Inducción de tolerancia oral a leche de vaca en pacientes con alergia a leche de vaca IGE mediada

Tesis doctoral inédita leída en la Universidad Autónoma de Madrid, Facultad de Medicina. Departamento de Medicina. Fecha de lectura:26 de Junio de 201

Evaluación de la eficacia y seguridad de una pauta flexible, guiada por tomografía de coherencia óptica (OCT), de ranibizumab (Lucentis®) en el tratamiento de la degeneración macular asociada a la edad (DMAE) exudativa

Los estudios pivotales de ranibizumab en el tratamiento de la Degeneración Macular Asociada a la Edad (DMAE) exudativa, conocidos por los acrónimos MARINA y ANCHOR, demostraron que la administración mensual de ranibizumab conseguía mejorar la agudeza visual media de los pacientes. Para tratar de reducir los riesgos asociados al tratamiento continuado, reducir el coste económico y evitar la inyección cuando la lesión está inactiva se han realizado varios ensayos clínicos con diversas pautas de administración fijas o flexibles. Los autores del estudio PrONTO, una serie de 40 pacientes tratados en un solo centro, observaron que, con un régimen flexible de administración de ranibizumab, se podía conseguir un beneficio anatómico y visual similar a los ensayos realizados con inyección mensual, con un número significativamente menor de inyecciones. En la presente Tesis, se pretende analizar la eficacia de una pauta flexible de ranibizumab en una serie clínica más extensa, así como la existencia de factores basales, anatómicos y visuales, que pueden influir en los resultados visuales y en la respuesta anatómica del paciente. El objetivo principal de este estudio es evaluar el cambio en la Mejor Agudeza Visual Corregida (MAVC) entre las visitas basal y final (12 meses), tras la administración de ranibizumab en una pauta flexible

Intercultural and Community Schools. Learning to Live Together

We must remember the need to create communicative relationships among groups from different cultures, as well as to reinforce the configuration and organisation of the Spanish school system. The objective of this article is to highlight the urgent need to recognise cultural, religious and linguistic diversity as values. Furthermore, Spain has rejected the French assimilationist model, both in legal and practical spheres, and the only way to integrate this model is by implementing intercultural models. Following the Convention on the Promotion of the Diversity of Cultural Expression of the European Union, providing respect and recognition of plurality from intercultural inclusive positions is primordial in the learning context. We cannot talk about building an intercultural society without considering democratic practice and citizen participation; to this regard, dialogue and collaboration between the school community and educational centres are imperative. It is necessary to adopt an inclusive intercultural policy, to open education centres outside of traditional school hours, to reach agreements with cultural institutions, etc. Only in this way will an intercultural society become a reality

Enzymatic Synthesis of a Novel Pterostilbene α-Glucoside by the Combination of Cyclodextrin Glucanotransferase and Amyloglucosidase

The synthesis of a novel α-glucosylated derivative of pterostilbene was performed by a transglycosylation reaction using starch as glucosyl donor, catalyzed by cyclodextrin glucanotransferase (CGTase) from Thermoanaerobacter sp. The reaction was carried out in a buffer containing 20% (v/v) DMSO to enhance the solubility of pterostilbene. Due to the formation of several polyglucosylated products with CGTase, the yield of monoglucoside was increased by the treatment with a recombinant amyloglucosidase (STA1) from Saccharomyces cerevisiae (var. diastaticus). This enzyme was not able to hydrolyze the linkage between the glucose and pterostilbene. The monoglucoside was isolated and characterized by combining ESI-MS and 2D-NMR methods. Pterostilbene α-d-glucopyranoside is a novel compound. The α-glucosylation of pterostilbene enhanced its solubility in water to approximately 0.1 g/L. The α-glucosylation caused a slight loss of antioxidant activity towards ABTS˙+ radicals. Pterostilbene α-d-glucopyranoside was less toxic than pterostilbene for human SH-S5Y5 neurons, MRC5 fibroblasts and HT-29 colon cancer cells, and similar for RAW 264.7 macrophages.This research was funded by the Spanish Ministry of Economy and Competitiveness (Grants BIO2016-76601-C3-1-R and BIO2016-76601-C3-3-R).Peer reviewe