Why children are not vaccinated: a review of the grey literature

SummaryIn collaboration with WHO, IMMUNIZATIONbasics analyzed 126 documents from the global grey literature to identify reasons why eligible children had incomplete or no vaccinations.The main reasons for under-vaccination were related to immunization services and to parental knowledge and attitudes. The most frequently cited factors were: access to services, health staff attitudes and practices, reliability of services, false contraindications, parents’ practical knowledge of vaccination, fear of side effects, conflicting priorities and parental beliefs. Some family demographic characteristics were strong, but underlying, risk factors for under-vaccination.Studies must be well designed to capture a complete picture of the simultaneous causes of under-vaccination and to avoid biased results. Although the grey literature contains studies of varying quality, it includes many well-designed studies.Every immunization program should strive to provide quality services that are accessible, convenient, reliable, friendly, affordable and acceptable, and should solicit feedback from families and community leaders. Every program should monitor missed and under-vaccinated children and assess and address the causes. Although global reviews, such as this one, can play a useful role in identifying key questions for local study, local enquiry and follow-up remain essential

Determinants of Functionality in the Ubiquitin Conjugating Enzyme Family

AbstractThe E2 enzymes are key enzymes in the ubiquitin and ubiquitin-like protein ligation pathways. To understand the functionality of the different E2 enzymes, we analyzed 190 protein sequences and 211 structures and electrostatic potentials. Key findings include: The ScUbc1 orthologs are defined by a C-terminal UBA domain. An N-terminal sequence motif that is highly conserved in all E2s except for Cdc34 orthologs is important for the stabilization of the L7 loop and is likely to be involved in E1 binding. ScUbc11p has a different electrostatic potential from E2-Cp and other proteins with which it has high sequence similarity but different functionality. All the E2s known to ubiquitinate histones have a negative potential. The members of the NCUBE family have a positive electrostatic potential, although its form is different from that of the SUMO conjugating E2s. The specificities of only the ScUbc4/Ubc5 and ScUbc1p orthologs are reflected in their L4 and L7 loops

Enabling precision medicine in neonatology, an integrated repository for preterm birth research.

Preterm birth, or the delivery of an infant prior to 37 weeks of gestation, is a significant cause of infant morbidity and mortality. In the last decade, the advent and continued development of molecular profiling technologies has enabled researchers to generate vast amount of 'omics' data, which together with integrative computational approaches, can help refine the current knowledge about disease mechanisms, diagnostics, and therapeutics. Here we describe the March of Dimes' Database for Preterm Birth Research (http://www.immport.org/resources/mod), a unique resource that contains a variety of 'omics' datasets related to preterm birth. The database is open publicly, and as of January 2018, links 13 molecular studies with data across tens of thousands of patients from 6 measurement modalities. The data in the repository are highly diverse and include genomic, transcriptomic, immunological, and microbiome data. Relevant datasets are augmented with additional molecular characterizations of almost 25,000 biological samples from public databases. We believe our data-sharing efforts will lead to enhanced research collaborations and coordination accelerating the overall pace of discovery in preterm birth research

Cognitive Arousal Mediates the Relationship between Perceived Ostracism and Sleep Quality but it is not Moderated by Experiential Avoidance

Previous research suggests that longer‐term perceived ostracism is related to poor sleep quality. In this study, we investigated the mediating effect of cognitive arousal on the perceived ostracism‐sleep quality relationship. We also investigated whether experiential avoidance was a moderator of the cognitive arousal‐sleep quality relationship. Participants (N = 251) were recruited through online research portals to take part in an online survey. A path analysis was used to test a moderated mediation effect between variables. It was found that cognitive arousal mediated the perceived ostracism‐sleep quality relationship, however, experiential avoidance was not a significant moderator. These findings suggest that further research needs to be conducted to elucidate the mechanism of experiential avoidance to account for when it may impact sleep quality. Moreover, treatment interventions targeted at reducing cognitive arousal (e.g., cognitive behavioral therapy) prior to sleep are likely to bear some fruit

Supplementary Material: PREMATURE EXPRESSION OF AN AGE-ASSOCIATED MUSCLE SENESCENCE PATHWAY IN HIV INFECTION

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On Orbital Period Changes in Nova Outbursts

We propose a new mechanism that produces an orbital period change during a nova outburst. When the ejected material carries away the specific angular momentum of the white dwarf, the orbital period increases. A magnetic field on the surface of the secondary star forces a fraction of the ejected material to corotate with the star, and hence the binary system. The ejected material thus takes angular momentum from the binary orbit and the orbital period decreases. We show that for sufficiently strong magnetic fields on the surface of the secondary star, the total change to the orbital period could even be negative during a nova outburst, contrary to previous expectations. Accurate determinations of pre- and post-outburst orbital periods of recurrent nova systems could test the new mechanism, in addition to providing meaningful constraints on otherwise difficult to measure physical quantities. We apply our mechanism to outbursts of the recurrent nova U Sco.Comment: Accepted for publication in MNRA

Listening to the parent voice to inform person-centred neonatal care.

Family integrated care (FIC), where parents are an integral part of their baby’s care and decision-making can enhance parental involvement and empowerment, contributing to decreased parental separation and stress. It follows that parents can also be a central part of neonatal education for staff in the neonatal speciality. This paper focuses on what students and staff can learn from parents about what they feel is important to make their experience better. A narrative, interpretive approach was undertaken to collect and analyse parent interview narratives. A specific question was posed to a purposive sample of parents who have had premature babies about what health professionals can learn from them. Thematic analysis revealed five key themes relating to the importance of: communicating; listening; empathising; acknowledging (the parent’s role); realising (what matters to parents). These elements were incorporated into a framework named by the mnemonic, ‘CLEAR’. This highlights what parents want staff to be cognisant of when caring for them and their babies. Learning from the parents in our care enables a greater understanding of their experiences at difficult and challenging times. Having a deeper understanding of parents’ experiences can contribute to enhanced empathic learning.Peer reviewedFinal Accepted Versio

Quantitative diffusion tensor imaging detects dopaminergic neuronal degeneration in a murine model of Parkinson\u27s disease.

Early diagnosis of Parkinson\u27s disease (PD) is required to improve therapeutic responses. Indeed, a clinical diagnosis of resting tremor, rigidity, movement and postural deficiencies usually reflect \u3e50% loss of the nigrostriatal system in disease. In a step to address this, quantitative diffusion tensor magnetic resonance imaging (DTI) was used to assess nigrostriatal degeneration in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) intoxication model of dopaminergic nigral degeneration. We now demonstrate increased average diffusion (p\u3c0.005) and decreased fractional anisotropy (p\u3c0.03) in the substantia nigra (SN) of 5- to 7-day MPTP-treated animals when compared to saline controls. Transverse diffusivity demonstrated the most significant differences (p \u3c or = 0.002) and correlated with the numbers of SN dopaminergic neurons (r=-0.75, p=0.012). No differences were found in the striatum, corpus callosum, cerebral cortex, or ventricles. These results demonstrate that DTI may be used as a surrogate biomarker of nigral dopaminergic neuronal degeneration

Air Pollution With 2.5 Micron Particulate Matters and Testing the Decay of the Aerosol Concentration as a Function of Time to Compare the Efficiency of AHPCO® and Bi-Polar Units in Reducing the Indoor Particle Counts

One of the top environmental concerns of the world today is air pollution, which is affecting our health every day (Bickerstaff & Walker, 2001). Studies have shown that air pollution has a major effect in human health by increasing sickness and death (Dockery, & Pope III, 1994). A major form of air pollution is aerosol; scientists describe it as tiny, airborne solid and liquid particles that are released by Earth's surface both naturally and as a product of human activities (Simmon, & Voiland, 2010; NOAA Earth System Research Laboratory [NOAA], 2017). Our biggest problem with air pollution is the aerosols in the form of Particulate Matter (PM), also known as particulate pollution. The most dangerous particulate matters are those which are less than 10 micrometers, because when inhaled, they can reach deep down into our lungs and even into our bloodstreams (U.S Environmental Protection Agency [EPA], “Particulate Matter (PM) Basic,” 2017). The purpose of this study was to test a new kind of air purifier, and help the public make the right choice for their health. In this research several experiments were conducted using the Air Oasis filter-less air purifier with Advanced Hydrated Photo Catalytic Oxidation (AHPCO) and Bi-polar units inside the fiberglass chambers to estimate the decay of aerosol concentration as function of time. In higher concentration a prominent rate of decay was measured when using the Air Oasis units however, there has not been any significant change at the lower concentration