Performance of the ADAPT-Treated CardioCel® Scaffold in pediatric patients with congenital cardiac anomalies: Medium to Long-Term outcomes

Background: A Phase II Clinical Trial reviewed the performance (morbidity and calcification) of the tissue-engineered ADAPT® bovine pericardial scaffold (CardioCel®) in pediatric patients (n = 30) with congenital cardiac defects. In that study, CardioCel® demonstrated no graft-related morbidity and mortality in 25 patients, over 12 months. Five patients died due to non-graft-related events. Echocardiography revealed hemodynamically stable repairs with no calcification of the scaffold. Magnetic resonance imaging (MRI) at 12 months in 10 patients confirmed the absence of calcification. These patients were followed up for further up to 10 years. We present the results of this retrospective review of these patients that were followed for further medium to long-term (median 7.2 years, 25%: 3.6 years 75%: 9.25 years) postoperatively in these patients. Methods: Between April 2008 and September 2009, CardioCel® was implanted in 30 patients with congenital cardiac defects. Efficacy measures included graft-related mortality, morbidity and haemodynamic abnormalities. Calcification was assessed by standard 2D-M mode echocardiography and MRI at 12 months. Medium to long-term assessment included routine clinical assessments and echocardiography. Results: Median age at surgery was 18 months (27 days−13 years). Twenty-five patients (142 patient years) were followed for up to 10 years. The 10-year survival rate is estimated as 86.9% (95% CI 71.4–100.0%) over the entire follow-up period. One patient was lost to follow-up. No graft-related mortality was encountered up to a median follow-up of 7.2 years. Two patients died (pacemaker complications >5 years and arrhythmia >7 years postoperatively). No graft failure, thromboembolic events, infections or device-related reinterventions were recorded. Non-significant residual leaks occurred in 3 patients. Echocardiography demonstrated the absence of calcification in all implants. Conclusion: The tissue-engineered ADAPT® bovine pericardial scaffold demonstrated excellent medium to long-term performance (up to 10 years) when used as a scaffold for repair of congenital cardiac defects in children. Durability, acellularity, biostability and non-calcifying potential of CardioCel® makes it a very attractive tissue for congenital cardiac repair procedures

Fluctuations of a Greenlandic tidewater glacier driven by changes in atmospheric forcing : observations and modelling of Kangiata Nunaata Sermia, 1859–present

Acknowledgements. The authors wish to thank Stephen Price, Mauri Pelto, and the anonymous reviewer for their reviews and comments that helped to improve the manuscript. RACMO2.1 data were provided by Jan van Angelen and Michiel van den Broeke, IMAU, Utrecht University. MAR v3.2 data used for runoff calculations were provided by Xavier Fettweis, Department of Geography, University of Liège. The photogrammetric DEM used in Figs. 1 and 3 was provided by Kurt H. Kjær, Centre for GeoGenetics, University of Copenhagen. This research was financially supported by J. M. Lea’s PhD funding, NERC grant number NE/I528742/1. Support for F. M. Nick was provided through the Conoco-Phillips/Lundin Northern Area Program CRIOS project (Calving Rates and Impact on Sea Level).Peer reviewedPublisher PD

The Delta E-Commerce Connection: Preliminary Findings

A USDA Fund for Rural America project is creating economic opportunities for small agricultural and rural businesses in the Lower Mississippi Delta by assisting in e-commerce business development. Select rural businesses are provided technical support in web site development, marketing strategy formulation, electronic retailing services, and space on a secure server for one year. Businesses retaining web sites after this time assume responsibility for maintaining and funding the site. Characteristics of rural businesses adopting e-commerce are compared with those not adopting. Preliminary results suggest the amount of time invested in initial web site design, satisfaction with design, economic benefits from owning a web site, and number of levels traveled in the e-commerce roadmap (a measure of technological progress) as determinants of success. These findings will assist in selecting and guiding participant involvement to maximize the likelihood of success

The glacial geomorphology of upper Godthåbsfjord (Nuup Kangerlua) in south-west Greenland

© 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group on behalf of Journal of Maps. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.The Greenland Ice Sheet (GrIS) is known to have experienced widespread retreat over the last century. Information on outlet glacier dynamics, prior to this, are limited due to both a lack of observations and a paucity of mapped or mappable deglacial evidence which restricts our understanding of centennial to millennial timescale dynamics of the GrIS. Here we present glacial geomorphological mapping, for upper Godthåbsfjord, covering 5800 km 2 at a scale of 1:92,000, using a combination of ASTER GDEM V2, a medium-resolution DEM (error < 10 m horizontal and < 6 m vertical accuracy), panchromatic orthophotographs and ground truthing. This work provides a detailed geomorphological assessment for the area, compiled as a single map, comprising of moraines, meltwater channels, streamlined bedrock, sediment lineations, ice-dammed lakes, trimlines, terraces, gullied sediment and marine limits. Whilst some of the landforms have been previously identified, the new information presented here improves our understanding of ice margin behaviour and can be used for future numerical modelling and landform dating programmes. Data also form the basis for palaeoglaciological reconstructions and contribute towards understanding of the centennial to millennial timescale record of this sector of the GrIS.Peer reviewedFinal Published versio

Use of ultrasonics in swine improvement

"Today's swine producer must produce pork that is highly acceptable to consumers yet within a cost that permits a profit. Ultrasonics allows objective measurement of back fat and loin-eye area, two traits that recent research has shown to have a close relationship to total red meat in an animal. Progressive swine breeders consider these two highly inheritable carcass traits in their selection programs to increase the red meat portion of animals."--First page.M.A. Alexander, J.W. Massey, J.C. Rea, and R.O. Bates (Department of Animal Science, College of Agriculture)Revised 5/88/10

Discovery of a Transiting Planet Near the Snow-Line

In most theories of planet formation, the snow-line represents a boundary between the emergence of the interior rocky planets and the exterior ice giants. The wide separation of the snow-line makes the discovery of transiting worlds challenging, yet transits would allow for detailed subsequent characterization. We present the discovery of Kepler-421b, a Uranus-sized exoplanet transiting a G9/K0 dwarf once every 704.2 days in a near-circular orbit. Using public Kepler photometry, we demonstrate that the two observed transits can be uniquely attributed to the 704.2 day period. Detailed light curve analysis with BLENDER validates the planetary nature of Kepler-421b to >4 sigmas confidence. Kepler-421b receives the same insolation as a body at ~2AU in the Solar System and for a Uranian albedo would have an effective temperature of ~180K. Using a time-dependent model for the protoplanetary disk, we estimate that Kepler-421b's present semi-major axis was beyond the snow-line after ~3Myr, indicating that Kepler-421b may have formed at its observed location.Comment: 14 pages, 10 figures, 3 tables. Accepted in Ap

The missing GeV {\gamma}-ray binary: Searching for HESS J0632+057 with Fermi-LAT

The very high energy (VHE; >100 GeV) source HESS J0632+057 has been recently confirmed as a \gamma-ray binary, a subclass of the high mass X-ray binary (HMXB) population, through the detection of an orbital period of 321 days. We performed a deep search for the emission of HESS J0632+057 in the GeV energy range using data from the Fermi Large Area Telescope (LAT). The analysis was challenging due to the source being located in close proximity to the bright \gamma-ray pulsar PSR J0633+0632 and lying in a crowded region of the Galactic plane where there is prominent diffuse emission. We formulated a Bayesian block algorithm adapted to work with weighted photon counts, in order to define the off-pulse phases of PSR J0633+0632. A detailed spectral-spatial model of a 5 deg circular region centred on the known location of HESS J0632+057 was generated to accurately model the LAT data. No significant emission from the location of HESS J0632+057 was detected in the 0.1-100 GeV energy range integrating over ~3.5 years of data; with a 95% flux upper limit of F_{0.1-100 GeV} < 3 x 10-8 ph cm-2 s-1. A search for emission over different phases of the orbit also yielded no significant detection. A search for source emission on shorter timescales (days--months) did not yield any significant detections. We also report the results of a search for radio pulsations using the 100-m Green Bank Telescope (GBT). No periodic signals or individual dispersed bursts of a likely astronomical origin were detected. We estimated the flux density limit of < 90/40 \mu Jy at 2/9 GHz. The LAT flux upper limits combined with the detection of HESS J0632+057 in the 136-400 TeV energy band by the MAGIC collaboration imply that the VHE spectrum must turn over at energies <136 GeV placing constraints on any theoretical models invoked to explain the \gamma-ray emission.Comment: 11 pages, 4 figures, accepted for publication in Monthly Notices of the Royal Astronomical Society (MNRAS) Main Journa

Spontaneous Pneumo-Mediastinum in a Post-COVID-19 Patient with Systemic Sclerosis

Pulmonary involvement is the most common cause of death among patients with systemic sclerosis (SSc). The current coronavirus disease 2019 (COVID-19) is particularly problematic to manage in SSc patients since they may experience a more severe evolution of COVID-19 due to the pre-existent interstitial lung disease (ILD) and the administration of immunosuppressive treatments. In addition, the remarkable radiological similarities between SSc-ILD and COVID-19 complicate the differential diagnosis between these two entities. Herein, we present the first case of spontaneous pneumo-mediastinum in a post-COVID-19 patient with SSc. In our patient, both smoking and pulmonary fibrosis could lead to cyst formation, which possibly spontaneously broke and caused pneumo-mediastinum. Moreover, megaesophagus perforation due to the smooth muscle atrophy, replacement with fibrosis, and achalasia may extend into the mediastinum or pleural space and has also been described as a rare case of spontaneous pneumo-pericardium. Finally, spontaneous pneumo-mediastinum and pneumothorax have been recently reported as an established complication of severe COVID-19 pneumonia and among COVID-19 long-term complication. This case report underlines that the worsening of respiratory symptoms in SSc patients, especially when recovered from COVID-19, requires further investigations for ruling out other tentative diagnoses besides the evolution of the SSc-ILD

Discovery of Pulsations and a Possible Spectral Feature in the X-ray Emission from Rotating Radio Transient J1819-1458

PSR J1819-1458 is a rotating radio transient (RRAT) source with an inferred surface dipole magnetic field strength of 5e13 G and a 4.26-s spin period. We present XMM-Newton observations of the X-ray counterpart of this source, CXOU J181939.1-145804, in which we identify pulsations and a possible spectral feature. The X-ray pulsations are at the period predicted by the radio ephemeris, providing an unambiguous identification with the radio source and confirmation of its neutron star nature. The X-ray pulse has a 0.3-5 keV pulsed fraction of 34% and is aligned with the expected phase of the radio pulse. The X-ray spectrum is fit well by an absorbed blackbody with kT = 0.14 keV with the addition of an absorption feature at 1 keV, with total absorbed flux of 1.5e-13 ergs/cm^2/s (0.3-5 keV). This absorption feature is well modeled by a Gaussian or resonant cyclotron scattering model, but its significance is dependent on the choice of continuum model. We find no evidence for any X-ray bursts or aperiodic variability on timescales of 6 ms to the duration of the observation and can place the most stringent limit to date of < 3e-9 ergs/cm^2/s on the absorbed 0.3-5 keV flux of any bursts.Comment: 5 figures, accepted by Ap