Evaluation of different cultivars of sorghum for fodder quality and agronomic performance in Semi-Arid Tropics

Thirty four improved sorghum cultivars were evaluated for fodder quality and agronomic performance using two cuts harvested during the rainy season 2014 at ICRISAT, Patancheru following randomized complete block design with two replications. Within cuts consistent significant cultivar difference were only observed for biomass yields which ranged from 17.3 - 33.8 t ha-1 in the first cut to 3.2 and 17.4 t ha-1 in the second cut. Within and across cuts cultivar-dependent variations in fodder quality traits were statistically largely insignificant and inconsistent

Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362

A numerical model for residual circulation and pollutant transport in a tidal estuary (Hooghly) of NE coast of India

129-137To study pollutant dispersal in the estuary a non-linear vertically integrated numerical model has been applied to the Hooghly estuary along the east coast of India. The horizontal density gradient terms are included in a two-dimensional depth-averaged hydrodynamic model. Biochemical oxygen demand (BOD) was adopted as a tracer for water quality. The model uses a realistic tidal forcing, fresh water flow based on observations and climatic winds over the region of interest. The effects of wind and horizontal density gradients on the residual circulation are found to be significant. Pollutants discharged in the upper estuary do not affect the Haldia channel. The model predictions compare reasonably well with observed elevations and currents in the estuary. For verification of pollutant transport model, observational data is presently unavailable, however, the salinity distribution compares well with the observations

Short-chain fatty acid receptors inhibit invasive phenotypes in breast cancer cells

10.1371/journal.pone.0186334PLoS ONE1210e018633