contradictory
pattern of high road-kill numbers associated with a regular use of road passages is attributable to the variation in behavioral
responses toward the highway between individuals. We investigated the responses of seven radio-tracked stone martens
(Martes foina) to a highway by measuring their utilization distribution, response turning angles and highway crossing
patterns. We compared the observed responses to simulated movement parameterized by the observed space use and
movement characteristics of each individual, but naı¨ve to the presence of the highway. Our results suggested that martens
demonstrate a diversity of responses to the highway, including attraction, indifference, or avoidance. Martens also varied in
their highway crossing patterns, with some crossing repeatedly at the same location (often coincident with highway
passages). We suspect that the response variability derives from the individual’s familiarity of the landscape, including their
awareness of highway passage locations. Because of these variable yet potentially attributable responses, we support the
use of exclusionary fencing to guide transient (e.g., dispersers) individuals to existing passages to reduce the road-kill risk
Comparative population genetic structure of the endangered southern brown bandicoot, Isoodon obesulus, in fragmented landscapes of Southern Australia
Genetic connectivity is a key factor for maintaining the persistence of populations in fragmented landscapes. In highly modified landscapes such us peri-urban areas, organisms' dispersal among fragmented habitat patches can be reduced due to the surrounding matrix, leading to subsequent decreased gene flow and increased potential extinction risk in isolated sub-populations. However, few studies have compared within species how dispersal/gene flow varies between regions and among different forms of matrix that might be encountered. In the current study, we investigated gene flow and dispersal in an endangered marsupial, the southern brown bandicoot (Isoodon obesulus) in a heavily modified peri-urban landscape in South Australia, Australia. We used 14 microsatellite markers to genotype 254 individuals which were sampled from 15 sites. Analyses revealed significant genetic structure. Our analyses also indicated that dispersal was mostly limited to neighbouring sites. Comparisons of these results with analyses of a different population of the same species revealed that gene flow/dispersal was more limited in this peri-urban landscape than in a pine plantation landscape approximately 400 km to the south-east. These findings increase our understanding of how the nature of fragmentation can lead to profound differences in levels of genetic connectivity among populations of the same species.You Li, Steven J.B. Cooper, Melanie L. Lancaster, Jasmin G. Packer, Susan M. Carthe
Origin and global diversification patterns of tropical rain forests: inferences from a complete genus-level phylogeny of palms
Random repeated cross sectional study on breeding site characterization of Anopheles sinensis larvae in distinct villages of Yongcheng City, People's Republic of China
Protocol for the atWork trial: a randomised controlled trial of a workplace intervention targeting subjective health complaints
- …