Religion and Innovation in Europe: Implications for Product Life-Cycle Management

This paper analyzes the relationship between religion and innovation in Europe. To the best knowledge of the authors, no paper has been published about the association of religion with innovation and innovative products and services, at an individual level, for all the countries that belong to the European Union. This is the main goal of our paper. The results show that the orientation of innovativeness depends on religion. This study contains a segmentation of the main religions in Europe, taking into account their innovative profile. Connecting the characteristics of the religious segments found and the innovations life-cycle concept, companies have a tool to manage different innovations’ evolutive stages taking into consideration the religion of their customers. The European policy-makers, still dominated by a traditional innovation approach, gain a demand-side perspective to improve citizen’s innovativeness awareness and acceptance. Finally, religiosity does not seem to have a very strong relationship with attitudes towards innovation once we control for religious affiliation

What kind of guidance is expected by parents of ten children with congenital glaucoma, from the nurse in the hospital as seen by parents, doctors, social workers and nurses, themselves

Thesis (M.S.)--Boston Universit

Meson-Baryon s-wave Resonances with Strangeness -3

Starting from a consistent SU(6) extension of the Weinberg-Tomozawa (WT) meson-baryon chiral Lagrangian (Phys. Rev. D74 (2006) 034025), we study the s-wave meson-baryon resonances in the strangeness S=-3 and negative parity sector. Those resonances are generated by solving the Bethe-Salpeter equation with the WT interaction used as kernel. The considered mesons are those of the 35-SU(6)-plet, which includes the pseudoscalar (PS) octet of pions and the vector (V) nonet of the rho meson. For baryons we consider the 56-SU(6)-plet, made of the 1/2+ octet of the nucleon and the 3/2+ decuplet of the Delta. Quantum numbers I(J^P)=0(3/2^-) are suggested for the experimental resonances Omega*(2250)- and Omega*(2380)-. Among other, resonances with I=1 are found, with minimal quark content sss\bar{l}l', being s the strange quark and l, l' any of the the light up or down quarks. A clear signal for such a pentaquark would be a baryonic resonance with strangeness -3 and electric charge of -2 or 0, in proton charge units. We suggest looking for K- Xi- resonances with masses around 2100 and 2240 MeV in the sector 1(1/2^-), and for pi Omega- and K- Xi*- resonances with masses around 2260 MeV in the sector 1(3/2^-).Comment: 3 pages, 1 Postscript figure, 7 table

Letter from Marino Recio to Geraldine Ferraro

Letter from Marino Recio, of Marino Recio Associates, to Geraldine Ferraro.https://ir.lawnet.fordham.edu/vice_presidential_campaign_correspondence_1984_international/1369/thumbnail.jp

Computing Hypercircles by Moving Hyperplanes

Let K be a field of characteristic zero, alpha algebraic of degree n over K. Given a proper parametrization psi of a rational curve C, we present a new algorithm to compute the hypercircle associated to the parametrization psi. As a consequence, we can decide if the curve C is defined over K and, if not, to compute the minimum field of definition of C containing K. The algorithm exploits the conjugate curves of C but avoids computation in the normal closure of K(alpha) over K.Comment: 16 page

Hot-spot analysis for drug discovery targeting protein-protein interactions

Introduction: Protein-protein interactions are important for biological processes and pathological situations, and are attractive targets for drug discovery. However, rational drug design targeting protein-protein interactions is still highly challenging. Hot-spot residues are seen as the best option to target such interactions, but their identification requires detailed structural and energetic characterization, which is only available for a tiny fraction of protein interactions. Areas covered: In this review, the authors cover a variety of computational methods that have been reported for the energetic analysis of protein-protein interfaces in search of hot-spots, and the structural modeling of protein-protein complexes by docking. This can help to rationalize the discovery of small-molecule inhibitors of protein-protein interfaces of therapeutic interest. Computational analysis and docking can help to locate the interface, molecular dynamics can be used to find suitable cavities, and hot-spot predictions can focus the search for inhibitors of protein-protein interactions. Expert opinion: A major difficulty for applying rational drug design methods to protein-protein interactions is that in the majority of cases the complex structure is not available. Fortunately, computational docking can complement experimental data. An interesting aspect to explore in the future is the integration of these strategies for targeting PPIs with large-scale mutational analysis.This work has been funded by grants BIO2016-79930-R and SEV-2015-0493 from the Spanish Ministry of Economy, Industry and Competitiveness, and grant EFA086/15 from EU Interreg V POCTEFA. M Rosell is supported by an FPI fellowship from the Severo Ochoa program. The authors are grateful for the support of the the Joint BSC-CRG-IRB Programme in Computational Biology.Peer ReviewedPostprint (author's final draft