Value Assessment of Business-to-Government Innovations: a Case Study

This article studies value assessments of IT solutions in public as well as in private contexts and aims to identify benefits of business-to-government innovations. The work analyzes the case of the implementation of European common e-customs solutions. Over the last few years, e-customs has become a widely studied topic within the European Union. However, only a little research has been conducted in order to identify benefits of such IT innovations. For this reason, this paper is dedicated to the value assessment of e-customs solutions. Within the framework of a European funded project, the study was conducted collecting data from interviews and workshops involving stakeholders coming from public as well as private organizations. By applying a theoretical value assessment framework, four main areas of improvement due to common e-customs solutions’ implementation were identified: increased security, reduction of administrative burden, facilitated compliance, and better communication. This article contributes towards value assessment research and in particular to a standardized e-customs solution as an example of business-to-government innovations

Challenges of Global Trade and the Transfer to e-Enabled Business Models in the Swiss Socks Market

Recent research has acknowledged the need to shift from the traditional one to one e-enabled business model to a many-to-many one. With the introduction of the Internet in the 1990’s companies such as Blacksocks SA and Jacob Rohner AG suddenly found a mean and the environment to think about e-enabling their business models or even start a company purely based on that existence. Building on a wide range of analysis of the terms business models and e-business models, e-business models to our understanding depict a company’s capability to apply, use or even exist throughout the presence of an e-enabled environment. The internet itself is being seen as a family of tools, methodologies and concepts to represent the e-enabled environment. Currie and others are drawing the attention to value creation from e-business models and Joyce and Winch discuss the evolvement of a business model to become e-enabled (Currie, 2004). In contrast to their key findings, the EU research project ITAIDE and the underlying business cases in this paper go beyond. The argumentation and the conclusion we will infer in the paper show that e-enabled business models are much more than applying tools, methodologies through the simple existence of the Internet. Further than the reach of companies, collaborative and decent research environments such as ITAIDE allow companies and ecosystems to adopt from the research findings and transfer those into applicable and scalable e-business models

Time to Switch to Second-line Antiretroviral Therapy in Children With Human Immunodeficiency Virus in Europe and Thailand.

Background: Data on durability of first-line antiretroviral therapy (ART) in children with human immunodeficiency virus (HIV) are limited. We assessed time to switch to second-line therapy in 16 European countries and Thailand. Methods: Children aged <18 years initiating combination ART (≥2 nucleoside reverse transcriptase inhibitors [NRTIs] plus nonnucleoside reverse transcriptase inhibitor [NNRTI] or boosted protease inhibitor [PI]) were included. Switch to second-line was defined as (i) change across drug class (PI to NNRTI or vice versa) or within PI class plus change of ≥1 NRTI; (ii) change from single to dual PI; or (iii) addition of a new drug class. Cumulative incidence of switch was calculated with death and loss to follow-up as competing risks. Results: Of 3668 children included, median age at ART initiation was 6.1 (interquartile range (IQR), 1.7-10.5) years. Initial regimens were 32% PI based, 34% nevirapine (NVP) based, and 33% efavirenz based. Median duration of follow-up was 5.4 (IQR, 2.9-8.3) years. Cumulative incidence of switch at 5 years was 21% (95% confidence interval, 20%-23%), with significant regional variations. Median time to switch was 30 (IQR, 16-58) months; two-thirds of switches were related to treatment failure. In multivariable analysis, older age, severe immunosuppression and higher viral load (VL) at ART start, and NVP-based initial regimens were associated with increased risk of switch. Conclusions: One in 5 children switched to a second-line regimen by 5 years of ART, with two-thirds failure related. Advanced HIV, older age, and NVP-based regimens were associated with increased risk of switch

Du mot &#224; l&#8217;action. Histoire et analyse linguistique de &#8220;La France, pays de mission?&#8221;

Capita a volte di incontrare dei libri che continuano ad essere citati dopo molti anni e che per questo producono una forte intertestualit\ue0, ponendosi come "fondatori" in rapporto al discorso che essi contribuiscono a legittimare. "La France pays de mission?" di Yvan Daniel e Henri Godin \ue8 uno di questi libri. Pubblicato nell'estate del 1943, questa opera circol\uf2 ampiamente durante i mesi seguenti e incoraggi\uf2 l'azione dei preti operai e dei laici cattolici impegnati nella "conquista" degli ambienti operai. ___ Il arrive parfois de rencontrer des livres qui continuent \ue0 \ueatre cit\ue9s apr\ue8s plusieurs ann\ue9es et qui, par l\ue0-m\ueame, donnent lieu \ue0 une forte intertextualit\ue9, se posant donc comme \uab fondateurs \ubb par rapport au discours qu\u2019ils contribuent \ue0 l\ue9gitimer. \uab La France pays de mission ? \ubb d\u2019Yvan Daniel et d\u2019Henri Godin est l\u2019un de ces livres. Publi\ue9 en \ue9t\ue9 1943, cet ouvrage circule amplement pendant les mois suivants et encourage l\u2019action des pr\ueatres et des la\uefcs catholiques qui se sont engag\ue9s dans la \uab conqu\ueate \ubb des milieux ouvriers

4. Pour une approche historico-linguistique des documents historiques. Croisements inter/transdisciplinaires en France et en Italie

Depuis quelques années désormais, nous nous sommes penchées sur la possibilité de croiser les méthodes linguistiques avec celles de l’histoire dans l’effort d’interroger les documents historiques de deux observatoires complémentaires (interdisciplinarité) mais aussi de mieux faire ressortir le lien entre la parole et l’action du point de vue du réel historique et des événements (transdisciplinarité). Dans ces brèves notes, nous avons essayé de faire le point sur la manière dont ces croisements inter/transdisciplinaires se sont produits en France et en Italie, ainsi que de montrer de quelles manières il est possible de rendre complémentaires les méthodes qualitatives et quantitatives, en présentant enfin des pistes de recherches concernant les catégories de «sujet» et de «temps»

Pour une approche historico-linguistique des documents historiques. Croisements inter/transdisciplinaires en France et en Italie

open2noDepuis quelques années désormais, nous nous sommes penchées sur la possibilité de croiser les méthodes linguistiques avec celles de l’histoire dans l’e ort d’interroger les documents historiques de deux observatoires complémentaires (interdisciplina- rité) mais aussi de mieux faire ressortir le lien entre la parole et l’action du point de vue du réel historique et des événements (transdisciplinarité). Dans ces brèves notes, nous avons essayé de faire le point sur la manière dont ces croisements in- ter/transdisciplinaires se sont produits en France et en Italie, ainsi que de montrer de quelles manières il est possible de rendre complémentaires les méthodes quali- tatives et quantitatives, en présentant en n des pistes de recherches concernant les catégories de « sujet » et de « temps ».openMARGOTTI, Marta; RAUS, RacheleMARGOTTI, Marta; RAUS, Rachel

Pour une approche historico-linguistique des documents historiques. Croisements inter/transdisciplinaires en France et en Italie

Depuis quelques années désormais, nous nous sommes penchées sur la possibilité de croiser les méthodes linguistiques avec celles de l’histoire dans l’effort d’interroger les documents historiques de deux observatoires complémentaires (interdisciplinarité) mais aussi de mieux faire ressortir le lien entre la parole et l’action du point de vue du réel historique et des événements (transdisciplinarité). Dans ces brèves notes, nous avons essayé de faire le point sur la manière dont ces croisements inter/transdisciplinaires se sont produits en France et en Italie, ainsi que de montrer de quelles manières il est possible de rendre complémentaires les méthodes qualitatives et quantitatives, en présentant enfin des pistes de recherches concernant les catégories de «sujet» et de «temps»

Tra linguistica e storia: incroci metodologici e percorsi di ricerca [Interventi di Jean-Philippe Genet, Michele A. Cortelazzo, Jacques Guilhaumou, Pietro Trifone, Marta Margotti, Rachele Raus, Francesca Socrate]

Contemporanea, n°2, 2013Textes croisés paru dans "Contemporanea", n°2, 2013Textes croisés parus dans "Contemporanea", n°2, 201

Prevalence and Clinical Outcomes of Poor Immune Response Despite Virologically Suppressive Antiretroviral Therapy Among Children and Adolescents With Human Immunodeficiency Virus in Europe and Thailand: Cohort Study

International audienceIn human immunodeficiency virus (HIV)-positive adults, low CD4 cell counts despite fully suppressed HIV-1 RNA on antiretroviral therapy (ART) have been associated with increased risk of morbidity and mortality. We assessed the prevalence and outcomes of poor immune response (PIR) in children receiving suppressive ART

Prevalence and Clinical Outcomes of Poor Immune Response Despite Virologically Suppressive Antiretroviral Therapy Among Children and Adolescents With Human Immunodeficiency Virus in Europe and Thailand: Cohort Study

BACKGROUND: In human immunodeficiency virus (HIV)-positive adults, low CD4 cell counts despite fully suppressed HIV-1 RNA on antiretroviral therapy (ART) have been associated with increased risk of morbidity and mortality. We assessed the prevalence and outcomes of poor immune response (PIR) in children receiving suppressive ART. METHODS: Sixteen cohorts from the European Pregnancy and Paediatric HIV Cohort Collaboration (EPPICC) contributed data. Children &lt;18 years at ART initiation, with sustained viral suppression (VS) (≤400 copies/mL) for ≥1 year were included. The prevalence of PIR (defined as World Health Organization advanced/severe immunosuppression for age) at 1 year of VS was described. Factors associated with PIR were assessed using logistic regression. Rates of acquired immunodeficiency syndrome (AIDS) or death on suppressive ART were calculated by PIR status. RESULTS: Of 2318 children included, median age was 6.4 years and 68% had advanced/severe immunosuppression at ART initiation. At 1 year of VS, 12% had PIR. In multivariable analysis, PIR was associated with older age and worse immunological stage at ART start, hepatitis B coinfection, and residing in Thailand (all P ≤ .03). Rates of AIDS/death (95% confidence interval) per 100 000 person-years were 1052 (547, 2022) among PIR versus 261 (166, 409) among immune responders; rate ratio of 4.04 (1.83, 8.92; P &lt; .001). CONCLUSIONS: One in eight children in our cohort experienced PIR despite sustained VS. While the overall rate of AIDS/death was low, children with PIR had a 4-fold increase in risk of event as compared with immune responders