508 research outputs found
Innovative masters degree programs in teacher education
Several factors have caused many universities to review and revise their graduate teacher education programs
Hook3 is a scaffold for the opposite-polarity microtubule-based motors cytoplasmic dynein-1 and KIF1C.
The unidirectional and opposite-polarity microtubule-based motors, dynein and kinesin, drive long-distance intracellular cargo transport. Cellular observations suggest that opposite-polarity motors may be coupled. We recently identified an interaction between the cytoplasmic dynein-1 activating adaptor Hook3 and the kinesin-3 KIF1C. Here, using in vitro reconstitutions with purified components, we show that KIF1C and dynein/dynactin can exist in a complex scaffolded by Hook3. Full-length Hook3 binds to and activates dynein/dynactin motility. Hook3 also binds to a short region in the "tail" of KIF1C, but unlike dynein/dynactin, this interaction does not activate KIF1C. Hook3 scaffolding allows dynein to transport KIF1C toward the microtubule minus end, and KIF1C to transport dynein toward the microtubule plus end. In cells, KIF1C can recruit Hook3 to the cell periphery, although the cellular role of the complex containing both motors remains unknown. We propose that Hook3's ability to scaffold dynein/dynactin and KIF1C may regulate bidirectional motility, promote motor recycling, or sequester the pool of available dynein/dynactin activating adaptors
Approaches to Managing and Collecting Born-Digital Literary Materials for Scholarly Use
Digital Humanities Initiative Level 1 Start Up funding is requested to support a series of site visits and planning meetings among personnel working with the born-digital components of three significant collections of literary material: the Salman Rushdie papers at Emory University's Woodruff Library, the Michael Joyce Papers at the Harry Ransom Humanities Research Center at the University of Texas at Austin, and the Deena Larsen Collection at the Maryland Institute for Technology in the Humanities (MITH) at the University of Maryland. The meetings and site visits will facilitate the preparation of a larger collaborative grant proposal among the three institutions aimed at developing archival tools and best practices for preserving and curating the born-digital documents and records of contemporary authorship. Initial findings will be made available through a jointly authored and publicly distributed online white paper, as well as conference presentations at relevant venues
Sensitivity of a tonne-scale NEXT detector for neutrinoless double beta decay searches
The Neutrino Experiment with a Xenon TPC (NEXT) searches for the neutrinoless
double-beta decay of Xe-136 using high-pressure xenon gas TPCs with
electroluminescent amplification. A scaled-up version of this technology with
about 1 tonne of enriched xenon could reach in less than 5 years of operation a
sensitivity to the half-life of neutrinoless double-beta decay decay better
than 1E27 years, improving the current limits by at least one order of
magnitude. This prediction is based on a well-understood background model
dominated by radiogenic sources. The detector concept presented here represents
a first step on a compelling path towards sensitivity to the parameter space
defined by the inverted ordering of neutrino masses, and beyond.Comment: 22 pages, 11 figure
Hard Two-Photon Contribution to Elastic Lepton-Proton Scattering: Determined by the OLYMPUS Experiment
The OLYMPUS collaboration reports on a precision measurement of the
positron-proton to electron-proton elastic cross section ratio, ,
a direct measure of the contribution of hard two-photon exchange to the elastic
cross section. In the OLYMPUS measurement, 2.01~GeV electron and positron beams
were directed through a hydrogen gas target internal to the DORIS storage ring
at DESY. A toroidal magnetic spectrometer instrumented with drift chambers and
time-of-flight scintillators detected elastically scattered leptons in
coincidence with recoiling protons over a scattering angle range of to . The relative luminosity between the two beam species
was monitored using tracking telescopes of interleaved GEM and MWPC detectors
at , as well as symmetric M{\o}ller/Bhabha calorimeters at
. A total integrated luminosity of 4.5~fb was collected. In
the extraction of , radiative effects were taken into account
using a Monte Carlo generator to simulate the convolutions of internal
bremsstrahlung with experiment-specific conditions such as detector acceptance
and reconstruction efficiency. The resulting values of , presented
here for a wide range of virtual photon polarization ,
are smaller than some hadronic two-photon exchange calculations predict, but
are in reasonable agreement with a subtracted dispersion model and a
phenomenological fit to the form factor data.Comment: 5 pages, 3 figures, 2 table
System size and energy dependence of near-side di-hadron correlations
Two-particle azimuthal () and pseudorapidity ()
correlations using a trigger particle with large transverse momentum () in
+Au, Cu+Cu and Au+Au collisions at =\xspace 62.4 GeV and
200~GeV from the STAR experiment at RHIC are presented. The \ns correlation is
separated into a jet-like component, narrow in both and
, and the ridge, narrow in but broad in .
Both components are studied as a function of collision centrality, and the
jet-like correlation is studied as a function of the trigger and associated
. The behavior of the jet-like component is remarkably consistent for
different collision systems, suggesting it is produced by fragmentation. The
width of the jet-like correlation is found to increase with the system size.
The ridge, previously observed in Au+Au collisions at = 200
GeV, is also found in Cu+Cu collisions and in collisions at
=\xspace 62.4 GeV, but is found to be substantially smaller at
=\xspace 62.4 GeV than at = 200 GeV for the
same average number of participants ().
Measurements of the ridge are compared to models.Comment: 17 pages, 14 figures, submitted to Phys. Rev.
Measurements of and Production in + Collisions at = 200 GeV
We report measurements of charmed-hadron (, ) production cross
sections at mid-rapidity in + collisions at a center-of-mass energy of
200 GeV by the STAR experiment. Charmed hadrons were reconstructed via the
hadronic decays , and their charge conjugates,
covering the range of 0.62.0 GeV/ and 2.06.0 GeV/ for
and , respectively. From this analysis, the charm-pair production cross
section at mid-rapidity is = 170 45
(stat.) (sys.) b. The extracted charm-pair cross section is
compared to perturbative QCD calculations. The transverse momentum differential
cross section is found to be consistent with the upper bound of a Fixed-Order
Next-to-Leading Logarithm calculation.Comment: 15 pages, 16 figures. Revised version submitted to Phys. Rev.
Measurements of Dihadron Correlations Relative to the Event Plane in Au+Au Collisions at GeV
Dihadron azimuthal correlations containing a high transverse momentum (\pt)
trigger particle are sensitive to the properties of the nuclear medium created
at RHIC through the strong interactions occurring between the traversing parton
and the medium, i.e. jet-quenching. Previous measurements revealed a strong
modification to dihadron azimuthal correlations in Au+Au collisions with
respect to \pp\ and \dAu\ collisions. The modification increases with the
collision centrality, suggesting a path-length dependence to the jet-quenching
effect. This paper reports STAR measurements of dihadron azimuthal correlations
in mid-central (20-60\%) Au+Au collisions at \snn=200~GeV as a function of
the trigger particle's azimuthal angle relative to the event plane,
\phis=|\phit-\psiEP|. The azimuthal correlation is studied as a function of
both the trigger and associated particle \pt. The subtractions of the
combinatorial background and anisotropic flow, assuming Zero Yield At Minimum
(\zyam), are described. The away-side correlation is strongly modified, and the
modification varies with \phis, which is expected to be related to the
path-length that the away-side parton traverses. The pseudo-rapidity (\deta)
dependence of the near-side correlation, sensitive to long range \deta
correlations (the ridge), is also investigated. The ridge and jet-like
components of the near-side correlation are studied as a function of \phis.
The ridge appears to drop with increasing \phis while the jet-like component
remains approximately constant. ...Comment: 50 pages, 39 figures, 6 table
Studies of di-jet survival and surface emission bias in Au+Au collisions via angular correlations with respect to back-to-back leading hadrons
We report first results from an analysis based on a new multi-hadron
correlation technique, exploring jet-medium interactions and di-jet surface
emission bias at RHIC. Pairs of back-to-back high transverse momentum hadrons
are used for triggers to study associated hadron distributions. In contrast
with two- and three-particle correlations with a single trigger with similar
kinematic selections, the associated hadron distribution of both trigger sides
reveals no modification in either relative pseudo-rapidity or relative
azimuthal angle from d+Au to central Au+Au collisions. We determine associated
hadron yields and spectra as well as production rates for such correlated
back-to-back triggers to gain additional insights on medium properties.Comment: By the STAR Collaboration. 6 pages, 2 figure
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